Item talk:Q249578
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Analysis of DNA-vaccinated fish reveals viral antigen in muscle, kidney, and thymus, and transient histopathologic changes",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70027896",
"url": "https://pubs.usgs.gov/publication/70027896"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70027896
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s10126-004-5129-z",
"url": "https://doi.org/10.1007/s10126-004-5129-z"
},
{
"@type": "PropertyValue",
"propertyID": "ISSN",
"value": "14362228"
}
],
"journal": {
"@type": "Periodical",
"name": "Marine Biotechnology",
"volumeNumber": "7",
"issueNumber": "5"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Marine Biotechnology"
}
],
"datePublished": "2005",
"dateModified": "2017-01-04",
"abstract": "A highly efficacious DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was used in a systematic study to analyze vaccine tissue distribution, persistence, expression patterns, and histopathologic effects. Vaccine plasmid pIHNw-G, containing the gene for the viral glycoprotein, was detected immediately after intramuscular injection in all tissues analyzed, including blood, but at later time points was found primarily in muscle tissue, where it persisted to 90 days. Glycoprotein expression was detected in muscle, kidney, and thymus tissues, with levels peaking at 14 days and becoming undetectable by 28 days. Histologic examination revealed no vaccine-specific pathologic changes at the standard effective dose of 0.1 ??g DNA per fish, but at a high dose of 50 ??g an increased inflammatory response was evident. Transient damage associated with needle injection was localized in muscle tissue, but by 90 days after vaccination no damage was detected in any tissue, indicating the vaccine to be safe and well tolerated. ?? Springer Science+Business Media, Inc. 2005.",
"description": "14 p.",
"publisher": {
"@type": "Organization",
"name": "Springer-Verlag"
},
"author": [
{
"@type": "Person",
"name": "Conway, C. M.",
"givenName": "C. M.",
"familyName": "Conway"
},
{
"@type": "Person",
"name": "Garver, K.A.",
"givenName": "K.A.",
"familyName": "Garver"
},
{
"@type": "Person",
"name": "Elliott, D.G.",
"givenName": "D.G.",
"familyName": "Elliott"
},
{
"@type": "Person",
"name": "Kurath, Gael gkurath@usgs.gov",
"givenName": "Gael",
"familyName": "Kurath",
"email": "gkurath@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0003-3294-560X",
"url": "https://orcid.org/0000-0003-3294-560X"
},
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
}
],
"funder": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
"OpenAlex": {
"abstract_inverted_index": null,
"apc_list": {
"value": 2590,
"currency": "EUR",
"value_usd": 3390,
"provenance": "doaj"
},
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5077781145",
"display_name": "Kyle A. Garver",
"orcid": "https://orcid.org/0000-0001-8931-3051"
},
"institutions": [
{
"id": "https://openalex.org/I201448701",
"display_name": "University of Washington",
"ror": "https://ror.org/00cvxb145",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I201448701"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Kyle A. Garver",
"raw_affiliation_strings": [
"Department of Pathobiology, University of Washington, Seattle, WA, 98195, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Pathobiology, University of Washington, Seattle, WA, 98195, USA",
"institution_ids": [
"https://openalex.org/I201448701"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5002726131",
"display_name": "Carla M. Conway",
"orcid": "https://orcid.org/0000-0002-3851-3616"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Carla M. Conway",
"raw_affiliation_strings": [
"Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5081486211",
"display_name": "Diane G. Elliott",
"orcid": "https://orcid.org/0000-0002-4809-6692"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Diane G. Elliott",
"raw_affiliation_strings": [
"Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5077553505",
"display_name": "Gael Kurath",
"orcid": "https://orcid.org/0000-0003-3294-560X"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Gael Kurath",
"raw_affiliation_strings": [
"Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Western Fisheries Research Center, United States Geological Survey, Biological Resources Division, 6505 NE 65th St, Seattle, WA, 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
}
],
"best_oa_location": null,
"biblio": {
"volume": "7",
"issue": "5",
"first_page": "540",
"last_page": "553"
},
"citation_normalized_percentile": {
"value": 0.849671,
"is_in_top_1_percent": false,
"is_in_top_10_percent": false
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W1978866940",
"cited_by_count": 51,
"cited_by_percentile_year": {
"min": 93,
"max": 94
},
"concepts": [
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.8574752
},
{
"id": "https://openalex.org/C167508917",
"wikidata": "https://www.wikidata.org/wiki/Q578537",
"display_name": "DNA vaccination",
"level": 4,
"score": 0.80516106
},
{
"id": "https://openalex.org/C2778966499",
"wikidata": "https://www.wikidata.org/wiki/Q880931",
"display_name": "Infectious hematopoietic necrosis virus",
"level": 4,
"score": 0.6581309
},
{
"id": "https://openalex.org/C2780091579",
"wikidata": "https://www.wikidata.org/wiki/Q9377",
"display_name": "Kidney",
"level": 2,
"score": 0.5846508
},
{
"id": "https://openalex.org/C159047783",
"wikidata": "https://www.wikidata.org/wiki/Q7215",
"display_name": "Virology",
"level": 1,
"score": 0.58204657
},
{
"id": "https://openalex.org/C2778514504",
"wikidata": "https://www.wikidata.org/wiki/Q797559",
"display_name": "Muscle tissue",
"level": 2,
"score": 0.5250259
},
{
"id": "https://openalex.org/C48023723",
"wikidata": "https://www.wikidata.org/wiki/Q856198",
"display_name": "Real-time polymerase chain reaction",
"level": 3,
"score": 0.4965344
},
{
"id": "https://openalex.org/C503630168",
"wikidata": "https://www.wikidata.org/wiki/Q178069",
"display_name": "Necrosis",
"level": 2,
"score": 0.48544532
},
{
"id": "https://openalex.org/C2522874641",
"wikidata": "https://www.wikidata.org/wiki/Q808",
"display_name": "Virus",
"level": 2,
"score": 0.46003115
},
{
"id": "https://openalex.org/C22070199",
"wikidata": "https://www.wikidata.org/wiki/Q192995",
"display_name": "Vaccination",
"level": 2,
"score": 0.45855138
},
{
"id": "https://openalex.org/C147483822",
"wikidata": "https://www.wikidata.org/wiki/Q103537",
"display_name": "Antigen",
"level": 2,
"score": 0.45053715
},
{
"id": "https://openalex.org/C2780931953",
"wikidata": "https://www.wikidata.org/wiki/Q9371",
"display_name": "Spleen",
"level": 2,
"score": 0.4499043
},
{
"id": "https://openalex.org/C2776291583",
"wikidata": "https://www.wikidata.org/wiki/Q432083",
"display_name": "Intramuscular injection",
"level": 2,
"score": 0.4204548
},
{
"id": "https://openalex.org/C203014093",
"wikidata": "https://www.wikidata.org/wiki/Q101929",
"display_name": "Immunology",
"level": 1,
"score": 0.3615041
},
{
"id": "https://openalex.org/C104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.24029917
},
{
"id": "https://openalex.org/C2909208804",
"wikidata": "https://www.wikidata.org/wiki/Q127282",
"display_name": "Fish <Actinopterygii>",
"level": 2,
"score": 0.23159388
},
{
"id": "https://openalex.org/C2780801004",
"wikidata": "https://www.wikidata.org/wiki/Q1415366",
"display_name": "Immunization",
"level": 3,
"score": 0.158104
},
{
"id": "https://openalex.org/C126322002",
"wikidata": "https://www.wikidata.org/wiki/Q11180",
"display_name": "Internal medicine",
"level": 1,
"score": 0.13684365
},
{
"id": "https://openalex.org/C134018914",
"wikidata": "https://www.wikidata.org/wiki/Q162606",
"display_name": "Endocrinology",
"level": 1,
"score": 0.12602869
},
{
"id": "https://openalex.org/C71924100",
"wikidata": "https://www.wikidata.org/wiki/Q11190",
"display_name": "Medicine",
"level": 0,
"score": 0.07363856
},
{
"id": "https://openalex.org/C55493867",
"wikidata": "https://www.wikidata.org/wiki/Q7094",
"display_name": "Biochemistry",
"level": 1,
"score": 0.0
},
{
"id": "https://openalex.org/C54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.0
},
{
"id": "https://openalex.org/C505870484",
"wikidata": "https://www.wikidata.org/wiki/Q180538",
"display_name": "Fishery",
"level": 1,
"score": 0.0
},
{
"id": "https://openalex.org/C2994167347",
"wikidata": "https://www.wikidata.org/wiki/Q187986",
"display_name": "Rainbow trout",
"level": 3,
"score": 0.0
}
],
"corresponding_author_ids": [],
"corresponding_institution_ids": [],
"countries_distinct_count": 1,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 1
},
{
"year": 2023,
"cited_by_count": 2
},
{
"year": 2022,
"cited_by_count": 1
},
{
"year": 2020,
"cited_by_count": 2
},
{
"year": 2019,
"cited_by_count": 7
},
{
"year": 2017,
"cited_by_count": 3
},
{
"year": 2016,
"cited_by_count": 3
},
{
"year": 2015,
"cited_by_count": 2
},
{
"year": 2014,
"cited_by_count": 4
},
{
"year": 2013,
"cited_by_count": 4
},
{
"year": 2012,
"cited_by_count": 2
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Analysis of DNA-Vaccinated Fish Reveals Viral Antigen in Muscle, Kidney and Thymus, and Transient Histopathologic Changes",
"doi": "https://doi.org/10.1007/s10126-004-5129-z",
"fulltext_origin": "ngrams",
"fwci": 1.299,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W1978866940",
"ids": {
"openalex": "https://openalex.org/W1978866940",
"doi": "https://doi.org/10.1007/s10126-004-5129-z",
"mag": "1978866940",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/16075347"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 2,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/fish-immunology",
"display_name": "Fish Immunology",
"score": 0.566191
},
{
"id": "https://openalex.org/keywords/muscle-tissue",
"display_name": "Muscle tissue",
"score": 0.5250259
},
{
"id": "https://openalex.org/keywords/intramuscular-injection",
"display_name": "Intramuscular injection",
"score": 0.4204548
}
],
"language": "en",
"locations": [
{
"is_oa": false,
"landing_page_url": "https://doi.org/10.1007/s10126-004-5129-z",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S55645480",
"display_name": "Marine Biotechnology",
"issn_l": "1436-2228",
"issn": [
"1436-2228",
"1436-2236"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319900",
"host_organization_name": "Springer Science+Business Media",
"host_organization_lineage": [
"https://openalex.org/P4310319965",
"https://openalex.org/P4310319900"
],
"host_organization_lineage_names": [
"Springer Nature",
"Springer Science+Business Media"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/16075347",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 2,
"mesh": [
{
"descriptor_ui": "D000956",
"descriptor_name": "Antigens, Viral",
"qualifier_ui": "Q000032",
"qualifier_name": "analysis",
"is_major_topic": true
},
{
"descriptor_ui": "D029142",
"descriptor_name": "Infectious hematopoietic necrosis virus",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D019444",
"descriptor_name": "Vaccines, DNA",
"qualifier_ui": "Q000493",
"qualifier_name": "pharmacokinetics",
"is_major_topic": true
},
{
"descriptor_ui": "D014765",
"descriptor_name": "Viral Vaccines",
"qualifier_ui": "Q000493",
"qualifier_name": "pharmacokinetics",
"is_major_topic": true
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D000956",
"descriptor_name": "Antigens, Viral",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D000956",
"descriptor_name": "Antigens, Viral",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000517",
"qualifier_name": "prevention & control",
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D006023",
"descriptor_name": "Glycoproteins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D006023",
"descriptor_name": "Glycoproteins",
"qualifier_ui": "Q000096",
"qualifier_name": "biosynthesis",
"is_major_topic": false
},
{
"descriptor_ui": "D007150",
"descriptor_name": "Immunohistochemistry",
"qualifier_ui": "Q000379",
"qualifier_name": "methods",
"is_major_topic": false
},
{
"descriptor_ui": "D007150",
"descriptor_name": "Immunohistochemistry",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D029142",
"descriptor_name": "Infectious hematopoietic necrosis virus",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D029142",
"descriptor_name": "Infectious hematopoietic necrosis virus",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D007273",
"descriptor_name": "Injections, Intramuscular",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007273",
"descriptor_name": "Injections, Intramuscular",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D007668",
"descriptor_name": "Kidney",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007668",
"descriptor_name": "Kidney",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D007668",
"descriptor_name": "Kidney",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": false
},
{
"descriptor_ui": "D007668",
"descriptor_name": "Kidney",
"qualifier_ui": "Q000473",
"qualifier_name": "pathology",
"is_major_topic": false
},
{
"descriptor_ui": "D009132",
"descriptor_name": "Muscles",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D009132",
"descriptor_name": "Muscles",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D009132",
"descriptor_name": "Muscles",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": false
},
{
"descriptor_ui": "D009132",
"descriptor_name": "Muscles",
"qualifier_ui": "Q000473",
"qualifier_name": "pathology",
"is_major_topic": false
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": false
},
{
"descriptor_ui": "D017686",
"descriptor_name": "Oncorhynchus mykiss",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": false
},
{
"descriptor_ui": "D010957",
"descriptor_name": "Plasmids",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D010957",
"descriptor_name": "Plasmids",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D016133",
"descriptor_name": "Polymerase Chain Reaction",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D018353",
"descriptor_name": "Rhabdoviridae Infections",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D018353",
"descriptor_name": "Rhabdoviridae Infections",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D018353",
"descriptor_name": "Rhabdoviridae Infections",
"qualifier_ui": "Q000517",
"qualifier_name": "prevention & control",
"is_major_topic": false
},
{
"descriptor_ui": "D012680",
"descriptor_name": "Sensitivity and Specificity",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013950",
"descriptor_name": "Thymus Gland",
"qualifier_ui": "Q000473",
"qualifier_name": "pathology",
"is_major_topic": false
},
{
"descriptor_ui": "D013950",
"descriptor_name": "Thymus Gland",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D013950",
"descriptor_name": "Thymus Gland",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013950",
"descriptor_name": "Thymus Gland",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": false
},
{
"descriptor_ui": "D013997",
"descriptor_name": "Time Factors",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014018",
"descriptor_name": "Tissue Distribution",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019444",
"descriptor_name": "Vaccines, DNA",
"qualifier_ui": "Q000009",
"qualifier_name": "adverse effects",
"is_major_topic": false
},
{
"descriptor_ui": "D019444",
"descriptor_name": "Vaccines, DNA",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019444",
"descriptor_name": "Vaccines, DNA",
"qualifier_ui": "Q000008",
"qualifier_name": "administration & dosage",
"is_major_topic": false
},
{
"descriptor_ui": "D014765",
"descriptor_name": "Viral Vaccines",
"qualifier_ui": "Q000009",
"qualifier_name": "adverse effects",
"is_major_topic": false
},
{
"descriptor_ui": "D014765",
"descriptor_name": "Viral Vaccines",
"qualifier_ui": "Q000008",
"qualifier_name": "administration & dosage",
"is_major_topic": false
},
{
"descriptor_ui": "D014765",
"descriptor_name": "Viral Vaccines",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W1978866940/ngrams",
"open_access": {
"is_oa": false,
"oa_status": "closed",
"oa_url": null,
"any_repository_has_fulltext": false
},
"primary_location": {
"is_oa": false,
"landing_page_url": "https://doi.org/10.1007/s10126-004-5129-z",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S55645480",
"display_name": "Marine Biotechnology",
"issn_l": "1436-2228",
"issn": [
"1436-2228",
"1436-2236"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319900",
"host_organization_name": "Springer Science+Business Media",
"host_organization_lineage": [
"https://openalex.org/P4310319965",
"https://openalex.org/P4310319900"
],
"host_organization_lineage_names": [
"Springer Nature",
"Springer Science+Business Media"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
"primary_topic": {
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9999,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2005-07-22",
"publication_year": 2005,
"referenced_works": [
"https://openalex.org/W1497016347",
"https://openalex.org/W1531370425",
"https://openalex.org/W1584938436",
"https://openalex.org/W169719383",
"https://openalex.org/W1963810035",
"https://openalex.org/W1963817295",
"https://openalex.org/W1964563407",
"https://openalex.org/W1965426825",
"https://openalex.org/W1970108223",
"https://openalex.org/W1970708694",
"https://openalex.org/W1971111190",
"https://openalex.org/W1977265507",
"https://openalex.org/W1982215631",
"https://openalex.org/W1982806555",
"https://openalex.org/W1983800850",
"https://openalex.org/W1991612229",
"https://openalex.org/W2000918807",
"https://openalex.org/W2001649920",
"https://openalex.org/W2001902704",
"https://openalex.org/W2005229360",
"https://openalex.org/W2013905916",
"https://openalex.org/W2014495927",
"https://openalex.org/W2016691501",
"https://openalex.org/W2024590181",
"https://openalex.org/W2026280553",
"https://openalex.org/W2030450068",
"https://openalex.org/W2031598154",
"https://openalex.org/W2037198447",
"https://openalex.org/W2039450289",
"https://openalex.org/W2055548115",
"https://openalex.org/W2059504962",
"https://openalex.org/W2069386634",
"https://openalex.org/W2075107225",
"https://openalex.org/W2077586500",
"https://openalex.org/W2078732069",
"https://openalex.org/W2078898829",
"https://openalex.org/W2081545679",
"https://openalex.org/W2083227565",
"https://openalex.org/W2084177945",
"https://openalex.org/W2085628741",
"https://openalex.org/W2088068373",
"https://openalex.org/W2088653547",
"https://openalex.org/W2088978732",
"https://openalex.org/W2105744540",
"https://openalex.org/W2112202563",
"https://openalex.org/W2128631684",
"https://openalex.org/W2161703938",
"https://openalex.org/W2233324270",
"https://openalex.org/W2418755526",
"https://openalex.org/W3023077910",
"https://openalex.org/W306054505",
"https://openalex.org/W4285719527",
"https://openalex.org/W619868465",
"https://openalex.org/W62293751",
"https://openalex.org/W72051964"
],
"referenced_works_count": 55,
"related_works": [
"https://openalex.org/W8016080",
"https://openalex.org/W3026940941",
"https://openalex.org/W2358802477",
"https://openalex.org/W2261163828",
"https://openalex.org/W2183197098",
"https://openalex.org/W2121575693",
"https://openalex.org/W2081545679",
"https://openalex.org/W2056204173",
"https://openalex.org/W2054547841",
"https://openalex.org/W1544120862"
],
"sustainable_development_goals": [],
"title": "Analysis of DNA-Vaccinated Fish Reveals Viral Antigen in Muscle, Kidney and Thymus, and Transient Histopathologic Changes",
"topics": [
{
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9999,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11684",
"display_name": "Dynamics and Pathogenesis of Cholera Bacteria",
"score": 0.998,
"subfield": {
"id": "https://openalex.org/subfields/1310",
"display_name": "Endocrinology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11135",
"display_name": "Paramyxovirus Infections and Epidemiology",
"score": 0.9978,
"subfield": {
"id": "https://openalex.org/subfields/2713",
"display_name": "Epidemiology"
},
"field": {
"id": "https://openalex.org/fields/27",
"display_name": "Medicine"
},
"domain": {
"id": "https://openalex.org/domains/4",
"display_name": "Health Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-14T05:17:47.972531",
"versions": []
}
}
