Item talk:Q61204

From geokb

{

 "USGS Publications Warehouse": {
   "schema": {
     "@context": "https://schema.org",
     "@type": "CreativeWork",
     "additionalType": "USGS Numbered Series",
     "name": "Differential expression profiles of microRNA in the little brown bat (Myotis lucifugus) associated with white nose syndrome affected and unaffected individuals",
     "identifier": [
       {
         "@type": "PropertyValue",
         "propertyID": "USGS Publications Warehouse IndexID",
         "value": "ofr20131099",
         "url": "https://pubs.usgs.gov/publication/ofr20131099"
       },
       {
         "@type": "PropertyValue",
         "propertyID": "USGS Publications Warehouse Internal ID",
         "value": 70045702
       },
       {
         "@type": "PropertyValue",
         "propertyID": "DOI",
         "value": "10.3133/ofr20131099",
         "url": "https://doi.org/10.3133/ofr20131099"
       }
     ],
     "inLanguage": "en",
     "isPartOf": [
       {
         "@type": "CreativeWorkSeries",
         "name": "Open-File Report"
       }
     ],
     "datePublished": "2013",
     "dateModified": "2024-03-04",
     "abstract": "First documented in New York State in 2006, white nose syndrome (WNS) quickly became the leading cause of mortality in hibernating bat species in the United States. WNS is caused by a psychrophilic fungus, Geomyces destructans. Clinical signs of this pathogen are expressed as a dusty white fungus predominately around the nose and on the wings of affected bats. Relatively new biomarkers, such as microRNAs (miRNAs) are being targeted as markers to predict the syndrome prior to the clinical manifestation. The primary objective of this study was to identify miRNAs that could serve as biomarkers and proxies of little brown bat health. Bats were collected from hibernacula that had tested positive and negative for WNS. Genetic sequencing was completed using the Ion Torrent platform. A number of miRNAs were identified from the liver as putative biomarkers of WNS. However, given the small sample size for each treatment, this data set has only coarsely identified miRNAs indicative of WNS, and further validation is required.",
     "description": "iv, 11 p.",
     "publisher": {
       "@type": "Organization",
       "name": "U.S. Geological Survey"
     },
     "author": [
       {
         "@type": "Person",
         "name": "Iwanowicz, L. R.",
         "givenName": "L. R.",
         "familyName": "Iwanowicz",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "ORCID",
           "value": "0000-0002-1197-6178",
           "url": "https://orcid.org/0000-0002-1197-6178"
         }
       },
       {
         "@type": "Person",
         "name": "King, T.L.",
         "givenName": "T.L.",
         "familyName": "King"
       },
       {
         "@type": "Person",
         "name": "Iwanowicz, D.D.",
         "givenName": "D.D.",
         "familyName": "Iwanowicz"
       },
       {
         "@type": "Person",
         "name": "Hitt, N.P.",
         "givenName": "N.P.",
         "familyName": "Hitt",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "ORCID",
           "value": "0000-0002-1046-4568",
           "url": "https://orcid.org/0000-0002-1046-4568"
         }
       }
     ],
     "funder": [
       {
         "@type": "Organization",
         "name": "Leetown Science Center",
         "url": "https://www.usgs.gov/centers/eesc"
       },
       {
         "@type": "Organization",
         "name": "Eastern Ecological Science Center",
         "url": "https://www.usgs.gov/centers/eesc"
       }
     ]
   }
 },
 "OpenAlex": {
   "abstract_inverted_index": {
     "First": [
       0
     ],
     "documented": [
       1
     ],
     "in": [
       2,
       6,
       19,
       23
     ],
     "New": [
       3
     ],
     "York": [
       4
     ],
     "State": [
       5
     ],
     "2006,": [
       7
     ],
     "white": [
       8,
       46
     ],
     "nose": [
       9,
       51
     ],
     "syndrome": [
       10,
       74
     ],
     "(WNS)": [
       11
     ],
     "quickly": [
       12
     ],
     "became": [
       13
     ],
     "the": [
       14,
       24,
       50,
       54,
       73,
       77,
       120,
       131,
       140
     ],
     "leading": [
       15
     ],
     "cause": [
       16
     ],
     "of": [
       17,
       38,
       56,
       83,
       97,
       126,
       136,
       156
     ],
     "mortality": [
       18
     ],
     "hibernating": [
       20
     ],
     "bat": [
       21,
       100
     ],
     "species": [
       22
     ],
     "United": [
       25
     ],
     "States.": [
       26
     ],
     "WNS": [
       27
     ],
     "is": [
       28,
       161
     ],
     "caused": [
       29
     ],
     "by": [
       30
     ],
     "a": [
       31,
       44
     ],
     "psychrophilic": [
       32
     ],
     "fungus,": [
       33
     ],
     "Geomyces": [
       34
     ],
     "destructans.": [
       35
     ],
     "Clinical": [
       36
     ],
     "signs": [
       37
     ],
     "this": [
       39,
       84,
       147
     ],
     "pathogen": [
       40
     ],
     "are": [
       41,
       66
     ],
     "expressed": [
       42
     ],
     "as": [
       43,
       63,
       69,
       93,
       133
     ],
     "dusty": [
       45
     ],
     "fungus": [
       47
     ],
     "predominately": [
       48
     ],
     "around": [
       49
     ],
     "and": [
       52,
       95,
       111,
       158
     ],
     "on": [
       53
     ],
     "wings": [
       55
     ],
     "affected": [
       57
     ],
     "bats.": [
       58
     ],
     "Relatively": [
       59
     ],
     "new": [
       60
     ],
     "biomarkers,": [
       61
     ],
     "such": [
       62
     ],
     "microRNAs": [
       64
     ],
     "(miRNAs)": [
       65
     ],
     "being": [
       67
     ],
     "targeted": [
       68
     ],
     "markers": [
       70
     ],
     "to": [
       71,
       76,
       87
     ],
     "predict": [
       72
     ],
     "prior": [
       75
     ],
     "clinical": [
       78
     ],
     "manifestation.": [
       79
     ],
     "The": [
       80
     ],
     "primary": [
       81
     ],
     "objective": [
       82
     ],
     "study": [
       85
     ],
     "was": [
       86,
       117
     ],
     "identify": [
       88
     ],
     "miRNAs": [
       89,
       127,
       154
     ],
     "that": [
       90,
       107
     ],
     "could": [
       91
     ],
     "serve": [
       92
     ],
     "biomarkers": [
       94,
       135
     ],
     "proxies": [
       96
     ],
     "little": [
       98
     ],
     "brown": [
       99
     ],
     "health.": [
       101
     ],
     "Bats": [
       102
     ],
     "were": [
       103,
       128
     ],
     "collected": [
       104
     ],
     "from": [
       105,
       130
     ],
     "hibernacula": [
       106
     ],
     "had": [
       108
     ],
     "tested": [
       109
     ],
     "positive": [
       110
     ],
     "negative": [
       112
     ],
     "for": [
       113,
       144
     ],
     "WNS.": [
       114,
       137
     ],
     "Genetic": [
       115
     ],
     "sequencing": [
       116
     ],
     "completed": [
       118
     ],
     "using": [
       119
     ],
     "Ion": [
       121
     ],
     "Torrent": [
       122
     ],
     "platform.": [
       123
     ],
     "A": [
       124
     ],
     "number": [
       125
     ],
     "identified": [
       129,
       153
     ],
     "liver": [
       132
     ],
     "putative": [
       134
     ],
     "However,": [
       138
     ],
     "given": [
       139
     ],
     "small": [
       141
     ],
     "sample": [
       142
     ],
     "size": [
       143
     ],
     "each": [
       145
     ],
     "treatment,": [
       146
     ],
     "data": [
       148
     ],
     "set": [
       149
     ],
     "has": [
       150
     ],
     "only": [
       151
     ],
     "coarsely": [
       152
     ],
     "indicative": [
       155
     ],
     "WNS,": [
       157
     ],
     "further": [
       159
     ],
     "validation": [
       160
     ],
     "required.": [
       162
     ]
   },
   "apc_list": null,
   "apc_paid": null,
   "authorships": [
     {
       "author_position": "first",
       "author": {
         "id": "https://openalex.org/A5038245467",
         "display_name": "Deborah D. Iwanowicz",
         "orcid": "https://orcid.org/0000-0002-9613-8594"
       },
       "institutions": [],
       "countries": [],
       "is_corresponding": false,
       "raw_author_name": "D.D. Iwanowicz",
       "raw_affiliation_strings": [],
       "affiliations": []
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5012293449",
         "display_name": "Luke R. Iwanowicz",
         "orcid": "https://orcid.org/0000-0002-1197-6178"
       },
       "institutions": [],
       "countries": [],
       "is_corresponding": false,
       "raw_author_name": "L. R. Iwanowicz",
       "raw_affiliation_strings": [],
       "affiliations": []
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5078557395",
         "display_name": "Nathaniel P. Hitt",
         "orcid": "https://orcid.org/0000-0002-1046-4568"
       },
       "institutions": [],
       "countries": [],
       "is_corresponding": false,
       "raw_author_name": "N.P. Hitt",
       "raw_affiliation_strings": [],
       "affiliations": []
     },
     {
       "author_position": "last",
       "author": {
         "id": "https://openalex.org/A5059790287",
         "display_name": "Tiffany Lethabo King",
         "orcid": null
       },
       "institutions": [],
       "countries": [],
       "is_corresponding": false,
       "raw_author_name": "T.L. King",
       "raw_affiliation_strings": [],
       "affiliations": []
     }
   ],
   "best_oa_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.3133/ofr20131099",
     "pdf_url": "https://pubs.usgs.gov/of/2013/1099/pdf/ofr2013-1099.pdf",
     "source": {
       "id": "https://openalex.org/S4210194219",
       "display_name": "Antarctica A Keystone in a Changing World",
       "issn_l": "0196-1497",
       "issn": [
         "0196-1497",
         "2331-1258",
         "2332-4899"
       ],
       "is_oa": true,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4310316088",
       "host_organization_name": "United States Department of the Interior",
       "host_organization_lineage": [
         "https://openalex.org/P4310316088"
       ],
       "host_organization_lineage_names": [
         "United States Department of the Interior"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "biblio": {
     "volume": null,
     "issue": null,
     "first_page": null,
     "last_page": null
   },
   "citation_normalized_percentile": {
     "value": 0.513422,
     "is_in_top_1_percent": false,
     "is_in_top_10_percent": false
   },
   "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W1592560284",
   "cited_by_count": 1,
   "cited_by_percentile_year": {
     "min": 67,
     "max": 74
   },
   "concepts": [
     {
       "id": "https://openalex.org/c2910803384",
       "wikidata": "https://www.wikidata.org/wiki/Q746127",
       "display_name": "Myotis lucifugus",
       "level": 2,
       "score": 0.9809036,
       "qid": null
     },
     {
       "id": "https://openalex.org/c86803240",
       "wikidata": "https://www.wikidata.org/wiki/Q420",
       "display_name": "Biology",
       "level": 0,
       "score": 0.80516243,
       "qid": "Q158998"
     },
     {
       "id": "https://openalex.org/c2778311950",
       "wikidata": "https://www.wikidata.org/wiki/Q7363",
       "display_name": "Nose",
       "level": 2,
       "score": 0.544966,
       "qid": null
     },
     {
       "id": "https://openalex.org/c90856448",
       "wikidata": "https://www.wikidata.org/wiki/Q431",
       "display_name": "Zoology",
       "level": 1,
       "score": 0.41886544,
       "qid": "Q166179"
     },
     {
       "id": "https://openalex.org/c105702510",
       "wikidata": "https://www.wikidata.org/wiki/Q514",
       "display_name": "Anatomy",
       "level": 1,
       "score": 0.119614035,
       "qid": "Q166320"
     }
   ],
   "corresponding_author_ids": [],
   "corresponding_institution_ids": [],
   "countries_distinct_count": 0,
   "counts_by_year": [
     {
       "year": 2014,
       "cited_by_count": 1
     }
   ],
   "created_date": "2016-06-24",
   "datasets": [],
   "display_name": "Differential expression profiles of microRNA in the little brown bat (Myotis lucifugus) associated with white nose syndrome affected and unaffected individuals",
   "doi": "https://doi.org/10.3133/ofr20131099",
   "fwci": 0.366,
   "grants": [],
   "has_fulltext": false,
   "id": "https://openalex.org/W1592560284",
   "ids": {
     "openalex": "https://openalex.org/W1592560284",
     "doi": "https://doi.org/10.3133/ofr20131099",
     "mag": "1592560284"
   },
   "indexed_in": [
     "crossref"
   ],
   "institutions_distinct_count": 0,
   "is_paratext": false,
   "is_retracted": false,
   "keywords": [
     {
       "id": "https://openalex.org/keywords/myotis-lucifugus",
       "display_name": "Myotis lucifugus",
       "score": 0.9809036
     },
     {
       "id": "https://openalex.org/keywords/white-nose-syndrome",
       "display_name": "White-Nose Syndrome",
       "score": 0.540418
     }
   ],
   "language": "en",
   "locations": [
     {
       "is_oa": true,
       "landing_page_url": "https://doi.org/10.3133/ofr20131099",
       "pdf_url": "https://pubs.usgs.gov/of/2013/1099/pdf/ofr2013-1099.pdf",
       "source": {
         "id": "https://openalex.org/S4210194219",
         "display_name": "Antarctica A Keystone in a Changing World",
         "issn_l": "0196-1497",
         "issn": [
           "0196-1497",
           "2331-1258",
           "2332-4899"
         ],
         "is_oa": true,
         "is_in_doaj": false,
         "is_core": true,
         "host_organization": "https://openalex.org/P4310316088",
         "host_organization_name": "United States Department of the Interior",
         "host_organization_lineage": [
           "https://openalex.org/P4310316088"
         ],
         "host_organization_lineage_names": [
           "United States Department of the Interior"
         ],
         "type": "journal"
       },
       "license": null,
       "license_id": null,
       "version": "publishedVersion",
       "is_accepted": true,
       "is_published": true
     }
   ],
   "locations_count": 1,
   "mesh": [],
   "ngrams_url": "https://api.openalex.org/works/W1592560284/ngrams",
   "open_access": {
     "is_oa": true,
     "oa_status": "bronze",
     "oa_url": "https://pubs.usgs.gov/of/2013/1099/pdf/ofr2013-1099.pdf",
     "any_repository_has_fulltext": false
   },
   "primary_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.3133/ofr20131099",
     "pdf_url": "https://pubs.usgs.gov/of/2013/1099/pdf/ofr2013-1099.pdf",
     "source": {
       "id": "https://openalex.org/S4210194219",
       "display_name": "Antarctica A Keystone in a Changing World",
       "issn_l": "0196-1497",
       "issn": [
         "0196-1497",
         "2331-1258",
         "2332-4899"
       ],
       "is_oa": true,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4310316088",
       "host_organization_name": "United States Department of the Interior",
       "host_organization_lineage": [
         "https://openalex.org/P4310316088"
       ],
       "host_organization_lineage_names": [
         "United States Department of the Interior"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "primary_topic": {
     "id": "https://openalex.org/T11228",
     "display_name": "Ecology and Behavior of Bats",
     "score": 0.9998,
     "subfield": {
       "id": "https://openalex.org/subfields/1105",
       "display_name": "Ecology, Evolution, Behavior and Systematics"
     },
     "field": {
       "id": "https://openalex.org/fields/11",
       "display_name": "Agricultural and Biological Sciences"
     },
     "domain": {
       "id": "https://openalex.org/domains/1",
       "display_name": "Life Sciences"
     }
   },
   "publication_date": "2013-01-01",
   "publication_year": 2013,
   "referenced_works": [
     "https://openalex.org/W1607335700",
     "https://openalex.org/W1833414654",
     "https://openalex.org/W1977381537",
     "https://openalex.org/W2017426710",
     "https://openalex.org/W2018130888",
     "https://openalex.org/W2027738370",
     "https://openalex.org/W2028831862",
     "https://openalex.org/W2040535386",
     "https://openalex.org/W2068427566",
     "https://openalex.org/W2078771095",
     "https://openalex.org/W2091070751",
     "https://openalex.org/W2115093090",
     "https://openalex.org/W2116685570",
     "https://openalex.org/W2125011614",
     "https://openalex.org/W2135166338",
     "https://openalex.org/W2163482204",
     "https://openalex.org/W2164788793",
     "https://openalex.org/W2169687789",
     "https://openalex.org/W2170514882",
     "https://openalex.org/W2171036736"
   ],
   "referenced_works_count": 20,
   "related_works": [
     "https://openalex.org/W3199580975",
     "https://openalex.org/W3197506370",
     "https://openalex.org/W2425267062",
     "https://openalex.org/W2335410770",
     "https://openalex.org/W2316815804",
     "https://openalex.org/W2316236593",
     "https://openalex.org/W2275656873",
     "https://openalex.org/W2136081785",
     "https://openalex.org/W2095959704",
     "https://openalex.org/W1974852933"
   ],
   "sustainable_development_goals": [
     {
       "id": "https://metadata.un.org/sdg/3",
       "score": 0.71,
       "display_name": "Good health and well-being"
     }
   ],
   "title": "Differential expression profiles of microRNA in the little brown bat (Myotis lucifugus) associated with white nose syndrome affected and unaffected individuals",
   "topics": [
     {
       "id": "https://openalex.org/T11228",
       "display_name": "Ecology and Behavior of Bats",
       "score": 0.9998,
       "subfield": {
         "id": "https://openalex.org/subfields/1105",
         "display_name": "Ecology, Evolution, Behavior and Systematics"
       },
       "field": {
         "id": "https://openalex.org/fields/11",
         "display_name": "Agricultural and Biological Sciences"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12047",
       "display_name": "Viral Hemorrhagic Fevers and Zoonotic Infections",
       "score": 0.9765,
       "subfield": {
         "id": "https://openalex.org/subfields/2725",
         "display_name": "Infectious Diseases"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12365",
       "display_name": "Effects of Heat Stress on Livestock Production",
       "score": 0.9514,
       "subfield": {
         "id": "https://openalex.org/subfields/1103",
         "display_name": "Animal Science and Zoology"
       },
       "field": {
         "id": "https://openalex.org/fields/11",
         "display_name": "Agricultural and Biological Sciences"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     }
   ],
   "type": "article",
   "type_crossref": "journal-article",
   "updated_date": "2024-08-10T09:25:57.188158",
   "versions": [],
   "qid": "Q61204"
 }

}