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{
{
   "id": "https://openalex.org/T13415",
   "OpenAlex": {
  "display_name": "Lysosomal Calcium Signaling in Physiology and Pathology",
    "display_name": "Lysosomal Calcium Signaling in Physiology and Pathology",
  "description": "This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.",
    "description": "This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.",
  "keywords": [
    "keywords": [
    "Lysosomal Calcium Signaling",
      "Lysosomal Calcium Signaling",
    "Two-pore Channels",
      "Two-pore Channels",
    "NAADP",
      "NAADP",
    "TRPML1",
      "TRPML1",
    "Endolysosomal Trafficking",
      "Endolysosomal Trafficking",
    "Cyclic ADP-Ribose",
      "Cyclic ADP-Ribose",
    "Mucolipidosis Type IV",
      "Mucolipidosis Type IV",
    "Intracellular Calcium Release",
      "Intracellular Calcium Release",
    "Nicotinic Acid Adenine Dinucleotide Phosphate",
      "Nicotinic Acid Adenine Dinucleotide Phosphate",
    "Lysosomal Storage Diseases"
      "Lysosomal Storage Diseases"
  ],
    ],
  "ids": {
    "ids": {
    "openalex": "https://openalex.org/T13415",
      "openalex": "https://openalex.org/T13415",
    "wikipedia": "https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling"
      "wikipedia": "https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling"
  },
  "subfield": {
    "id": "https://openalex.org/subfields/1314",
    "display_name": "Physiology"
  },
  "field": {
    "id": "https://openalex.org/fields/13",
    "display_name": "Biochemistry, Genetics and Molecular Biology"
  },
  "domain": {
    "id": "https://openalex.org/domains/1",
    "display_name": "Life Sciences"
  },
  "siblings": [
    {
      "id": "https://openalex.org/T12976",
      "display_name": "Influence of Magnetic Fields on Biological Systems"
     },
     },
     {
     "subfield": {
       "id": "https://openalex.org/T11193",
       "id": "https://openalex.org/subfields/1314",
       "display_name": "Molecular Physiology of Purinergic Signalling"
       "display_name": "Physiology"
     },
     },
     {
     "field": {
       "id": "https://openalex.org/T11505",
       "id": "https://openalex.org/fields/13",
       "display_name": "Reproductive Physiology and Endocrine Disruption in Fish"
       "display_name": "Biochemistry, Genetics and Molecular Biology"
     }
     },
  ],
    "domain": {
  "works_count": 9663,
      "id": "https://openalex.org/domains/1",
  "cited_by_count": 288243,
      "display_name": "Life Sciences"
  "updated_date": "2024-08-26T05:32:36.297173",
    },
  "created_date": "2024-01-23"
    "updated_date": "2024-08-12T05:18:46.035266",
    "created_date": "2024-01-23",
    "type": "topic",
    "oa_id": "T13415",
    "id": "https://openalex.org/T13415"
  }
}
}
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