Item talk:Q168153

From geokb

{

 "OpenAlex": {
   "cited_by_count": 900958,
   "created_date": "2024-01-23",
   "description": "This cluster of papers focuses on the efficacy and resistance of various tyrosine kinase inhibitors, such as Imatinib, Dasatinib, and Nilotinib, in the treatment of Chronic Myeloid Leukemia (CML). The papers discuss molecular mechanisms of resistance, mutation analysis, leukemia stem cells, treatment discontinuation, and long-term outcomes of different targeted therapies.",
   "display_name": "Efficacy and Resistance in CML Treatment",
   "domain": {
     "id": "https://openalex.org/domains/4",
     "display_name": "Health Sciences"
   },
   "field": {
     "id": "https://openalex.org/fields/27",
     "display_name": "Medicine"
   },
   "id": "https://openalex.org/T11215",
   "ids": {
     "openalex": "https://openalex.org/T11215",
     "wikipedia": "https://en.wikipedia.org/wiki/Chronic_myelogenous_leukemia"
   },
   "keywords": [
     "Imatinib",
     "BCR-ABL",
     "Tyrosine Kinase Inhibitors",
     "Resistance",
     "Mutation",
     "Leukemia Stem Cells",
     "Molecular Response",
     "Treatment Discontinuation",
     "Dasatinib",
     "Nilotinib"
   ],
   "siblings": [
     {
       "id": "https://openalex.org/T10309",
       "display_name": "Acute Myeloid Leukemia"
     },
     {
       "id": "https://openalex.org/T10649",
       "display_name": "Diagnosis and Treatment of Multiple Myeloma"
     },
     {
       "id": "https://openalex.org/T11660",
       "display_name": "Diseases Related to Blood Group Variants"
     },
     {
       "id": "https://openalex.org/T10345",
       "display_name": "Hematopoietic Stem Cell Biology"
     },
     {
       "id": "https://openalex.org/T11616",
       "display_name": "Hemophagocytic Lymphohistiocytosis and Related Disorders"
     },
     {
       "id": "https://openalex.org/T12548",
       "display_name": "Hemostatic Agents and Techniques"
     },
     {
       "id": "https://openalex.org/T11280",
       "display_name": "Management and Treatment of Hemophilia"
     },
     {
       "id": "https://openalex.org/T10746",
       "display_name": "Platelet Disorders and Thrombosis Mechanisms"
     },
     {
       "id": "https://openalex.org/T10452",
       "display_name": "Regulation of Iron Metabolism and Anemia"
     },
     {
       "id": "https://openalex.org/T11534",
       "display_name": "Role of Erythropoietin in Disease Treatment and Management"
     },
     {
       "id": "https://openalex.org/T10881",
       "display_name": "Thrombosis and Coagulation Disorders"
     }
   ],
   "subfield": {
     "id": "https://openalex.org/subfields/2720",
     "display_name": "Hematology"
   },
   "updated_date": "2024-08-19T06:04:56.280184",
   "works_count": 56342,
   "oa_id": "T11215"
 }

}