Item talk:Q239283
From geokb
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"name": "Effects on circulating steroid hormones and gene expression along the hypothalamus\u2013pituitary\u2013gonadal axis in adult Japanese quail exposed to 17\u03b2-trenbolone across multiple generations",
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"abstract": "We investigated the effects of the androgenic growth promoter 17\u03b2-trenbolone (17\u03b2TB) on adult Japanese quail (Coturnix japonica) exposed across three generations. The F0 generation was exposed after sexual maturity to 0, 1, 5, 10, 20, and 40\u2009ppm through feed. The F1 generation was exposed in ovo by maternal transfer and through feed at the same doses as their parents. The F2 generation was exposed in ovo only. Levels of plasma sex steroids, gonadal Cytochrome P450 aromatase (CYP19A1) mRNA and select brain neuroendocrine peptide mRNAs were measured. In males, testosterone levels did not differ in any generation from those in controls. Estradiol was significantly elevated in 17\u03b2TB treated F0 and F1 males. In F0 and F1 females, testosterone was suppressed by 17\u03b2TB, whereas estradiol was significantly higher at 40\u2009ppm in F0 and at 10\u2009ppm in F1 females. CYP19A1 expression in F1 males and females increased suggesting a compensatory response to the androgenic effects of 17\u03b2TB. Few significant effects were observed in the F2 birds indicating that in ovo exposure had limited effects on the monitored endpoints. Overall, our results confirmed endocrine disrupting effects of dietary 17\u03b2TB in Japanese quail but the response was dependent on sex, developmental stage at initiation of exposure, and dose.",
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