Item talk:Q49264
From geokb
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"abstract": "Prarthana (pronounced: Praa-th-na) is a Biologist at the Western Fisheries Research Center interested in the toxicological effects of chemical exposure to fish health. Her current research examines stormwater toxicity in salmonids at various life stages, with a particular focus on 6PPD and its transformation products such as 6PPD-quinone."
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"abstract": "Prior to coming to the USGS, Prarthana utilized zebrafish as a model organism to investigate the developmental toxicity of different environmental chemicals such as polycyclic aromatic hydrocarbons (PAHs), Per- and polyfluoroalkyl substances (PFASs), 2,3,7,8-Tetrachlorodibenzodioxin (TCDD), and uranium. Her research leveraged techniques such as whole-animal transcriptomics and proteomics, behavioral assays at different zebrafish life stages, and CRISPR Cas9 and Cas12a to generate various gene knockout animals. She also has experience building Adverse Outcome Pathways (AOPs) specifically related to the Aryl hydrocarbon receptor.Prarthana began working at the USGS in February 2023. Along with John Hansen\u2019s group, she plans to investigate 6PPD-quinone toxicity in different salmonids native to the Pacific Northwest including, coho salmon and cutthroat trout. Her research questions focus on identifying the mechanisms of 6PPD-quinone toxicity and understanding the sublethal immune system effects from exposure to this emerging contaminant of concern."
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"abstract": "Shankar, P., Cavallin J.E., Ellman, M.E., Santana Rodriguez, K.J., Lasee, S., Blackwell B.R., Vliet, S.M., LaLone, C., Villeneuve, D.L., Comparison of Zebrafish Toxicity Between Different Developmental Windows of Exposure to Three Environmentally Relevant PFAS Compounds. Poster Presentation at the Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting. Nov 17th, 202"
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"abstract": "Shankar, P.*, Cavallin J.E., Ellman, M.E., Santana Rodriguez, K.J., Lasee, S., Blackwell B.R., Vliet, S.M., LaLone, C., Villeneuve, D.L., Comparison of zebrafish toxicity between different developmental windows of exposure to three environmentally relevant PFAS compounds. Oral Presentation at the Midwest Society of Toxicology (SOT) Regional Chapter. Virtual. April 29th, 2022."
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"abstract": "Shankar, P.*, Villeneuve, D.L., AOP Development: Bridging Aryl Hydrocarbon Receptor activation with craniofacial and cardiac malformations using a Key Event Relationship (KER)-by-KER approach. Poster Presentation at the SOT Annual Meeting, San Diego, California. March 30th, 2022."
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"abstract": "Cheng, V.*, Corton C.J., Bushel, P.J., Ellinger-Zigelbauer, H., Estrella, H., Gosink, M., Podtelezhnikov, A., Tanis, K.Q., Mitchell, C.A., Shankar, P., Sistare, F.D. A Collaborative Initiative to Establish Molecular Biomarkers for Assessing Risk of Chemical Carcinogenesis to Reduce Reliance on Conventional Rodent Carcinogenicity Studies. Poster Presentation at the SOT Annual Meeting, San Diego, Ca"
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"abstract": "Shankar, P.*, Villeneuve, D.L., Bridging Aryl Hydrocarbon Receptor Activation with Craniofacial Malformations using a Key Event Relationship (KER) by KER Approach. Oral Presentation at the AOP Work-In-Progress Monthly Seminar Series (US Environmental Protection Agency (EPA)). Virtual. Jan 19th, 2022."
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"abstract": "Shankar, P.*, Elucidating the signaling events downstream of aryl hydrocarbon receptor (AHR) activation in zebrafish. Oral Presentation at the Great Lakes Toxicology and Ecology Division (GLTED) of the US EPA Weekly Seminar Series, Virtual. May 26th, 2021."
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