Item talk:Q243509
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70047923",
"url": "https://pubs.usgs.gov/publication/70047923"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70047923
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1073/pnas.1300592110",
"url": "https://doi.org/10.1073/pnas.1300592110"
}
],
"journal": {
"@type": "Periodical",
"name": "Proceedings of the National Academy of Sciences",
"volumeNumber": "110",
"issueNumber": "26"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Proceedings of the National Academy of Sciences"
}
],
"datePublished": "2013",
"dateModified": "2013-08-30",
"abstract": "Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thoracic region extends well into Hox10-expressing areas of the embryo, suggesting that these proteins are unable to block rib formation. Here, we show that this is not a result of the loss of rib-repressing properties by the snake proteins, but rather to a single base pair change in a Hox/Paired box (Pax)-responsive enhancer, which prevents the binding of Hox proteins. This polymorphism is also found in Paenungulata, such as elephants and manatees, which have extended rib cages. In vivo, this modified enhancer failed to respond to Hox10 activity, supporting its role in the extension of rib cages. In contrast, the enhancer could still interact with Hoxb6 and Pax3 to promote rib formation. These results suggest that a polymorphism in the Hox/Pax-responsive enhancer may have played a role in the evolution of the vertebrate spine by differently modulating its response to rib-suppressing and rib-promoting Hox proteins.",
"description": "5 p.",
"publisher": {
"@type": "Organization",
"name": "National Academy of Science"
},
"author": [
{
"@type": "Person",
"name": "Hunter, Margaret E. mhunter@usgs.gov",
"givenName": "Margaret E.",
"familyName": "Hunter",
"email": "mhunter@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0002-4760-9302",
"url": "https://orcid.org/0000-0002-4760-9302"
},
"affiliation": [
{
"@type": "Organization",
"name": "Wetland and Aquatic Research Center",
"url": "https://www.usgs.gov/centers/wetland-and-aquatic-research-center"
}
]
},
{
"@type": "Person",
"name": "Nunes, Andreia",
"givenName": "Andreia",
"familyName": "Nunes"
},
{
"@type": "Person",
"name": "Casaca, Ana",
"givenName": "Ana",
"familyName": "Casaca"
},
{
"@type": "Person",
"name": "Woltering, Joost M.",
"givenName": "Joost M.",
"familyName": "Woltering"
},
{
"@type": "Person",
"name": "N\u00f3voa, Ana",
"givenName": "Ana",
"familyName": "N\u00f3voa"
},
{
"@type": "Person",
"name": "Duboule, Denis",
"givenName": "Denis",
"familyName": "Duboule"
},
{
"@type": "Person",
"name": "Vinagre, T\u00e2nia",
"givenName": "T\u00e2nia",
"familyName": "Vinagre"
},
{
"@type": "Person",
"name": "Guerreiro, Isabel",
"givenName": "Isabel",
"familyName": "Guerreiro"
},
{
"@type": "Person",
"name": "Mallo, Mois\u00e9s",
"givenName": "Mois\u00e9s",
"familyName": "Mallo"
}
],
"funder": [
{
"@type": "Organization",
"name": "Southeast Ecological Science Center",
"url": "https://www.usgs.gov/regions/southeast"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"Patterning": [
0
],
"of": [
1,
9,
28,
43,
65,
68,
93,
130,
166
],
"the": [
2,
6,
20,
35,
44,
66,
72,
91,
128,
135,
155,
164,
167
],
"vertebrate": [
3,
168
],
"skeleton": [
4
],
"requires": [
5
],
"coordinated": [
7
],
"activity": [
8
],
"Hox": [
10,
94,
179
],
"genes.": [
11
],
"In": [
12,
32,
113,
133
],
"particular,": [
13
],
"Hox10": [
14,
122
],
"proteins": [
15,
49
],
"are": [
16,
50
],
"essential": [
17
],
"to": [
18,
24,
52,
77,
119,
121,
144,
175
],
"set": [
19
],
"transition": [
21
],
"from": [
22
],
"thoracic": [
23,
36
],
"lumbar": [
25
],
"vertebrae": [
26
],
"because": [
27
],
"their": [
29
],
"rib-repressing": [
30,
69
],
"activity.": [
31
],
"snakes,": [
33
],
"however,": [
34
],
"region": [
37
],
"extends": [
38
],
"well": [
39
],
"into": [
40
],
"Hox10-expressing": [
41
],
"areas": [
42
],
"embryo,": [
45
],
"suggesting": [
46
],
"that": [
47,
59,
151
],
"these": [
48
],
"unable": [
51
],
"block": [
53
],
"rib": [
54,
111,
131,
146
],
"formation.": [
55,
147
],
"Here,": [
56
],
"we": [
57
],
"show": [
58
],
"this": [
60,
115
],
"is": [
61,
98
],
"not": [
62
],
"a": [
63,
78,
84,
152,
161
],
"result": [
64
],
"loss": [
67
],
"properties": [
70
],
"by": [
71,
170
],
"snake": [
73
],
"proteins,": [
74
],
"but": [
75
],
"rather": [
76
],
"single": [
79
],
"base": [
80
],
"pair": [
81
],
"change": [
82
],
"in": [
83,
101,
127,
154,
163
],
"Hox/Paired": [
85
],
"box": [
86
],
"(Pax)-responsive": [
87
],
"enhancer,": [
88
],
"which": [
89,
108
],
"prevents": [
90
],
"binding": [
92
],
"proteins.": [
95,
180
],
"This": [
96
],
"polymorphism": [
97,
153
],
"also": [
99
],
"found": [
100
],
"Paenungulata,": [
102
],
"such": [
103
],
"as": [
104
],
"elephants": [
105
],
"and": [
106,
142,
177
],
"manatees,": [
107
],
"have": [
109,
159
],
"extended": [
110
],
"cages.": [
112,
132
],
"vivo,": [
114
],
"modified": [
116
],
"enhancer": [
117,
136,
157
],
"failed": [
118
],
"respond": [
120
],
"activity,": [
123
],
"supporting": [
124
],
"its": [
125,
173
],
"role": [
126,
162
],
"extension": [
129
],
"contrast,": [
134
],
"could": [
137
],
"still": [
138
],
"interact": [
139
],
"with": [
140
],
"Hoxb6": [
141
],
"Pax3": [
143
],
"promote": [
145
],
"These": [
148
],
"results": [
149
],
"suggest": [
150
],
"Hox/Pax-responsive": [
156
],
"may": [
158
],
"played": [
160
],
"evolution": [
165
],
"spine": [
169
],
"differently": [
171
],
"modulating": [
172
],
"response": [
174
],
"rib-suppressing": [
176
],
"rib-promoting": [
178
]
},
"apc_list": null,
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5013053450",
"display_name": "Isabel Guerreiro",
"orcid": "https://orcid.org/0000-0003-1390-3535"
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
},
{
"id": "https://openalex.org/I114457229",
"display_name": "University of Geneva",
"ror": "https://ror.org/01swzsf04",
"country_code": "CH",
"type": "education",
"lineage": [
"https://openalex.org/I114457229"
]
}
],
"countries": [
"CH",
"PT"
],
"is_corresponding": false,
"raw_author_name": "Isabel Guerreiro",
"raw_affiliation_strings": [
"Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;",
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
},
{
"raw_affiliation_string": "Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;",
"institution_ids": [
"https://openalex.org/I114457229"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5090579929",
"display_name": "Andreia M. Nunes",
"orcid": "https://orcid.org/0000-0001-9996-013X"
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
}
],
"countries": [
"PT"
],
"is_corresponding": false,
"raw_author_name": "Andreia Nunes",
"raw_affiliation_strings": [
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5085882534",
"display_name": "Joost M. Woltering",
"orcid": "https://orcid.org/0000-0002-2630-6572"
},
"institutions": [
{
"id": "https://openalex.org/I114457229",
"display_name": "University of Geneva",
"ror": "https://ror.org/01swzsf04",
"country_code": "CH",
"type": "education",
"lineage": [
"https://openalex.org/I114457229"
]
}
],
"countries": [
"CH"
],
"is_corresponding": false,
"raw_author_name": "Joost M. Woltering",
"raw_affiliation_strings": [
"Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;",
"institution_ids": [
"https://openalex.org/I114457229"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5073126542",
"display_name": "Ana Casaca",
"orcid": "https://orcid.org/0000-0002-0706-8038"
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
}
],
"countries": [
"PT"
],
"is_corresponding": false,
"raw_author_name": "Ana Casaca",
"raw_affiliation_strings": [
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5055805470",
"display_name": "Ana N\u00f3voa",
"orcid": "https://orcid.org/0000-0002-5668-5630"
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
}
],
"countries": [
"PT"
],
"is_corresponding": false,
"raw_author_name": "Ana N\u00f3voa",
"raw_affiliation_strings": [
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5036154221",
"display_name": "T\u00e2nia Vinagre",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
}
],
"countries": [
"PT"
],
"is_corresponding": false,
"raw_author_name": "T\u00e2nia Vinagre",
"raw_affiliation_strings": [
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5034872140",
"display_name": "Margaret E. Hunter",
"orcid": "https://orcid.org/0000-0002-4760-9302"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Margaret E. Hunter",
"raw_affiliation_strings": [
"Southeast Ecological Science Center, US Geological Survey, Gainesville, FL 32653;"
],
"affiliations": [
{
"raw_affiliation_string": "Southeast Ecological Science Center, US Geological Survey, Gainesville, FL 32653;",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5036343790",
"display_name": "Denis Duboule",
"orcid": "https://orcid.org/0000-0001-9961-2960"
},
"institutions": [
{
"id": "https://openalex.org/I114457229",
"display_name": "University of Geneva",
"ror": "https://ror.org/01swzsf04",
"country_code": "CH",
"type": "education",
"lineage": [
"https://openalex.org/I114457229"
]
},
{
"id": "https://openalex.org/I5124864",
"display_name": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne",
"ror": "https://ror.org/02s376052",
"country_code": "CH",
"type": "education",
"lineage": [
"https://openalex.org/I2799323385",
"https://openalex.org/I5124864"
]
}
],
"countries": [
"CH"
],
"is_corresponding": false,
"raw_author_name": "Denis Duboule",
"raw_affiliation_strings": [
"Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;",
"School of Life Sciences, Ecole Polytechnique Federale, 1015 Lausanne, Switzerland; and"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Genetics and Evolution, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;",
"institution_ids": [
"https://openalex.org/I114457229"
]
},
{
"raw_affiliation_string": "School of Life Sciences, Ecole Polytechnique Federale, 1015 Lausanne, Switzerland; and",
"institution_ids": [
"https://openalex.org/I5124864"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5101747118",
"display_name": "Mois\u00e9s Mallo",
"orcid": "https://orcid.org/0000-0002-9744-0912"
},
"institutions": [
{
"id": "https://openalex.org/I48057805",
"display_name": "Instituto Gulbenkian de Ci\u00eancia",
"ror": "https://ror.org/04b08hq31",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I48057805"
]
},
{
"id": "https://openalex.org/I141596103",
"display_name": "University of Lisbon",
"ror": "https://ror.org/01c27hj86",
"country_code": "PT",
"type": "education",
"lineage": [
"https://openalex.org/I141596103"
]
}
],
"countries": [
"PT"
],
"is_corresponding": false,
"raw_author_name": "Mois\u00e9s Mallo",
"raw_affiliation_strings": [
"Department of Histology and Embryology, Faculty of Medicine, University of Lisbon, 1749-016 Lisbon, Portugal",
"Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"
],
"affiliations": [
{
"raw_affiliation_string": "Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;",
"institution_ids": [
"https://openalex.org/I48057805"
]
},
{
"raw_affiliation_string": "Department of Histology and Embryology, Faculty of Medicine, University of Lisbon, 1749-016 Lisbon, Portugal",
"institution_ids": [
"https://openalex.org/I141596103"
]
}
]
}
],
"best_oa_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1073/pnas.1300592110",
"pdf_url": "https://www.pnas.org/content/pnas/110/26/10682.full.pdf",
"source": {
"id": "https://openalex.org/S125754415",
"display_name": "Proceedings of the National Academy of Sciences",
"issn_l": "0027-8424",
"issn": [
"0027-8424",
"1091-6490"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320052",
"host_organization_name": "National Academy of Sciences",
"host_organization_lineage": [
"https://openalex.org/P4310320052"
],
"host_organization_lineage_names": [
"National Academy of Sciences"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"biblio": {
"volume": "110",
"issue": "26",
"first_page": "10682",
"last_page": "10686"
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2041866520",
"cited_by_count": 86,
"cited_by_percentile_year": {
"min": 97,
"max": 98
},
"concepts": [
{
"id": "https://openalex.org/c111039654",
"wikidata": "https://www.wikidata.org/wiki/Q253149",
"display_name": "Hox gene",
"level": 4,
"score": 0.9647192,
"qid": null
},
{
"id": "https://openalex.org/c111936080",
"wikidata": "https://www.wikidata.org/wiki/Q913367",
"display_name": "Enhancer",
"level": 4,
"score": 0.9194845,
"qid": null
},
{
"id": "https://openalex.org/c86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.7483214,
"qid": "Q158998"
},
{
"id": "https://openalex.org/c2778961482",
"wikidata": "https://www.wikidata.org/wiki/Q25241",
"display_name": "Vertebrate",
"level": 3,
"score": 0.6831962,
"qid": null
},
{
"id": "https://openalex.org/c105702510",
"wikidata": "https://www.wikidata.org/wiki/Q514",
"display_name": "Anatomy",
"level": 1,
"score": 0.43776786,
"qid": "Q166320"
},
{
"id": "https://openalex.org/c95444343",
"wikidata": "https://www.wikidata.org/wiki/Q7141",
"display_name": "Cell biology",
"level": 1,
"score": 0.43369874,
"qid": "Q158967"
},
{
"id": "https://openalex.org/c2777971045",
"wikidata": "https://www.wikidata.org/wiki/Q1377526",
"display_name": "Axial skeleton",
"level": 2,
"score": 0.43269768,
"qid": null
},
{
"id": "https://openalex.org/c54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.4162844,
"qid": "Q158979"
},
{
"id": "https://openalex.org/c78458016",
"wikidata": "https://www.wikidata.org/wiki/Q840400",
"display_name": "Evolutionary biology",
"level": 1,
"score": 0.3935407,
"qid": "Q226241"
},
{
"id": "https://openalex.org/c104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.36849493,
"qid": null
},
{
"id": "https://openalex.org/c86339819",
"wikidata": "https://www.wikidata.org/wiki/Q407384",
"display_name": "Transcription factor",
"level": 3,
"score": 0.342992,
"qid": null
}
],
"corresponding_author_ids": [],
"corresponding_institution_ids": [],
"countries_distinct_count": 3,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 2
},
{
"year": 2023,
"cited_by_count": 5
},
{
"year": 2022,
"cited_by_count": 9
},
{
"year": 2021,
"cited_by_count": 7
},
{
"year": 2020,
"cited_by_count": 3
},
{
"year": 2019,
"cited_by_count": 7
},
{
"year": 2018,
"cited_by_count": 11
},
{
"year": 2017,
"cited_by_count": 10
},
{
"year": 2016,
"cited_by_count": 7
},
{
"year": 2015,
"cited_by_count": 12
},
{
"year": 2014,
"cited_by_count": 9
},
{
"year": 2013,
"cited_by_count": 4
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine",
"doi": "https://doi.org/10.1073/pnas.1300592110",
"fulltext_origin": "ngrams",
"fwci": 4.321,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W2041866520",
"ids": {
"openalex": "https://openalex.org/W2041866520",
"doi": "https://doi.org/10.1073/pnas.1300592110",
"mag": "2041866520",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/23674686",
"pmcid": "https://www.ncbi.nlm.nih.gov/pmc/articles/3696775"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 5,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/regulation-of-bone-homeostasis",
"display_name": "Regulation of Bone Homeostasis",
"score": 0.464493
}
],
"language": "en",
"locations": [
{
"is_oa": true,
"landing_page_url": "https://doi.org/10.1073/pnas.1300592110",
"pdf_url": "https://www.pnas.org/content/pnas/110/26/10682.full.pdf",
"source": {
"id": "https://openalex.org/S125754415",
"display_name": "Proceedings of the National Academy of Sciences",
"issn_l": "0027-8424",
"issn": [
"0027-8424",
"1091-6490"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320052",
"host_organization_name": "National Academy of Sciences",
"host_organization_lineage": [
"https://openalex.org/P4310320052"
],
"host_organization_lineage_names": [
"National Academy of Sciences"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": true,
"landing_page_url": "https://europepmc.org/articles/pmc3696775",
"pdf_url": "https://europepmc.org/articles/pmc3696775?pdf=render",
"source": {
"id": "https://openalex.org/S4306400806",
"display_name": "Europe PMC (PubMed Central)",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1303153112",
"host_organization_name": "European Bioinformatics Institute",
"host_organization_lineage": [
"https://openalex.org/I1303153112"
],
"host_organization_lineage_names": [
"European Bioinformatics Institute"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": true,
"landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696775",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S2764455111",
"display_name": "PubMed Central",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/23674686",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 4,
"mesh": [
{
"descriptor_ui": "D005801",
"descriptor_name": "Genes, Homeobox",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D051761",
"descriptor_name": "Paired Box Transcription Factors",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": true
},
{
"descriptor_ui": "D013131",
"descriptor_name": "Spine",
"qualifier_ui": "Q000196",
"qualifier_name": "embryology",
"is_major_topic": true
},
{
"descriptor_ui": "D013131",
"descriptor_name": "Spine",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D001483",
"descriptor_name": "Base Sequence",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019521",
"descriptor_name": "Body Patterning",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D019521",
"descriptor_name": "Body Patterning",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017812",
"descriptor_name": "Colubridae",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017812",
"descriptor_name": "Colubridae",
"qualifier_ui": "Q000033",
"qualifier_name": "anatomy & histology",
"is_major_topic": false
},
{
"descriptor_ui": "D017812",
"descriptor_name": "Colubridae",
"qualifier_ui": "Q000196",
"qualifier_name": "embryology",
"is_major_topic": false
},
{
"descriptor_ui": "D017812",
"descriptor_name": "Colubridae",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D017124",
"descriptor_name": "Conserved Sequence",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D004742",
"descriptor_name": "Enhancer Elements, Genetic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019143",
"descriptor_name": "Evolution, Molecular",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D000080905",
"descriptor_name": "Homeobox A10 Proteins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D018398",
"descriptor_name": "Homeodomain Proteins",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D018398",
"descriptor_name": "Homeodomain Proteins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D051379",
"descriptor_name": "Mice",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D008822",
"descriptor_name": "Mice, Transgenic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D008969",
"descriptor_name": "Molecular Sequence Data",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D051787",
"descriptor_name": "Myogenic Regulatory Factor 5",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D051787",
"descriptor_name": "Myogenic Regulatory Factor 5",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D051761",
"descriptor_name": "Paired Box Transcription Factors",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020641",
"descriptor_name": "Polymorphism, Single Nucleotide",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D012689",
"descriptor_name": "Sequence Homology, Nucleic Acid",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013131",
"descriptor_name": "Spine",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013131",
"descriptor_name": "Spine",
"qualifier_ui": "Q000033",
"qualifier_name": "anatomy & histology",
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2041866520/ngrams",
"open_access": {
"is_oa": true,
"oa_status": "bronze",
"oa_url": "https://www.pnas.org/content/pnas/110/26/10682.full.pdf",
"any_repository_has_fulltext": true
},
"primary_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1073/pnas.1300592110",
"pdf_url": "https://www.pnas.org/content/pnas/110/26/10682.full.pdf",
"source": {
"id": "https://openalex.org/S125754415",
"display_name": "Proceedings of the National Academy of Sciences",
"issn_l": "0027-8424",
"issn": [
"0027-8424",
"1091-6490"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320052",
"host_organization_name": "National Academy of Sciences",
"host_organization_lineage": [
"https://openalex.org/P4310320052"
],
"host_organization_lineage_names": [
"National Academy of Sciences"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"primary_topic": {
"id": "https://openalex.org/T10268",
"display_name": "Notch Signaling Pathway in Development and Disease",
"score": 0.9997,
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2013-05-14",
"publication_year": 2013,
"referenced_works": [
"https://openalex.org/W1982395272",
"https://openalex.org/W2000019005",
"https://openalex.org/W2007813753",
"https://openalex.org/W2041247874",
"https://openalex.org/W2045937790",
"https://openalex.org/W2047134031",
"https://openalex.org/W2048249977",
"https://openalex.org/W2060330024",
"https://openalex.org/W2083338784",
"https://openalex.org/W2099290714",
"https://openalex.org/W2103945066",
"https://openalex.org/W2113300574",
"https://openalex.org/W2113648023",
"https://openalex.org/W2131918846",
"https://openalex.org/W2134101898",
"https://openalex.org/W2137504683",
"https://openalex.org/W2138109258",
"https://openalex.org/W2144182691",
"https://openalex.org/W2150426905",
"https://openalex.org/W2170185022",
"https://openalex.org/W2171140271",
"https://openalex.org/W2189428547",
"https://openalex.org/W2314225431",
"https://openalex.org/W4238534741",
"https://openalex.org/W4255194479"
],
"referenced_works_count": 25,
"related_works": [
"https://openalex.org/W38240740",
"https://openalex.org/W2994693398",
"https://openalex.org/W2285867737",
"https://openalex.org/W2134101898",
"https://openalex.org/W2127677836",
"https://openalex.org/W2091583598",
"https://openalex.org/W2050195688",
"https://openalex.org/W2025425734",
"https://openalex.org/W2001966722",
"https://openalex.org/W1634383009"
],
"sustainable_development_goals": [
{
"score": 0.47,
"display_name": "Life on land",
"id": "https://metadata.un.org/sdg/15"
}
],
"title": "Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine",
"topics": [
{
"id": "https://openalex.org/T10268",
"display_name": "Notch Signaling Pathway in Development and Disease",
"score": 0.9997,
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11219",
"display_name": "Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling",
"score": 0.9788,
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11685",
"display_name": "Zebrafish as a Model Organism for Multidisciplinary Research",
"score": 0.9788,
"subfield": {
"id": "https://openalex.org/subfields/1307",
"display_name": "Cell Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-06T07:55:01.400713",
"versions": [],
"qid": null
}
}
