Item talk:Q251223
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Sensing disease and danger: A survey of vertebrate PRRs and their origins",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70043625",
"url": "https://pubs.usgs.gov/publication/70043625"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70043625
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.dci.2011.01.008",
"url": "https://doi.org/10.1016/j.dci.2011.01.008"
}
],
"journal": {
"@type": "Periodical",
"name": "Developmental and Comparative Immunology",
"volumeNumber": "35",
"issueNumber": "9"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Developmental and Comparative Immunology"
}
],
"datePublished": "2011",
"dateModified": "2013-04-30",
"abstract": "A key facet of the innate immune response lays in its ability to recognize and respond to invading microorganisms and cellular disturbances. Through the use of germ-line encoded PRRs, the innate immune system is capable of detecting invariant pathogen motifs termed pathogen-associated molecular patterns (PAMPS) that are distinct from host encoded proteins or products released from dying cells, which are known as damage-associated molecular patterns (DAMPs). PAMPs and DAMPs include both protein and nucleic acids for the detection and response to pathogens and metabolic \"danger\" signals. This is by far one of the most active areas of research as recent studies have shown retinoic acid inducible gene 1 (RIG1)-like receptors (RLRs), the nucleotide-binding domain, leucine-rich repeat containing proteins (NLRs) and Toll-like receptors (TLRs) and the recently described AIM-like receptors (ALRs) are responsible for initiating interferon production or the assembly and activation of the inflammasome, ultimately resulting in the release of bioactive IL-1 family members. Overall, the vertebrate PRR recognition machinery consists of seven domains (e.g., Death, NACHT, CARD, TIR, LRR, PYD, helicase), most of which can be traced to the very origins of the deuterostomes. This review is intended to provide an overview of the basic components that are used by vertebrates to detect and respond to pathogens, with an emphasis on these receptors in fish as well as a brief note on their likely origins.",
"description": "12 p.",
"publisher": {
"@type": "Organization",
"name": "Elsevier"
},
"author": [
{
"@type": "Person",
"name": "Hansen, John D. jhansen@usgs.gov",
"givenName": "John D.",
"familyName": "Hansen",
"email": "jhansen@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0002-3006-2734",
"url": "https://orcid.org/0000-0002-3006-2734"
},
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Vojtech, Lucia N.",
"givenName": "Lucia N.",
"familyName": "Vojtech"
},
{
"@type": "Person",
"name": "Laing, Kerry J.",
"givenName": "Kerry J.",
"familyName": "Laing"
}
],
"funder": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
],
"spatialCoverage": [
{
"@type": "Place",
"additionalType": "country",
"name": "United States",
"url": "https://geonames.org/4074035"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"A": [
0
],
"key": [
1
],
"facet": [
2
],
"of": [
3,
25,
35,
91,
96,
141,
149,
161,
173,
182,
193
],
"the": [
4,
23,
29,
76,
92,
111,
124,
137,
142,
147,
155,
179,
183,
194
],
"innate": [
5,
30
],
"immune": [
6,
31
],
"response": [
7,
79
],
"lays": [
8
],
"in": [
9,
146,
214
],
"its": [
10
],
"ability": [
11
],
"to": [
12,
16,
80,
178,
189,
202,
206
],
"recognize": [
13
],
"and": [
14,
19,
67,
72,
78,
82,
119,
123,
139,
204
],
"respond": [
15,
205
],
"invading": [
17
],
"microorganisms": [
18
],
"cellular": [
20
],
"disturbances.": [
21
],
"Through": [
22
],
"use": [
24
],
"germ-line": [
26
],
"encoded": [
27,
50
],
"PRRs,": [
28
],
"system": [
32
],
"is": [
33,
87,
187
],
"capable": [
34
],
"detecting": [
36
],
"invariant": [
37
],
"pathogen": [
38
],
"motifs": [
39
],
"termed": [
40
],
"pathogen-associated": [
41
],
"molecular": [
42,
63
],
"patterns": [
43,
64
],
"(PAMPS)": [
44
],
"that": [
45,
197
],
"are": [
46,
59,
130,
198
],
"distinct": [
47
],
"from": [
48,
55
],
"host": [
49
],
"proteins": [
51,
117
],
"or": [
52,
136
],
"products": [
53
],
"released": [
54
],
"dying": [
56
],
"cells,": [
57
],
"which": [
58,
174
],
"known": [
60
],
"as": [
61,
98,
216,
218
],
"damage-associated": [
62
],
"(DAMPs).": [
65
],
"PAMPs": [
66
],
"DAMPs": [
68
],
"include": [
69
],
"both": [
70
],
"protein": [
71
],
"nucleic": [
73
],
"acids": [
74
],
"for": [
75,
132
],
"detection": [
77
],
"pathogens": [
81
],
"metabolic": [
83
],
"\u201cdanger\u201d": [
84
],
"signals.": [
85
],
"This": [
86,
185
],
"by": [
88,
200
],
"far": [
89
],
"one": [
90
],
"most": [
93,
172
],
"active": [
94
],
"areas": [
95
],
"research": [
97
],
"recent": [
99
],
"studies": [
100
],
"have": [
101
],
"shown": [
102
],
"retinoic": [
103
],
"acid": [
104
],
"inducible": [
105
],
"gene": [
106
],
"1": [
107
],
"(RIG1)-like": [
108
],
"receptors": [
109,
121,
128,
213
],
"(RLRs),": [
110
],
"nucleotide-binding": [
112
],
"domain,": [
113
],
"leucine-rich": [
114
],
"repeat": [
115
],
"containing": [
116
],
"(NLRs)": [
118
],
"Toll-like": [
120
],
"(TLRs)": [
122
],
"recently": [
125
],
"described": [
126
],
"AIM-like": [
127
],
"(ALRs)": [
129
],
"responsible": [
131
],
"initiating": [
133
],
"interferon": [
134
],
"production": [
135
],
"assembly": [
138
],
"activation": [
140
],
"inflammasome,": [
143
],
"ultimately": [
144
],
"resulting": [
145
],
"release": [
148
],
"bioactive": [
150
],
"IL-1": [
151
],
"family": [
152
],
"members.": [
153
],
"Overall,": [
154
],
"vertebrate": [
156
],
"PRR": [
157
],
"recognition": [
158
],
"machinery": [
159
],
"consists": [
160
],
"seven": [
162
],
"domains": [
163
],
"(e.g.,": [
164
],
"Death,": [
165
],
"NACHT,": [
166
],
"CARD,": [
167
],
"TIR,": [
168
],
"LRR,": [
169
],
"PYD,": [
170
],
"helicase),": [
171
],
"can": [
175
],
"be": [
176
],
"traced": [
177
],
"very": [
180
],
"origins": [
181
],
"deuterostomes.": [
184
],
"review": [
186
],
"intended": [
188
],
"provide": [
190
],
"an": [
191,
209
],
"overview": [
192
],
"basic": [
195
],
"components": [
196
],
"used": [
199
],
"vertebrates": [
201
],
"detect": [
203
],
"pathogens,": [
207
],
"with": [
208
],
"emphasis": [
210
],
"on": [
211,
222
],
"these": [
212
],
"fish": [
215
],
"well": [
217
],
"a": [
219
],
"brief": [
220
],
"note": [
221
],
"their": [
223
],
"likely": [
224
],
"origins.": [
225
]
},
"apc_list": {
"value": 3350,
"currency": "USD",
"value_usd": 3350,
"provenance": "doaj"
},
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5066824903",
"display_name": "John D. Hansen",
"orcid": "https://orcid.org/0000-0002-3006-2734"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
},
{
"id": "https://openalex.org/I201448701",
"display_name": "University of Washington",
"ror": "https://ror.org/00cvxb145",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I201448701"
]
}
],
"countries": [
"US"
],
"is_corresponding": true,
"raw_author_name": "John D. Hansen",
"raw_affiliation_strings": [
"Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98115, United States",
"U.S. Geological Survey, Western Fisheries Research Center, Seattle, WA 98115, United States"
],
"affiliations": [
{
"raw_affiliation_string": "U.S. Geological Survey, Western Fisheries Research Center, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I1286329397"
]
},
{
"raw_affiliation_string": "Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I201448701"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5013386124",
"display_name": "Lucia Vojtech",
"orcid": "https://orcid.org/0000-0003-2343-0719"
},
"institutions": [
{
"id": "https://openalex.org/I201448701",
"display_name": "University of Washington",
"ror": "https://ror.org/00cvxb145",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I201448701"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Lucia N. Vojtech",
"raw_affiliation_strings": [
"Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98115, United States"
],
"affiliations": [
{
"raw_affiliation_string": "Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98115, United States",
"institution_ids": [
"https://openalex.org/I201448701"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5027949391",
"display_name": "Kerry J. Laing",
"orcid": "https://orcid.org/0000-0001-9245-5325"
},
"institutions": [
{
"id": "https://openalex.org/I4210089486",
"display_name": "Fred Hutch Cancer Center",
"ror": "https://ror.org/007ps6h72",
"country_code": "US",
"type": "nonprofit",
"lineage": [
"https://openalex.org/I4210089486"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Kerry J. Laing",
"raw_affiliation_strings": [
"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States"
],
"affiliations": [
{
"raw_affiliation_string": "Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States",
"institution_ids": [
"https://openalex.org/I4210089486"
]
}
]
}
],
"best_oa_location": null,
"biblio": {
"volume": "35",
"issue": "9",
"first_page": "886",
"last_page": "897"
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2138560966",
"cited_by_count": 204,
"cited_by_percentile_year": {
"min": 98,
"max": 99
},
"concepts": [
{
"id": "https://openalex.org/c86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.86015075,
"qid": "Q158998"
},
{
"id": "https://openalex.org/c136449434",
"wikidata": "https://www.wikidata.org/wiki/Q428253",
"display_name": "Innate immune system",
"level": 3,
"score": 0.8090667,
"qid": null
},
{
"id": "https://openalex.org/c111289621",
"wikidata": "https://www.wikidata.org/wiki/Q418772",
"display_name": "Pattern recognition receptor",
"level": 4,
"score": 0.774014,
"qid": null
},
{
"id": "https://openalex.org/c188899842",
"wikidata": "https://www.wikidata.org/wiki/Q1483180",
"display_name": "Pathogen-associated molecular pattern",
"level": 5,
"score": 0.71705925,
"qid": null
},
{
"id": "https://openalex.org/c2777209026",
"wikidata": "https://www.wikidata.org/wiki/Q412405",
"display_name": "Inflammasome",
"level": 3,
"score": 0.57480085,
"qid": null
},
{
"id": "https://openalex.org/c170493617",
"wikidata": "https://www.wikidata.org/wiki/Q208467",
"display_name": "Receptor",
"level": 2,
"score": 0.55927473,
"qid": null
},
{
"id": "https://openalex.org/c95444343",
"wikidata": "https://www.wikidata.org/wiki/Q7141",
"display_name": "Cell biology",
"level": 1,
"score": 0.4753846,
"qid": "Q158967"
},
{
"id": "https://openalex.org/c8891405",
"wikidata": "https://www.wikidata.org/wiki/Q1059",
"display_name": "Immune system",
"level": 2,
"score": 0.47320908,
"qid": null
},
{
"id": "https://openalex.org/c43929388",
"wikidata": "https://www.wikidata.org/wiki/Q4050587",
"display_name": "TRIF",
"level": 5,
"score": 0.46364298,
"qid": null
},
{
"id": "https://openalex.org/c2776954689",
"wikidata": "https://www.wikidata.org/wiki/Q21100537",
"display_name": "RIG-I",
"level": 4,
"score": 0.4251241,
"qid": null
},
{
"id": "https://openalex.org/c54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.39085612,
"qid": "Q158979"
},
{
"id": "https://openalex.org/c203014093",
"wikidata": "https://www.wikidata.org/wiki/Q101929",
"display_name": "Immunology",
"level": 1,
"score": 0.3785623,
"qid": "Q166282"
},
{
"id": "https://openalex.org/c70721500",
"wikidata": "https://www.wikidata.org/wiki/Q177005",
"display_name": "Computational biology",
"level": 1,
"score": 0.33294553,
"qid": "Q226210"
},
{
"id": "https://openalex.org/c2776709828",
"wikidata": "https://www.wikidata.org/wiki/Q408004",
"display_name": "Toll-like receptor",
"level": 4,
"score": 0.31094116,
"qid": null
}
],
"corresponding_author_ids": [
"https://openalex.org/A5066824903"
],
"corresponding_institution_ids": [
"https://openalex.org/I1286329397",
"https://openalex.org/I201448701"
],
"countries_distinct_count": 1,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 9
},
{
"year": 2023,
"cited_by_count": 11
},
{
"year": 2022,
"cited_by_count": 14
},
{
"year": 2021,
"cited_by_count": 10
},
{
"year": 2020,
"cited_by_count": 9
},
{
"year": 2019,
"cited_by_count": 9
},
{
"year": 2018,
"cited_by_count": 23
},
{
"year": 2017,
"cited_by_count": 15
},
{
"year": 2016,
"cited_by_count": 23
},
{
"year": 2015,
"cited_by_count": 21
},
{
"year": 2014,
"cited_by_count": 17
},
{
"year": 2013,
"cited_by_count": 22
},
{
"year": 2012,
"cited_by_count": 17
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Sensing disease and danger: A survey of vertebrate PRRs and their origins",
"doi": "https://doi.org/10.1016/j.dci.2011.01.008",
"fulltext_origin": "ngrams",
"fwci": 2.196,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W2138560966",
"ids": {
"openalex": "https://openalex.org/W2138560966",
"doi": "https://doi.org/10.1016/j.dci.2011.01.008",
"mag": "2138560966",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/21241729"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 3,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/pathogen-recognition",
"display_name": "Pathogen Recognition",
"score": 0.566696
},
{
"id": "https://openalex.org/keywords/innate-antiviral-responses",
"display_name": "Innate Antiviral Responses",
"score": 0.553862
},
{
"id": "https://openalex.org/keywords/damps",
"display_name": "DAMPs",
"score": 0.541153
},
{
"id": "https://openalex.org/keywords/immune-sensing",
"display_name": "Immune Sensing",
"score": 0.530939
},
{
"id": "https://openalex.org/keywords/adaptive-immunity-regulation",
"display_name": "Adaptive Immunity Regulation",
"score": 0.517526
}
],
"language": "en",
"locations": [
{
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.dci.2011.01.008",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S81563257",
"display_name": "Developmental & Comparative Immunology",
"issn_l": "0145-305X",
"issn": [
"0145-305X",
"1879-0089"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/21241729",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 2,
"mesh": [
{
"descriptor_ui": "D054884",
"descriptor_name": "Host-Pathogen Interactions",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D007239",
"descriptor_name": "Infections",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D007239",
"descriptor_name": "Infections",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D007372",
"descriptor_name": "Interferons",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D051192",
"descriptor_name": "Receptors, Pattern Recognition",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D020816",
"descriptor_name": "Amino Acid Motifs",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020816",
"descriptor_name": "Amino Acid Motifs",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017209",
"descriptor_name": "Apoptosis",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005075",
"descriptor_name": "Biological Evolution",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005399",
"descriptor_name": "Fishes",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D054884",
"descriptor_name": "Host-Pathogen Interactions",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D006801",
"descriptor_name": "Humans",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007113",
"descriptor_name": "Immunity, Innate",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007239",
"descriptor_name": "Infections",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007239",
"descriptor_name": "Infections",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D058847",
"descriptor_name": "Inflammasomes",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D058847",
"descriptor_name": "Inflammasomes",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D007372",
"descriptor_name": "Interferons",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D009696",
"descriptor_name": "Nucleic Acids",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D009696",
"descriptor_name": "Nucleic Acids",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D051192",
"descriptor_name": "Receptors, Pattern Recognition",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D051192",
"descriptor_name": "Receptors, Pattern Recognition",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D051192",
"descriptor_name": "Receptors, Pattern Recognition",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D014714",
"descriptor_name": "Vertebrates",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2138560966/ngrams",
"open_access": {
"is_oa": false,
"oa_status": "closed",
"oa_url": null,
"any_repository_has_fulltext": false
},
"primary_location": {
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.dci.2011.01.008",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S81563257",
"display_name": "Developmental & Comparative Immunology",
"issn_l": "0145-305X",
"issn": [
"0145-305X",
"1879-0089"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
"primary_topic": {
"id": "https://openalex.org/T11668",
"display_name": "Innate Immunity to Viral Infection",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2011-09-01",
"publication_year": 2011,
"referenced_works": [
"https://openalex.org/W1503037824",
"https://openalex.org/W1506240583",
"https://openalex.org/W1534675570",
"https://openalex.org/W1548907681",
"https://openalex.org/W1549733473",
"https://openalex.org/W1743744546",
"https://openalex.org/W1924634855",
"https://openalex.org/W1968178474",
"https://openalex.org/W1970154782",
"https://openalex.org/W1973101085",
"https://openalex.org/W1974781808",
"https://openalex.org/W1979838502",
"https://openalex.org/W1983419107",
"https://openalex.org/W1983470819",
"https://openalex.org/W1984338631",
"https://openalex.org/W1987015602",
"https://openalex.org/W1992433051",
"https://openalex.org/W1994601965",
"https://openalex.org/W2000076863",
"https://openalex.org/W2007080498",
"https://openalex.org/W2007608885",
"https://openalex.org/W2008205505",
"https://openalex.org/W2009708031",
"https://openalex.org/W2010057180",
"https://openalex.org/W2013433092",
"https://openalex.org/W2016401408",
"https://openalex.org/W2016840733",
"https://openalex.org/W2017515700",
"https://openalex.org/W2018991353",
"https://openalex.org/W2028787589",
"https://openalex.org/W2031388429",
"https://openalex.org/W2032558535",
"https://openalex.org/W2032980461",
"https://openalex.org/W2036334370",
"https://openalex.org/W2036589719",
"https://openalex.org/W2037502650",
"https://openalex.org/W2038143978",
"https://openalex.org/W2038366923",
"https://openalex.org/W2042288276",
"https://openalex.org/W2042590551",
"https://openalex.org/W2042816890",
"https://openalex.org/W2048032544",
"https://openalex.org/W2048682843",
"https://openalex.org/W2050607396",
"https://openalex.org/W2050798656",
"https://openalex.org/W2051565439",
"https://openalex.org/W2051658957",
"https://openalex.org/W2055773854",
"https://openalex.org/W2061881258",
"https://openalex.org/W2063641548",
"https://openalex.org/W2066890134",
"https://openalex.org/W2072065615",
"https://openalex.org/W2072118838",
"https://openalex.org/W2074324320",
"https://openalex.org/W2079936328",
"https://openalex.org/W2081343476",
"https://openalex.org/W2083874217",
"https://openalex.org/W2084379510",
"https://openalex.org/W2089380674",
"https://openalex.org/W2091596699",
"https://openalex.org/W2094045593",
"https://openalex.org/W2095090055",
"https://openalex.org/W2098854209",
"https://openalex.org/W2100492066",
"https://openalex.org/W2100665873",
"https://openalex.org/W2104298833",
"https://openalex.org/W2107997395",
"https://openalex.org/W2111260918",
"https://openalex.org/W2111581525",
"https://openalex.org/W2114737175",
"https://openalex.org/W2114769428",
"https://openalex.org/W2115185894",
"https://openalex.org/W2119492463",
"https://openalex.org/W2125566625",
"https://openalex.org/W2128847991",
"https://openalex.org/W2131617804",
"https://openalex.org/W2136329789",
"https://openalex.org/W2137590150",
"https://openalex.org/W2140815975",
"https://openalex.org/W2140821779",
"https://openalex.org/W2144134574",
"https://openalex.org/W2146049932",
"https://openalex.org/W2148579227",
"https://openalex.org/W2150594596",
"https://openalex.org/W2152765142",
"https://openalex.org/W2155538302",
"https://openalex.org/W2159685069",
"https://openalex.org/W2162760851",
"https://openalex.org/W2162761876",
"https://openalex.org/W2164549814",
"https://openalex.org/W2165655956",
"https://openalex.org/W2170605026",
"https://openalex.org/W2171283389",
"https://openalex.org/W2220972622",
"https://openalex.org/W617576412"
],
"referenced_works_count": 95,
"related_works": [
"https://openalex.org/W4384038121",
"https://openalex.org/W2944019960",
"https://openalex.org/W2401155949",
"https://openalex.org/W2181540971",
"https://openalex.org/W2150324671",
"https://openalex.org/W2080298383",
"https://openalex.org/W2040527513",
"https://openalex.org/W2017170089",
"https://openalex.org/W2004731666",
"https://openalex.org/W1569130359"
],
"sustainable_development_goals": [
{
"score": 0.72,
"display_name": "Life below water",
"id": "https://metadata.un.org/sdg/14"
}
],
"title": "Sensing disease and danger: A survey of vertebrate PRRs and their origins",
"topics": [
{
"id": "https://openalex.org/T11668",
"display_name": "Innate Immunity to Viral Infection",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T10371",
"display_name": "Innate Immune Recognition and Signaling Pathways",
"score": 0.9978,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11078",
"display_name": "Molecular Mechanisms of Inflammasome Activation and Regulation",
"score": 0.9968,
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "review",
"type_crossref": "journal-article",
"updated_date": "2024-08-07T06:10:52.046398",
"versions": [],
"qid": null
}
}
