Item talk:Q240691

From geokb

{

 "USGS Publications Warehouse": {
   "@context": "https://schema.org",
   "@type": "Article",
   "additionalType": "Journal Article",
   "name": "Safety of aquaflor (florfenicol, 50% type a medicated article), administered in feed to channel catfish, Ictalurus punctatus",
   "identifier": [
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse IndexID",
       "value": "70006850",
       "url": "https://pubs.usgs.gov/publication/70006850"
     },
     {
       "@type": "PropertyValue",
       "propertyID": "USGS Publications Warehouse Internal ID",
       "value": 70006850
     },
     {
       "@type": "PropertyValue",
       "propertyID": "DOI",
       "value": "10.1080/01926230390241828",
       "url": "https://doi.org/10.1080/01926230390241828"
     }
   ],
   "journal": {
     "@type": "Periodical",
     "name": "Toxicologic Pathology",
     "volumeNumber": "31",
     "issueNumber": "6"
   },
   "inLanguage": "en",
   "isPartOf": [
     {
       "@type": "CreativeWorkSeries",
       "name": "Toxicologic Pathology"
     }
   ],
   "datePublished": "2003",
   "dateModified": "2012-10-09",
   "abstract": "Aquaflor, a feed premix containing the broad spectrum antibacterial agent florfenicol (50% w/w), is being developed for use to control enteric septicemia (ESC) in channel catfish Ictalurus punctatus caused by the gram-negative enterobacterium Edwardsiella ictaluri. The recommended dose of Aquaflor to control ESC is 10 mg/kg body weight (BW)/day for 10 days. The study objective was to determine the safety of Aquaflor administered in feed to channel catfish at doses of 0 (control), 10, 30, and 50 mg/kg BW/day for 20 consecutive days. Parameters evaluated included daily mortality, behavioral (appetite, distribution, flight/fright response), and water chemistry observations, initial and terminal weight measurements, and gross and microscopic pathology. Medicated feed consumption was 67-86% of target with group mean doses of 8.5 mg/kg BW/day, 24.6 mg/kg BW/day, and 34.9 mg/kg BW/day. There were no mortalities or clinically observable changes noted at any of the dose levels tested. Aquaflor-related changes were limited to the food consumption and histopathology data. Although Aquaflor-related decreased feed consumption was noted in the 30 and 50 mg/kg BW/day groups, there were no differences in fish growth among the treatment groups. Aquaflor-related histopathology findings were limited to a histomorphologically evident dose-dependent decrease in hematopoietic/lymphopoietic tissue in the anterior kidneys, posterior kidneys, and spleens of channel catfish.",
   "description": "9 p.",
   "publisher": {
     "@type": "Organization",
     "name": "SAGE Publications"
   },
   "author": [
     {
       "@type": "Person",
       "name": "Gaikowski, Mark P. mgaikowski@usgs.gov",
       "givenName": "Mark P.",
       "familyName": "Gaikowski",
       "email": "mgaikowski@usgs.gov",
       "identifier": {
         "@type": "PropertyValue",
         "propertyID": "ORCID",
         "value": "0000-0002-6507-9341",
         "url": "https://orcid.org/0000-0002-6507-9341"
       },
       "affiliation": [
         {
           "@type": "Organization",
           "name": "Upper Midwest Environmental Sciences Center",
           "url": "https://www.usgs.gov/centers/upper-midwest-environmental-sciences-center"
         }
       ]
     },
     {
       "@type": "Person",
       "name": "Gingerich, William H.",
       "givenName": "William H.",
       "familyName": "Gingerich"
     },
     {
       "@type": "Person",
       "name": "Endris, Richard G.",
       "givenName": "Richard G.",
       "familyName": "Endris"
     },
     {
       "@type": "Person",
       "name": "Wolf, Jeffery C.",
       "givenName": "Jeffery C.",
       "familyName": "Wolf"
     }
   ],
   "funder": [
     {
       "@type": "Organization",
       "name": "Upper Midwest Environmental Sciences Center",
       "url": "https://www.usgs.gov/centers/upper-midwest-environmental-sciences-center"
     }
   ]
 },
 "OpenAlex": {
   "abstract_inverted_index": {
     "Aquaflor,": [
       0
     ],
     "a": [
       1,
       188
     ],
     "feed": [
       2,
       64,
       108,
       159
     ],
     "premix": [
       3
     ],
     "containing": [
       4
     ],
     "the": [
       5,
       30,
       58,
       141,
       150,
       164,
       179,
       197
     ],
     "broad": [
       6
     ],
     "spectrum": [
       7
     ],
     "antibacterial": [
       8
     ],
     "agent": [
       9
     ],
     "florfenicol": [
       10
     ],
     "(50%": [
       11
     ],
     "w/w),": [
       12
     ],
     "is": [
       13,
       43
     ],
     "being": [
       14
     ],
     "developed": [
       15
     ],
     "for": [
       16,
       49,
       79
     ],
     "use": [
       17
     ],
     "to": [
       18,
       40,
       56,
       65,
       149,
       187
     ],
     "control": [
       19,
       41
     ],
     "enteric": [
       20
     ],
     "septicemia": [
       21
     ],
     "(ESC)": [
       22
     ],
     "in": [
       23,
       63,
       163,
       175,
       193,
       196
     ],
     "channel": [
       24,
       66,
       205
     ],
     "catfish": [
       25,
       67
     ],
     "Ictalurus": [
       26
     ],
     "punctatus": [
       27
     ],
     "caused": [
       28
     ],
     "by": [
       29
     ],
     "gram-negative": [
       31
     ],
     "enterobacterium": [
       32
     ],
     "Edwardsiella": [
       33
     ],
     "ictaluri.": [
       34
     ],
     "The": [
       35,
       52
     ],
     "recommended": [
       36
     ],
     "dose": [
       37,
       142
     ],
     "of": [
       38,
       60,
       70,
       112,
       118,
       140,
       204
     ],
     "Aquaflor": [
       39,
       61
     ],
     "ESC": [
       42
     ],
     "10": [
       44,
       50
     ],
     "mg/kg": [
       45,
       77,
       120,
       123,
       127,
       168
     ],
     "body": [
       46
     ],
     "weight": [
       47,
       100
     ],
     "(BW)/day": [
       48
     ],
     "days.": [
       51,
       82
     ],
     "study": [
       53
     ],
     "objective": [
       54
     ],
     "was": [
       55,
       110,
       161
     ],
     "determine": [
       57
     ],
     "safety": [
       59
     ],
     "administered": [
       62
     ],
     "at": [
       68,
       138
     ],
     "doses": [
       69,
       117
     ],
     "0": [
       71
     ],
     "(control),": [
       72
     ],
     "10,": [
       73
     ],
     "30,": [
       74
     ],
     "and": [
       75,
       93,
       98,
       102,
       104,
       125,
       153,
       166,
       202
     ],
     "50": [
       76,
       167
     ],
     "BW/day": [
       78,
       169
     ],
     "20": [
       80
     ],
     "consecutive": [
       81
     ],
     "Parameters": [
       83
     ],
     "evaluated": [
       84
     ],
     "included": [
       85
     ],
     "daily": [
       86
     ],
     "mortality,": [
       87
     ],
     "behavioral": [
       88
     ],
     "(appetite,": [
       89
     ],
     "distribution,": [
       90
     ],
     "flight/fright": [
       91
     ],
     "response),": [
       92
     ],
     "water": [
       94
     ],
     "chemistry": [
       95
     ],
     "observations,": [
       96
     ],
     "initial": [
       97
     ],
     "terminal": [
       99
     ],
     "measurements,": [
       101
     ],
     "gross": [
       103
     ],
     "microscopic": [
       105
     ],
     "pathology.": [
       106
     ],
     "Medicated": [
       107
     ],
     "consumption": [
       109,
       152,
       160
     ],
     "67-86%": [
       111
     ],
     "target": [
       113
     ],
     "with": [
       114
     ],
     "group": [
       115
     ],
     "mean": [
       116
     ],
     "8.5": [
       119
     ],
     "BW/day,": [
       121,
       124
     ],
     "24.6": [
       122
     ],
     "34.9": [
       126
     ],
     "BW/day.": [
       128
     ],
     "There": [
       129
     ],
     "were": [
       130,
       147,
       172,
       185
     ],
     "no": [
       131,
       173
     ],
     "mortalities": [
       132
     ],
     "or": [
       133
     ],
     "clinically": [
       134
     ],
     "observable": [
       135
     ],
     "changes": [
       136,
       146
     ],
     "noted": [
       137,
       162
     ],
     "any": [
       139
     ],
     "levels": [
       143
     ],
     "tested.": [
       144
     ],
     "Aquaflor-related": [
       145,
       157,
       182
     ],
     "limited": [
       148,
       186
     ],
     "food": [
       151
     ],
     "histopathology": [
       154,
       183
     ],
     "data.": [
       155
     ],
     "Although": [
       156
     ],
     "decreased": [
       158
     ],
     "30": [
       165
     ],
     "groups,": [
       170
     ],
     "there": [
       171
     ],
     "differences": [
       174
     ],
     "fish": [
       176
     ],
     "growth": [
       177
     ],
     "among": [
       178
     ],
     "treatment": [
       180
     ],
     "groups.": [
       181
     ],
     "findings": [
       184
     ],
     "histomorphologically": [
       189
     ],
     "evident": [
       190
     ],
     "dose-dependent": [
       191
     ],
     "decrease": [
       192
     ],
     "hematopoietic/lymphopoietic": [
       194
     ],
     "tissue": [
       195
     ],
     "anterior": [
       198
     ],
     "kidneys,": [
       199,
       201
     ],
     "posterior": [
       200
     ],
     "spleens": [
       203
     ],
     "catfish.": [
       206
     ]
   },
   "apc_list": null,
   "apc_paid": null,
   "authorships": [
     {
       "author_position": "first",
       "author": {
         "id": "https://openalex.org/A5019534951",
         "display_name": "Mark P. Gaikowski",
         "orcid": "https://orcid.org/0000-0002-6507-9341"
       },
       "institutions": [
         {
           "id": "https://openalex.org/I1286329397",
           "display_name": "United States Geological Survey",
           "ror": "https://ror.org/035a68863",
           "country_code": "US",
           "type": "government",
           "lineage": [
             "https://openalex.org/I1286329397",
             "https://openalex.org/I1335927249"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Mark P. Gaikowski",
       "raw_affiliation_strings": [
         "U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin 54603,"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin 54603,",
           "institution_ids": [
             "https://openalex.org/I1286329397"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5006817535",
         "display_name": "Jeffrey C. Wolf",
         "orcid": "https://orcid.org/0000-0002-1901-0634"
       },
       "institutions": [
         {
           "id": "https://openalex.org/I4210090135",
           "display_name": "Experimental Pathology Laboratories",
           "ror": "https://ror.org/00dv9aw81",
           "country_code": "US",
           "type": "company",
           "lineage": [
             "https://openalex.org/I4210090135"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Jeffrey C. Wolf",
       "raw_affiliation_strings": [
         "Experimental Pathology Laboratories, Inc, Herndon, Virginia 20172"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "Experimental Pathology Laboratories, Inc, Herndon, Virginia 20172",
           "institution_ids": [
             "https://openalex.org/I4210090135"
           ]
         }
       ]
     },
     {
       "author_position": "middle",
       "author": {
         "id": "https://openalex.org/A5014242289",
         "display_name": "R. G. Endris",
         "orcid": null
       },
       "institutions": [],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "Richard G. Endris",
       "raw_affiliation_strings": [
         "Schering-Plough Animal Health Corporation, Union, New Jersey 07083, USA"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "Schering-Plough Animal Health Corporation, Union, New Jersey 07083, USA",
           "institution_ids": []
         }
       ]
     },
     {
       "author_position": "last",
       "author": {
         "id": "https://openalex.org/A5003275499",
         "display_name": "William H. Gingerich",
         "orcid": null
       },
       "institutions": [
         {
           "id": "https://openalex.org/I1286329397",
           "display_name": "United States Geological Survey",
           "ror": "https://ror.org/035a68863",
           "country_code": "US",
           "type": "government",
           "lineage": [
             "https://openalex.org/I1286329397",
             "https://openalex.org/I1335927249"
           ]
         }
       ],
       "countries": [
         "US"
       ],
       "is_corresponding": false,
       "raw_author_name": "William H. Gingerich",
       "raw_affiliation_strings": [
         "U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin 54603"
       ],
       "affiliations": [
         {
           "raw_affiliation_string": "U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin 54603",
           "institution_ids": [
             "https://openalex.org/I1286329397"
           ]
         }
       ]
     }
   ],
   "best_oa_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.1080/01926230390241828",
     "pdf_url": "https://journals.sagepub.com/doi/pdf/10.1080/01926230390241828",
     "source": {
       "id": "https://openalex.org/S145558524",
       "display_name": "Toxicologic Pathology",
       "issn_l": "0192-6233",
       "issn": [
         "0192-6233",
         "1533-1601"
       ],
       "is_oa": false,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4310320017",
       "host_organization_name": "SAGE Publishing",
       "host_organization_lineage": [
         "https://openalex.org/P4310320017"
       ],
       "host_organization_lineage_names": [
         "SAGE Publishing"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "biblio": {
     "volume": "31",
     "issue": "6",
     "first_page": "689",
     "last_page": "697"
   },
   "citation_normalized_percentile": {
     "value": 0.827892,
     "is_in_top_1_percent": false,
     "is_in_top_10_percent": false
   },
   "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2124436914",
   "cited_by_count": 49,
   "cited_by_percentile_year": {
     "min": 92,
     "max": 93
   },
   "concepts": [
     {
       "id": "https://openalex.org/C2778949639",
       "wikidata": "https://www.wikidata.org/wiki/Q1711508",
       "display_name": "Ictalurus",
       "level": 4,
       "score": 0.98956895
     },
     {
       "id": "https://openalex.org/C2778189562",
       "wikidata": "https://www.wikidata.org/wiki/Q59576",
       "display_name": "Catfish",
       "level": 3,
       "score": 0.9627055
     },
     {
       "id": "https://openalex.org/C2780663544",
       "wikidata": "https://www.wikidata.org/wiki/Q408400",
       "display_name": "Florfenicol",
       "level": 3,
       "score": 0.81942785
     },
     {
       "id": "https://openalex.org/C544855455",
       "wikidata": "https://www.wikidata.org/wiki/Q1070952",
       "display_name": "Histopathology",
       "level": 2,
       "score": 0.7655584
     },
     {
       "id": "https://openalex.org/C2911177997",
       "wikidata": "https://www.wikidata.org/wiki/Q5346148",
       "display_name": "Edwardsiella ictaluri",
       "level": 5,
       "score": 0.75374925
     },
     {
       "id": "https://openalex.org/C140793950",
       "wikidata": "https://www.wikidata.org/wiki/Q168091",
       "display_name": "Animal science",
       "level": 1,
       "score": 0.5731192
     },
     {
       "id": "https://openalex.org/C86803240",
       "wikidata": "https://www.wikidata.org/wiki/Q420",
       "display_name": "Biology",
       "level": 0,
       "score": 0.4242396
     },
     {
       "id": "https://openalex.org/C42972112",
       "wikidata": "https://www.wikidata.org/wiki/Q170201",
       "display_name": "Veterinary medicine",
       "level": 1,
       "score": 0.37762403
     },
     {
       "id": "https://openalex.org/C71924100",
       "wikidata": "https://www.wikidata.org/wiki/Q11190",
       "display_name": "Medicine",
       "level": 0,
       "score": 0.33492458
     },
     {
       "id": "https://openalex.org/C42407357",
       "wikidata": "https://www.wikidata.org/wiki/Q521",
       "display_name": "Physiology",
       "level": 1,
       "score": 0.32925713
     },
     {
       "id": "https://openalex.org/C501593827",
       "wikidata": "https://www.wikidata.org/wiki/Q12187",
       "display_name": "Antibiotics",
       "level": 2,
       "score": 0.17549297
     },
     {
       "id": "https://openalex.org/C505870484",
       "wikidata": "https://www.wikidata.org/wiki/Q180538",
       "display_name": "Fishery",
       "level": 1,
       "score": 0.16053963
     },
     {
       "id": "https://openalex.org/C142724271",
       "wikidata": "https://www.wikidata.org/wiki/Q7208",
       "display_name": "Pathology",
       "level": 1,
       "score": 0.16006386
     },
     {
       "id": "https://openalex.org/C2909208804",
       "wikidata": "https://www.wikidata.org/wiki/Q127282",
       "display_name": "Fish <Actinopterygii>",
       "level": 2,
       "score": 0.13871562
     },
     {
       "id": "https://openalex.org/C89423630",
       "wikidata": "https://www.wikidata.org/wiki/Q7193",
       "display_name": "Microbiology",
       "level": 1,
       "score": 0.08946636
     }
   ],
   "corresponding_author_ids": [],
   "corresponding_institution_ids": [],
   "countries_distinct_count": 1,
   "counts_by_year": [
     {
       "year": 2024,
       "cited_by_count": 1
     },
     {
       "year": 2023,
       "cited_by_count": 5
     },
     {
       "year": 2022,
       "cited_by_count": 4
     },
     {
       "year": 2021,
       "cited_by_count": 2
     },
     {
       "year": 2020,
       "cited_by_count": 1
     },
     {
       "year": 2018,
       "cited_by_count": 2
     },
     {
       "year": 2016,
       "cited_by_count": 1
     },
     {
       "year": 2014,
       "cited_by_count": 4
     },
     {
       "year": 2013,
       "cited_by_count": 5
     },
     {
       "year": 2012,
       "cited_by_count": 3
     }
   ],
   "created_date": "2016-06-24",
   "datasets": [],
   "display_name": "Safety of Aquaflor (Florfenicol, 50% Type A Medicated Article), Administered in Feed to Channel Catfish, Ictalurus punctatus",
   "doi": "https://doi.org/10.1080/01926230390241828",
   "fulltext_origin": "ngrams",
   "fwci": 0.914,
   "grants": [],
   "has_fulltext": true,
   "id": "https://openalex.org/W2124436914",
   "ids": {
     "openalex": "https://openalex.org/W2124436914",
     "doi": "https://doi.org/10.1080/01926230390241828",
     "mag": "2124436914",
     "pmid": "https://pubmed.ncbi.nlm.nih.gov/14585738"
   },
   "indexed_in": [
     "crossref",
     "pubmed"
   ],
   "institutions_distinct_count": 2,
   "is_paratext": false,
   "is_retracted": false,
   "keywords": [
     {
       "id": "https://openalex.org/keywords/florfenicol",
       "display_name": "Florfenicol",
       "score": 0.81942785
     },
     {
       "id": "https://openalex.org/keywords/histopathology",
       "display_name": "Histopathology",
       "score": 0.7655584
     },
     {
       "id": "https://openalex.org/keywords/edwardsiella-ictaluri",
       "display_name": "Edwardsiella ictaluri",
       "score": 0.75374925
     },
     {
       "id": "https://openalex.org/keywords/fish-immunology",
       "display_name": "Fish Immunology",
       "score": 0.466136
     }
   ],
   "language": "en",
   "locations": [
     {
       "is_oa": true,
       "landing_page_url": "https://doi.org/10.1080/01926230390241828",
       "pdf_url": "https://journals.sagepub.com/doi/pdf/10.1080/01926230390241828",
       "source": {
         "id": "https://openalex.org/S145558524",
         "display_name": "Toxicologic Pathology",
         "issn_l": "0192-6233",
         "issn": [
           "0192-6233",
           "1533-1601"
         ],
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": true,
         "host_organization": "https://openalex.org/P4310320017",
         "host_organization_name": "SAGE Publishing",
         "host_organization_lineage": [
           "https://openalex.org/P4310320017"
         ],
         "host_organization_lineage_names": [
           "SAGE Publishing"
         ],
         "type": "journal"
       },
       "license": null,
       "license_id": null,
       "version": "publishedVersion",
       "is_accepted": true,
       "is_published": true
     },
     {
       "is_oa": false,
       "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/14585738",
       "pdf_url": null,
       "source": {
         "id": "https://openalex.org/S4306525036",
         "display_name": "PubMed",
         "issn_l": null,
         "issn": null,
         "is_oa": false,
         "is_in_doaj": false,
         "is_core": false,
         "host_organization": "https://openalex.org/I1299303238",
         "host_organization_name": "National Institutes of Health",
         "host_organization_lineage": [
           "https://openalex.org/I1299303238"
         ],
         "host_organization_lineage_names": [
           "National Institutes of Health"
         ],
         "type": "repository"
       },
       "license": null,
       "license_id": null,
       "version": null,
       "is_accepted": false,
       "is_published": false
     }
   ],
   "locations_count": 2,
   "mesh": [
     {
       "descriptor_ui": "D000821",
       "descriptor_name": "Animal Feed",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D000900",
       "descriptor_name": "Anti-Bacterial Agents",
       "qualifier_ui": "Q000633",
       "qualifier_name": "toxicity",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D007059",
       "descriptor_name": "Ictaluridae",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D013839",
       "descriptor_name": "Thiamphenicol",
       "qualifier_ui": "Q000633",
       "qualifier_name": "toxicity",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D013839",
       "descriptor_name": "Thiamphenicol",
       "qualifier_ui": "Q000031",
       "qualifier_name": "analogs & derivatives",
       "is_major_topic": true
     },
     {
       "descriptor_ui": "D000818",
       "descriptor_name": "Animals",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D000900",
       "descriptor_name": "Anti-Bacterial Agents",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D000900",
       "descriptor_name": "Anti-Bacterial Agents",
       "qualifier_ui": "Q000008",
       "qualifier_name": "administration & dosage",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D001522",
       "descriptor_name": "Behavior, Animal",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D001522",
       "descriptor_name": "Behavior, Animal",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D001835",
       "descriptor_name": "Body Weight",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D001835",
       "descriptor_name": "Body Weight",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004032",
       "descriptor_name": "Diet",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004305",
       "descriptor_name": "Dose-Response Relationship, Drug",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004435",
       "descriptor_name": "Eating",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D004435",
       "descriptor_name": "Eating",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D006410",
       "descriptor_name": "Hematopoiesis",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D006410",
       "descriptor_name": "Hematopoiesis",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D007668",
       "descriptor_name": "Kidney",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D007668",
       "descriptor_name": "Kidney",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D007668",
       "descriptor_name": "Kidney",
       "qualifier_ui": "Q000473",
       "qualifier_name": "pathology",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008136",
       "descriptor_name": "Longevity",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008136",
       "descriptor_name": "Longevity",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008221",
       "descriptor_name": "Lymphoid Tissue",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008221",
       "descriptor_name": "Lymphoid Tissue",
       "qualifier_ui": "Q000473",
       "qualifier_name": "pathology",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D008221",
       "descriptor_name": "Lymphoid Tissue",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D013154",
       "descriptor_name": "Spleen",
       "qualifier_ui": "Q000187",
       "qualifier_name": "drug effects",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D013154",
       "descriptor_name": "Spleen",
       "qualifier_ui": "Q000473",
       "qualifier_name": "pathology",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D013154",
       "descriptor_name": "Spleen",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D013839",
       "descriptor_name": "Thiamphenicol",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D013839",
       "descriptor_name": "Thiamphenicol",
       "qualifier_ui": "Q000008",
       "qualifier_name": "administration & dosage",
       "is_major_topic": false
     },
     {
       "descriptor_ui": "D018675",
       "descriptor_name": "Toxicity Tests",
       "qualifier_ui": "",
       "qualifier_name": null,
       "is_major_topic": false
     }
   ],
   "ngrams_url": "https://api.openalex.org/works/W2124436914/ngrams",
   "open_access": {
     "is_oa": true,
     "oa_status": "bronze",
     "oa_url": "https://journals.sagepub.com/doi/pdf/10.1080/01926230390241828",
     "any_repository_has_fulltext": false
   },
   "primary_location": {
     "is_oa": true,
     "landing_page_url": "https://doi.org/10.1080/01926230390241828",
     "pdf_url": "https://journals.sagepub.com/doi/pdf/10.1080/01926230390241828",
     "source": {
       "id": "https://openalex.org/S145558524",
       "display_name": "Toxicologic Pathology",
       "issn_l": "0192-6233",
       "issn": [
         "0192-6233",
         "1533-1601"
       ],
       "is_oa": false,
       "is_in_doaj": false,
       "is_core": true,
       "host_organization": "https://openalex.org/P4310320017",
       "host_organization_name": "SAGE Publishing",
       "host_organization_lineage": [
         "https://openalex.org/P4310320017"
       ],
       "host_organization_lineage_names": [
         "SAGE Publishing"
       ],
       "type": "journal"
     },
     "license": null,
     "license_id": null,
     "version": "publishedVersion",
     "is_accepted": true,
     "is_published": true
   },
   "primary_topic": {
     "id": "https://openalex.org/T10838",
     "display_name": "Assessment of Animal Welfare in Various Species",
     "score": 0.9986,
     "subfield": {
       "id": "https://openalex.org/subfields/3404",
       "display_name": "Small Animals"
     },
     "field": {
       "id": "https://openalex.org/fields/34",
       "display_name": "Veterinary"
     },
     "domain": {
       "id": "https://openalex.org/domains/4",
       "display_name": "Health Sciences"
     }
   },
   "publication_date": "2003-10-01",
   "publication_year": 2003,
   "referenced_works": [
     "https://openalex.org/W1485578711",
     "https://openalex.org/W1494506878",
     "https://openalex.org/W1532080041",
     "https://openalex.org/W1741159976",
     "https://openalex.org/W1856219842",
     "https://openalex.org/W1980948845",
     "https://openalex.org/W1984043948",
     "https://openalex.org/W1984054744",
     "https://openalex.org/W1995758608",
     "https://openalex.org/W2022445948",
     "https://openalex.org/W2038868319",
     "https://openalex.org/W2040812193",
     "https://openalex.org/W2043065765",
     "https://openalex.org/W2045765034",
     "https://openalex.org/W2061501937",
     "https://openalex.org/W2108517613",
     "https://openalex.org/W2118868082",
     "https://openalex.org/W2120894817",
     "https://openalex.org/W2144838279",
     "https://openalex.org/W2156790473",
     "https://openalex.org/W2164362730",
     "https://openalex.org/W2168745915",
     "https://openalex.org/W2169520803",
     "https://openalex.org/W2267105727",
     "https://openalex.org/W2270263114",
     "https://openalex.org/W2326382126",
     "https://openalex.org/W2413561802",
     "https://openalex.org/W2414401574",
     "https://openalex.org/W2415941469",
     "https://openalex.org/W2419205608",
     "https://openalex.org/W2587615966",
     "https://openalex.org/W2771264754",
     "https://openalex.org/W2915076599",
     "https://openalex.org/W2999942435",
     "https://openalex.org/W958144550"
   ],
   "referenced_works_count": 35,
   "related_works": [
     "https://openalex.org/W4313408640",
     "https://openalex.org/W2890098231",
     "https://openalex.org/W2165003917",
     "https://openalex.org/W2155158366",
     "https://openalex.org/W2124436914",
     "https://openalex.org/W2092878801",
     "https://openalex.org/W2060583951",
     "https://openalex.org/W2051916814",
     "https://openalex.org/W2039280490",
     "https://openalex.org/W1981723572"
   ],
   "sustainable_development_goals": [],
   "title": "Safety of Aquaflor (Florfenicol, 50% Type A Medicated Article), Administered in Feed to Channel Catfish, Ictalurus punctatus",
   "topics": [
     {
       "id": "https://openalex.org/T10838",
       "display_name": "Assessment of Animal Welfare in Various Species",
       "score": 0.9986,
       "subfield": {
         "id": "https://openalex.org/subfields/3404",
         "display_name": "Small Animals"
       },
       "field": {
         "id": "https://openalex.org/fields/34",
         "display_name": "Veterinary"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10506",
       "display_name": "Immunological Responses in Aquatic Organisms",
       "score": 0.9986,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10152",
       "display_name": "Animal Nutrition and Gut Health",
       "score": 0.9928,
       "subfield": {
         "id": "https://openalex.org/subfields/1103",
         "display_name": "Animal Science and Zoology"
       },
       "field": {
         "id": "https://openalex.org/fields/11",
         "display_name": "Agricultural and Biological Sciences"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     }
   ],
   "type": "article",
   "type_crossref": "journal-article",
   "updated_date": "2024-08-13T18:49:01.286212",
   "versions": []
 }

}