Item talk:Q247959

From geokb

{

 "USGS Publications Warehouse": {
   "@context": "https://schema.org",
   "@type": "Article",
   "additionalType": "Journal Article",
   "name": "Effects of cadmium, estradiol-17beta and their interaction on gonadal condition and metamorphosis of male and female African clawed frog, Xenopus laevis",
   "identifier": [
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse IndexID",
       "value": "70150438",
       "url": "https://pubs.usgs.gov/publication/70150438"
     },
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse Internal ID",
       "value": 70150438
     },
     {
       "@type": "PropertyValue",
       "propertyID": "DOI",
       "value": "10.1016/j.chemosphere.2010.02.044",
       "url": "https://doi.org/10.1016/j.chemosphere.2010.02.044"
     }
   ],
   "journal": {
     "@type": "Periodical",
     "name": "Chemosphere",
     "volumeNumber": "79",
     "issueNumber": "5"
   },
   "inLanguage": "en",
   "isPartOf": [
     {
       "@type": "CreativeWorkSeries",
       "name": "Chemosphere"
     }
   ],
   "datePublished": "2010",
   "dateModified": "2015-06-26",
   "abstract": "To assess interaction effects between cadmium (Cd, a putative xenoestrogen) and estradiol-17beta (E(2)) on sex differentiation and metamorphosis, Xenopus laevis were exposed to solvent-control (0.005% ethanol), Cd (10microgL(-1)), E(2) (1microgL(-1)), or Cd and E(2) (Cd+E(2)) in FETAX medium from fertilization to 75d postfertilization. Each treatment was applied to four aquaria, each with 30 fertilized eggs. Mortality was recorded and animals were sampled as they completed metamorphosis (Nieuwkoop and Faber stage 66). Gonadal sex of individuals (including >or= tadpoles NF stage 55 at day 75) was determined gross-morphologically and used to compute sex ratios. Time course and percent completion of metamorphosis, snout-vent length (SVL), hindlimb length (HLL) and weight were analyzed for each gender separately. Survival rates did not differ among treatments. The E(2) and Cd+E(2) treatments significantly skewed sex ratios towards females; however, no sex-ratio differences were observed between the control and Cd treatments or between the E(2) and Cd+E(2) treatments. Time course of metamorphosis was generally delayed and percent completion of metamorphosis was generally reduced in males and females exposed to Cd, E(2) or their combination compared to control animals. In males, but not females, the effect of Cd+E(2) was greater than that of individual chemicals. Weight at completion of metamorphosis was reduced only in females and only by the Cd+E(2) treatment. In conclusion, although Cd at an environmentally relevant concentration did not exhibit direct or indirect feminizing effects in Xenopus tadpoles, the metal and E(2) both had similar inhibitory effects on metamorphosis that were of greater magnitude in males than females.",
   "description": "7 p.",
   "publisher": {
     "@type": "Organization",
     "name": "Pergamon Press"
   },
   "author": [
     {
       "@type": "Person",
       "name": "Sharma, Bibek",
       "givenName": "Bibek",
       "familyName": "Sharma"
     },
     {
       "@type": "Person",
       "name": "Pati\u00f1o, Reynaldo r.patino@usgs.gov",
       "givenName": "Reynaldo",
       "familyName": "Pati\u00f1o",
       "email": "r.patino@usgs.gov",
       "identifier": {
         "@type": "PropertyValue",
         "propertyID": "ORCID",
         "value": "0000-0002-4831-8400",
         "url": "https://orcid.org/0000-0002-4831-8400"
       },
       "affiliation": [
         {
           "@type": "Organization",
           "name": "Coop Res Unit Atlanta",
           "url": "https://www1.usgs.gov/coopunits/unit/Georgia"
         }
       ]
     }
   ],
   "funder": [
     {
       "@type": "Organization",
       "name": "Coop Res Unit Atlanta",
       "url": "https://www1.usgs.gov/coopunits/unit/Georgia"
     }
   ]
 },
 "OpenAlex": {
   "abstract_inverted_index": {
     "To": [
       0
     ],
     "assess": [
       1
     ],
     "interaction": [
       2
     ],
     "effects": [
       3,
       243,
       255
     ],
     "between": [
       4,
       146,
       153
     ],
     "cadmium": [
       5
     ],
     "(Cd,": [
       6
     ],
     "a": [
       7
     ],
     "putative": [
       8
     ],
     "xenoestrogen)": [
       9
     ],
     "and": [
       10,
       16,
       36,
       65,
       74,
       93,
       101,
       112,
       129,
       149,
       156,
       168,
       178,
       219,
       249
     ],
     "estradiol-17\u03b2": [
       11
     ],
     "(E2)": [
       12
     ],
     "on": [
       13,
       256
     ],
     "sex": [
       14,
       79,
       97,
       136
     ],
     "differentiation": [
       15
     ],
     "metamorphosis,": [
       17,
       105
     ],
     "Xenopus": [
       18,
       245
     ],
     "laevis": [
       19
     ],
     "were": [
       20,
       67,
       114,
       144,
       259
     ],
     "exposed": [
       21,
       180
     ],
     "to": [
       22,
       46,
       54,
       95,
       181,
       188
     ],
     "solvent-control": [
       23
     ],
     "(0.005%": [
       24
     ],
     "ethanol),": [
       25
     ],
     "Cd": [
       26,
       35,
       130,
       150,
       157,
       199,
       223,
       230
     ],
     "(10": [
       27
     ],
     "\u03bcg": [
       28,
       32
     ],
     "L\u22121),": [
       29,
       33
     ],
     "E2": [
       30,
       37,
       128,
       132,
       155,
       159,
       183,
       201,
       225,
       250
     ],
     "(1": [
       31
     ],
     "or": [
       34,
       152,
       184,
       240
     ],
     "(Cd": [
       38
     ],
     "+": [
       39,
       131,
       158,
       200,
       224
     ],
     "E2)": [
       40
     ],
     "in": [
       41,
       176,
       217,
       244,
       263
     ],
     "FETAX": [
       42
     ],
     "medium": [
       43
     ],
     "from": [
       44
     ],
     "fertilization": [
       45
     ],
     "75": [
       47
     ],
     "d": [
       48
     ],
     "postfertilization.": [
       49
     ],
     "Each": [
       50
     ],
     "treatment": [
       51
     ],
     "was": [
       52,
       63,
       90,
       165,
       173,
       202,
       214
     ],
     "applied": [
       53
     ],
     "four": [
       55
     ],
     "aquaria,": [
       56
     ],
     "each": [
       57,
       117
     ],
     "with": [
       58
     ],
     "30": [
       59
     ],
     "fertilized": [
       60
     ],
     "eggs.": [
       61
     ],
     "Mortality": [
       62
     ],
     "recorded": [
       64
     ],
     "animals": [
       66
     ],
     "sampled": [
       68
     ],
     "as": [
       69
     ],
     "they": [
       70
     ],
     "completed": [
       71
     ],
     "metamorphosis": [
       72,
       164,
       172,
       213,
       257
     ],
     "(Nieuwkoop": [
       73
     ],
     "Faber": [
       75
     ],
     "stage": [
       76,
       85
     ],
     "66).": [
       77
     ],
     "Gonadal": [
       78
     ],
     "of": [
       80,
       104,
       163,
       171,
       198,
       206,
       212,
       260
     ],
     "individuals": [
       81
     ],
     "(including": [
       82
     ],
     "tadpoles": [
       83
     ],
     "\u2a7eNF": [
       84
     ],
     "55": [
       86
     ],
     "at": [
       87,
       210,
       231
     ],
     "day": [
       88
     ],
     "75)": [
       89
     ],
     "determined": [
       91
     ],
     "gross-morphologically": [
       92
     ],
     "used": [
       94
     ],
     "compute": [
       96
     ],
     "ratios.": [
       98
     ],
     "Time": [
       99,
       161
     ],
     "course": [
       100,
       162
     ],
     "percent": [
       102,
       169
     ],
     "completion": [
       103,
       170,
       211
     ],
     "snout-vent": [
       106
     ],
     "length": [
       107,
       110
     ],
     "(SVL),": [
       108
     ],
     "hindlimb": [
       109
     ],
     "(HLL)": [
       111
     ],
     "weight": [
       113
     ],
     "analyzed": [
       115
     ],
     "for": [
       116
     ],
     "gender": [
       118
     ],
     "separately.": [
       119
     ],
     "Survival": [
       120
     ],
     "rates": [
       121
     ],
     "did": [
       122,
       236
     ],
     "not": [
       123,
       194,
       237
     ],
     "differ": [
       124
     ],
     "among": [
       125
     ],
     "treatments.": [
       126,
       160
     ],
     "The": [
       127
     ],
     "treatments": [
       133,
       151
     ],
     "significantly": [
       134
     ],
     "skewed": [
       135
     ],
     "ratios": [
       137
     ],
     "towards": [
       138
     ],
     "females;": [
       139
     ],
     "however,": [
       140
     ],
     "no": [
       141
     ],
     "sex-ratio": [
       142
     ],
     "differences": [
       143
     ],
     "observed": [
       145
     ],
     "the": [
       147,
       154,
       196,
       222,
       247
     ],
     "control": [
       148,
       189
     ],
     "generally": [
       166,
       174
     ],
     "delayed": [
       167
     ],
     "reduced": [
       175,
       215
     ],
     "males": [
       177,
       264
     ],
     "females": [
       179,
       218
     ],
     "Cd,": [
       182
     ],
     "their": [
       185
     ],
     "combination": [
       186
     ],
     "compared": [
       187
     ],
     "animals.": [
       190
     ],
     "In": [
       191,
       227
     ],
     "males,": [
       192
     ],
     "but": [
       193
     ],
     "females,": [
       195
     ],
     "effect": [
       197
     ],
     "greater": [
       203,
       261
     ],
     "than": [
       204,
       265
     ],
     "that": [
       205,
       258
     ],
     "individual": [
       207
     ],
     "chemicals.": [
       208
     ],
     "Weight": [
       209
     ],
     "only": [
       216,
       220
     ],
     "by": [
       221
     ],
     "treatment.": [
       226
     ],
     "conclusion,": [
       228
     ],
     "although": [
       229
     ],
     "an": [
       232
     ],
     "environmentally": [
       233
     ],
     "relevant": [
       234
     ],
     "concentration": [
       235
     ],
     "exhibit": [
       238
     ],
     "direct": [
       239
     ],
     "indirect": [
       241
     ],
     "feminizing": [
       242
     ],
     "tadpoles,": [
       246
     ],
     "metal": [
       248
     ],
     "both": [
       251
     ],
     "had": [
       252
     ],
     "similar": [
       253
     ],
     "inhibitory": [
       254
     ],
     "magnitude": [
       262
     ],
     "females.": [
       266
     ]
   },
   "apc_list": {
     "value": 3610,
     "currency": "USD",
     "value_usd": 3610,
     "provenance": "doaj"
   },
   "apc_paid": null,
   "authorships": [
     {
       "author_position": "first",
       "author": {
         "id": "https://openalex.org/A5052117287",
         "display_name": "Bibek Sharma",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I12315562",
           "display_name": "Texas Tech University",
           "ror": "https://ror.org/0405mnx93",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I12315562"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Bibek Sharma",
       "raw_affiliation_strings": [
         "Department of Natural Resources Management, Texas Tech University, Lubbock, TX 79409-2125, USA"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "Department of Natural Resources Management, Texas Tech University, Lubbock, TX 79409-2125, USA",
           "institution_ids": [
             "https://openalex.org/I12315562"
           ]
         }
       ]
     },
     {
       "author_position": "last",
       "author": {
         "id": "https://openalex.org/A5087145032",
         "display_name": "Reynaldo Pati\u00f1o",
         "orcid": "https://orcid.org/0000-0002-4831-8400"
       },
       "institutions": [
         {
           "id": "https://openalex.org/I12315562",
           "display_name": "Texas Tech University",
           "ror": "https://ror.org/0405mnx93",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I12315562"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": true,
       "raw_author_name": "Reynaldo Pati\u00f1o",
       "raw_affiliation_strings": [
         "USGS Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock, TX 79409-2120, USA"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "USGS Texas Cooperative Fish and Wildlife Research Unit, Texas Tech University, Lubbock, TX 79409-2120, USA",
           "institution_ids": [
             "https://openalex.org/I12315562"
           ]
         }
       ]
     }
   ],
   "best_oa_location": null,
   "biblio": {
     "volume": "79",
     "issue": "5",
     "first_page": "499",
     "last_page": "505"
   },
   "citation_normalized_percentile": {
     "value": 0.867404,
     "is_in_top_1_percent": false,
     "is_in_top_10_percent": false
   },
   "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W1979783172",
   "cited_by_count": 25,
   "cited_by_percentile_year": {
     "min": 90,
     "max": 91
   },
   "concepts": [
     {
       "id": "https://openalex.org/C136397037",
       "wikidata": "https://www.wikidata.org/wiki/Q33753",
       "display_name": "Metamorphosis",
       "level": 3,
       "score": 0.98361015
     },
     {
       "id": "https://openalex.org/C86803240",
       "wikidata": "https://www.wikidata.org/wiki/Q420",
       "display_name": "Biology",
       "level": 0,
       "score": 0.833019
     },
     {
       "id": "https://openalex.org/C2779272402",
       "wikidata": "https://www.wikidata.org/wiki/Q423964",
       "display_name": "Xenoestrogen",
       "level": 5,
       "score": 0.7764896
     },
     {
       "id": "https://openalex.org/C2776718933",
       "wikidata": "https://www.wikidata.org/wiki/Q654718",
       "display_name": "African clawed frog",
       "level": 4,
       "score": 0.7184692
     },
     {
       "id": "https://openalex.org/C2779535977",
       "wikidata": "https://www.wikidata.org/wiki/Q1342298",
       "display_name": "Xenopus",
       "level": 3,
       "score": 0.7098554
     },
     {
       "id": "https://openalex.org/C173758957",
       "wikidata": "https://www.wikidata.org/wiki/Q129270",
       "display_name": "Larva",
       "level": 2,
       "score": 0.59758955
     },
     {
       "id": "https://openalex.org/C57520943",
       "wikidata": "https://www.wikidata.org/wiki/Q1068155",
       "display_name": "Sex ratio",
       "level": 3,
       "score": 0.5695707
     },
     {
       "id": "https://openalex.org/C544657597",
       "wikidata": "https://www.wikidata.org/wiki/Q1091",
       "display_name": "Cadmium",
       "level": 2,
       "score": 0.47398964
     },
     {
       "id": "https://openalex.org/C134018914",
       "wikidata": "https://www.wikidata.org/wiki/Q162606",
       "display_name": "Endocrinology",
       "level": 1,
       "score": 0.36059898
     },
     {
       "id": "https://openalex.org/C90856448",
       "wikidata": "https://www.wikidata.org/wiki/Q431",
       "display_name": "Zoology",
       "level": 1,
       "score": 0.35345894
     },
     {
       "id": "https://openalex.org/C126322002",
       "wikidata": "https://www.wikidata.org/wiki/Q11180",
       "display_name": "Internal medicine",
       "level": 1,
       "score": 0.34764698
     },
     {
       "id": "https://openalex.org/C18903297",
       "wikidata": "https://www.wikidata.org/wiki/Q7150",
       "display_name": "Ecology",
       "level": 1,
       "score": 0.31276876
     },
     {
       "id": "https://openalex.org/C2908647359",
       "wikidata": "https://www.wikidata.org/wiki/Q2625603",
       "display_name": "Population",
       "level": 2,
       "score": 0.13588527
     },
     {
       "id": "https://openalex.org/C54355233",
       "wikidata": "https://www.wikidata.org/wiki/Q7162",
       "display_name": "Genetics",
       "level": 1,
       "score": 0.11828807
     },
     {
       "id": "https://openalex.org/C84606932",
       "wikidata": "https://www.wikidata.org/wiki/Q416496",
       "display_name": "Estrogen receptor",
       "level": 4,
       "score": 0.10026103
     },
     {
       "id": "https://openalex.org/C185592680",
       "wikidata": "https://www.wikidata.org/wiki/Q2329",
       "display_name": "Chemistry",
       "level": 0,
       "score": 0.09168264
     },
     {
       "id": "https://openalex.org/C71924100",
       "wikidata": "https://www.wikidata.org/wiki/Q11190",
       "display_name": "Medicine",
       "level": 0,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C149923435",
       "wikidata": "https://www.wikidata.org/wiki/Q37732",
       "display_name": "Demography",
       "level": 1,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C178790620",
       "wikidata": "https://www.wikidata.org/wiki/Q11351",
       "display_name": "Organic chemistry",
       "level": 1,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C121608353",
       "wikidata": "https://www.wikidata.org/wiki/Q12078",
       "display_name": "Cancer",
       "level": 2,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C144024400",
       "wikidata": "https://www.wikidata.org/wiki/Q21201",
       "display_name": "Sociology",
       "level": 0,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C530470458",
       "wikidata": "https://www.wikidata.org/wiki/Q128581",
       "display_name": "Breast cancer",
       "level": 3,
       "score": 0.0
     },
     {
       "id": "https://openalex.org/C104317684",
       "wikidata": "https://www.wikidata.org/wiki/Q7187",
       "display_name": "Gene",
       "level": 2,
       "score": 0.0
     }
   ],
   "corresponding_author_ids": [
     "https://openalex.org/A5087145032"
   ],
   "corresponding_institution_ids": [
     "https://openalex.org/I12315562"
   ],
   "countries_distinct_count": 1,
   "counts_by_year": [
     {
       "year": 2024,
       "cited_by_count": 1
     },
     {
       "year": 2023,
       "cited_by_count": 1
     },
     {
       "year": 2022,
       "cited_by_count": 5
     },
     {
       "year": 2021,
       "cited_by_count": 1
     },
     {
       "year": 2020,
       "cited_by_count": 2
     },
     {
       "year": 2019,
       "cited_by_count": 2
     },
     {
       "year": 2018,
       "cited_by_count": 1
     },
     {
       "year": 2016,
       "cited_by_count": 3
     },
     {
       "year": 2015,
       "cited_by_count": 2
     },
     {
       "year": 2014,
       "cited_by_count": 2
     },
     {
       "year": 2013,
       "cited_by_count": 2
     },
     {
       "year": 2012,
       "cited_by_count": 2
     }
   ],
   "created_date": "2016-06-24",
   "datasets": [],
   "display_name": "Effects of cadmium, estradiol-17\u03b2 and their interaction on gonadal condition and metamorphosis of male and female African clawed frog, Xenopus laevis",
   "doi": "https://doi.org/10.1016/j.chemosphere.2010.02.044",
   "fulltext_origin": "ngrams",
   "fwci": 1.238,
   "grants": [],
   "has_fulltext": true,
   "id": "https://openalex.org/W1979783172",
   "ids": {
     "openalex": "https://openalex.org/W1979783172",
     "doi": "https://doi.org/10.1016/j.chemosphere.2010.02.044",
     "mag": "1979783172",
     "pmid": "https://pubmed.ncbi.nlm.nih.gov/20299069"
   },
   "indexed_in": [
     "crossref",
     "pubmed"
   ],
   "institutions_distinct_count": 1,
   "is_paratext": false,
   "is_retracted": false,
   "keywords": [
     {
       "id": "https://openalex.org/keywords/xenoestrogen",
       "display_name": "Xenoestrogen",
       "score": 0.7764896
     },
     {
       "id": "https://openalex.org/keywords/african-clawed-frog",
       "display_name": "African clawed frog",
       "score": 0.7184692
     },
     {
       "id": "https://openalex.org/keywords/contaminant-effects",
       "display_name": "Contaminant Effects",
       "score": 0.448049
     }
   ],
   "language": "en",
   "locations": [
     {
       "is_oa": false,
       "landing_page_url": "https://doi.org/10.1016/j.chemosphere.2010.02.044",
       "pdf_url": null,
       "source": {
         "id": "https://openalex.org/S203465130",
         "display_name": "Chemosphere",
         "issn_l": "0045-6535",
         "issn": [
           "0045-6535",
           "1879-1298"
         ],
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": true,
         "host_organization": "https://openalex.org/P4310320990",
         "host_organization_name": "Elsevier BV",
         "host_organization_lineage": [
           "https://openalex.org/P4310320990"
         ],
         "host_organization_lineage_names": [
           "Elsevier BV"
         ],
         "type": "journal"
       },
       "license": null,
       "license_id": null,
       "version": null,
       "is_accepted": false,
       "is_published": false
     },
     {
       "is_oa": false,
       "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/20299069",
       "pdf_url": null,
       "source": {
         "id": "https://openalex.org/S4306525036",
         "display_name": "PubMed",
         "issn_l": null,
         "issn": null,
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": false,
         "host_organization": "https://openalex.org/I1299303238",
         "host_organization_name": "National Institutes of Health",
         "host_organization_lineage": [
           "https://openalex.org/I1299303238"
         ],
         "host_organization_lineage_names": [
           "National Institutes of Health"
         ],
         "type": "repository"
       },
       "license": null,
       "license_id": null,
       "version": null,
       "is_accepted": false,
       "is_published": false
     }
   ],
   "locations_count": 2,
   "mesh": [
     {
       "descriptor_ui": "D002104",
       "descriptor_name": "Cadmium",
       "qualifier_ui": "Q000633",
       "qualifier_name": "toxicity",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D004958",
       "descriptor_name": "Estradiol",
       "qualifier_ui": "Q000633",
       "qualifier_name": "toxicity",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D006066",
       "descriptor_name": "Gonads",
       "qualifier_ui": "Q000033",
       "qualifier_name": "anatomy & histology",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D008675",
       "descriptor_name": "Metamorphosis, Biological",
       "qualifier_ui": "Q000502",
       "qualifier_name": "physiology",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D014874",
       "descriptor_name": "Water Pollutants, Chemical",
       "qualifier_ui": "Q000633",
       "qualifier_name": "toxicity",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D000818",
       "descriptor_name": "Animals",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D002104",
       "descriptor_name": "Cadmium",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004625",
       "descriptor_name": "Embryo, Nonmammalian",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004958",
       "descriptor_name": "Estradiol",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D005260",
       "descriptor_name": "Female",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D006066",
       "descriptor_name": "Gonads",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D006066",
       "descriptor_name": "Gonads",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008297",
       "descriptor_name": "Male",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008675",
       "descriptor_name": "Metamorphosis, Biological",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008675",
       "descriptor_name": "Metamorphosis, Biological",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D012733",
       "descriptor_name": "Sex Differentiation",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D014874",
       "descriptor_name": "Water Pollutants, Chemical",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D014982",
       "descriptor_name": "Xenopus laevis",
       "qualifier_ui": "Q000378",
       "qualifier_name": "metabolism",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D014982",
       "descriptor_name": "Xenopus laevis",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     }
   ],
   "ngrams_url": "https://api.openalex.org/works/W1979783172/ngrams",
   "open_access": {
     "is_oa": false,
     "oa_status": "closed",
     "oa_url": null,
     "any_repository_has_fulltext": false
   },
   "primary_location": {
     "is_oa": false,
     "landing_page_url": "https://doi.org/10.1016/j.chemosphere.2010.02.044",
     "pdf_url": null,
     "source": {
       "id": "https://openalex.org/S203465130",
       "display_name": "Chemosphere",
       "issn_l": "0045-6535",
       "issn": [
         "0045-6535",
         "1879-1298"
       ],
       "is_oa": false,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4310320990",
       "host_organization_name": "Elsevier BV",
       "host_organization_lineage": [
         "https://openalex.org/P4310320990"
       ],
       "host_organization_lineage_names": [
         "Elsevier BV"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": null,
     "is_accepted": false,
     "is_published": false
   },
   "primary_topic": {
     "id": "https://openalex.org/T10419",
     "display_name": "Antibiotic Resistance in Aquatic Environments and Wastewater",
     "score": 0.9947,
     "subfield": {
       "id": "https://openalex.org/subfields/2310",
       "display_name": "Pollution"
     },
     "field": {
       "id": "https://openalex.org/fields/23",
       "display_name": "Environmental Science"
     },
     "domain": {
       "id": "https://openalex.org/domains/3",
       "display_name": "Physical Sciences"
     }
   },
   "publication_date": "2010-04-01",
   "publication_year": 2010,
   "referenced_works": [
     "https://openalex.org/W1479965447",
     "https://openalex.org/W1518787232",
     "https://openalex.org/W1958574545",
     "https://openalex.org/W1967141926",
     "https://openalex.org/W1974562202",
     "https://openalex.org/W1975407473",
     "https://openalex.org/W1981976677",
     "https://openalex.org/W1986626542",
     "https://openalex.org/W1987876430",
     "https://openalex.org/W1992534907",
     "https://openalex.org/W1995008656",
     "https://openalex.org/W1998690351",
     "https://openalex.org/W2008413660",
     "https://openalex.org/W2028687047",
     "https://openalex.org/W2029431294",
     "https://openalex.org/W2031791994",
     "https://openalex.org/W2039289088",
     "https://openalex.org/W2042272299",
     "https://openalex.org/W2051291198",
     "https://openalex.org/W2056449588",
     "https://openalex.org/W2057784159",
     "https://openalex.org/W2059933412",
     "https://openalex.org/W2079239008",
     "https://openalex.org/W2081364820",
     "https://openalex.org/W2082416949",
     "https://openalex.org/W2111774991",
     "https://openalex.org/W2123661950",
     "https://openalex.org/W2124901325",
     "https://openalex.org/W2129109249",
     "https://openalex.org/W2136050503",
     "https://openalex.org/W2145639882",
     "https://openalex.org/W2150132198",
     "https://openalex.org/W2151665990",
     "https://openalex.org/W2314282317",
     "https://openalex.org/W2327097432",
     "https://openalex.org/W2468103611",
     "https://openalex.org/W4244440629",
     "https://openalex.org/W4246633342"
   ],
   "referenced_works_count": 38,
   "related_works": [
     "https://openalex.org/W4319915968",
     "https://openalex.org/W33377599",
     "https://openalex.org/W3113153056",
     "https://openalex.org/W2527259077",
     "https://openalex.org/W2411719663",
     "https://openalex.org/W2130165422",
     "https://openalex.org/W2106376078",
     "https://openalex.org/W2012900767",
     "https://openalex.org/W1979783172",
     "https://openalex.org/W123342229"
   ],
   "sustainable_development_goals": [
     {
       "id": "https://metadata.un.org/sdg/14",
       "score": 0.56,
       "display_name": "Life below water"
     }
   ],
   "title": "Effects of cadmium, estradiol-17\u03b2 and their interaction on gonadal condition and metamorphosis of male and female African clawed frog, Xenopus laevis",
   "topics": [
     {
       "id": "https://openalex.org/T10419",
       "display_name": "Antibiotic Resistance in Aquatic Environments and Wastewater",
       "score": 0.9947,
       "subfield": {
         "id": "https://openalex.org/subfields/2310",
         "display_name": "Pollution"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10302",
       "display_name": "Importance and Conservation of Freshwater Biodiversity",
       "score": 0.9944,
       "subfield": {
         "id": "https://openalex.org/subfields/2309",
         "display_name": "Nature and Landscape Conservation"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10447",
       "display_name": "Aquatic Ecotoxicology and Biomarkers of Pollution",
       "score": 0.9909,
       "subfield": {
         "id": "https://openalex.org/subfields/2307",
         "display_name": "Health, Toxicology and Mutagenesis"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     }
   ],
   "type": "article",
   "type_crossref": "journal-article",
   "updated_date": "2024-08-14T02:15:50.709177",
   "versions": []
 }

}