Item talk:Q252660
From geokb
{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "Vaccination with F1-V fusion protein protects black-footed ferrets (Mustela nigripes) against plague upon oral challenge with Yersinia pestis", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70033291", "url": "https://pubs.usgs.gov/publication/70033291" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70033291 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.7589/0090-3558-44.1.1", "url": "https://doi.org/10.7589/0090-3558-44.1.1" }, { "@type": "PropertyValue", "propertyID": "ISSN", "value": "00903558" } ], "journal": { "@type": "Periodical", "name": "Journal of Wildlife Diseases", "volumeNumber": "44", "issueNumber": "1" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Journal of Wildlife Diseases" } ], "datePublished": "2008", "dateModified": "2017-10-04", "abstract": "Previous studies have established that vaccination of black-footed ferrets (Mustela nigripes) with F1-V fusion protein by subcutaneous (SC) injection protects the animals against plague upon injection of the bacterium\u00a0Yersinia pestis. This study demonstrates that the F1-V antigen can also protect ferrets against plague contracted via ingestion of a\u00a0Y. pestis-infected mouse, a probable route for natural infection. Eight black-footed ferret kits were vaccinated with F1-V protein by SC injection at approximately 60 days-of-age. A booster vaccination was administered 3 mo later via SC injection. Four additional ferret kits received placebos. The animals were challenged 6 wk after the boost by feeding each one a\u00a0Y. pestis-infected mouse. All eight vaccinates survived challenge, while the four controls succumbed to plague within 3 days after exposure. To determine the duration of antibody postvaccination, 18 additional black-footed ferret kits were vaccinated and boosted with F1-V by SC injection at 60 and 120 days-of-age. High titers to both F1 and V (mean reciprocal titers of 18,552 and 99,862, respectively) were found in all vaccinates up to 2 yr postvaccination, whereas seven control animals remained antibody negative throughout the same time period.", "description": "7 p.", "publisher": { "@type": "Organization", "name": "Wildlife Disease Association" }, "author": [ { "@type": "Person", "name": "Smith, Susan susansmith@usgs.gov", "givenName": "Susan", "familyName": "Smith", "email": "susansmith@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0001-6478-5028", "url": "https://orcid.org/0000-0001-6478-5028" }, "affiliation": [ { "@type": "Organization", "name": "National Wildlife Health Center", "url": "https://www.usgs.gov/centers/nwhc" } ] }, { "@type": "Person", "name": "Rocke, Tonie E. trocke@usgs.gov", "givenName": "Tonie E.", "familyName": "Rocke", "email": "trocke@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-3933-1563", "url": "https://orcid.org/0000-0003-3933-1563" }, "affiliation": [ { "@type": "Organization", "name": "National Wildlife Health Center", "url": "https://www.usgs.gov/centers/nwhc" } ] }, { "@type": "Person", "name": "Marinari, Paul E.", "givenName": "Paul E.", "familyName": "Marinari" }, { "@type": "Person", "name": "Powell, B.S.", "givenName": "B.S.", "familyName": "Powell" }, { "@type": "Person", "name": "Kreeger, J.", "givenName": "J.", "familyName": "Kreeger" }, { "@type": "Person", "name": "Enama, J.T.", "givenName": "J.T.", "familyName": "Enama" } ], "funder": [ { "@type": "Organization", "name": "National Wildlife Health Center", "url": "https://www.usgs.gov/centers/nwhc" } ] }, "OpenAlex": { "abstract_inverted_index": { "Previous": [ 0 ], "studies": [ 1 ], "have": [ 2 ], "established": [ 3 ], "that": [ 4, 34 ], "vaccination": [ 5, 76 ], "of": [ 6, 26, 47, 129, 161 ], "black-footed": [ 7, 59, 134 ], "ferrets": [ 8, 41 ], "(Mustela": [ 9 ], "nigripes)": [ 10 ], "with": [ 11, 64, 141 ], "F1-V": [ 12, 36, 65, 142 ], "fusion": [ 13 ], "protein": [ 14, 66 ], "by": [ 15, 67, 100, 143 ], "subcutaneous": [ 16 ], "(SC)": [ 17 ], "injection": [ 18, 25, 69, 145 ], "protects": [ 19 ], "the": [ 20, 27, 35, 98, 114, 127, 184 ], "animals": [ 21, 92, 179 ], "against": [ 22, 42 ], "plague": [ 23, 43, 119 ], "upon": [ 24 ], "bacterium": [ 28 ], "Yersinia": [ 29 ], "pestis.": [ 30 ], "This": [ 31 ], "study": [ 32 ], "demonstrates": [ 33 ], "antigen": [ 37 ], "can": [ 38 ], "also": [ 39 ], "protect": [ 40 ], "contracted": [ 44 ], "via": [ 45, 82 ], "ingestion": [ 46 ], "a": [ 48, 52, 104 ], "Y.": [ 49, 105 ], "pestis-infected": [ 50, 106 ], "mouse,": [ 51 ], "probable": [ 53 ], "route": [ 54 ], "for": [ 55 ], "natural": [ 56 ], "infection.": [ 57 ], "Eight": [ 58 ], "ferret": [ 60, 87, 135 ], "kits": [ 61, 88, 136 ], "were": [ 62, 93, 137, 166 ], "vaccinated": [ 63, 138 ], "SC": [ 68, 83, 144 ], "at": [ 70, 146 ], "approximately": [ 71 ], "60": [ 72, 147 ], "days-of-age.": [ 73, 150 ], "A": [ 74 ], "booster": [ 75 ], "was": [ 77 ], "administered": [ 78 ], "3": [ 79, 121 ], "mo": [ 80 ], "later": [ 81 ], "injection.": [ 84 ], "Four": [ 85 ], "additional": [ 86, 133 ], "received": [ 89 ], "placebos.": [ 90 ], "The": [ 91 ], "challenged": [ 94 ], "6": [ 95 ], "wk": [ 96 ], "after": [ 97, 123 ], "boost": [ 99 ], "feeding": [ 101 ], "each": [ 102 ], "one": [ 103 ], "mouse.": [ 107 ], "All": [ 108 ], "eight": [ 109 ], "vaccinates": [ 110, 170 ], "survived": [ 111 ], "challenge,": [ 112 ], "while": [ 113 ], "four": [ 115 ], "controls": [ 116 ], "succumbed": [ 117 ], "to": [ 118, 153, 172 ], "within": [ 120 ], "days": [ 122 ], "exposure.": [ 124 ], "To": [ 125 ], "determine": [ 126 ], "duration": [ 128 ], "antibody": [ 130, 181 ], "postvaccination,": [ 131, 175 ], "18": [ 132 ], "and": [ 139, 148, 156, 163 ], "boosted": [ 140 ], "120": [ 149 ], "High": [ 151 ], "titers": [ 152, 160 ], "both": [ 154 ], "F1": [ 155 ], "V": [ 157 ], "(mean": [ 158 ], "reciprocal": [ 159 ], "18,552": [ 162 ], "99,862,": [ 164 ], "respectively)": [ 165 ], "found": [ 167 ], "in": [ 168 ], "all": [ 169 ], "up": [ 171 ], "2": [ 173 ], "yr": [ 174 ], "whereas": [ 176 ], "seven": [ 177 ], "control": [ 178 ], "remained": [ 180 ], "negative": [ 182 ], "throughout": [ 183 ], "same": [ 185 ], "time": [ 186 ], "period.": [ 187 ] }, "apc_list": null, "apc_paid": null, "authorships": [ { "author_position": "first", "author": { "id": "https://openalex.org/A5010964128", "display_name": "Tonie E. 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