Item talk:Q247868
From geokb
{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "Virulence correlates with fitness in vivo for two M group genotypes of Infectious hematopoietic necrosis virus (IHNV).", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70044457", "url": "https://pubs.usgs.gov/publication/70044457" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70044457 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.virol.2010.04.023", "url": "https://doi.org/10.1016/j.virol.2010.04.023" } ], "journal": { "@type": "Periodical", "name": "Virology", "volumeNumber": "404", "issueNumber": "1" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Virology" } ], "datePublished": "2010", "dateModified": "2013-04-02", "abstract": "The nature of the association between viral fitness and virulence remains elusive in vertebrate virus systems, partly due to a lack of in vivo experiments using statistically sufficient numbers of replicate hosts. We examined the relationship between virulence and fitness in Infectious hematopoietic necrosis virus (IHNV), in vivo, in intact living rainbow trout. Trout were infected with a high or low virulence genotype of M genogroup IHNV, or a mixture of the two genotypes, so as to calculate relative fitness and the effect of a competition environment on fitness. Fitness was measured as total viral load in the host at time of peak viral density, quantified by genotype-specific quantitative RT-PCR (qRT-PCR). The more virulent IHNV genotype reached higher densities in both single and mixed infections. There was no effect of competition on the performance of either genotype. Our results suggest a positive link between IHNV genotype fitness and virulence.", "description": "8 p.", "publisher": { "@type": "Organization", "name": "Elsevier" }, "author": [ { "@type": "Person", "name": "Kurath, Gael gkurath@usgs.gov", "givenName": "Gael", "familyName": "Kurath", "email": "gkurath@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-3294-560X", "url": "https://orcid.org/0000-0003-3294-560X" }, "affiliation": [ { "@type": "Organization", "name": "Western Fisheries Research Center", "url": "https://www.usgs.gov/centers/western-fisheries-research-center" } ] }, { "@type": "Person", "name": "Wargo, Andrew R.", "givenName": "Andrew R.", "familyName": "Wargo", "affiliation": [ { "@type": "Organization", "name": "Western Fisheries Research Center", "url": "https://www.usgs.gov/centers/western-fisheries-research-center" } ] }, { "@type": "Person", "name": "Garver, Kyle A.", "givenName": "Kyle A.", "familyName": "Garver", "affiliation": [ { "@type": "Organization", "name": "Western Fisheries Research Center", "url": "https://www.usgs.gov/centers/western-fisheries-research-center" } ] } ], "funder": [ { "@type": "Organization", "name": "Western Fisheries Research Center", "url": "https://www.usgs.gov/centers/western-fisheries-research-center" } ], "spatialCoverage": [ { "@type": "Place", "additionalType": "country", "name": "United States", "url": "https://geonames.org/4074035" } ] }, "OpenAlex": { "abstract_inverted_index": { "The": [ 0, 111 ], "nature": [ 1 ], "of": [ 2, 21, 29, 63, 70, 83, 101, 129, 134 ], "the": [ 3, 34, 71, 81, 97, 132 ], "association": [ 4 ], "between": [ 5, 36, 143 ], "viral": [ 6, 94, 103 ], "fitness": [ 7, 39, 79, 146 ], "and": [ 8, 38, 80, 122, 147 ], "virulence": [ 9, 37, 61 ], "remains": [ 10 ], "elusive": [ 11 ], "in": [ 12, 22, 40, 46, 48, 96, 119 ], "vertebrate": [ 13 ], "virus": [ 14, 44 ], "systems,": [ 15 ], "partly": [ 16 ], "due": [ 17 ], "to": [ 18, 76 ], "a": [ 19, 57, 68, 84, 140 ], "lack": [ 20 ], "vivo": [ 23 ], "experiments": [ 24 ], "using": [ 25 ], "statistically": [ 26 ], "sufficient": [ 27 ], "numbers": [ 28 ], "replicate": [ 30 ], "hosts.": [ 31 ], "We": [ 32 ], "examined": [ 33 ], "relationship": [ 35 ], "Infectious": [ 41 ], "hematopoietic": [ 42 ], "necrosis": [ 43 ], "(IHNV),": [ 45 ], "vivo,": [ 47 ], "intact": [ 49 ], "living": [ 50 ], "rainbow": [ 51 ], "trout.": [ 52 ], "Trout": [ 53 ], "were": [ 54 ], "infected": [ 55 ], "with": [ 56 ], "high": [ 58 ], "or": [ 59, 67 ], "low": [ 60 ], "genotype": [ 62, 115, 145 ], "M": [ 64 ], "genogroup": [ 65 ], "IHNV,": [ 66 ], "mixture": [ 69 ], "two": [ 72 ], "genotypes,": [ 73 ], "so": [ 74 ], "as": [ 75, 92 ], "calculate": [ 77 ], "relative": [ 78 ], "effect": [ 82, 128 ], "competition": [ 85, 130 ], "environment": [ 86 ], "on": [ 87, 131 ], "fitness.": [ 88 ], "Fitness": [ 89 ], "was": [ 90, 126 ], "measured": [ 91 ], "total": [ 93 ], "load": [ 95 ], "host": [ 98 ], "at": [ 99 ], "time": [ 100 ], "peak": [ 102 ], "density,": [ 104 ], "quantified": [ 105 ], "by": [ 106 ], "genotype-specific": [ 107 ], "quantitative": [ 108 ], "RT-PCR": [ 109 ], "(qRT-PCR).": [ 110 ], "more": [ 112 ], "virulent": [ 113 ], "IHNV": [ 114, 144 ], "reached": [ 116 ], "higher": [ 117 ], "densities": [ 118 ], "both": [ 120 ], "single": [ 121 ], "mixed": [ 123 ], "infections.": [ 124 ], "There": [ 125 ], "no": [ 127 ], "performance": [ 133 ], "either": [ 135 ], "genotype.": [ 136 ], "Our": [ 137 ], "results": [ 138 ], "suggest": [ 139 ], "positive": [ 141 ], "link": [ 142 ], "virulence.": [ 148 ] }, "apc_list": { "value": 3040, "currency": "USD", "value_usd": 3040, "provenance": "doaj" }, "apc_paid": null, "authorships": [ { "author_position": "first", "author": { "id": "https://openalex.org/A5055387148", "display_name": "Andrew Wargo", "orcid": "https://orcid.org/0000-0002-9209-3077" }, "institutions": [ { "id": "https://openalex.org/I4210166920", "display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center", "ror": "https://ror.org/05r7z1k40", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I106745318", "https://openalex.org/I1308126019", "https://openalex.org/I1343035065", "https://openalex.org/I4210166920" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Andrew R Wargo", "raw_affiliation_strings": [ "Western Fisheries Research Center, Seattle, WA 98115-5016, USA. awargo@u.washington.edu" ], "affiliations": [ { "raw_affiliation_string": "Western Fisheries Research Center, Seattle, WA 98115-5016, USA. awargo@u.washington.edu", "institution_ids": [ "https://openalex.org/I4210166920" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5077781145", "display_name": "Kyle A. Garver", "orcid": "https://orcid.org/0000-0001-8931-3051" }, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Kyle A Garver", "raw_affiliation_strings": [], "affiliations": [] }, { "author_position": "last", "author": { "id": "https://openalex.org/A5077553505", "display_name": "Gael Kurath", "orcid": "https://orcid.org/0000-0003-3294-560X" }, "institutions": [], "countries": [], "is_corresponding": false, "raw_author_name": "Gael Kurath", "raw_affiliation_strings": [], "affiliations": [] } ], "best_oa_location": null, "biblio": { "volume": "404", "issue": "1", "first_page": "51", "last_page": "58" }, "citation_normalized_percentile": { "value": 0.903044, "is_in_top_1_percent": false, "is_in_top_10_percent": true }, "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2031713601", "cited_by_count": 41, "cited_by_percentile_year": { "min": 94, "max": 95 }, "concepts": [ { "id": "https://openalex.org/C2778966499", "wikidata": "https://www.wikidata.org/wiki/Q880931", "display_name": "Infectious hematopoietic necrosis virus", "level": 4, "score": 0.95194054 }, { "id": "https://openalex.org/C60987743", "wikidata": "https://www.wikidata.org/wiki/Q1460232", "display_name": "Virulence", "level": 3, "score": 0.9387629 }, { "id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.92390275 }, { "id": "https://openalex.org/C135763542", "wikidata": "https://www.wikidata.org/wiki/Q106016", "display_name": "Genotype", "level": 3, "score": 0.7825575 }, { "id": "https://openalex.org/C159047783", "wikidata": "https://www.wikidata.org/wiki/Q7215", "display_name": "Virology", "level": 1, "score": 0.6273316 }, { "id": "https://openalex.org/C2522874641", "wikidata": "https://www.wikidata.org/wiki/Q808", "display_name": "Virus", "level": 2, "score": 0.57208157 }, { "id": "https://openalex.org/C2994167347", "wikidata": "https://www.wikidata.org/wiki/Q187986", "display_name": "Rainbow trout", "level": 3, "score": 0.5337976 }, { "id": "https://openalex.org/C91306197", "wikidata": "https://www.wikidata.org/wiki/Q45767", "display_name": "Competition (biology)", "level": 2, "score": 0.41460812 }, { "id": "https://openalex.org/C89423630", "wikidata": "https://www.wikidata.org/wiki/Q7193", "display_name": "Microbiology", "level": 1, "score": 0.3490923 }, { "id": "https://openalex.org/C54355233", "wikidata": "https://www.wikidata.org/wiki/Q7162", "display_name": "Genetics", "level": 1, "score": 0.2878562 }, { "id": "https://openalex.org/C104317684", "wikidata": "https://www.wikidata.org/wiki/Q7187", "display_name": "Gene", "level": 2, "score": 0.20487612 }, { "id": "https://openalex.org/C18903297", "wikidata": "https://www.wikidata.org/wiki/Q7150", "display_name": "Ecology", "level": 1, "score": 0.11863235 }, { "id": "https://openalex.org/C2909208804", "wikidata": "https://www.wikidata.org/wiki/Q127282", "display_name": "Fish <Actinopterygii>", "level": 2, "score": 0.09607822 }, { "id": "https://openalex.org/C505870484", "wikidata": "https://www.wikidata.org/wiki/Q180538", "display_name": "Fishery", "level": 1, "score": 0.0 } ], "corresponding_author_ids": [], "corresponding_institution_ids": [], "countries_distinct_count": 1, "counts_by_year": [ { "year": 2024, "cited_by_count": 1 }, { "year": 2023, "cited_by_count": 1 }, { "year": 2022, "cited_by_count": 3 }, { "year": 2021, "cited_by_count": 9 }, { "year": 2020, "cited_by_count": 3 }, { "year": 2019, "cited_by_count": 2 }, { "year": 2017, "cited_by_count": 2 }, { "year": 2016, "cited_by_count": 5 }, { "year": 2015, "cited_by_count": 1 }, { "year": 2014, "cited_by_count": 4 }, { "year": 2013, "cited_by_count": 3 }, { "year": 2012, "cited_by_count": 3 } ], "created_date": "2016-06-24", "datasets": [], "display_name": "Virulence correlates with fitness in vivo for two M group genotypes of Infectious hematopoietic necrosis virus (IHNV)", "doi": "https://doi.org/10.1016/j.virol.2010.04.023", "fulltext_origin": "ngrams", "fwci": 1.733, "grants": [], "has_fulltext": true, "id": "https://openalex.org/W2031713601", "ids": { "openalex": "https://openalex.org/W2031713601", "doi": "https://doi.org/10.1016/j.virol.2010.04.023", "mag": "2031713601", "pmid": "https://pubmed.ncbi.nlm.nih.gov/20494388" }, "indexed_in": [ "crossref", "pubmed" ], "institutions_distinct_count": 1, "is_paratext": false, "is_retracted": false, "keywords": [ { "id": "https://openalex.org/keywords/fish-immunology", "display_name": "Fish Immunology", "score": 0.478865 } ], "language": "en", "locations": [ { "is_oa": false, "landing_page_url": "https://doi.org/10.1016/j.virol.2010.04.023", "pdf_url": null, "source": { "id": "https://openalex.org/S6147291", "display_name": "Virology", "issn_l": "0042-6822", "issn": [ "0042-6822", "1089-862X", "1096-0341" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": [ "https://openalex.org/P4310320990" ], "host_organization_lineage_names": [ "Elsevier BV" ], "type": "journal" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false }, { "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/20494388", "pdf_url": null, "source": { "id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": [ "https://openalex.org/I1299303238" ], "host_organization_lineage_names": [ "National Institutes of Health" ], "type": "repository" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false } ], "locations_count": 2, "mesh": [ { "descriptor_ui": "D005393", "descriptor_name": "Fish Diseases", "qualifier_ui": "Q000821", "qualifier_name": "virology", "is_major_topic": true }, { "descriptor_ui": "D029142", "descriptor_name": "Infectious hematopoietic necrosis virus", "qualifier_ui": "Q000472", "qualifier_name": "pathogenicity", "is_major_topic": true }, { "descriptor_ui": "D029142", "descriptor_name": "Infectious hematopoietic necrosis virus", "qualifier_ui": "Q000502", "qualifier_name": "physiology", "is_major_topic": true }, { "descriptor_ui": "D017686", "descriptor_name": "Oncorhynchus mykiss", "qualifier_ui": "Q000821", "qualifier_name": "virology", "is_major_topic": true }, { "descriptor_ui": "D018353", "descriptor_name": "Rhabdoviridae Infections", "qualifier_ui": "Q000662", "qualifier_name": "veterinary", "is_major_topic": true }, { "descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D005393", "descriptor_name": "Fish Diseases", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D005393", "descriptor_name": "Fish Diseases", "qualifier_ui": "Q000473", "qualifier_name": "pathology", "is_major_topic": false }, { "descriptor_ui": "D005838", "descriptor_name": "Genotype", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D029142", "descriptor_name": "Infectious hematopoietic necrosis virus", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D029142", "descriptor_name": "Infectious hematopoietic necrosis virus", "qualifier_ui": "Q000145", "qualifier_name": "classification", "is_major_topic": false }, { "descriptor_ui": "D029142", "descriptor_name": "Infectious hematopoietic necrosis virus", "qualifier_ui": "Q000254", "qualifier_name": "growth & development", "is_major_topic": false }, { "descriptor_ui": "D017686", "descriptor_name": "Oncorhynchus mykiss", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D012367", "descriptor_name": "RNA, Viral", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D012367", "descriptor_name": "RNA, Viral", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false }, { "descriptor_ui": "D012367", "descriptor_name": "RNA, Viral", "qualifier_ui": "Q000235", "qualifier_name": "genetics", "is_major_topic": false }, { "descriptor_ui": "D020133", "descriptor_name": "Reverse Transcriptase Polymerase Chain Reaction", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D018353", "descriptor_name": "Rhabdoviridae Infections", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D018353", "descriptor_name": "Rhabdoviridae Infections", "qualifier_ui": "Q000821", "qualifier_name": "virology", "is_major_topic": false }, { "descriptor_ui": "D019562", "descriptor_name": "Viral Load", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D014774", "descriptor_name": "Virulence", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false } ], "ngrams_url": "https://api.openalex.org/works/W2031713601/ngrams", "open_access": { "is_oa": false, "oa_status": "closed", "oa_url": null, "any_repository_has_fulltext": false }, "primary_location": { "is_oa": false, "landing_page_url": "https://doi.org/10.1016/j.virol.2010.04.023", "pdf_url": null, "source": { "id": "https://openalex.org/S6147291", "display_name": "Virology", "issn_l": "0042-6822", "issn": [ "0042-6822", "1089-862X", "1096-0341" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": [ "https://openalex.org/P4310320990" ], "host_organization_lineage_names": [ "Elsevier BV" ], "type": "journal" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false }, "primary_topic": { "id": "https://openalex.org/T11764", "display_name": "Evolutionary Dynamics of Genetic Adaptation and Mutation", "score": 0.9997, "subfield": { "id": "https://openalex.org/subfields/1311", "display_name": "Genetics" }, "field": { "id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" } }, "publication_date": "2010-08-01", "publication_year": 2010, "referenced_works": [ "https://openalex.org/W1508451045", "https://openalex.org/W1535862536", "https://openalex.org/W1536778494", "https://openalex.org/W1561556104", "https://openalex.org/W1963616587", "https://openalex.org/W1964412600", "https://openalex.org/W1972645048", "https://openalex.org/W1982806555", "https://openalex.org/W1983358040", "https://openalex.org/W1989635378", "https://openalex.org/W1991612229", "https://openalex.org/W1996629646", "https://openalex.org/W2002981040", "https://openalex.org/W2003124479", "https://openalex.org/W2008013204", "https://openalex.org/W2013728855", "https://openalex.org/W2016109307", "https://openalex.org/W2017348279", "https://openalex.org/W2025363484", "https://openalex.org/W2025528994", "https://openalex.org/W2027971649", "https://openalex.org/W2028154433", "https://openalex.org/W2028570104", "https://openalex.org/W2029728095", "https://openalex.org/W2039591969", "https://openalex.org/W2040231337", "https://openalex.org/W2040797098", "https://openalex.org/W2047976861", "https://openalex.org/W2055421491", "https://openalex.org/W2060905071", "https://openalex.org/W2062920384", "https://openalex.org/W2068253484", "https://openalex.org/W2070649137", "https://openalex.org/W2080291495", "https://openalex.org/W2082962768", "https://openalex.org/W2087341116", "https://openalex.org/W2101493463", "https://openalex.org/W2104634067", "https://openalex.org/W2107728953", "https://openalex.org/W2109523152", "https://openalex.org/W2114596116", "https://openalex.org/W2116067373", "https://openalex.org/W2118085379", "https://openalex.org/W2121285554", "https://openalex.org/W2121575693", "https://openalex.org/W2124139689", "https://openalex.org/W2124195543", "https://openalex.org/W2124208765", "https://openalex.org/W2126203350", "https://openalex.org/W2126923314", "https://openalex.org/W2128868625", "https://openalex.org/W2137085164", "https://openalex.org/W2141603917", "https://openalex.org/W2156502917", "https://openalex.org/W2157813453", "https://openalex.org/W2173759386", "https://openalex.org/W2769459294", "https://openalex.org/W3003597168", "https://openalex.org/W4244962194" ], "referenced_works_count": 59, "related_works": [ "https://openalex.org/W4310745443", "https://openalex.org/W4244452048", "https://openalex.org/W292120301", "https://openalex.org/W2618102471", "https://openalex.org/W2372274602", "https://openalex.org/W2354055819", "https://openalex.org/W2338441408", "https://openalex.org/W2327650558", "https://openalex.org/W2186570461", "https://openalex.org/W2138580168" ], "sustainable_development_goals": [], "title": "Virulence correlates with fitness in vivo for two M group genotypes of Infectious hematopoietic necrosis virus (IHNV)", "topics": [ { "id": "https://openalex.org/T11764", "display_name": "Evolutionary Dynamics of Genetic Adaptation and Mutation", "score": 0.9997, "subfield": { "id": "https://openalex.org/subfields/1311", "display_name": "Genetics" }, "field": { "id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" } }, { "id": "https://openalex.org/T10482", "display_name": "Disease Transmission and Population Dynamics", "score": 0.9975, "subfield": { "id": "https://openalex.org/subfields/2739", "display_name": "Public Health, Environmental and Occupational Health" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } }, { "id": "https://openalex.org/T10506", "display_name": "Immunological Responses in Aquatic Organisms", "score": 0.9964, "subfield": { "id": "https://openalex.org/subfields/2403", "display_name": "Immunology" }, "field": { "id": "https://openalex.org/fields/24", "display_name": "Immunology and Microbiology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" } } ], "type": "article", "type_crossref": "journal-article", "updated_date": "2024-08-12T18:29:21.280057", "versions": [] }
}