Item talk:Q317289

{

 "OpenAlex": {
   "id": "https://openalex.org/T11914",
   "display_name": "Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy",
   "description": "This cluster of papers focuses on the use of Poly(ADP-ribose) Polymerase (PARP) inhibitors, such as Olaparib and Niraparib, as a targeted therapy for cancer, particularly in the context of BRCA mutations and DNA repair deficiency. The concept of synthetic lethality, homologous recombination, and the therapeutic potential of PARP inhibitors in various cancers, including platinum-sensitive ovarian cancer, are extensively explored.",
   "keywords": [
     "PARP Inhibitors",
     "BRCA Mutation",
     "DNA Repair",
     "Olaparib",
     "Synthetic Lethality",
     "Homologous Recombination",
     "Cancer Therapy",
     "Platinum-Sensitive Ovarian Cancer",
     "BRCA1/2 Deficiency",
     "Cell Death"
   ],
   "ids": {
     "openalex": "https://openalex.org/T11914",
     "wikipedia": "https://en.wikipedia.org/wiki/PARP_inhibitor"
   },
   "subfield": {
     "id": "https://openalex.org/subfields/2730",
     "display_name": "Oncology"
   },
   "field": {
     "id": "https://openalex.org/fields/27",
     "display_name": "Medicine"
   },
   "domain": {
     "id": "https://openalex.org/domains/4",
     "display_name": "Health Sciences"
   },
   "siblings": [
     {
       "id": "https://openalex.org/T11067",
       "display_name": "Advancements in Colorectal Cancer Research"
     },
     {
       "id": "https://openalex.org/T11221",
       "display_name": "Bisphosphonates in Cancer Treatment and Bone Health"
     },
     {
       "id": "https://openalex.org/T12758",
       "display_name": "Cancer Chemopreventive Properties of Saffron"
     },
     {
       "id": "https://openalex.org/T10158",
       "display_name": "Cancer Immunotherapy"
     },
     {
       "id": "https://openalex.org/T12379",
       "display_name": "Cancer of Unknown Primary Site"
     },
     {
       "id": "https://openalex.org/T10336",
       "display_name": "Cancer Stem Cells and Tumor Metastasis"
     },
     {
       "id": "https://openalex.org/T10178",
       "display_name": "Cancer Survivorship and Quality of Life"
     },
     {
       "id": "https://openalex.org/T11752",
       "display_name": "Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment"
     },
     {
       "id": "https://openalex.org/T11491",
       "display_name": "Chimeric Antigen Receptor T Cell Therapy"
     },
     {
       "id": "https://openalex.org/T10335",
       "display_name": "Colorectal Cancer Research and Treatment"
     },
     {
       "id": "https://openalex.org/T10556",
       "display_name": "Global Cancer Incidence and Mortality Patterns"
     },
     {
       "id": "https://openalex.org/T10552",
       "display_name": "Global Trends in Colorectal Cancer Research"
     },
     {
       "id": "https://openalex.org/T10755",
       "display_name": "HER2 Signaling in Breast Cancer Treatment"
     },
     {
       "id": "https://openalex.org/T11296",
       "display_name": "Impact of COVID-19 on Cancer Patients and Care"
     },
     {
       "id": "https://openalex.org/T12103",
       "display_name": "Impact of Obesity on Cancer Risk and Prognosis"
     },
     {
       "id": "https://openalex.org/T11355",
       "display_name": "Inflammation's Role in Cancer Development and Progression"
     },
     {
       "id": "https://openalex.org/T11469",
       "display_name": "Lymphangiogenesis in Cancer Metastasis and Disease"
     },
     {
       "id": "https://openalex.org/T12172",
       "display_name": "Management of Febrile Neutropenia in Cancer Patients"
     },
     {
       "id": "https://openalex.org/T10570",
       "display_name": "Mechanisms of Multidrug Resistance in Cancer"
     },
     {
       "id": "https://openalex.org/T10392",
       "display_name": "Melanoma"
     },
     {
       "id": "https://openalex.org/T13434",
       "display_name": "Nanotechnology in Cancer Treatment and Diagnosis"
     },
     {
       "id": "https://openalex.org/T10231",
       "display_name": "Pancreatic Cancer Research and Treatment"
     },
     {
       "id": "https://openalex.org/T10163",
       "display_name": "Platinum-Based Cancer Chemotherapy"
     },
     {
       "id": "https://openalex.org/T11827",
       "display_name": "Polyomavirus-Associated Carcinogenesis and Clinical Manifestations"
     },
     {
       "id": "https://openalex.org/T11532",
       "display_name": "Role of Chemokine Receptors in Cancer Metastasis"
     },
     {
       "id": "https://openalex.org/T14364",
       "display_name": "Role of Clusterin in Cancer and Disease"
     },
     {
       "id": "https://openalex.org/T12505",
       "display_name": "Role of Fibroblast Activation in Cancer Progression"
     },
     {
       "id": "https://openalex.org/T11503",
       "display_name": "Role of STAT3 in Cancer Inflammation and Immunity"
     },
     {
       "id": "https://openalex.org/T12334",
       "display_name": "Small Cell Lung Cancer"
     },
     {
       "id": "https://openalex.org/T10583",
       "display_name": "The p53 Signaling Network in Cancer Research"
     },
     {
       "id": "https://openalex.org/T14326",
       "display_name": "Tumors of the Ear and Temporal Bone"
     },
     {
       "id": "https://openalex.org/T12278",
       "display_name": "Vascular Tumors and Angiosarcoma"
     },
     {
       "id": "https://openalex.org/T10685",
       "display_name": "Viral-Related Cancers in Immunocompromised Patients"
     }
   ],
   "works_count": 25658,
   "cited_by_count": 537933,
   "updated_date": "2024-08-26T06:07:46.232497",
   "created_date": "2024-01-23"
 }

}