Item talk:Q167509

{

 "OpenAlex": {
   "display_name": "DNA Topoisomerases: Structure, Function, and Inhibition",
   "description": "This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.",
   "keywords": [
     "Topoisomerases",
     "DNA",
     "Inhibitors",
     "Chemotherapy",
     "Genetic Variants",
     "Irinotecan",
     "Quinolones",
     "Anticancer Drugs",
     "Enzyme Mechanism",
     "Genomic Stability"
   ],
   "ids": {
     "openalex": "https://openalex.org/T11845",
     "wikipedia": "https://en.wikipedia.org/wiki/DNA_topoisomerase"
   },
   "subfield": {
     "id": "https://openalex.org/subfields/1312",
     "display_name": "Molecular Biology"
   },
   "field": {
     "id": "https://openalex.org/fields/13",
     "display_name": "Biochemistry, Genetics and Molecular Biology"
   },
   "domain": {
     "id": "https://openalex.org/domains/1",
     "display_name": "Life Sciences"
   },
   "updated_date": "2024-08-12T05:58:48.188657",
   "created_date": "2024-01-23",
   "type": "topic",
   "oa_id": "T11845",
   "id": "https://openalex.org/T11845"
 }

}