Item talk:Q317456

{

 "OpenAlex": {
   "id": "https://openalex.org/T12829",
   "display_name": "Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer",
   "description": "This cluster of papers focuses on the use of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as palbociclib, letrozole, ribociclib, and abemaciclib, in the treatment of hormone receptor-positive metastatic breast cancer. The papers cover various aspects including clinical trials, mechanisms of action, therapeutic resistance, combination strategies, and potential biomarkers.",
   "keywords": [
     "CDK4/6 Inhibitors",
     "Breast Cancer",
     "Palbociclib",
     "Letrozole",
     "Ribociclib",
     "Abemaciclib",
     "Hormone Receptor-Positive",
     "Metastatic Breast Cancer",
     "Cell Cycle Control",
     "Therapeutic Resistance"
   ],
   "ids": {
     "openalex": "https://openalex.org/T12829",
     "wikipedia": "https://en.wikipedia.org/wiki/Palbociclib#Breast_cancer_therapy"
   },
   "subfield": {
     "id": "https://openalex.org/subfields/2740",
     "display_name": "Pulmonary and Respiratory Medicine"
   },
   "field": {
     "id": "https://openalex.org/fields/27",
     "display_name": "Medicine"
   },
   "domain": {
     "id": "https://openalex.org/domains/4",
     "display_name": "Health Sciences"
   },
   "siblings": [
     {
       "id": "https://openalex.org/T12333",
       "display_name": "Abdominal Compartment Syndrome and Intra-abdominal Hypertension"
     },
     {
       "id": "https://openalex.org/T10417",
       "display_name": "Advancements in Lung Cancer Research"
     },
     {
       "id": "https://openalex.org/T10543",
       "display_name": "Advancements in Prostate Cancer Research"
     },
     {
       "id": "https://openalex.org/T10990",
       "display_name": "Airborne Transmission of Respiratory Viruses"
     },
     {
       "id": "https://openalex.org/T12419",
       "display_name": "Analysis of Cardiac and Respiratory Sounds"
     },
     {
       "id": "https://openalex.org/T13657",
       "display_name": "Aortic Atherosclerotic Disease and Embolic Events"
     },
     {
       "id": "https://openalex.org/T11487",
       "display_name": "Biomechanics of Traumatic Brain Injury"
     },
     {
       "id": "https://openalex.org/T11721",
       "display_name": "Blood Rheology and Coagulation Mechanisms"
     },
     {
       "id": "https://openalex.org/T11361",
       "display_name": "Breast Cancer Screening Technology"
     },
     {
       "id": "https://openalex.org/T10697",
       "display_name": "Classification and Management of Vasculitides"
     },
     {
       "id": "https://openalex.org/T11260",
       "display_name": "Clinical Management of Tracheal and Airway Disorders"
     },
     {
       "id": "https://openalex.org/T13697",
       "display_name": "Complications of Gallstone Disease"
     },
     {
       "id": "https://openalex.org/T12018",
       "display_name": "Congenital Coronary Artery Anomalies and Their Management"
     },
     {
       "id": "https://openalex.org/T10618",
       "display_name": "Diagnosis and Management of Aortic Diseases"
     },
     {
       "id": "https://openalex.org/T10518",
       "display_name": "Diagnosis and Management of Biliary Tract Disorders"
     },
     {
       "id": "https://openalex.org/T12418",
       "display_name": "Diagnosis and Management of Chronic Cough"
     },
     {
       "id": "https://openalex.org/T11967",
       "display_name": "Diagnosis and Management of Hyponatremia"
     },
     {
       "id": "https://openalex.org/T11356",
       "display_name": "Diagnosis and Management of Pleural Diseases"
     },
     {
       "id": "https://openalex.org/T10816",
       "display_name": "Diagnosis and Treatment of Carotid Artery Disease"
     },
     {
       "id": "https://openalex.org/T10202",
       "display_name": "Diagnosis and Treatment of Lung Cancer"
     },
     {
       "id": "https://openalex.org/T10728",
       "display_name": "Diagnosis and Treatment of Pulmonary Hypertension"
     },
     {
       "id": "https://openalex.org/T12067",
       "display_name": "Diagnosis and Treatment of Renal Artery Stenosis"
     },
     {
       "id": "https://openalex.org/T10696",
       "display_name": "Gastric Cancer Research and Treatment"
     },
     {
       "id": "https://openalex.org/T10870",
       "display_name": "Idiopathic Pulmonary Fibrosis: Diagnosis and Management"
     },
     {
       "id": "https://openalex.org/T13176",
       "display_name": "Injuries in Alpine Skiing and Snowboarding"
     },
     {
       "id": "https://openalex.org/T11026",
       "display_name": "Malignant Pleural Mesothelioma Research"
     },
     {
       "id": "https://openalex.org/T10983",
       "display_name": "Management and Pathophysiology of Abdominal Aortic Aneurysms"
     },
     {
       "id": "https://openalex.org/T12845",
       "display_name": "Management and Treatment of Tumor Lysis Syndrome"
     },
     {
       "id": "https://openalex.org/T11600",
       "display_name": "Management of Brain Metastases in Cancer Patients"
     },
     {
       "id": "https://openalex.org/T12876",
       "display_name": "Management of Hyperkalemia in Kidney Diseases"
     },
     {
       "id": "https://openalex.org/T10322",
       "display_name": "Mechanical Ventilation in Respiratory Failure and ARDS"
     },
     {
       "id": "https://openalex.org/T11297",
       "display_name": "Mechanisms and Implications of Ferroptosis in Cancer"
     },
     {
       "id": "https://openalex.org/T13077",
       "display_name": "Mechanisms of Chemotherapy-Induced Cognitive Impairment"
     },
     {
       "id": "https://openalex.org/T12992",
       "display_name": "Metastatic Carcinomas from Lung and Breast"
     },
     {
       "id": "https://openalex.org/T10549",
       "display_name": "Neonatal Lung Development and Respiratory Morbidity"
     },
     {
       "id": "https://openalex.org/T11176",
       "display_name": "Particle Therapy for Cancer Treatment"
     },
     {
       "id": "https://openalex.org/T11579",
       "display_name": "Patent Foramen Ovale and Cerebrovascular Events"
     },
     {
       "id": "https://openalex.org/T12198",
       "display_name": "Pathobiology and Management of Mucositis in Cancer Therapy"
     },
     {
       "id": "https://openalex.org/T10957",
       "display_name": "Photodynamic Therapy in Oncology and Microbiology"
     },
     {
       "id": "https://openalex.org/T10606",
       "display_name": "Prevalence and Management of Kidney Stones"
     },
     {
       "id": "https://openalex.org/T10124",
       "display_name": "Prostate Cancer Research and Treatment"
     },
     {
       "id": "https://openalex.org/T13759",
       "display_name": "Pulmonary Calcification and Nodular Tumors in the Lung"
     },
     {
       "id": "https://openalex.org/T11651",
       "display_name": "Pulmonary Drug Delivery Techniques"
     },
     {
       "id": "https://openalex.org/T10449",
       "display_name": "Renal Cell Carcinoma"
     },
     {
       "id": "https://openalex.org/T10253",
       "display_name": "Sarcoma Research and Treatment"
     },
     {
       "id": "https://openalex.org/T12689",
       "display_name": "Silymarin in Liver Diseases and Cancer Treatment"
     },
     {
       "id": "https://openalex.org/T12818",
       "display_name": "Spontaneous Pneumomediastinum in COVID-19 Patients"
     },
     {
       "id": "https://openalex.org/T10143",
       "display_name": "Standardisation and Management of COPD"
     },
     {
       "id": "https://openalex.org/T10665",
       "display_name": "Therapeutic Advances in Cystic Fibrosis Research"
     },
     {
       "id": "https://openalex.org/T11149",
       "display_name": "Translation of Canine Cancer Research to Humans"
     },
     {
       "id": "https://openalex.org/T11554",
       "display_name": "Vascular Access for Coronary Procedures and Trauma Management"
     }
   ],
   "works_count": 23965,
   "cited_by_count": 163140,
   "updated_date": "2024-08-26T06:11:24.806328",
   "created_date": "2024-01-23"
 }

}