Item talk:Q254538
From geokb
{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "SARS-CoV-2 utilization of ACE2 from different bat species allows for virus entry and replication in vitro", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70246659", "url": "https://pubs.usgs.gov/publication/70246659" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70246659 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.virol.2023.07.002", "url": "https://doi.org/10.1016/j.virol.2023.07.002" } ], "journal": { "@type": "Periodical", "name": "Virology", "volumeNumber": "586", "issueNumber": null }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Virology" } ], "datePublished": "2023", "dateModified": "2023-08-08", "abstract": "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to have a zoonotic origin with bats suspected as a natural host. In this work, we individually express the ACE2 of seven bat species including, little brown, great roundleaf, Pearson's horseshoe, greater horseshoe, Brazilian free-tailed, Egyptian rousette, and Chinese rufous horseshoe in DF1 cells and determine their ability to support attachment and replication of SARS-CoV-2 viruses. We demonstrate that the ACE2 receptor of all seven species made DF1 cells permissible to SARS-CoV-2. The level of virus replication differed between bat species and variants tested. The Wuhan lineage SARS-CoV-2 virus replicated to higher titers than either variant virus tested. All viruses tested grew to higher titers in cells expressing the human ACE2 gene compared to a bat ACE2. This study provides a practical\u00a0in vitromethod for further testing of animal species for potential susceptibility to current and emerging SARS-CoV-2 viruses.", "description": "8 p,", "publisher": { "@type": "Organization", "name": "Elsevier" }, "author": [ { "@type": "Person", "name": "Briggs, Kelsey", "givenName": "Kelsey", "familyName": "Briggs", "affiliation": [ { "@type": "Organization", "name": "Exotic and Emerging Avian Disease Research Unit, Southeast Poultry Research Laboratory, 9 U.S. National Poultry Research Center, Agricultural Research Service, USDA, 934 CollegeStation Road, Athens, GA 30605" } ] }, { "@type": "Person", "name": "Sweeney, Ryan", "givenName": "Ryan", "familyName": "Sweeney", "affiliation": [ { "@type": "Organization", "name": "Exotic and Emerging Avian Disease Research Unit, Southeast Poultry Research Laboratory, 9 U.S. National Poultry Research Center, Agricultural Research Service, USDA, 934 College Station Road, Athens, GA 30605" } ] }, { "@type": "Person", "name": "Blehert, David S. dblehert@usgs.gov", "givenName": "David S.", "familyName": "Blehert", "email": "dblehert@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0002-1065-9760", "url": "https://orcid.org/0000-0002-1065-9760" }, "affiliation": [ { "@type": "Organization", "name": "National Wildlife Health Center", "url": "https://www.usgs.gov/centers/nwhc" } ] }, { "@type": "Person", "name": "Spackman, Erica", "givenName": "Erica", "familyName": "Spackman" }, { "@type": "Person", "name": "Suarez, David L.", "givenName": "David L.", "familyName": "Suarez" }, { "@type": "Person", "name": "Kapczynski, Darrel", "givenName": "Darrel", "familyName": "Kapczynski", "affiliation": [ { "@type": "Organization", "name": "Exotic and Emerging Avian Disease Research Unit, Southeast Poultry Research Laboratory, 9 U.S. National Poultry Research Center, Agricultural Research Service, USDA, 934 CollegeStation Road, Athens, GA 30605" } ] } ], 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