Item talk:Q239490
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{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "Influence of temperature on the efficacy of homologous and heterologous DNA vaccines against viral hemorrhagic septicemia in Pacific Herring", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70189537", "url": "https://pubs.usgs.gov/publication/70189537" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70189537 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1080/08997659.2017.1307287", "url": "https://doi.org/10.1080/08997659.2017.1307287" } ], "journal": { "@type": "Periodical", "name": "Journal of Aquatic Animal Health", "volumeNumber": "29", "issueNumber": "3" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Journal of Aquatic Animal Health" } ], "datePublished": "2017", "dateModified": "2017-07-14", "abstract": "Homologous and heterologous (genogroup Ia) DNA vaccines against viral hemorrhagic septicemia virus (genogroup IVa) conferred partial protection in Pacific Herring\u00a0Clupea pallasii. Early protection at 2 weeks postvaccination (PV) was low and occurred only at an elevated temperature (12.6\u00b0C, 189 degree days), where the relative percent survival following viral exposure was similar for the two vaccines (IVa and Ia) and higher than that of negative controls at the same temperature. Late protection at 10 weeks PV was induced by both vaccines but was higher with the homologous vaccine at both 9.0\u00b0C and 12.6\u00b0C. Virus neutralization titers were detected among 55% of all vaccinated fish at 10 weeks PV. The results suggest that the immune response profile triggered by DNA vaccination of herring was similar to that reported for Rainbow Trout\u00a0Oncorhynchus mykiss\u00a0by Lorenzen and LaPatra in 2005, who found interferon responses in the early days PV and the transition to adaptive response later. However, the protective effect was far less prominent in herring, possibly reflecting different physiologies or adaptations of the two fish species.", "description": "8 p.", "publisher": { "@type": "Organization", "name": "Taylor & Francis" }, "author": [ { "@type": "Person", "name": "Hart, Lucas lhart@usgs.gov", "givenName": "Lucas", "familyName": "Hart", "email": "lhart@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0001-7035-8778", "url": "https://orcid.org/0000-0001-7035-8778" }, "affiliation": [ { "@type": "Organization", "name": "Western Fisheries Research Center", "url": "https://www.usgs.gov/centers/western-fisheries-research-center" } ] }, { "@type": "Person", "name": "Lorenzen, Niels", "givenName": "Niels", "familyName": "Lorenzen" }, { "@type": "Person", "name": "Hershberger, Paul phershberger@usgs.gov", "givenName": "Paul", "familyName": "Hershberger", "email": "phershberger@usgs.gov", "identifier": { "@type": "PropertyValue", 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