Item talk:Q252974
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Transcriptional profiling of MHC class I genes in rainbow trout infected with infectious hematopoietic necrosis virus",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70179351",
"url": "https://pubs.usgs.gov/publication/70179351"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70179351
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.molimm.2007.10.003",
"url": "https://doi.org/10.1016/j.molimm.2007.10.003"
}
],
"journal": {
"@type": "Periodical",
"name": "Molecular Immunology",
"volumeNumber": "45",
"issueNumber": "6"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Molecular Immunology"
}
],
"datePublished": "2008",
"dateModified": "2016-12-29",
"abstract": "Major histocompatibility complex (MHC) molecules are important mediators of cell-mediated immunity in vertebrates. MHC class IA molecules are important for host anti-viral immunity as they present intracellular antigens and regulate natural killer cell (NK) activity. MHC class Ib molecules on the other hand are less understood and have demonstrated diverse immune and non-immune functions in mammals. Rainbow trout possess a single classical MHC IA locus (Onmy-UBA) that is believed to function similar to that of mammalian MHC class Ia. Numerous MHC class Ib genes with undetermined functions have also been described in trout. Here we utilize quantitative reverse transcriptase PCR (qRT-PCR) techniques to survey the levels of basal and inducible transcription for selected trout MHC class Ib genes, sIgM and sentinels of IFN induction in response to viral infection. Basal transcription of all the class Ib genes examined in this study was lower than Onmy-UBA in na\u00efve fish. UBA, along with all of the non-classical genes were induced in fish infected with virus but not in control fish. Our results support a non-classical designation for the majority of the class IB genes surveyed in this study based upon expression levels while also indicating that they may play an important role in anti-viral immunity in trout.",
"description": "12 p. ",
"publisher": {
"@type": "Organization",
"name": "Elsevier"
},
"author": [
{
"@type": "Person",
"name": "Landis, Eric D.",
"givenName": "Eric D.",
"familyName": "Landis",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Purcell, Maureen K. mpurcell@usgs.gov",
"givenName": "Maureen K.",
"familyName": "Purcell",
"email": "mpurcell@usgs.gov",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Thorgaard, Gary H.",
"givenName": "Gary H.",
"familyName": "Thorgaard"
},
{
"@type": "Person",
"name": "Wheeler , Paul A.",
"givenName": "Paul A.",
"familyName": "Wheeler "
},
{
"@type": "Person",
"name": "Hansen, John D. jhansen@usgs.gov",
"givenName": "John D.",
"familyName": "Hansen",
"email": "jhansen@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0002-3006-2734",
"url": "https://orcid.org/0000-0002-3006-2734"
},
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
}
],
"funder": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"Major": [
0
],
"histocompatibility": [
1
],
"complex": [
2
],
"(MHC)": [
3
],
"molecules": [
4,
16,
38
],
"are": [
5,
17,
43
],
"important": [
6,
18,
198
],
"mediators": [
7
],
"of": [
8,
74,
106,
121,
131,
152,
177
],
"cell-mediated": [
9
],
"immunity": [
10,
22,
202
],
"in": [
11,
54,
91,
124,
138,
145,
158,
165,
183,
200,
203
],
"vertebrates.": [
12
],
"MHC": [
13,
35,
62,
76,
80,
114
],
"class": [
14,
36,
77,
81,
115,
134,
179
],
"IA": [
15,
63
],
"for": [
19,
111,
174
],
"host": [
20
],
"anti-viral": [
21,
201
],
"as": [
23
],
"they": [
24,
194
],
"present": [
25
],
"intracellular": [
26
],
"antigens": [
27
],
"and": [
28,
46,
51,
108,
119
],
"regulate": [
29
],
"natural": [
30
],
"killer": [
31
],
"cell": [
32
],
"(NK)": [
33
],
"activity.": [
34
],
"Ib": [
37,
82,
116,
135
],
"on": [
39
],
"the": [
40,
104,
133,
153,
175,
178
],
"other": [
41
],
"hand": [
42
],
"less": [
44
],
"understood": [
45
],
"have": [
47,
87
],
"demonstrated": [
48
],
"diverse": [
49
],
"immune": [
50
],
"non-immune": [
52
],
"functions": [
53,
86
],
"mammals.": [
55
],
"Rainbow": [
56
],
"trout": [
57,
113
],
"possess": [
58
],
"a": [
59,
171
],
"single": [
60
],
"classical": [
61
],
"locus": [
64
],
"(Onmy-UBA)": [
65
],
"that": [
66,
73,
193
],
"is": [
67
],
"believed": [
68
],
"to": [
69,
72,
102,
126
],
"function": [
70
],
"similar": [
71
],
"mammalian": [
75
],
"Ia.": [
78
],
"Numerous": [
79
],
"genes": [
83,
136,
155,
181
],
"with": [
84,
150,
161
],
"undetermined": [
85
],
"also": [
88,
191
],
"been": [
89
],
"described": [
90
],
"trout.": [
92,
204
],
"Here": [
93
],
"we": [
94
],
"utilize": [
95
],
"quantitative": [
96
],
"reverse": [
97
],
"transcriptase": [
98
],
"PCR": [
99
],
"(qRT-PCR)": [
100
],
"techniques": [
101
],
"survey": [
103
],
"levels": [
105,
189
],
"basal": [
107
],
"inducible": [
109
],
"transcription": [
110,
130
],
"selected": [
112
],
"genes,": [
117
],
"sIgM": [
118
],
"sentinels": [
120
],
"IFN": [
122
],
"induction": [
123
],
"response": [
125
],
"viral": [
127
],
"infection.": [
128
],
"Basal": [
129
],
"all": [
132,
151
],
"examined": [
137
],
"this": [
139,
184
],
"study": [
140,
185
],
"was": [
141
],
"lower": [
142
],
"than": [
143
],
"Onmy-UBA": [
144
],
"na\u00efve": [
146
],
"fish.": [
147,
167
],
"UBA,": [
148
],
"along": [
149
],
"non-classical": [
154,
172
],
"were": [
156
],
"induced": [
157
],
"fish": [
159
],
"infected": [
160
],
"virus": [
162
],
"but": [
163
],
"not": [
164
],
"control": [
166
],
"Our": [
168
],
"results": [
169
],
"support": [
170
],
"designation": [
173
],
"majority": [
176
],
"IB": [
180
],
"surveyed": [
182
],
"based": [
186
],
"upon": [
187
],
"expression": [
188
],
"while": [
190
],
"indicating": [
192
],
"may": [
195
],
"play": [
196
],
"an": [
197
],
"role": [
199
]
},
"apc_list": {
"value": 2970,
"currency": "USD",
"value_usd": 2970,
"provenance": "doaj"
},
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5032169320",
"display_name": "Eric D. Landis",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I126744593",
"display_name": "University of Maryland, Baltimore",
"ror": "https://ror.org/04rq5mt64",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I126744593"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Eric D. Landis",
"raw_affiliation_strings": [
"Molecular Medicine, University of Maryland Medical School, Baltimore, MD, United States",
"U.S. Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States"
],
"affiliations": [
{
"raw_affiliation_string": "Molecular Medicine, University of Maryland Medical School, Baltimore, MD, United States",
"institution_ids": [
"https://openalex.org/I126744593"
]
},
{
"raw_affiliation_string": "U.S. Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5065071885",
"display_name": "Maureen K. Purcell",
"orcid": "https://orcid.org/0000-0003-0154-8433"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Maureen K. Purcell",
"raw_affiliation_strings": [
"U.S. Geological Survey Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States"
],
"affiliations": [
{
"raw_affiliation_string": "U.S. Geological Survey Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5000037103",
"display_name": "Gary H. Thorgaard",
"orcid": "https://orcid.org/0000-0002-9316-6426"
},
"institutions": [
{
"id": "https://openalex.org/I72951846",
"display_name": "Washington State University",
"ror": "https://ror.org/05dk0ce17",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I72951846"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Gary H. Thorgaard",
"raw_affiliation_strings": [
"School of Biological Sciences, Washington State University, Pullman, WA 99164, United States"
],
"affiliations": [
{
"raw_affiliation_string": "School of Biological Sciences, Washington State University, Pullman, WA 99164, United States",
"institution_ids": [
"https://openalex.org/I72951846"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5027929796",
"display_name": "Paul Wheeler",
"orcid": "https://orcid.org/0000-0002-5399-3531"
},
"institutions": [
{
"id": "https://openalex.org/I72951846",
"display_name": "Washington State University",
"ror": "https://ror.org/05dk0ce17",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I72951846"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Paul A. Wheeler",
"raw_affiliation_strings": [
"School of Biological Sciences, Washington State University, Pullman, WA 99164, United States"
],
"affiliations": [
{
"raw_affiliation_string": "School of Biological Sciences, Washington State University, Pullman, WA 99164, United States",
"institution_ids": [
"https://openalex.org/I72951846"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5066824903",
"display_name": "John D. Hansen",
"orcid": "https://orcid.org/0000-0002-3006-2734"
},
"institutions": [
{
"id": "https://openalex.org/I126744593",
"display_name": "University of Maryland, Baltimore",
"ror": "https://ror.org/04rq5mt64",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I126744593"
]
},
{
"id": "https://openalex.org/I201448701",
"display_name": "University of Washington",
"ror": "https://ror.org/00cvxb145",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I201448701"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "John D. Hansen",
"raw_affiliation_strings": [
"Department of Pathobiology, University of Washington, Seattle, WA, United States",
"Molecular Medicine, University of Maryland Medical School, Baltimore, MD, United States",
"U.S. Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States"
],
"affiliations": [
{
"raw_affiliation_string": "Molecular Medicine, University of Maryland Medical School, Baltimore, MD, United States",
"institution_ids": [
"https://openalex.org/I126744593"
]
},
{
"raw_affiliation_string": "Department of Pathobiology, University of Washington, Seattle, WA, United States",
"institution_ids": [
"https://openalex.org/I201448701"
]
},
{
"raw_affiliation_string": "U.S. Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
}
],
"best_oa_location": null,
"biblio": {
"volume": "45",
"issue": "6",
"first_page": "1646",
"last_page": "1657"
},
"citation_normalized_percentile": {
"value": 0.878392,
"is_in_top_1_percent": false,
"is_in_top_10_percent": false
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W1986738097",
"cited_by_count": 38,
"cited_by_percentile_year": {
"min": 92,
"max": 93
},
"concepts": [
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.82787645
},
{
"id": "https://openalex.org/C2778966499",
"wikidata": "https://www.wikidata.org/wiki/Q880931",
"display_name": "Infectious hematopoietic necrosis virus",
"level": 4,
"score": 0.73870736
},
{
"id": "https://openalex.org/C170627219",
"wikidata": "https://www.wikidata.org/wiki/Q13218497",
"display_name": "MHC class I",
"level": 4,
"score": 0.72868437
},
{
"id": "https://openalex.org/C207936829",
"wikidata": "https://www.wikidata.org/wiki/Q423163",
"display_name": "Major histocompatibility complex",
"level": 3,
"score": 0.72829884
},
{
"id": "https://openalex.org/C2994167347",
"wikidata": "https://www.wikidata.org/wiki/Q187986",
"display_name": "Rainbow trout",
"level": 3,
"score": 0.6710278
},
{
"id": "https://openalex.org/C22845430",
"wikidata": "https://www.wikidata.org/wiki/Q224879",
"display_name": "Transporter associated with antigen processing",
"level": 5,
"score": 0.64912695
},
{
"id": "https://openalex.org/C2779363728",
"wikidata": "https://www.wikidata.org/wiki/Q2258881",
"display_name": "Trout",
"level": 3,
"score": 0.48327285
},
{
"id": "https://openalex.org/C8891405",
"wikidata": "https://www.wikidata.org/wiki/Q1059",
"display_name": "Immune system",
"level": 2,
"score": 0.4686441
},
{
"id": "https://openalex.org/C167672396",
"wikidata": "https://www.wikidata.org/wiki/Q417800",
"display_name": "CD8",
"level": 3,
"score": 0.4625034
},
{
"id": "https://openalex.org/C104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.46094
},
{
"id": "https://openalex.org/C2779341262",
"wikidata": "https://www.wikidata.org/wiki/Q182581",
"display_name": "Immunity",
"level": 3,
"score": 0.41095966
},
{
"id": "https://openalex.org/C54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.34713608
},
{
"id": "https://openalex.org/C203014093",
"wikidata": "https://www.wikidata.org/wiki/Q101929",
"display_name": "Immunology",
"level": 1,
"score": 0.3345493
},
{
"id": "https://openalex.org/C159047783",
"wikidata": "https://www.wikidata.org/wiki/Q7215",
"display_name": "Virology",
"level": 1,
"score": 0.32914257
},
{
"id": "https://openalex.org/C2909208804",
"wikidata": "https://www.wikidata.org/wiki/Q127282",
"display_name": "Fish <Actinopterygii>",
"level": 2,
"score": 0.0554097
},
{
"id": "https://openalex.org/C505870484",
"wikidata": "https://www.wikidata.org/wiki/Q180538",
"display_name": "Fishery",
"level": 1,
"score": 0.0
}
],
"corresponding_author_ids": [],
"corresponding_institution_ids": [],
"countries_distinct_count": 1,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 1
},
{
"year": 2023,
"cited_by_count": 1
},
{
"year": 2022,
"cited_by_count": 4
},
{
"year": 2021,
"cited_by_count": 3
},
{
"year": 2020,
"cited_by_count": 2
},
{
"year": 2019,
"cited_by_count": 5
},
{
"year": 2018,
"cited_by_count": 2
},
{
"year": 2017,
"cited_by_count": 1
},
{
"year": 2015,
"cited_by_count": 1
},
{
"year": 2014,
"cited_by_count": 3
},
{
"year": 2013,
"cited_by_count": 3
},
{
"year": 2012,
"cited_by_count": 5
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Transcriptional profiling of MHC class I genes in rainbow trout infected with infectious hematopoietic necrosis virus",
"doi": "https://doi.org/10.1016/j.molimm.2007.10.003",
"fulltext_origin": "ngrams",
"fwci": 0.956,
"grants": [
{
"funder": "https://openalex.org/F4320306116",
"funder_display_name": "U.S. Department of the Interior",
"award_id": null
},
{
"funder": "https://openalex.org/F4320332483",
"funder_display_name": "Cooperative State Research, Education, and Extension Service",
"award_id": null
}
],
"has_fulltext": true,
"id": "https://openalex.org/W1986738097",
"ids": {
"openalex": "https://openalex.org/W1986738097",
"doi": "https://doi.org/10.1016/j.molimm.2007.10.003",
"mag": "1986738097",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/18187194"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 4,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/fish-immunology",
"display_name": "Fish Immunology",
"score": 0.512064
}
],
"language": "en",
"locations": [
{
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.molimm.2007.10.003",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S92126311",
"display_name": "Molecular Immunology",
"issn_l": "0161-5890",
"issn": [
"0161-5890",
"1872-9142"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/18187194",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 2,
"mesh": [
{
"descriptor_ui": "D015395",
"descriptor_name": "Histocompatibility Antigens Class I",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D029142",
"descriptor_name": "Infectious hematopoietic necrosis virus",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": true
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020869",
"descriptor_name": "Gene Expression Profiling",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D015395",
"descriptor_name": "Histocompatibility Antigens Class I",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D015395",
"descriptor_name": "Histocompatibility Antigens Class I",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D029142",
"descriptor_name": "Infectious hematopoietic necrosis virus",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "Q000821",
"qualifier_name": "virology",
"is_major_topic": false
},
{
"descriptor_ui": "D020133",
"descriptor_name": "Reverse Transcriptase Polymerase Chain Reaction",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014158",
"descriptor_name": "Transcription, Genetic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014779",
"descriptor_name": "Virus Replication",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W1986738097/ngrams",
"open_access": {
"is_oa": false,
"oa_status": "closed",
"oa_url": null,
"any_repository_has_fulltext": false
},
"primary_location": {
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.molimm.2007.10.003",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S92126311",
"display_name": "Molecular Immunology",
"issn_l": "0161-5890",
"issn": [
"0161-5890",
"1872-9142"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
"primary_topic": {
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2008-03-01",
"publication_year": 2008,
"referenced_works": [
"https://openalex.org/W144857297",
"https://openalex.org/W1503419019",
"https://openalex.org/W1963962536",
"https://openalex.org/W1969123002",
"https://openalex.org/W1979524380",
"https://openalex.org/W1980863092",
"https://openalex.org/W1981735559",
"https://openalex.org/W1982691620",
"https://openalex.org/W1983358040",
"https://openalex.org/W1989184359",
"https://openalex.org/W1992073708",
"https://openalex.org/W1993251639",
"https://openalex.org/W1994569001",
"https://openalex.org/W1995186647",
"https://openalex.org/W1997939418",
"https://openalex.org/W2001039766",
"https://openalex.org/W2001837094",
"https://openalex.org/W2012121356",
"https://openalex.org/W2013728855",
"https://openalex.org/W2014527443",
"https://openalex.org/W2029124806",
"https://openalex.org/W2031758569",
"https://openalex.org/W2044304871",
"https://openalex.org/W2048550097",
"https://openalex.org/W2050689767",
"https://openalex.org/W2055395815",
"https://openalex.org/W2057883354",
"https://openalex.org/W2062178241",
"https://openalex.org/W2062763734",
"https://openalex.org/W2064360143",
"https://openalex.org/W2066215633",
"https://openalex.org/W2067222550",
"https://openalex.org/W2073578515",
"https://openalex.org/W2076548223",
"https://openalex.org/W2076934806",
"https://openalex.org/W2079190535",
"https://openalex.org/W2082962768",
"https://openalex.org/W2083884970",
"https://openalex.org/W2089106709",
"https://openalex.org/W2091843987",
"https://openalex.org/W2105870369",
"https://openalex.org/W2110988104",
"https://openalex.org/W2115266947",
"https://openalex.org/W2127359116",
"https://openalex.org/W2136284683",
"https://openalex.org/W2143923297",
"https://openalex.org/W2166254968",
"https://openalex.org/W2411609146"
],
"referenced_works_count": 48,
"related_works": [
"https://openalex.org/W760197577",
"https://openalex.org/W4310745443",
"https://openalex.org/W292120301",
"https://openalex.org/W2187293700",
"https://openalex.org/W2143023706",
"https://openalex.org/W2132207019",
"https://openalex.org/W2085107982",
"https://openalex.org/W2033189213",
"https://openalex.org/W1991142812",
"https://openalex.org/W1592776416"
],
"sustainable_development_goals": [
{
"id": "https://metadata.un.org/sdg/14",
"display_name": "Life below water",
"score": 0.71
}
],
"title": "Transcriptional profiling of MHC class I genes in rainbow trout infected with infectious hematopoietic necrosis virus",
"topics": [
{
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11020",
"display_name": "Natural Killer Cells in Immunity",
"score": 0.9997,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T10031",
"display_name": "Regulatory T Cell Development and Function",
"score": 0.9986,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-15T04:39:38.724648",
"versions": []
}
}
