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OpenAlex: !!python/object/new:pyalex.api.Topic
{
   dictitems:
  "id": "https://openalex.org/T12255",
    cited_by_count: 184397
   "display_name": "Immunogenicity of Biosimilar Therapeutics in Drug Development",
    created_date: '2024-01-23'
  "description": "This cluster of papers focuses on the immunogenicity of biosimilar therapeutics, including the validation of bioanalytical methods for assessing immunogenicity, the impact of manufacturing changes on immunogenicity, and the clinical outcomes and safety of switching from reference biologics to biosimilars. The use of dried blood spots for bioanalysis and the regulatory considerations for biosimilars are also prominent topics within this cluster.",
    description: This cluster of papers focuses on the immunogenicity of biosimilar
  "keywords": [
      therapeutics, including the validation of bioanalytical methods for assessing
     "Biosimilars",
      immunogenicity, the impact of manufacturing changes on immunogenicity, and the
    "Immunogenicity",
      clinical outcomes and safety of switching from reference biologics to biosimilars.
    "Bioanalytical Methods",
      The use of dried blood spots for bioanalysis and the regulatory considerations
    "Therapeutic Proteins",
      for biosimilars are also prominent topics within this cluster.
    "Dried Blood Spots",
     display_name: Immunogenicity of Biosimilar Therapeutics in Drug Development
    "Erythropoietin Antibodies",
     domain:
    "Monoclonal Antibodies",
      display_name: Life Sciences
    "Regulatory Guidelines",
      id: https://openalex.org/domains/1
    "Biopharmaceuticals",
     field:
     "Clinical Outcomes"
      display_name: Immunology and Microbiology
  ],
      id: https://openalex.org/fields/24
  "ids": {
     id: https://openalex.org/T12255
    "openalex": "https://openalex.org/T12255",
     ids:
     "wikipedia": "https://en.wikipedia.org/wiki/Biosimilar"
      openalex: https://openalex.org/T12255
  },
      wikipedia: https://en.wikipedia.org/wiki/Biosimilar
  "subfield": {
     keywords:
     "id": "https://openalex.org/subfields/2403",
    - Biosimilars
     "display_name": "Immunology"
    - Immunogenicity
  },
     - Bioanalytical Methods
  "field": {
    - Therapeutic Proteins
    "id": "https://openalex.org/fields/24",
    - Dried Blood Spots
    "display_name": "Immunology and Microbiology"
    - Erythropoietin Antibodies
  },
    - Monoclonal Antibodies
  "domain": {
    - Regulatory Guidelines
    "id": "https://openalex.org/domains/1",
    - Biopharmaceuticals
     "display_name": "Life Sciences"
    - Clinical Outcomes
  },
    siblings:
  "siblings": [
    - display_name: Genetic Basis of Primary Immunodeficiency Disorders
     {
       id: https://openalex.org/T11725
      "id": "https://openalex.org/T11725",
    - display_name: Human T-cell Leukemia Virus Type 1 Infection
      "display_name": "Genetic Basis of Primary Immunodeficiency Disorders"
       id: https://openalex.org/T12159
    },
    - display_name: Immunobiology of Dendritic Cells
    {
       id: https://openalex.org/T10580
       "id": "https://openalex.org/T12159",
    - display_name: Immunological Mechanisms in Atherosclerosis Development
      "display_name": "Human T-cell Leukemia Virus Type 1 Infection"
       id: https://openalex.org/T12955
    },
    - display_name: Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface
    {
       id: https://openalex.org/T11510
       "id": "https://openalex.org/T10580",
    - display_name: Immunological Responses in Aquatic Organisms
      "display_name": "Immunobiology of Dendritic Cells"
       id: https://openalex.org/T10506
    },
    - display_name: Immunotoxicology in Toxicologic Pathology Research
    {
       id: https://openalex.org/T14072
       "id": "https://openalex.org/T12955",
    - display_name: Immunotoxin Therapy for Cancer Treatment
      "display_name": "Immunological Mechanisms in Atherosclerosis Development"
       id: https://openalex.org/T12477
    },
    - display_name: Innate Immune Recognition and Signaling Pathways
    {
       id: https://openalex.org/T10371
       "id": "https://openalex.org/T11510",
    - display_name: Innate Immunity to Viral Infection
      "display_name": "Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface"
       id: https://openalex.org/T11668
    },
    - display_name: Innate Lymphoid Cells in Immunity
    {
       id: https://openalex.org/T12528
       "id": "https://openalex.org/T10506",
    - display_name: Invertebrate Immunity and Host Defense Mechanisms
      "display_name": "Immunological Responses in Aquatic Organisms"
       id: https://openalex.org/T11403
    },
    - display_name: Macrophage Activation and Polarization
    {
       id: https://openalex.org/T11313
       "id": "https://openalex.org/T14072",
    - display_name: Mechanisms of Apoptotic Cell Clearance and Immune Regulation
      "display_name": "Immunotoxicology in Toxicologic Pathology Research"
       id: https://openalex.org/T12672
    },
    - display_name: Natural Killer Cells in Immunity
    {
       id: https://openalex.org/T11020
       "id": "https://openalex.org/T12477",
    - display_name: Reciprocal Development of TH17 and Treg Cells
      "display_name": "Immunotoxin Therapy for Cancer Treatment"
       id: https://openalex.org/T10469
    },
    - display_name: Regulatory T Cell Development and Function
    {
       id: https://openalex.org/T10031
       "id": "https://openalex.org/T10371",
    - display_name: Role of Complement System in Immune Response
      "display_name": "Innate Immune Recognition and Signaling Pathways"
       id: https://openalex.org/T10993
    },
    - display_name: Role of Galectins in Immunity and Disease
    {
       id: https://openalex.org/T12387
       "id": "https://openalex.org/T11668",
    - display_name: Role of Macrophage Migration Inhibitory Factor
      "display_name": "Innate Immunity to Viral Infection"
       id: https://openalex.org/T13254
    },
    - display_name: Role of Mast Cells in Immunoregulation and Disease
    {
       id: https://openalex.org/T11346
       "id": "https://openalex.org/T12528",
    - display_name: Role of Neutrophil Extracellular Traps in Immunity
      "display_name": "Innate Lymphoid Cells in Immunity"
       id: https://openalex.org/T11597
    },
    - display_name: Role of Pentraxins in Innate Immunity and Inflammation
    {
       id: https://openalex.org/T14245
       "id": "https://openalex.org/T11403",
    - display_name: Role of TREM-1 and Endocan in Inflammation
      "display_name": "Invertebrate Immunity and Host Defense Mechanisms"
       id: https://openalex.org/T14165
    },
    - display_name: Trained Immunity in Health and Disease
    {
      id: https://openalex.org/T13410
       "id": "https://openalex.org/T11313",
    subfield:
      "display_name": "Macrophage Activation and Polarization"
      display_name: Immunology
    },
      id: https://openalex.org/subfields/2403
    {
    updated_date: '2024-05-20T05:17:23.196634'
       "id": "https://openalex.org/T12672",
    works_count: 28125
      "display_name": "Mechanisms of Apoptotic Cell Clearance and Immune Regulation"
    },
    {
       "id": "https://openalex.org/T11020",
      "display_name": "Natural Killer Cells in Immunity"
    },
    {
       "id": "https://openalex.org/T10469",
      "display_name": "Reciprocal Development of TH17 and Treg Cells"
    },
    {
       "id": "https://openalex.org/T10031",
      "display_name": "Regulatory T Cell Development and Function"
    },
    {
       "id": "https://openalex.org/T10993",
      "display_name": "Role of Complement System in Immune Response"
    },
    {
       "id": "https://openalex.org/T12387",
      "display_name": "Role of Galectins in Immunity and Disease"
    },
    {
       "id": "https://openalex.org/T13254",
      "display_name": "Role of Macrophage Migration Inhibitory Factor"
    },
    {
       "id": "https://openalex.org/T11346",
      "display_name": "Role of Mast Cells in Immunoregulation and Disease"
    },
    {
       "id": "https://openalex.org/T11597",
      "display_name": "Role of Neutrophil Extracellular Traps in Immunity"
    },
    {
       "id": "https://openalex.org/T14245",
      "display_name": "Role of Pentraxins in Innate Immunity and Inflammation"
    },
    {
       "id": "https://openalex.org/T14165",
      "display_name": "Role of TREM-1 and Endocan in Inflammation"
    },
    {
       "id": "https://openalex.org/T13410",
      "display_name": "Trained Immunity in Health and Disease"
    }
  ],
  "works_count": 30310,
  "cited_by_count": 213605,
  "updated_date": "2024-08-26T05:29:10.382859",
  "created_date": "2024-01-23"
}
Retrieved from "https://geokb.wikibase.cloud/wiki/Special:MobileDiff/1125494"