Item talk:Q245189

From geokb

{

 "USGS Publications Warehouse": {
   "@context": "https://schema.org",
   "@type": "Article",
   "additionalType": "Journal Article",
   "name": "Discovery and characterization of secretory IgD in rainbow trout: secretory IgD is produced through a novel splicing mechanism",
   "identifier": [
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse IndexID",
       "value": "70032377",
       "url": "https://pubs.usgs.gov/publication/70032377"
     },
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse Internal ID",
       "value": 70032377
     },
     {
       "@type": "PropertyValue",
       "propertyID": "DOI",
       "value": "10.4049/jimmunol.1101938",
       "url": "https://doi.org/10.4049/jimmunol.1101938"
     },
     {
       "@type": "PropertyValue",
       "propertyID": "ISSN",
       "value": "00221767"
     }
   ],
   "journal": {
     "@type": "Periodical",
     "name": "Journal of Immunology",
     "volumeNumber": "188",
     "issueNumber": "3"
   },
   "inLanguage": "en",
   "isPartOf": [
     {
       "@type": "CreativeWorkSeries",
       "name": "Journal of Immunology"
     }
   ],
   "datePublished": "2012",
   "dateModified": "2016-12-19",
   "abstract": "The gene encoding IgH \u03b4 has been found in all species of teleosts studied to date. However, catfish (Ictalurus punctatus) is the only species of fish in which a secretory form of IgD has been characterized, and it occurs through the use of a dedicated \u03b4-secretory exon, which is absent from all other species examined. Our studies have revealed that rainbow trout (Oncorhynchus mykiss) use a novel strategy for the generation of secreted IgD. The trout secretory \u03b4 transcript is produced via a run-on event in which the splice donor site at the end of the last constant domain exon (D7) is ignored and transcription continues until a stop codon is reached 33 nt downstream of the splice site, resulting in the production of an in-frame, 11-aa secretory tail at the end of the D7 domain. In silico analysis of several published IgD genes suggested that this unique splicing mechanism may also be used in other species of fish, reptiles, and amphibians. Alternative splicing of the secretory \u03b4 transcript resulted in two \u03b4-H chains, which incorporated C\u03bc1 and variable domains. Secreted IgD was found in two heavily glycosylated isoforms, which are assembled as monomeric polypeptides associated with L chains. Secretory \u03b4 mRNA and IgD+ plasma cells were detected in all immune tissues at a lower frequency than secretory IgM. Our data demonstrate that secretory IgD is more prevalent and widespread across taxa than previously thought, and thus illustrate the potential that IgD may have a conserved role in immunity.",
   "description": "9 p. ",
   "publisher": {
     "@type": "Organization",
     "name": "The American Association of Immunologists "
   },
   "author": [
     {
       "@type": "Person",
       "name": "Greene, W.",
       "givenName": "W.",
       "familyName": "Greene"
     },
     {
       "@type": "Person",
       "name": "Kataria, P.",
       "givenName": "P.",
       "familyName": "Kataria"
     },
     {
       "@type": "Person",
       "name": "Bromage, E.S.",
       "givenName": "E.S.",
       "familyName": "Bromage"
     },
     {
       "@type": "Person",
       "name": "Rego, K.",
       "givenName": "K.",
       "familyName": "Rego"
     },
     {
       "@type": "Person",
       "name": "Ramirez-Gomez, F.",
       "givenName": "F.",
       "familyName": "Ramirez-Gomez"
     },
     {
       "@type": "Person",
       "name": "Hansen, J.D.",
       "givenName": "J.D.",
       "familyName": "Hansen"
     },
     {
       "@type": "Person",
       "name": "Costa, G.",
       "givenName": "G.",
       "familyName": "Costa"
     }
   ],
   "funder": [
     {
       "@type": "Organization",
       "name": "Western Fisheries Research Center",
       "url": "https://www.usgs.gov/centers/western-fisheries-research-center"
     }
   ]
 },
 "OpenAlex": {
   "abstract_inverted_index": {
     "Abstract": [
       0
     ],
     "The": [
       1,
       75
     ],
     "gene": [
       2
     ],
     "encoding": [
       3
     ],
     "IgH": [
       4
     ],
     "\u03b4": [
       5,
       78,
       168,
       201
     ],
     "has": [
       6,
       34
     ],
     "been": [
       7,
       35
     ],
     "found": [
       8,
       184
     ],
     "in": [
       9,
       27,
       86,
       121,
       155,
       171,
       185,
       209,
       248
     ],
     "all": [
       10,
       52,
       210
     ],
     "species": [
       11,
       24,
       54,
       157
     ],
     "of": [
       12,
       25,
       32,
       43,
       72,
       95,
       116,
       124,
       133,
       140,
       158,
       165
     ],
     "teleosts": [
       13
     ],
     "studied": [
       14
     ],
     "to": [
       15
     ],
     "date.": [
       16
     ],
     "However,": [
       17
     ],
     "catfish": [
       18
     ],
     "(Ictalurus": [
       19
     ],
     "punctatus)": [
       20
     ],
     "is": [
       21,
       49,
       80,
       102,
       111,
       226
     ],
     "the": [
       22,
       41,
       70,
       88,
       93,
       96,
       117,
       122,
       131,
       134,
       166,
       239
     ],
     "only": [
       23
     ],
     "fish": [
       26
     ],
     "which": [
       28,
       48,
       87,
       175,
       190
     ],
     "a": [
       29,
       44,
       66,
       83,
       108,
       214,
       245
     ],
     "secretory": [
       30,
       77,
       128,
       167,
       218,
       224
     ],
     "form": [
       31
     ],
     "IgD": [
       33,
       143,
       182,
       225,
       242
     ],
     "characterized,": [
       36
     ],
     "and": [
       37,
       104,
       161,
       178,
       203,
       229,
       236
     ],
     "it": [
       38
     ],
     "occurs": [
       39
     ],
     "through": [
       40
     ],
     "use": [
       42,
       65
     ],
     "dedicated": [
       45
     ],
     "\u03b4-secretory": [
       46
     ],
     "exon,": [
       47
     ],
     "absent": [
       50
     ],
     "from": [
       51
     ],
     "other": [
       53,
       156
     ],
     "examined.": [
       55
     ],
     "Our": [
       56,
       220
     ],
     "studies": [
       57
     ],
     "have": [
       58,
       244
     ],
     "revealed": [
       59
     ],
     "that": [
       60,
       146,
       223,
       241
     ],
     "rainbow": [
       61
     ],
     "trout": [
       62,
       76
     ],
     "(Oncorhynchus": [
       63
     ],
     "mykiss)": [
       64
     ],
     "novel": [
       67
     ],
     "strategy": [
       68
     ],
     "for": [
       69
     ],
     "generation": [
       71
     ],
     "secreted": [
       73
     ],
     "IgD.": [
       74
     ],
     "transcript": [
       79,
       169
     ],
     "produced": [
       81
     ],
     "via": [
       82
     ],
     "run-on": [
       84
     ],
     "event": [
       85
     ],
     "splice": [
       89,
       118
     ],
     "donor": [
       90
     ],
     "site": [
       91
     ],
     "at": [
       92,
       130,
       213
     ],
     "end": [
       94,
       132
     ],
     "last": [
       97
     ],
     "constant": [
       98
     ],
     "domain": [
       99
     ],
     "exon": [
       100
     ],
     "(D7)": [
       101
     ],
     "ignored": [
       103
     ],
     "transcription": [
       105
     ],
     "continues": [
       106
     ],
     "until": [
       107
     ],
     "stop": [
       109
     ],
     "codon": [
       110
     ],
     "reached": [
       112
     ],
     "33": [
       113
     ],
     "nt": [
       114
     ],
     "downstream": [
       115
     ],
     "site,": [
       119
     ],
     "resulting": [
       120
     ],
     "production": [
       123
     ],
     "an": [
       125
     ],
     "in-frame,": [
       126
     ],
     "11-aa": [
       127
     ],
     "tail": [
       129
     ],
     "D7": [
       135
     ],
     "domain.": [
       136
     ],
     "In": [
       137
     ],
     "silico": [
       138
     ],
     "analysis": [
       139
     ],
     "several": [
       141
     ],
     "published": [
       142
     ],
     "genes": [
       144
     ],
     "suggested": [
       145
     ],
     "this": [
       147
     ],
     "unique": [
       148
     ],
     "splicing": [
       149,
       164
     ],
     "mechanism": [
       150
     ],
     "may": [
       151,
       243
     ],
     "also": [
       152
     ],
     "be": [
       153
     ],
     "used": [
       154
     ],
     "fish,": [
       159
     ],
     "reptiles,": [
       160
     ],
     "amphibians.": [
       162
     ],
     "Alternative": [
       163
     ],
     "resulted": [
       170
     ],
     "two": [
       172,
       186
     ],
     "\u03b4-H": [
       173
     ],
     "chains,": [
       174
     ],
     "incorporated": [
       176
     ],
     "C\u03bc1": [
       177
     ],
     "variable": [
       179
     ],
     "domains.": [
       180
     ],
     "Secreted": [
       181
     ],
     "was": [
       183
     ],
     "heavily": [
       187
     ],
     "glycosylated": [
       188
     ],
     "isoforms,": [
       189
     ],
     "are": [
       191
     ],
     "assembled": [
       192
     ],
     "as": [
       193
     ],
     "monomeric": [
       194
     ],
     "polypeptides": [
       195
     ],
     "associated": [
       196
     ],
     "with": [
       197
     ],
     "L": [
       198
     ],
     "chains.": [
       199
     ],
     "Secretory": [
       200
     ],
     "mRNA": [
       202
     ],
     "IgD+": [
       204
     ],
     "plasma": [
       205
     ],
     "cells": [
       206
     ],
     "were": [
       207
     ],
     "detected": [
       208
     ],
     "immune": [
       211
     ],
     "tissues": [
       212
     ],
     "lower": [
       215
     ],
     "frequency": [
       216
     ],
     "than": [
       217,
       233
     ],
     "IgM.": [
       219
     ],
     "data": [
       221
     ],
     "demonstrate": [
       222
     ],
     "more": [
       227
     ],
     "prevalent": [
       228
     ],
     "widespread": [
       230
     ],
     "across": [
       231
     ],
     "taxa": [
       232
     ],
     "previously": [
       234
     ],
     "thought,": [
       235
     ],
     "thus": [
       237
     ],
     "illustrate": [
       238
     ],
     "potential": [
       240
     ],
     "conserved": [
       246
     ],
     "role": [
       247
     ],
     "immunity.": [
       249
     ]
   },
   "apc_list": null,
   "apc_paid": null,
   "authorships": [
     {
       "author_position": "first",
       "author": {
         "id": "https://openalex.org/A5059438605",
         "display_name": "Francisco Ram\u00edrez-G\u00f3mez",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Francisco Ramirez-Gomez",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5054095832",
         "display_name": "Whitney Greene",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Whitney Greene",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5070271248",
         "display_name": "Katherine Rego",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Katherine Rego",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5066824903",
         "display_name": "John D. Hansen",
         "orcid": "https://orcid.org/0000-0002-3006-2734"
       },
       "institutions": [
         {
           "id": "https://openalex.org/I4210166920",
           "display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
           "ror": "https://ror.org/05r7z1k40",
           "country_code": "US",
           "type": "government",
           "lineage": [
             "https://openalex.org/I106745318",
             "https://openalex.org/I1308126019",
             "https://openalex.org/I1343035065",
             "https://openalex.org/I4210166920"
           ]
         },
         {
           "id": "https://openalex.org/I1286329397",
           "display_name": "United States Geological Survey",
           "ror": "https://ror.org/035a68863",
           "country_code": "US",
           "type": "government",
           "lineage": [
             "https://openalex.org/I1286329397",
             "https://openalex.org/I1335927249"
           ]
         },
         {
           "id": "https://openalex.org/I201448701",
           "display_name": "University of Washington",
           "ror": "https://ror.org/00cvxb145",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I201448701"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "John D. Hansen",
       "raw_affiliation_strings": [
         "\u2020United States Geological Survey, Western Fisheries Research Center, Seattle, WA 98115; and",
         "\u2021Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98195"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "\u2020United States Geological Survey, Western Fisheries Research Center, Seattle, WA 98115; and",
           "institution_ids": [
             "https://openalex.org/I4210166920",
             "https://openalex.org/I1286329397"
           ]
         },
         {
           "raw_affiliation_string": "\u2021Interdisciplinary Program in Pathobiology, University of Washington, Seattle, WA 98195",
           "institution_ids": [
             "https://openalex.org/I201448701"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5026785101",
         "display_name": "Greg Costa",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Greg Costa",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5082258444",
         "display_name": "Priti Kataria",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Priti Kataria",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     },
     {
       "author_position": "last",
       "author": {
         "id": "https://openalex.org/A5068053952",
         "display_name": "Erin Bromage",
         "orcid": "https://orcid.org/0000-0002-9462-6164"
       },
       "institutions": [
         {
           "id": "https://openalex.org/I100633361",
           "display_name": "University of Massachusetts Dartmouth",
           "ror": "https://ror.org/00fzmm222",
           "country_code": "US",
           "type": "education",
           "lineage": [
             "https://openalex.org/I100633361"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Erin S. Bromage",
       "raw_affiliation_strings": [
         "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "*Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA 02747;",
           "institution_ids": [
             "https://openalex.org/I100633361"
           ]
         }
       ]
     }
   ],
   "best_oa_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.4049/jimmunol.1101938",
     "pdf_url": "https://journals.aai.org/jimmunol/article-pdf/188/3/1341/1357783/1101938.pdf",
     "source": {
       "id": "https://openalex.org/S38008053",
       "display_name": "The Journal of Immunology",
       "issn_l": "0022-1767",
       "issn": [
         "0022-1767",
         "1550-6606"
       ],
       "is_oa": false,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4320800377",
       "host_organization_name": "American Association of Immunologists",
       "host_organization_lineage": [
         "https://openalex.org/P4320800377"
       ],
       "host_organization_lineage_names": [
         "American Association of Immunologists"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "biblio": {
     "volume": "188",
     "issue": "3",
     "first_page": "1341",
     "last_page": "1349"
   },
   "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2126451115",
   "cited_by_count": 135,
   "cited_by_percentile_year": {
     "min": 98,
     "max": 99
   },
   "concepts": [
     {
       "id": "https://openalex.org/c48010095",
       "wikidata": "https://www.wikidata.org/wiki/Q79447",
       "display_name": "Immunoglobulin D",
       "level": 4,
       "score": 0.8753257,
       "qid": null
     },
     {
       "id": "https://openalex.org/c86803240",
       "wikidata": "https://www.wikidata.org/wiki/Q420",
       "display_name": "Biology",
       "level": 0,
       "score": 0.7041124,
       "qid": "Q158998"
     },
     {
       "id": "https://openalex.org/c54458228",
       "wikidata": "https://www.wikidata.org/wiki/Q237218",
       "display_name": "RNA splicing",
       "level": 4,
       "score": 0.6848408,
       "qid": null
     },
     {
       "id": "https://openalex.org/c194583182",
       "wikidata": "https://www.wikidata.org/wiki/Q21114084",
       "display_name": "Alternative splicing",
       "level": 4,
       "score": 0.67705375,
       "qid": null
     },
     {
       "id": "https://openalex.org/c36823959",
       "wikidata": "https://www.wikidata.org/wiki/Q373027",
       "display_name": "Exon",
       "level": 3,
       "score": 0.6696699,
       "qid": null
     },
     {
       "id": "https://openalex.org/c53345823",
       "wikidata": "https://www.wikidata.org/wiki/Q5531554",
       "display_name": "Gene isoform",
       "level": 3,
       "score": 0.55759734,
       "qid": null
     },
     {
       "id": "https://openalex.org/c104317684",
       "wikidata": "https://www.wikidata.org/wiki/Q7187",
       "display_name": "Gene",
       "level": 2,
       "score": 0.48064247,
       "qid": null
     },
     {
       "id": "https://openalex.org/c2994167347",
       "wikidata": "https://www.wikidata.org/wiki/Q187986",
       "display_name": "Rainbow trout",
       "level": 3,
       "score": 0.46910578,
       "qid": null
     },
     {
       "id": "https://openalex.org/c54355233",
       "wikidata": "https://www.wikidata.org/wiki/Q7162",
       "display_name": "Genetics",
       "level": 1,
       "score": 0.45144886,
       "qid": "Q158979"
     },
     {
       "id": "https://openalex.org/c156399914",
       "wikidata": "https://www.wikidata.org/wiki/Q7444454",
       "display_name": "Secretory protein",
       "level": 3,
       "score": 0.41953346,
       "qid": null
     },
     {
       "id": "https://openalex.org/c95444343",
       "wikidata": "https://www.wikidata.org/wiki/Q7141",
       "display_name": "Cell biology",
       "level": 1,
       "score": 0.37981817,
       "qid": "Q158967"
     },
     {
       "id": "https://openalex.org/c159654299",
       "wikidata": "https://www.wikidata.org/wiki/Q79460",
       "display_name": "Antibody",
       "level": 2,
       "score": 0.30576333,
       "qid": null
     },
     {
       "id": "https://openalex.org/c2778453870",
       "wikidata": "https://www.wikidata.org/wiki/Q188930",
       "display_name": "B cell",
       "level": 3,
       "score": 0.17381674,
       "qid": null
     },
     {
       "id": "https://openalex.org/c67705224",
       "wikidata": "https://www.wikidata.org/wiki/Q11053",
       "display_name": "RNA",
       "level": 3,
       "score": 0.1383768,
       "qid": null
     },
     {
       "id": "https://openalex.org/c505870484",
       "wikidata": "https://www.wikidata.org/wiki/Q180538",
       "display_name": "Fishery",
       "level": 1,
       "score": 0.12289268,
       "qid": "Q226243"
     },
     {
       "id": "https://openalex.org/c2909208804",
       "wikidata": "https://www.wikidata.org/wiki/Q127282",
       "display_name": "Fish <Actinopterygii>",
       "level": 2,
       "score": 0.11187813,
       "qid": null
     }
   ],
   "corresponding_author_ids": [],
   "corresponding_institution_ids": [],
   "countries_distinct_count": 1,
   "counts_by_year": [
     {
       "year": 2024,
       "cited_by_count": 7
     },
     {
       "year": 2023,
       "cited_by_count": 8
     },
     {
       "year": 2022,
       "cited_by_count": 15
     },
     {
       "year": 2021,
       "cited_by_count": 12
     },
     {
       "year": 2020,
       "cited_by_count": 16
     },
     {
       "year": 2019,
       "cited_by_count": 13
     },
     {
       "year": 2018,
       "cited_by_count": 11
     },
     {
       "year": 2017,
       "cited_by_count": 7
     },
     {
       "year": 2016,
       "cited_by_count": 11
     },
     {
       "year": 2015,
       "cited_by_count": 11
     },
     {
       "year": 2014,
       "cited_by_count": 10
     },
     {
       "year": 2013,
       "cited_by_count": 10
     },
     {
       "year": 2012,
       "cited_by_count": 4
     }
   ],
   "created_date": "2016-06-24",
   "datasets": [],
   "display_name": "Discovery and Characterization of Secretory IgD in Rainbow Trout: Secretory IgD Is Produced through a Novel Splicing Mechanism",
   "doi": "https://doi.org/10.4049/jimmunol.1101938",
   "fulltext_origin": "pdf",
   "fwci": 5.041,
   "grants": [],
   "has_fulltext": true,
   "id": "https://openalex.org/W2126451115",
   "ids": {
     "openalex": "https://openalex.org/W2126451115",
     "doi": "https://doi.org/10.4049/jimmunol.1101938",
     "mag": "2126451115",
     "pmid": "https://pubmed.ncbi.nlm.nih.gov/22205025"
   },
   "indexed_in": [
     "crossref",
     "pubmed"
   ],
   "institutions_distinct_count": 4,
   "is_paratext": false,
   "is_retracted": false,
   "keywords": [
     {
       "id": "https://openalex.org/keywords/immunoglobulin-d",
       "display_name": "Immunoglobulin D",
       "score": 0.8753257
     },
     {
       "id": "https://openalex.org/keywords/secretory-protein",
       "display_name": "Secretory protein",
       "score": 0.41953346
     },
     {
       "id": "https://openalex.org/keywords/nkg2d-immunoreceptor",
       "display_name": "NKG2D Immunoreceptor",
       "score": 0.400632
     }
   ],
   "language": "en",
   "locations": [
     {
       "is_oa": true,
       "landing_page_url": "https://doi.org/10.4049/jimmunol.1101938",
       "pdf_url": "https://journals.aai.org/jimmunol/article-pdf/188/3/1341/1357783/1101938.pdf",
       "source": {
         "id": "https://openalex.org/S38008053",
         "display_name": "The Journal of Immunology",
         "issn_l": "0022-1767",
         "issn": [
           "0022-1767",
           "1550-6606"
         ],
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": true,
         "host_organization": "https://openalex.org/P4320800377",
         "host_organization_name": "American Association of Immunologists",
         "host_organization_lineage": [
           "https://openalex.org/P4320800377"
         ],
         "host_organization_lineage_names": [
           "American Association of Immunologists"
         ],
         "type": "journal"
       },
       "license": null,
       "license_id": null,
       "version": "publishedVersion",
       "is_accepted": true,
       "is_published": true
     },
     {
       "is_oa": false,
       "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/22205025",
       "pdf_url": null,
       "source": {
         "id": "https://openalex.org/S4306525036",
         "display_name": "PubMed",
         "issn_l": null,
         "issn": null,
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": false,
         "host_organization": "https://openalex.org/I1299303238",
         "host_organization_name": "National Institutes of Health",
         "host_organization_lineage": [
           "https://openalex.org/I1299303238"
         ],
         "host_organization_lineage_names": [
           "National Institutes of Health"
         ],
         "type": "repository"
       },
       "license": null,
       "license_id": null,
       "version": null,
       "is_accepted": false,
       "is_published": false
     }
   ],
   "locations_count": 2,
   "mesh": [
     {
       "descriptor_ui": "D007072",
       "descriptor_name": "Immunoglobulin D",
       "qualifier_ui": "Q000235",
       "qualifier_name": "genetics",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D017686",
       "descriptor_name": "Oncorhynchus mykiss",
       "qualifier_ui": "Q000276",
       "qualifier_name": "immunology",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D012326",
       "descriptor_name": "RNA Splicing",
       "qualifier_ui": "Q000276",
       "qualifier_name": "immunology",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D000818",
       "descriptor_name": "Animals",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D005399",
       "descriptor_name": "Fishes",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D006031",
       "descriptor_name": "Glycosylation",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D007072",
       "descriptor_name": "Immunoglobulin D",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008969",
       "descriptor_name": "Molecular Sequence Data",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D017686",
       "descriptor_name": "Oncorhynchus mykiss",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D017686",
       "descriptor_name": "Oncorhynchus mykiss",
       "qualifier_ui": "Q000235",
       "qualifier_name": "genetics",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D020033",
       "descriptor_name": "Protein Isoforms",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D012326",
       "descriptor_name": "RNA Splicing",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D012333",
       "descriptor_name": "RNA, Messenger",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D012333",
       "descriptor_name": "RNA, Messenger",
       "qualifier_ui": "Q000235",
       "qualifier_name": "genetics",
       "is_major_topic": false
     }
   ],
   "ngrams_url": "https://api.openalex.org/works/W2126451115/ngrams",
   "open_access": {
     "is_oa": true,
     "oa_status": "bronze",
     "oa_url": "https://journals.aai.org/jimmunol/article-pdf/188/3/1341/1357783/1101938.pdf",
     "any_repository_has_fulltext": false
   },
   "primary_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.4049/jimmunol.1101938",
     "pdf_url": "https://journals.aai.org/jimmunol/article-pdf/188/3/1341/1357783/1101938.pdf",
     "source": {
       "id": "https://openalex.org/S38008053",
       "display_name": "The Journal of Immunology",
       "issn_l": "0022-1767",
       "issn": [
         "0022-1767",
         "1550-6606"
       ],
       "is_oa": false,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4320800377",
       "host_organization_name": "American Association of Immunologists",
       "host_organization_lineage": [
         "https://openalex.org/P4320800377"
       ],
       "host_organization_lineage_names": [
         "American Association of Immunologists"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "primary_topic": {
     "id": "https://openalex.org/T11020",
     "display_name": "Natural Killer Cells in Immunity",
     "score": 0.9991,
     "subfield": {
       "id": "https://openalex.org/subfields/2403",
       "display_name": "Immunology"
     },
     "field": {
       "id": "https://openalex.org/fields/24",
       "display_name": "Immunology and Microbiology"
     },
     "domain": {
       "id": "https://openalex.org/domains/1",
       "display_name": "Life Sciences"
     }
   },
   "publication_date": "2012-02-01",
   "publication_year": 2012,
   "referenced_works": [
     "https://openalex.org/W1513604776",
     "https://openalex.org/W1568196150",
     "https://openalex.org/W1569893385",
     "https://openalex.org/W1579868622",
     "https://openalex.org/W1970759336",
     "https://openalex.org/W1973547726",
     "https://openalex.org/W1978273011",
     "https://openalex.org/W1987229882",
     "https://openalex.org/W1988469112",
     "https://openalex.org/W1992106521",
     "https://openalex.org/W1997939418",
     "https://openalex.org/W2004795695",
     "https://openalex.org/W2009580887",
     "https://openalex.org/W2010615831",
     "https://openalex.org/W2011312974",
     "https://openalex.org/W2011958508",
     "https://openalex.org/W2034087823",
     "https://openalex.org/W2057893650",
     "https://openalex.org/W2064626965",
     "https://openalex.org/W2068245361",
     "https://openalex.org/W2074596664",
     "https://openalex.org/W2076339600",
     "https://openalex.org/W2079788374",
     "https://openalex.org/W2082287793",
     "https://openalex.org/W2087486723",
     "https://openalex.org/W2088787071",
     "https://openalex.org/W2114463884",
     "https://openalex.org/W2115204722",
     "https://openalex.org/W2120511083",
     "https://openalex.org/W2121028436",
     "https://openalex.org/W2135643937",
     "https://openalex.org/W2143489045",
     "https://openalex.org/W2150754896",
     "https://openalex.org/W2158813832",
     "https://openalex.org/W2159781587",
     "https://openalex.org/W2161358817",
     "https://openalex.org/W2207743531",
     "https://openalex.org/W2444007734",
     "https://openalex.org/W284553870",
     "https://openalex.org/W28987035",
     "https://openalex.org/W4245064927"
   ],
   "referenced_works_count": 41,
   "related_works": [
     "https://openalex.org/W4387768639",
     "https://openalex.org/W4213427798",
     "https://openalex.org/W2885403345",
     "https://openalex.org/W2564462691",
     "https://openalex.org/W2321791250",
     "https://openalex.org/W2094867951",
     "https://openalex.org/W2065030615",
     "https://openalex.org/W2052498125",
     "https://openalex.org/W2023199111",
     "https://openalex.org/W1535548930"
   ],
   "sustainable_development_goals": [
     {
       "id": "https://metadata.un.org/sdg/14",
       "display_name": "Life below water",
       "score": 0.79
     }
   ],
   "title": "Discovery and Characterization of Secretory IgD in Rainbow Trout: Secretory IgD Is Produced through a Novel Splicing Mechanism",
   "topics": [
     {
       "id": "https://openalex.org/T11020",
       "display_name": "Natural Killer Cells in Immunity",
       "score": 0.9991,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10602",
       "display_name": "Glycosylation in Health and Disease",
       "score": 0.9986,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     }
   ],
   "type": "article",
   "type_crossref": "journal-article",
   "updated_date": "2024-08-08T07:10:53.026707",
   "versions": [],
   "qid": null
 }

}