Item talk:Q167536

OpenAlex: !!python/object/new:pyalex.api.Topic

 dictitems:
   cited_by_count: 809819
   created_date: '2024-01-23'
   description: This cluster of papers focuses on the genetic basis and clinical
     manifestations of primary immunodeficiency disorders, including immune dysregulation,
     Th17 cell deficiency, common variable immunodeficiency, and defects in the interferon-?
     pathway. It also discusses the use of hematopoietic stem cell transplantation
     and immunoglobulin replacement therapy in the management of these disorders.
   display_name: Genetic Basis of Primary Immunodeficiency Disorders
   domain:
     display_name: Life Sciences
     id: https://openalex.org/domains/1
   field:
     display_name: Immunology and Microbiology
     id: https://openalex.org/fields/24
   id: https://openalex.org/T11725
   ids:
     openalex: https://openalex.org/T11725
     wikipedia: https://en.wikipedia.org/wiki/Primary_immunodeficiency
   keywords:
   - Primary Immunodeficiency
   - Genetic Mutations
   - Immune Dysregulation
   - Human Inborn Errors
   - Th17 Cell Deficiency
   - Common Variable Immunodeficiency
   - Hematopoietic Stem Cell Transplantation
   - Interferon-? Pathway Defects
   - B Cell Abnormalities
   - Immunoglobulin Replacement Therapy
   siblings:
   - display_name: Human T-cell Leukemia Virus Type 1 Infection
     id: https://openalex.org/T12159
   - display_name: Immunobiology of Dendritic Cells
     id: https://openalex.org/T10580
   - display_name: Immunogenicity of Biosimilar Therapeutics in Drug Development
     id: https://openalex.org/T12255
   - display_name: Immunological Mechanisms in Atherosclerosis Development
     id: https://openalex.org/T12955
   - display_name: Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface
     id: https://openalex.org/T11510
   - display_name: Immunological Responses in Aquatic Organisms
     id: https://openalex.org/T10506
   - display_name: Immunotoxicology in Toxicologic Pathology Research
     id: https://openalex.org/T14072
   - display_name: Immunotoxin Therapy for Cancer Treatment
     id: https://openalex.org/T12477
   - display_name: Innate Immune Recognition and Signaling Pathways
     id: https://openalex.org/T10371
   - display_name: Innate Immunity to Viral Infection
     id: https://openalex.org/T11668
   - display_name: Innate Lymphoid Cells in Immunity
     id: https://openalex.org/T12528
   - display_name: Invertebrate Immunity and Host Defense Mechanisms
     id: https://openalex.org/T11403
   - display_name: Macrophage Activation and Polarization
     id: https://openalex.org/T11313
   - display_name: Mechanisms of Apoptotic Cell Clearance and Immune Regulation
     id: https://openalex.org/T12672
   - display_name: Natural Killer Cells in Immunity
     id: https://openalex.org/T11020
   - display_name: Reciprocal Development of TH17 and Treg Cells
     id: https://openalex.org/T10469
   - display_name: Regulatory T Cell Development and Function
     id: https://openalex.org/T10031
   - display_name: Role of Complement System in Immune Response
     id: https://openalex.org/T10993
   - display_name: Role of Galectins in Immunity and Disease
     id: https://openalex.org/T12387
   - display_name: Role of Macrophage Migration Inhibitory Factor
     id: https://openalex.org/T13254
   - display_name: Role of Mast Cells in Immunoregulation and Disease
     id: https://openalex.org/T11346
   - display_name: Role of Neutrophil Extracellular Traps in Immunity
     id: https://openalex.org/T11597
   - display_name: Role of Pentraxins in Innate Immunity and Inflammation
     id: https://openalex.org/T14245
   - display_name: Role of TREM-1 and Endocan in Inflammation
     id: https://openalex.org/T14165
   - display_name: Trained Immunity in Health and Disease
     id: https://openalex.org/T13410
   subfield:
     display_name: Immunology
     id: https://openalex.org/subfields/2403
   updated_date: '2024-05-20T05:16:48.357137'
   works_count: 87314