Item talk:Q255644
From geokb
{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "Metabolism and elimination of benzocaine by rainbow-trout, Oncorhynchus mykiss", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "1003500", "url": "https://pubs.usgs.gov/publication/1003500" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 1003500 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3109/00498259109039492", "url": "https://doi.org/10.3109/00498259109039492" } ], "journal": { "@type": "Periodical", "name": "Xenobiotica", "volumeNumber": "21", "issueNumber": "4" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Xenobiotica" } ], "datePublished": "1991", "dateModified": "2013-03-24", "abstract": "1. Branchial and urinary elimination of benzocaine residues was evaluated in adult rainbow trout, oncorhynchus mykiss, given a single dorsal aortic dose of c-14-benzocaine hydrochloride.^2. Branchial elimination of benzocaine residues was rapid and accounted for 59.2% Of the dose during the first 3 h after dosing. Renal elimination of radioactivity was considerably slower; the kidney excreted 2.7% Dose within 3 h and 9.0% Within 24 h. Gallbladder bile contained 2.0% Dose 24 h after injection.^3. Of the radioactivity in radiochromatograms from water taken 3 min after injection, 87.3% Was benzocaine and 12.7% Was n-acetylated benzocaine. After 60 min, 32.7% Was benzocaine and 67.3% Was n-acetylated benzocaine.^4. Of the radioactivity in radiochromatograms from urine taken 1 h after dosing, 7.6% Was para-aminobenzoic acid, 59.7% Was n-acetylated para-aminobenzoic acid, 19.5% Was benzocaine, and 8.0% Was n-acetylated benzocaine. The proportion of the radioactivity in urine changed with time so that by 20 h, 1.0% Was para-aminobenzoic acid and 96.6% Was n-acetylated para-aminobenzoic acid.^5. Benzocaine and a more hydrophobic metabolite, n-acetylated benzocaine, were eliminated primarily through the gills; renal and biliary pathways were less significant elimination routes for benzocaine residues.", "description": "pp. 525-533", "publisher": { "@type": "Organization", "name": "University of Wisconsin; U.S. Fish and Wildlife Service" }, "author": [ { "@type": "Person", "name": "Meinertz, J.R.", "givenName": "J.R.", "familyName": "Meinertz", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0002-8855-2648", "url": "https://orcid.org/0000-0002-8855-2648" }, "affiliation": [ { "@type": "Organization", "name": "Upper Midwest Environmental Sciences Center", "url": "https://www.usgs.gov/centers/upper-midwest-environmental-sciences-center" } ] }, { "@type": "Person", "name": "Allen, J. L.", "givenName": "J. L.", "familyName": "Allen" }, { "@type": "Person", "name": "Gingerich, W.H.", "givenName": "W.H.", "familyName": "Gingerich" } ], "funder": [ { "@type": "Organization", "name": "Upper Midwest Environmental Sciences Center", "url": "https://www.usgs.gov/centers/upper-midwest-environmental-sciences-center" } ] }, "OpenAlex": { "_id": "https://openalex.org/w1970204281", "abstract_inverted_index": { "1.": [ 0 ], "Branchial": [ 1, 26 ], "and": [ 2, 33, 62, 92, 103, 133, 157, 165, 179 ], "urinary": [ 3 ], "elimination": [ 4, 27, 48, 185 ], "of": [ 5, 22, 28, 37, 49, 140 ], "benzocaine": [ 6, 29, 91, 102, 188 ], "residues": [ 7, 30 ], "was": [ 8, 31, 51, 90, 94, 101, 105, 122, 126, 131, 135, 154, 159 ], "evaluated": [ 9 ], "in": [ 10, 80, 112, 143 ], "adult": [ 11 ], "rainbow": [ 12 ], "trout,": [ 13 ], "Oncorhynchus": [ 14 ], "mykiss,": [ 15 ], "given": [ 16 ], "a": [ 17, 166 ], "single": [ 18 ], "dorsal": [ 19 ], "aortic": [ 20 ], "dose": [ 21, 39, 58, 71 ], "14C-benzocaine": [ 23 ], "hydrochloride.": [ 24 ], "2.": [ 25 ], "rapid": [ 32 ], "accounted": [ 34 ], "for": [ 35, 187 ], "59.2%": [ 36 ], "the": [ 38, 41, 54, 78, 110, 141, 176 ], "during": [ 40 ], "first": [ 42 ], "3": [ 43, 60, 85 ], "h": [ 44, 61, 73, 118 ], "after": [ 45, 74, 87, 119 ], "dosing.": [ 46 ], "Renal": [ 47 ], "radioactivity": [ 50, 79, 111, 142 ], "considerably": [ 52 ], "slower;": [ 53 ], "kidney": [ 55 ], "excreted": [ 56 ], "2.7%": [ 57 ], "within": [ 59, 64 ], "9.0%": [ 63 ], "24": [ 65, 72 ], "h.": [ 66 ], "Gallbladder": [ 67 ], "bile": [ 68 ], "contained": [ 69 ], "2.0%": [ 70 ], "injection.": [ 75 ], "3.": [ 76 ], "Of": [ 77, 109 ], "radiochromatograms": [ 81, 113 ], "from": [ 82, 114 ], "water": [ 83 ], "taken": [ 84, 116 ], "min": [ 86 ], "injection,": [ 88 ], "87.3%": [ 89 ], "12.7%": [ 93 ], "N-acetylated": [ 95, 106, 127, 136, 160, 170 ], "benzocaine.": [ 96, 107, 137 ], "After": [ 97 ], "60": [ 98 ], "min,": [ 99 ], "32.7%": [ 100 ], "67.3%": [ 104 ], "4.": [ 108 ], "urine": [ 115, 144 ], "1": [ 117 ], "dosing,": [ 120 ], "7.6%": [ 121 ], "para-aminobenzoic": [ 123, 128, 155, 161 ], "acid,": [ 124, 129 ], "59.7%": [ 125 ], "19.5%": [ 130 ], "benzocaine,": [ 132, 171 ], "8.0%": [ 134 ], "The": [ 138 ], "proportion": [ 139 ], "changed": [ 145 ], "with": [ 146 ], "time": [ 147 ], "so": [ 148 ], "that": [ 149 ], "by": [ 150 ], "20": [ 151 ], "h,": [ 152 ], "1.0%": [ 153 ], "acid": [ 156 ], "96.6%": [ 158 ], "acid.": [ 162 ], "5.": [ 163 ], "Benzocaine": [ 164 ], "more": [ 167 ], "hydrophobic": [ 168 ], "metabolite,": [ 169 ], "were": [ 172, 182 ], "eliminated": [ 173 ], "primarily": [ 174 ], "through": [ 175 ], "gills;": [ 177 ], "renal": [ 178 ], "biliary": [ 180 ], "pathways": [ 181 ], "less": [ 183 ], "significant": [ 184 ], "routes": [ 186 ], "residues.": [ 189 ] }, "apc_list": null, "apc_paid": null, "authorships": [ { "author_position": "first", "author": { "id": "https://openalex.org/A5046151394", "display_name": "Jeffery R. Meinertz", "orcid": null }, "institutions": [ { "id": "https://openalex.org/I1343028186", "display_name": "United States Fish and Wildlife Service", "ror": "https://ror.org/04k7dar27", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1335927249", "https://openalex.org/I1343028186" ] }, { "id": "https://openalex.org/I4657992", "display_name": "University of Wisconsin\u2013La Crosse", "ror": "https://ror.org/00x8ccz20", "country_code": "US", "type": "education", "lineage": [ "https://openalex.org/I4657992" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "J. R. Meinertz", "raw_affiliation_strings": [ "Department of Biology, University of Wisconsin, La Crosse, Wisconsin, 54601, USA", "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA" ], "affiliations": [ { "raw_affiliation_string": "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA", "institution_ids": [ "https://openalex.org/I1343028186" ] }, { "raw_affiliation_string": "Department of Biology, University of Wisconsin, La Crosse, Wisconsin, 54601, USA", "institution_ids": [ "https://openalex.org/I4657992" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5003275499", "display_name": "William H. Gingerich", "orcid": null }, "institutions": [ { "id": "https://openalex.org/I1343028186", "display_name": "United States Fish and Wildlife Service", "ror": "https://ror.org/04k7dar27", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1335927249", "https://openalex.org/I1343028186" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "W. H. Gingerich", "raw_affiliation_strings": [ "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA" ], "affiliations": [ { "raw_affiliation_string": "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA", "institution_ids": [ "https://openalex.org/I1343028186" ] } ] }, { "author_position": "last", "author": { "id": "https://openalex.org/A5069117965", "display_name": "J. L. Allen", "orcid": null }, "institutions": [ { "id": "https://openalex.org/I1343028186", "display_name": "United States Fish and Wildlife Service", "ror": "https://ror.org/04k7dar27", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1335927249", "https://openalex.org/I1343028186" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "J. L. Allen", "raw_affiliation_strings": [ "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA" ], "affiliations": [ { "raw_affiliation_string": "US Fish and Wildlife Service, National Fisheries Research Center, PO Box 818, La Crosse, Wisconsin, 54602-0818, USA", "institution_ids": [ "https://openalex.org/I1343028186" ] } ] } ], "best_oa_location": null, "biblio": { "volume": "21", "issue": "4", "first_page": "525", "last_page": "533" }, "citation_normalized_percentile": { "value": 0.856044, "is_in_top_1_percent": false, "is_in_top_10_percent": false }, "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W1970204281", "cited_by_count": 34, "cited_by_percentile_year": { "min": 90, "max": 91 }, "concepts": [ { "id": "https://openalex.org/C2780235077", "wikidata": "https://www.wikidata.org/wiki/Q422745", "display_name": "Benzocaine", "level": 2, "score": 0.96202195 }, { "id": "https://openalex.org/C2994167347", "wikidata": "https://www.wikidata.org/wiki/Q187986", "display_name": "Rainbow trout", "level": 3, "score": 0.713573 }, { "id": "https://openalex.org/C185592680", "wikidata": "https://www.wikidata.org/wiki/Q2329", "display_name": "Chemistry", "level": 0, "score": 0.6971202 }, { "id": "https://openalex.org/C2777477808", "wikidata": "https://www.wikidata.org/wiki/Q407595", "display_name": "Metabolite", "level": 2, "score": 0.62886244 }, { "id": "https://openalex.org/C2780026642", "wikidata": "https://www.wikidata.org/wiki/Q40924", "display_name": "Urine", "level": 2, "score": 0.5834189 }, { "id": "https://openalex.org/C2779363728", "wikidata": "https://www.wikidata.org/wiki/Q2258881", "display_name": "Trout", "level": 3, "score": 0.5294989 }, { "id": "https://openalex.org/C126322002", "wikidata": "https://www.wikidata.org/wiki/Q11180", "display_name": "Internal medicine", "level": 1, "score": 0.35996157 }, { "id": "https://openalex.org/C134018914", "wikidata": "https://www.wikidata.org/wiki/Q162606", "display_name": "Endocrinology", "level": 1, "score": 0.33033472 }, { "id": "https://openalex.org/C55493867", "wikidata": "https://www.wikidata.org/wiki/Q7094", "display_name": "Biochemistry", "level": 1, "score": 0.23911765 }, { "id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.20187253 }, { "id": "https://openalex.org/C2909208804", "wikidata": "https://www.wikidata.org/wiki/Q127282", "display_name": "Fish <Actinopterygii>", "level": 2, "score": 0.13829508 }, { "id": "https://openalex.org/C505870484", "wikidata": "https://www.wikidata.org/wiki/Q180538", "display_name": "Fishery", "level": 1, "score": 0.11761823 }, { "id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.098415434 }, { "id": "https://openalex.org/C203014093", "wikidata": "https://www.wikidata.org/wiki/Q101929", "display_name": "Immunology", "level": 1, "score": 0.0 } ], "corresponding_author_ids": [], "corresponding_institution_ids": [], "countries_distinct_count": 1, "counts_by_year": [ { "year": 2023, "cited_by_count": 2 }, { "year": 2021, "cited_by_count": 1 }, { "year": 2017, "cited_by_count": 1 }, { "year": 2016, "cited_by_count": 2 }, { "year": 2014, "cited_by_count": 4 }, { "year": 2012, "cited_by_count": 1 } ], "created_date": "2016-06-24", "datasets": [], "display_name": "Metabolism and elimination of benzocaine by rainbow trout, Oncorhynchus mykiss", "doi": "https://doi.org/10.3109/00498259109039492", "fulltext_origin": "ngrams", "fwci": 1.216, "grants": [], "has_fulltext": true, "id": "https://openalex.org/W1970204281", "ids": { "openalex": "https://openalex.org/W1970204281", "doi": "https://doi.org/10.3109/00498259109039492", "mag": "1970204281", "pmid": "https://pubmed.ncbi.nlm.nih.gov/1897251" }, "indexed_in": [ "crossref", "pubmed" ], "institutions_distinct_count": 2, "is_paratext": false, "is_retracted": false, "keywords": [ { "id": "https://openalex.org/keywords/benzocaine", "display_name": "Benzocaine", "score": 0.96202195 }, { "id": "https://openalex.org/keywords/removal-methods", "display_name": "Removal Methods", "score": 0.444995 } ], "language": "en", "locations": [ { "is_oa": false, "landing_page_url": "https://doi.org/10.3109/00498259109039492", "pdf_url": null, "source": { "id": "https://openalex.org/S48760969", "display_name": "Xenobiotica", "issn_l": "0049-8254", "issn": [ "0049-8254", "1366-5928" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320547", "host_organization_name": "Taylor & Francis", "host_organization_lineage": [ "https://openalex.org/P4310320547" ], "host_organization_lineage_names": [ "Taylor & Francis" ], "type": "journal" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false }, { "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/1897251", "pdf_url": null, "source": { "id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": [ "https://openalex.org/I1299303238" ], "host_organization_lineage_names": [ "National Institutes of Health" ], "type": "repository" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false } ], "locations_count": 2, "mesh": [ { "descriptor_ui": "D001566", "descriptor_name": "Benzocaine", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true }, { "descriptor_ui": "D014337", "descriptor_name": "Trout", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": true }, { "descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D001566", "descriptor_name": "Benzocaine", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D014337", "descriptor_name": "Trout", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false } ], "ngrams_url": "https://api.openalex.org/works/W1970204281/ngrams", "open_access": { "is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false }, "primary_location": { "is_oa": false, "landing_page_url": "https://doi.org/10.3109/00498259109039492", "pdf_url": null, "source": { "id": "https://openalex.org/S48760969", "display_name": "Xenobiotica", "issn_l": "0049-8254", "issn": [ "0049-8254", "1366-5928" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320547", "host_organization_name": "Taylor & Francis", "host_organization_lineage": [ "https://openalex.org/P4310320547" ], "host_organization_lineage_names": [ "Taylor & Francis" ], "type": "journal" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false }, "primary_topic": { "id": "https://openalex.org/T11146", "display_name": "Long-Term Effects of Testosterone on Health", "score": 0.9941, "subfield": { "id": "https://openalex.org/subfields/2712", "display_name": "Endocrinology, Diabetes and Metabolism" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } }, "publication_date": "1991-01-01", "publication_year": 1991, "referenced_works": [ "https://openalex.org/W1507175977", "https://openalex.org/W1519587747", "https://openalex.org/W1569740810", "https://openalex.org/W1797601210", "https://openalex.org/W1912737307", "https://openalex.org/W1967648504", "https://openalex.org/W1980630941", "https://openalex.org/W1982914148", "https://openalex.org/W1993207015", "https://openalex.org/W2016714444", "https://openalex.org/W2021768296", "https://openalex.org/W2034125793", "https://openalex.org/W2034630924", "https://openalex.org/W2037238910", "https://openalex.org/W2043905987", "https://openalex.org/W2043929961", "https://openalex.org/W2095412485", "https://openalex.org/W2100235123", "https://openalex.org/W2122050315", "https://openalex.org/W2409469428", "https://openalex.org/W24124717", "https://openalex.org/W2413013109", "https://openalex.org/W2947460573", "https://openalex.org/W4237161264" ], "referenced_works_count": 24, "related_works": [ "https://openalex.org/W2894898143", "https://openalex.org/W2551946382", "https://openalex.org/W2418163144", "https://openalex.org/W2354055819", "https://openalex.org/W2072305804", "https://openalex.org/W2067134005", "https://openalex.org/W2054375520", "https://openalex.org/W2052872144", "https://openalex.org/W1996343328", "https://openalex.org/W1983366598" ], "sustainable_development_goals": [ { "score": 0.64, "display_name": "Life below water", "id": "https://metadata.un.org/sdg/14" } ], "title": "Metabolism and elimination of benzocaine by rainbow trout, Oncorhynchus mykiss", "topics": [ { "id": "https://openalex.org/T11146", "display_name": "Long-Term Effects of Testosterone on Health", "score": 0.9941, "subfield": { "id": "https://openalex.org/subfields/2712", "display_name": "Endocrinology, Diabetes and Metabolism" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } }, { "id": "https://openalex.org/T10419", "display_name": "Antibiotic Resistance in Aquatic Environments and Wastewater", "score": 0.9896, "subfield": { "id": "https://openalex.org/subfields/2310", "display_name": "Pollution" }, "field": { "id": "https://openalex.org/fields/23", "display_name": "Environmental Science" }, "domain": { "id": "https://openalex.org/domains/3", "display_name": "Physical Sciences" } }, { "id": "https://openalex.org/T13338", "display_name": "Effects of Beta-Adrenergic Agonists in Livestock", "score": 0.9822, "subfield": { "id": "https://openalex.org/subfields/1103", "display_name": "Animal Science and Zoology" }, "field": { "id": "https://openalex.org/fields/11", "display_name": "Agricultural and Biological Sciences" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" } } ], "type": "article", "type_crossref": "journal-article", "updated_date": "2024-08-15T03:45:23.107252", "versions": [] }
}