Item talk:Q234092
From geokb
{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "Investigating endocrine and physiological parameters of captive American kestrels exposed by diet to selected organophosphate flame retardants", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70148607", "url": "https://pubs.usgs.gov/publication/70148607" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70148607 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1021/acs.est.5b00857", "url": "https://doi.org/10.1021/acs.est.5b00857" } ], "journal": { "@type": "Periodical", "name": "Environmental Science & Technology", "volumeNumber": "49", "issueNumber": "12" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Environmental Science & Technology" } ], "datePublished": "2015", "dateModified": "2018-09-04", "abstract": "Organophosphate triesters are high production volume additive flame retardants (OPFRs) and plasticizers. Shown to accumulate in abiotic and biotic environmental compartments, little is known about the risks they pose. Captive adult male American kestrels (Falco sparverius) were fed the same dose (22 ng OPFR/g kestrel/d) daily (21 d) of tris(2- butoxyethyl) phosphate (TBOEP), tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) phosphate (TCIPP), or tris(1,2-dichloro-2-propyl) phosphate (TDCIPP). Concentrations were undetected in tissues (renal, hepatic), suggesting rapid metabolism. There were no changes in glutathione status, indicators of hepatic oxidative status, or the cholinergic system (i.e., cerebrum, plasma cholinesterases; cerebrum muscarinic, nicotinic receptors). Modest changes occurred in hepatocyte integrity and function (clinical chemistry). Significant effects on plasma free triiodothyronine (FT3) concentrations occurred with exposure to TBOEP, TCEP, TCIPP, and TDCIPP; TBOEP and TCEP had additional overall effects on free thyroxine (FT4), whereas TDCIPP also influenced total thyroxine (TT4). Relative increases (32%\u221296%) in circulating FT3, TT3, FT4, and/or TT4 were variable with each OPFR at 7 d exposure, but limited thereafter, which was likely maintained through decreased thyroid gland activity and increased hepatic deiodinase activity. The observed physiological and endocrine effects occurred at environmentally relevant concentrations and suggest parent OPFRs or metabolites may have been present despite rapid degradation.", "description": "8 p.", "publisher": { "@type": "Organization", "name": "American Chemical Society" }, "author": [ { "@type": "Person", "name": "Fernie, KJ", "givenName": "KJ", "familyName": "Fernie", "affiliation": [ { "@type": "Organization", "name": "Environment Canada, Burlington, Ontario, Canada" } ] }, { "@type": "Person", "name": "Palace, V.", "givenName": "V.", "familyName": "Palace", "affiliation": [ { "@type": "Organization", "name": "Stantec Consulting Services, Inc., Cottage Grove, WI" } ] }, { "@type": "Person", "name": "Peters, L.", "givenName": "L.", "familyName": "Peters" }, { "@type": "Person", "name": "Letcher, R.J.", "givenName": "R.J.", "familyName": "Letcher" }, { "@type": "Person", "name": "Basu, Niladri", "givenName": "Niladri", "familyName": "Basu" }, { "@type": "Person", "name": "Schultz, Sandra L. sschultz@usgs.gov", "givenName": "Sandra L.", "familyName": "Schultz", "email": "sschultz@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-3394-2857", "url": "https://orcid.org/0000-0003-3394-2857" }, "affiliation": [ { "@type": "Organization", "name": "Patuxent Wildlife Research Center", "url": "https://www.usgs.gov/centers/pwrc" } ] }, { "@type": "Person", "name": "Lazarus, Rebecca S. rlazarus@usgs.gov", "givenName": "Rebecca S.", "familyName": "Lazarus", "email": "rlazarus@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-1731-6469", "url": "https://orcid.org/0000-0003-1731-6469" }, "affiliation": [ { "@type": "Organization", "name": "Patuxent Wildlife Research Center", "url": "https://www.usgs.gov/centers/pwrc" } ] }, { "@type": "Person", "name": "Karouna-Renier, Natalie K. nkarouna@usgs.gov", "givenName": "Natalie K.", "familyName": "Karouna-Renier", "email": "nkarouna@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0001-7127-033X", "url": "https://orcid.org/0000-0001-7127-033X" }, "affiliation": [ { "@type": "Organization", "name": "Patuxent Wildlife Research Center", "url": "https://www.usgs.gov/centers/pwrc" } ] }, { "@type": "Person", "name": "Rattner, Barnett A. brattner@usgs.gov", "givenName": "Barnett A.", "familyName": "Rattner", "email": "brattner@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-3676-2843", "url": "https://orcid.org/0000-0003-3676-2843" }, "affiliation": [ { "@type": "Organization", "name": "Patuxent Wildlife Research Center", "url": "https://www.usgs.gov/centers/pwrc" } ] } ], "funder": [ { "@type": "Organization", "name": "Patuxent Wildlife Research Center", "url": "https://www.usgs.gov/centers/pwrc" }, { "@type": "Organization", "name": "Contaminant Biology Program", "url": null } ] }, "OpenAlex": { "abstract_inverted_index": { "Organophosphate": [ 0 ], "triesters": [ 1 ], "are": [ 2 ], "high": [ 3 ], "production": [ 4 ], "volume": [ 5 ], "additive": [ 6 ], "flame": [ 7 ], "retardants": [ 8 ], "(OPFRs)": [ 9 ], "and": [ 10, 17, 102, 121, 124, 172, 180, 188 ], "plasticizers.": [ 11 ], "Shown": [ 12 ], "to": [ 13, 117 ], "accumulate": [ 14 ], "in": [ 15, 65, 76, 99, 144 ], "abiotic": [ 16 ], "biotic": [ 18 ], "environmental": [ 19 ], "compartments,": [ 20 ], "little": [ 21 ], "is": [ 22 ], "known": [ 23 ], "about": [ 24 ], "the": [ 25, 38, 85 ], "risks": [ 26 ], "they": [ 27 ], "pose.": [ 28 ], "Captive": [ 29 ], "adult": [ 30 ], "male": [ 31 ], "American": [ 32 ], "kestrels": [ 33 ], "(Falco": [ 34 ], "sparverius)": [ 35 ], "were": [ 36, 63, 73, 151 ], "fed": [ 37 ], "same": [ 39 ], "dose": [ 40 ], "(22": [ 41 ], "ng": [ 42 ], "OPFR/g": [ 43 ], "kestrel/d)": [ 44 ], "daily": [ 45 ], "(21": [ 46 ], "d)": [ 47 ], "of": [ 48, 80 ], "tris(2-butoxyethyl)": [ 49 ], "phosphate": [ 50, 53, 56, 60 ], "(TBOEP),": [ 51 ], "tris(2-chloroethyl)": [ 52 ], "(TCEP),": [ 54 ], "tris(2-chloroisopropyl)": [ 55 ], "(TCIPP),": [ 57 ], "or": [ 58, 84, 192 ], "tris(1,2-dichloro-2-propyl)": [ 59 ], "(TDCIPP).": [ 61 ], "Concentrations": [ 62 ], "undetected": [ 64 ], "tissues": [ 66 ], "(renal,": [ 67 ], "hepatic),": [ 68 ], "suggesting": [ 69 ], "rapid": [ 70, 199 ], "metabolism.": [ 71 ], "There": [ 72 ], "no": [ 74 ], "changes": [ 75, 97 ], "glutathione": [ 77 ], "status,": [ 78, 83 ], "indicators": [ 79 ], "hepatic": [ 81, 174 ], "oxidative": [ 82 ], "cholinergic": [ 86 ], "system": [ 87 ], "(i.e.,": [ 88 ], "cerebrum,": [ 89 ], "plasma": [ 90, 109 ], "cholinesterases;": [ 91 ], "cerebrum": [ 92 ], "muscarinic,": [ 93 ], "nicotinic": [ 94 ], "receptors).": [ 95 ], "Modest": [ 96 ], "occurred": [ 98, 114, 183 ], "hepatocyte": [ 100 ], "integrity": [ 101 ], "function": [ 103 ], "(clinical": [ 104 ], "chemistry).": [ 105 ], "Significant": [ 106 ], "effects": [ 107, 129, 182 ], "on": [ 108, 130 ], "free": [ 110, 131 ], "triiodothyronine": [ 111 ], "(FT3)": [ 112 ], "concentrations": [ 113, 187 ], "with": [ 115, 153 ], "exposure": [ 116 ], "TBOEP,": [ 118 ], "TCEP,": [ 119 ], "TCIPP,": [ 120 ], "TDCIPP;": [ 122 ], "TBOEP": [ 123 ], "TCEP": [ 125 ], "had": [ 126 ], "additional": [ 127 ], "overall": [ 128 ], "thyroxine": [ 132, 139 ], "(FT4),": [ 133 ], "whereas": [ 134 ], "TDCIPP": [ 135 ], "also": [ 136 ], "influenced": [ 137 ], "total": [ 138 ], "(TT4).": [ 140 ], "Relative": [ 141 ], "increases": [ 142 ], "(32%-96%)": [ 143 ], "circulating": [ 145 ], "FT3,": [ 146 ], "TT3,": [ 147 ], "FT4,": [ 148 ], "and/or": [ 149 ], "TT4": [ 150 ], "variable": [ 152 ], "each": [ 154 ], "OPFR": [ 155 ], "at": [ 156, 184 ], "7": [ 157 ], "d": [ 158 ], "exposure,": [ 159 ], "but": [ 160 ], "limited": [ 161 ], "thereafter,": [ 162 ], "which": [ 163 ], "was": [ 164 ], "likely": [ 165 ], "maintained": [ 166 ], "through": [ 167 ], "decreased": [ 168 ], "thyroid": [ 169 ], "gland": [ 170 ], "activity": [ 171 ], "increased": [ 173 ], "deiodinase": [ 175 ], "activity.": [ 176 ], "The": [ 177 ], "observed": [ 178 ], "physiological": [ 179 ], "endocrine": [ 181 ], "environmentally": [ 185 ], "relevant": [ 186 ], "suggest": [ 189 ], "parent": [ 190 ], "OPFRs": [ 191 ], "metabolites": [ 193 ], "may": [ 194 ], "have": [ 195 ], "been": [ 196 ], "present": [ 197 ], "despite": [ 198 ], "degradation.": [ 200 ] }, "apc_list": null, "apc_paid": null, "authorships": [ { "author_position": "first", "author": { "id": "https://openalex.org/A5023176292", "display_name": "Kim J. Fernie", "orcid": "https://orcid.org/0000-0003-3073-3208" }, "institutions": [ { "id": "https://openalex.org/I1342547582", "display_name": "Environment and Climate Change Canada", "ror": "https://ror.org/026ny0e17", "country_code": "CA", "type": "government", "lineage": [ "https://openalex.org/I1342547582", "https://openalex.org/I2802286613" ] } ], "countries": [ "CA" ], "is_corresponding": false, "raw_author_name": "Kimberly J. Fernie", "raw_affiliation_strings": [ "Ecotoxicology & Wildlife Health Division, Environment Canada, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6" ], "affiliations": [ { "raw_affiliation_string": "Ecotoxicology & Wildlife Health Division, Environment Canada, 867 Lakeshore Road, Burlington, ON, Canada L7R 4A6", "institution_ids": [ "https://openalex.org/I1342547582" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5004323872", "display_name": "Vince Palace", "orcid": "https://orcid.org/0000-0003-2134-2299" }, "institutions": [ { "id": "https://openalex.org/I54324688", "display_name": "Stantec (Canada)", "ror": "https://ror.org/01gd3da15", "country_code": "CA", "type": "company", "lineage": [ "https://openalex.org/I54324688" ] } ], "countries": [ "CA" ], "is_corresponding": false, "raw_author_name": "Vince Palace", "raw_affiliation_strings": [ "Stantec Consulting Ltd., 386\rBroadway Avenue, Winnipeg, MB, Canada R3C 3R6" ], "affiliations": [ { "raw_affiliation_string": "Stantec Consulting Ltd., 386\rBroadway Avenue, Winnipeg, MB, Canada R3C 3R6", "institution_ids": [ "https://openalex.org/I54324688" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5048728235", "display_name": "Lisa Peters", "orcid": null }, "institutions": [ { "id": "https://openalex.org/I54324688", "display_name": "Stantec (Canada)", "ror": "https://ror.org/01gd3da15", "country_code": "CA", "type": "company", "lineage": [ "https://openalex.org/I54324688" ] } ], "countries": [ "CA" ], "is_corresponding": false, "raw_author_name": "Lisa E. Peters", "raw_affiliation_strings": [ "Stantec Consulting Ltd., 386\rBroadway Avenue, Winnipeg, MB, Canada R3C 3R6" ], "affiliations": [ { "raw_affiliation_string": "Stantec Consulting Ltd., 386\rBroadway Avenue, Winnipeg, MB, Canada R3C 3R6", "institution_ids": [ "https://openalex.org/I54324688" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5089429080", "display_name": "Niladri Basu", "orcid": "https://orcid.org/0000-0002-2695-1037" }, "institutions": [ { "id": "https://openalex.org/I5023651", "display_name": "McGill University", "ror": "https://ror.org/01pxwe438", "country_code": "CA", "type": "education", "lineage": [ "https://openalex.org/I5023651" ] } ], "countries": [ "CA" ], "is_corresponding": false, "raw_author_name": "Nil Basu", "raw_affiliation_strings": [ "McGill University, 21,111 Lakeshore\rRoad, Ste Anne de Bellevue, PQ, Canada H9X 3V9" ], "affiliations": [ { "raw_affiliation_string": "McGill University, 21,111 Lakeshore\rRoad, Ste Anne de Bellevue, PQ, Canada H9X 3V9", "institution_ids": [ "https://openalex.org/I5023651" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5028326798", "display_name": "Robert J. Letcher", "orcid": "https://orcid.org/0000-0002-8232-8565" }, "institutions": [ { "id": "https://openalex.org/I67031392", "display_name": "Carleton University", "ror": "https://ror.org/02qtvee93", "country_code": "CA", "type": "education", "lineage": [ "https://openalex.org/I67031392" ] } ], "countries": [ "CA" ], "is_corresponding": false, "raw_author_name": "Robert J. Letcher", "raw_affiliation_strings": [ "Ecotoxicology & Wildlife Health Division, Environment Canada, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1A 0H3" ], "affiliations": [ { "raw_affiliation_string": "Ecotoxicology & Wildlife Health Division, Environment Canada, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1A 0H3", "institution_ids": [ "https://openalex.org/I67031392" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5023668512", "display_name": "Natalie K. Karouna\u2010Renier", "orcid": "https://orcid.org/0000-0001-7127-033X" }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Natalie K. Karouna-Renier", "raw_affiliation_strings": [ "U.S.\rGeological Survey, Patuxent Wildlife Research Center, BARC East Building\r308, 10300 Baltimore Avenue, Beltsville, Maryland 20705, United States" ], "affiliations": [ { "raw_affiliation_string": "U.S.\rGeological Survey, Patuxent Wildlife Research Center, BARC East Building\r308, 10300 Baltimore Avenue, Beltsville, Maryland 20705, United States", "institution_ids": [ "https://openalex.org/I1286329397" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5058191581", "display_name": "Sandra Schultz", "orcid": null }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Sandra L. 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