Item talk:Q242809
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70043581",
"url": "https://pubs.usgs.gov/publication/70043581"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70043581
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.mce.2013.01.021",
"url": "https://doi.org/10.1016/j.mce.2013.01.021"
}
],
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Molecular and Cellular Endocrinology"
}
],
"datePublished": "2013",
"dateModified": "2013-03-11",
"abstract": "Prolactin (PRL) is a well-known regulator of ion and water transport within osmoregulatory tissues across vertebrate species, yet how PRL acts on some of its target tissues remains poorly understood. Using zebrafish as a model, we show that ionocytes in the gill directly respond to systemic PRL to regulate mechanisms of ion uptake. Ion-poor conditions led to increases in the expression of PRL receptor (prlra), Na+/Cl\u2212 cotransporter (ncc; slc12a10.2), Na+/H+ exchanger (nhe3b; slc9a3.2), and epithelial Ca2+ channel (ecac; trpv6) transcripts within the gill. Intraperitoneal injection of ovine PRL (oPRL) increased ncc and prlra transcripts, but did not affect nhe3b or ecac. Consistent with direct PRL action in the gill, addition of oPRL to cultured gill filaments stimulated ncc in a concentration-dependent manner, an effect blocked by a pure human PRL receptor antagonist (\u03941-9-G129R-hPRL). These results suggest that PRL signaling through PRL receptors in the gill regulates the expression of ncc, thereby linking this pituitary hormone with an effector of Cl\u2212 uptake in zebrafish for the first time.",
"description": "In Press, Corrected Proof",
"publisher": {
"@type": "Organization",
"name": "Elsevier"
},
"author": [
{
"@type": "Person",
"name": "Breves, Jason P.",
"givenName": "Jason P.",
"familyName": "Breves",
"affiliation": [
{
"@type": "Organization",
"name": "University of Massachusetts, Amherst"
}
]
},
{
"@type": "Person",
"name": "Goffin, Vincent",
"givenName": "Vincent",
"familyName": "Goffin"
},
{
"@type": "Person",
"name": "Serizier, Sandy B.",
"givenName": "Sandy B.",
"familyName": "Serizier"
},
{
"@type": "Person",
"name": "McCormick, Stephen D. smccormick@usgs.gov",
"givenName": "Stephen D.",
"familyName": "McCormick",
"email": "smccormick@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0003-0621-6200",
"url": "https://orcid.org/0000-0003-0621-6200"
},
"affiliation": [
{
"@type": "Organization",
"name": "Leetown Science Center",
"url": "https://www.usgs.gov/centers/eesc"
}
]
},
{
"@type": "Person",
"name": "Karlstrom, Rolf O.",
"givenName": "Rolf O.",
"familyName": "Karlstrom",
"affiliation": [
{
"@type": "Organization",
"name": "University of Massachusetts, Amherst"
}
]
}
],
"funder": [
{
"@type": "Organization",
"name": "Leetown Science Center",
"url": "https://www.usgs.gov/centers/eesc"
}
],
"spatialCoverage": [
{
"@type": "Place",
"additionalType": "country",
"name": "United States",
"url": "https://geonames.org/4074035"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"Prolactin": [
0
],
"(PRL)": [
1
],
"is": [
2
],
"a": [
3,
33,
119,
126
],
"well-known": [
4
],
"regulator": [
5
],
"of": [
6,
23,
50,
61,
85,
110,
148,
158
],
"ion": [
7,
51
],
"and": [
8,
73,
91
],
"water": [
9
],
"transport": [
10
],
"within": [
11,
80
],
"osmoregulatory": [
12
],
"tissues": [
13,
26
],
"across": [
14
],
"vertebrate": [
15
],
"species,": [
16
],
"yet": [
17
],
"how": [
18
],
"PRL": [
19,
46,
62,
87,
104,
129,
137,
140
],
"acts": [
20
],
"on": [
21
],
"some": [
22
],
"its": [
24
],
"target": [
25
],
"remains": [
27
],
"poorly": [
28
],
"understood.": [
29
],
"Using": [
30
],
"zebrafish": [
31,
162
],
"as": [
32
],
"model,": [
34
],
"we": [
35
],
"show": [
36
],
"that": [
37,
136
],
"ionocytes": [
38
],
"in": [
39,
58,
106,
118,
142,
161
],
"the": [
40,
59,
81,
107,
143,
146,
164
],
"gill": [
41,
114,
144
],
"directly": [
42
],
"respond": [
43
],
"to": [
44,
47,
56,
112
],
"systemic": [
45
],
"regulate": [
48
],
"mechanisms": [
49
],
"uptake.": [
52
],
"Ion-poor": [
53
],
"conditions": [
54
],
"led": [
55
],
"increases": [
57
],
"expression": [
60,
147
],
"receptor": [
63,
130
],
"(prlra),": [
64
],
"Na+/Cl\u2212": [
65
],
"cotransporter": [
66
],
"(ncc;": [
67
],
"slc12a10.2),": [
68
],
"Na+/H+": [
69
],
"exchanger": [
70
],
"(nhe3b;": [
71
],
"slc9a3.2),": [
72
],
"epithelial": [
74
],
"Ca2+": [
75
],
"channel": [
76
],
"(ecac;": [
77
],
"trpv6)": [
78
],
"transcripts": [
79
],
"gill.": [
82
],
"Intraperitoneal": [
83
],
"injection": [
84
],
"ovine": [
86
],
"(oPRL)": [
88
],
"increased": [
89
],
"ncc": [
90,
117
],
"prlra": [
92
],
"transcripts,": [
93
],
"but": [
94
],
"did": [
95
],
"not": [
96
],
"affect": [
97
],
"nhe3b": [
98
],
"or": [
99
],
"ecac.": [
100
],
"Consistent": [
101
],
"with": [
102,
155
],
"direct": [
103
],
"action": [
105
],
"gill,": [
108
],
"addition": [
109
],
"oPRL": [
111
],
"cultured": [
113
],
"filaments": [
115
],
"stimulated": [
116
],
"concentration-dependent": [
120
],
"manner,": [
121
],
"an": [
122,
156
],
"effect": [
123
],
"blocked": [
124
],
"by": [
125
],
"pure": [
127
],
"human": [
128
],
"antagonist": [
131
],
"(\u03941-9-G129R-hPRL).": [
132
],
"These": [
133
],
"results": [
134
],
"suggest": [
135
],
"signaling": [
138
],
"through": [
139
],
"receptors": [
141
],
"regulates": [
145
],
"ncc,": [
149
],
"thereby": [
150
],
"linking": [
151
],
"this": [
152
],
"pituitary": [
153
],
"hormone": [
154
],
"effector": [
157
],
"Cl\u2212": [
159
],
"uptake": [
160
],
"for": [
163
],
"first": [
165
],
"time.": [
166
]
},
"apc_list": {
"value": 3000,
"currency": "USD",
"value_usd": 3000,
"provenance": "doaj"
},
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5048061632",
"display_name": "Jason P. Breves",
"orcid": "https://orcid.org/0000-0003-1193-4389"
},
"institutions": [
{
"id": "https://openalex.org/I24603500",
"display_name": "University of Massachusetts Amherst",
"ror": "https://ror.org/0072zz521",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I24603500"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Jason P. Breves",
"raw_affiliation_strings": [
"Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA",
"institution_ids": [
"https://openalex.org/I24603500"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5002446834",
"display_name": "Sandy B. Serizier",
"orcid": "https://orcid.org/0000-0003-3294-368X"
},
"institutions": [
{
"id": "https://openalex.org/I24603500",
"display_name": "University of Massachusetts Amherst",
"ror": "https://ror.org/0072zz521",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I24603500"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Sandy B. Serizier",
"raw_affiliation_strings": [
"Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA",
"institution_ids": [
"https://openalex.org/I24603500"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5041012326",
"display_name": "Vincent Goffin",
"orcid": "https://orcid.org/0000-0002-8021-3086"
},
"institutions": [
{
"id": "https://openalex.org/I110736937",
"display_name": "D\u00e9l\u00e9gation Paris 5",
"ror": "https://ror.org/02e0y6e06",
"country_code": "FR",
"type": "government",
"lineage": [
"https://openalex.org/I110736937",
"https://openalex.org/I154526488"
]
},
{
"id": "https://openalex.org/I154526488",
"display_name": "Inserm",
"ror": "https://ror.org/02vjkv261",
"country_code": "FR",
"type": "government",
"lineage": [
"https://openalex.org/I154526488"
]
},
{
"id": "https://openalex.org/I4210091437",
"display_name": "Sorbonne Paris Cit\u00e9",
"ror": "https://ror.org/001z21q04",
"country_code": "FR",
"type": "other",
"lineage": [
"https://openalex.org/I4210091437"
]
},
{
"id": "https://openalex.org/I204730241",
"display_name": "Universit\u00e9 Paris Cit\u00e9",
"ror": "https://ror.org/05f82e368",
"country_code": "FR",
"type": "education",
"lineage": [
"https://openalex.org/I204730241"
]
}
],
"countries": [
"FR"
],
"is_corresponding": false,
"raw_author_name": "Vincent Goffin",
"raw_affiliation_strings": [
"Inserm, Unit 845, Research Center Growth and Signaling, Prolactin/GH Pathophysiology Laboratory, University Paris Descartes, Sorbonne Paris Cit\u00e9, Faculty of Medicine, Necker site, Paris F-75015, France"
],
"affiliations": [
{
"raw_affiliation_string": "Inserm, Unit 845, Research Center Growth and Signaling, Prolactin/GH Pathophysiology Laboratory, University Paris Descartes, Sorbonne Paris Cit\u00e9, Faculty of Medicine, Necker site, Paris F-75015, France",
"institution_ids": [
"https://openalex.org/I110736937",
"https://openalex.org/I154526488",
"https://openalex.org/I4210091437",
"https://openalex.org/I204730241"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5054146102",
"display_name": "Stephen D. McCormick",
"orcid": "https://orcid.org/0000-0003-0621-6200"
},
"institutions": [
{
"id": "https://openalex.org/I24603500",
"display_name": "University of Massachusetts Amherst",
"ror": "https://ror.org/0072zz521",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I24603500"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Stephen D. McCormick",
"raw_affiliation_strings": [
"Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA",
"USGS, Conte Anadromous Fish Research Center, Turners Falls, MA 01376, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA",
"institution_ids": [
"https://openalex.org/I24603500"
]
},
{
"raw_affiliation_string": "USGS, Conte Anadromous Fish Research Center, Turners Falls, MA 01376, USA",
"institution_ids": []
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5069574773",
"display_name": "Rolf O. Karlstrom",
"orcid": "https://orcid.org/0000-0002-2883-7377"
},
"institutions": [
{
"id": "https://openalex.org/I24603500",
"display_name": "University of Massachusetts Amherst",
"ror": "https://ror.org/0072zz521",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I24603500"
]
}
],
"countries": [
"US"
],
"is_corresponding": true,
"raw_author_name": "Rolf O. Karlstrom",
"raw_affiliation_strings": [
"Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA 01003, USA",
"institution_ids": [
"https://openalex.org/I24603500"
]
}
]
}
],
"best_oa_location": {
"is_oa": true,
"landing_page_url": "https://europepmc.org/articles/pmc3664226",
"pdf_url": "https://europepmc.org/articles/pmc3664226?pdf=render",
"source": {
"id": "https://openalex.org/S4306400806",
"display_name": "Europe PMC (PubMed Central)",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1303153112",
"host_organization_name": "European Bioinformatics Institute",
"host_organization_lineage": [
"https://openalex.org/I1303153112"
],
"host_organization_lineage_names": [
"European Bioinformatics Institute"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "acceptedVersion",
"is_accepted": true,
"is_published": false
},
"biblio": {
"volume": "369",
"issue": "1-2",
"first_page": "98",
"last_page": "106"
},
"citation_normalized_percentile": {
"value": 0.925582,
"is_in_top_1_percent": false,
"is_in_top_10_percent": true
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2034655287",
"cited_by_count": 61,
"cited_by_percentile_year": {
"min": 96,
"max": 97
},
"concepts": [
{
"id": "https://openalex.org/C2779064019",
"wikidata": "https://www.wikidata.org/wiki/Q66590068",
"display_name": "Prolactin",
"level": 3,
"score": 0.73495203
},
{
"id": "https://openalex.org/C2776878037",
"wikidata": "https://www.wikidata.org/wiki/Q169444",
"display_name": "Zebrafish",
"level": 3,
"score": 0.6603842
},
{
"id": "https://openalex.org/C126322002",
"wikidata": "https://www.wikidata.org/wiki/Q11180",
"display_name": "Internal medicine",
"level": 1,
"score": 0.65461445
},
{
"id": "https://openalex.org/C188053792",
"wikidata": "https://www.wikidata.org/wiki/Q3640664",
"display_name": "Cotransporter",
"level": 3,
"score": 0.6364495
},
{
"id": "https://openalex.org/C134018914",
"wikidata": "https://www.wikidata.org/wiki/Q162606",
"display_name": "Endocrinology",
"level": 1,
"score": 0.615915
},
{
"id": "https://openalex.org/C170493617",
"wikidata": "https://www.wikidata.org/wiki/Q208467",
"display_name": "Receptor",
"level": 2,
"score": 0.56631905
},
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.5620333
},
{
"id": "https://openalex.org/C95444343",
"wikidata": "https://www.wikidata.org/wiki/Q7141",
"display_name": "Cell biology",
"level": 1,
"score": 0.46416998
},
{
"id": "https://openalex.org/C51785407",
"wikidata": "https://www.wikidata.org/wiki/Q2627568",
"display_name": "Effector",
"level": 2,
"score": 0.44085595
},
{
"id": "https://openalex.org/C99975950",
"wikidata": "https://www.wikidata.org/wiki/Q911011",
"display_name": "Ion transporter",
"level": 3,
"score": 0.41103077
},
{
"id": "https://openalex.org/C71315377",
"wikidata": "https://www.wikidata.org/wiki/Q11364",
"display_name": "Hormone",
"level": 2,
"score": 0.33994722
},
{
"id": "https://openalex.org/C185592680",
"wikidata": "https://www.wikidata.org/wiki/Q2329",
"display_name": "Chemistry",
"level": 0,
"score": 0.33168924
},
{
"id": "https://openalex.org/C104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.19656944
},
{
"id": "https://openalex.org/C537181965",
"wikidata": "https://www.wikidata.org/wiki/Q658",
"display_name": "Sodium",
"level": 2,
"score": 0.15011689
},
{
"id": "https://openalex.org/C55493867",
"wikidata": "https://www.wikidata.org/wiki/Q7094",
"display_name": "Biochemistry",
"level": 1,
"score": 0.09478995
},
{
"id": "https://openalex.org/C41625074",
"wikidata": "https://www.wikidata.org/wiki/Q176088",
"display_name": "Membrane",
"level": 2,
"score": 0.079173386
},
{
"id": "https://openalex.org/C71924100",
"wikidata": "https://www.wikidata.org/wiki/Q11190",
"display_name": "Medicine",
"level": 0,
"score": 0.0
},
{
"id": "https://openalex.org/C178790620",
"wikidata": "https://www.wikidata.org/wiki/Q11351",
"display_name": "Organic chemistry",
"level": 1,
"score": 0.0
}
],
"corresponding_author_ids": [
"https://openalex.org/A5069574773"
],
"corresponding_institution_ids": [
"https://openalex.org/I24603500"
],
"countries_distinct_count": 2,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 4
},
{
"year": 2023,
"cited_by_count": 3
},
{
"year": 2022,
"cited_by_count": 7
},
{
"year": 2021,
"cited_by_count": 5
},
{
"year": 2020,
"cited_by_count": 6
},
{
"year": 2019,
"cited_by_count": 5
},
{
"year": 2018,
"cited_by_count": 4
},
{
"year": 2017,
"cited_by_count": 5
},
{
"year": 2016,
"cited_by_count": 7
},
{
"year": 2015,
"cited_by_count": 8
},
{
"year": 2014,
"cited_by_count": 7
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Prolactin regulates transcription of the ion uptake Na+/Cl\u2212 cotransporter (ncc) gene in zebrafish gill",
"doi": "https://doi.org/10.1016/j.mce.2013.01.021",
"fulltext_origin": "ngrams",
"fwci": 5.757,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W2034655287",
"ids": {
"openalex": "https://openalex.org/W2034655287",
"doi": "https://doi.org/10.1016/j.mce.2013.01.021",
"mag": "2034655287",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/23395804",
"pmcid": "https://www.ncbi.nlm.nih.gov/pmc/articles/3664226"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 5,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/nutrition",
"display_name": "Nutrition",
"score": 0.437643
}
],
"language": "en",
"locations": [
{
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.mce.2013.01.021",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S191044671",
"display_name": "Molecular and Cellular Endocrinology",
"issn_l": "0303-7207",
"issn": [
"0303-7207",
"1872-8057"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
{
"is_oa": true,
"landing_page_url": "https://europepmc.org/articles/pmc3664226",
"pdf_url": "https://europepmc.org/articles/pmc3664226?pdf=render",
"source": {
"id": "https://openalex.org/S4306400806",
"display_name": "Europe PMC (PubMed Central)",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1303153112",
"host_organization_name": "European Bioinformatics Institute",
"host_organization_lineage": [
"https://openalex.org/I1303153112"
],
"host_organization_lineage_names": [
"European Bioinformatics Institute"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "acceptedVersion",
"is_accepted": true,
"is_published": false
},
{
"is_oa": true,
"landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664226",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S2764455111",
"display_name": "PubMed Central",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "acceptedVersion",
"is_accepted": true,
"is_published": false
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/23395804",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 4,
"mesh": [
{
"descriptor_ui": "D005880",
"descriptor_name": "Gills",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D017136",
"descriptor_name": "Ion Transport",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D011388",
"descriptor_name": "Prolactin",
"qualifier_ui": "Q000031",
"qualifier_name": "analogs & derivatives",
"is_major_topic": true
},
{
"descriptor_ui": "D011388",
"descriptor_name": "Prolactin",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": true
},
{
"descriptor_ui": "D049992",
"descriptor_name": "Sodium Chloride Symporters",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D015027",
"descriptor_name": "Zebrafish",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D029961",
"descriptor_name": "Zebrafish Proteins",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005786",
"descriptor_name": "Gene Expression Regulation",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005786",
"descriptor_name": "Gene Expression Regulation",
"qualifier_ui": "Q000187",
"qualifier_name": "drug effects",
"is_major_topic": false
},
{
"descriptor_ui": "D005880",
"descriptor_name": "Gills",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005880",
"descriptor_name": "Gills",
"qualifier_ui": "Q000187",
"qualifier_name": "drug effects",
"is_major_topic": false
},
{
"descriptor_ui": "D011388",
"descriptor_name": "Prolactin",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D011388",
"descriptor_name": "Prolactin",
"qualifier_ui": "Q000494",
"qualifier_name": "pharmacology",
"is_major_topic": false
},
{
"descriptor_ui": "D011981",
"descriptor_name": "Receptors, Prolactin",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D011981",
"descriptor_name": "Receptors, Prolactin",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": false
},
{
"descriptor_ui": "D011981",
"descriptor_name": "Receptors, Prolactin",
"qualifier_ui": "Q000037",
"qualifier_name": "antagonists & inhibitors",
"is_major_topic": false
},
{
"descriptor_ui": "D049992",
"descriptor_name": "Sodium Chloride Symporters",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D049992",
"descriptor_name": "Sodium Chloride Symporters",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014158",
"descriptor_name": "Transcription, Genetic",
"qualifier_ui": "Q000187",
"qualifier_name": "drug effects",
"is_major_topic": false
},
{
"descriptor_ui": "D014158",
"descriptor_name": "Transcription, Genetic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014867",
"descriptor_name": "Water",
"qualifier_ui": "Q000737",
"qualifier_name": "chemistry",
"is_major_topic": false
},
{
"descriptor_ui": "D014867",
"descriptor_name": "Water",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D014882",
"descriptor_name": "Water-Electrolyte Balance",
"qualifier_ui": "Q000187",
"qualifier_name": "drug effects",
"is_major_topic": false
},
{
"descriptor_ui": "D014882",
"descriptor_name": "Water-Electrolyte Balance",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D015027",
"descriptor_name": "Zebrafish",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D029961",
"descriptor_name": "Zebrafish Proteins",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D029961",
"descriptor_name": "Zebrafish Proteins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2034655287/ngrams",
"open_access": {
"is_oa": true,
"oa_status": "green",
"oa_url": "https://europepmc.org/articles/pmc3664226?pdf=render",
"any_repository_has_fulltext": true
},
"primary_location": {
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.mce.2013.01.021",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S191044671",
"display_name": "Molecular and Cellular Endocrinology",
"issn_l": "0303-7207",
"issn": [
"0303-7207",
"1872-8057"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
"primary_topic": {
"id": "https://openalex.org/T11056",
"display_name": "Metabolic Theory of Ecology and Climate Change Impacts",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2303",
"display_name": "Ecology"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
"publication_date": "2013-04-01",
"publication_year": 2013,
"referenced_works": [
"https://openalex.org/W1528739196",
"https://openalex.org/W1960986021",
"https://openalex.org/W1970293285",
"https://openalex.org/W1970631877",
"https://openalex.org/W1976292966",
"https://openalex.org/W1977518722",
"https://openalex.org/W1979074119",
"https://openalex.org/W1980413383",
"https://openalex.org/W1984320712",
"https://openalex.org/W1985990006",
"https://openalex.org/W1987937160",
"https://openalex.org/W1993129613",
"https://openalex.org/W1994286487",
"https://openalex.org/W1996941168",
"https://openalex.org/W1997333390",
"https://openalex.org/W2001612882",
"https://openalex.org/W2008944620",
"https://openalex.org/W2021023682",
"https://openalex.org/W2027852427",
"https://openalex.org/W2030601224",
"https://openalex.org/W2031230730",
"https://openalex.org/W2033805763",
"https://openalex.org/W2040156418",
"https://openalex.org/W2045556058",
"https://openalex.org/W2056263538",
"https://openalex.org/W2065977697",
"https://openalex.org/W2068464393",
"https://openalex.org/W2069686768",
"https://openalex.org/W2074282399",
"https://openalex.org/W2075807009",
"https://openalex.org/W2086031202",
"https://openalex.org/W2090442141",
"https://openalex.org/W2100049460",
"https://openalex.org/W2104455852",
"https://openalex.org/W2107277218",
"https://openalex.org/W2107917203",
"https://openalex.org/W2109044922",
"https://openalex.org/W2109106935",
"https://openalex.org/W2111993060",
"https://openalex.org/W2112726670",
"https://openalex.org/W2113029203",
"https://openalex.org/W2113103296",
"https://openalex.org/W2116265561",
"https://openalex.org/W2126793993",
"https://openalex.org/W2127650782",
"https://openalex.org/W2128851882",
"https://openalex.org/W2131109497",
"https://openalex.org/W2135050611",
"https://openalex.org/W2135296770",
"https://openalex.org/W2135570498",
"https://openalex.org/W2141055051",
"https://openalex.org/W2144614212",
"https://openalex.org/W2145222614",
"https://openalex.org/W2149783560",
"https://openalex.org/W2156805627",
"https://openalex.org/W2158688247",
"https://openalex.org/W2162665952",
"https://openalex.org/W2168362750",
"https://openalex.org/W2169730136",
"https://openalex.org/W2190786347",
"https://openalex.org/W2464902035",
"https://openalex.org/W4236155346"
],
"referenced_works_count": 62,
"related_works": [
"https://openalex.org/W3164432699",
"https://openalex.org/W2418256395",
"https://openalex.org/W2280400327",
"https://openalex.org/W2167363404",
"https://openalex.org/W2110006713",
"https://openalex.org/W2080457188",
"https://openalex.org/W2076671058",
"https://openalex.org/W2039199381",
"https://openalex.org/W2037779842",
"https://openalex.org/W2003537302"
],
"sustainable_development_goals": [
{
"display_name": "Clean water and sanitation",
"id": "https://metadata.un.org/sdg/6",
"score": 0.5
}
],
"title": "Prolactin regulates transcription of the ion uptake Na+/Cl\u2212 cotransporter (ncc) gene in zebrafish gill",
"topics": [
{
"id": "https://openalex.org/T11056",
"display_name": "Metabolic Theory of Ecology and Climate Change Impacts",
"score": 0.9998,
"subfield": {
"id": "https://openalex.org/subfields/2303",
"display_name": "Ecology"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
{
"id": "https://openalex.org/T11685",
"display_name": "Zebrafish as a Model Organism for Multidisciplinary Research",
"score": 0.9935,
"subfield": {
"id": "https://openalex.org/subfields/1307",
"display_name": "Cell Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T10450",
"display_name": "Metabolism and Nutrition in Aquaculture Feeds",
"score": 0.9915,
"subfield": {
"id": "https://openalex.org/subfields/1104",
"display_name": "Aquatic Science"
},
"field": {
"id": "https://openalex.org/fields/11",
"display_name": "Agricultural and Biological Sciences"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-13T09:12:52.863172",
"versions": []
}
}
