OpenAlex: !!python/object/new:pyalex.api.Topic
dictitems:
cited_by_count: 265406
created_date: '2024-01-23'
description: This cluster of papers explores the evolution, function, and dysregulation
of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP,
TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal
trafficking. It also investigates the implications of these mechanisms in diseases
such as mucolipidosis type IV and lysosomal storage disorders.
display_name: Lysosomal Calcium Signaling in Physiology and Pathology
domain:
display_name: Life Sciences
id: https://openalex.org/domains/1
field:
display_name: Biochemistry, Genetics and Molecular Biology
id: https://openalex.org/fields/13
id: https://openalex.org/T13415
ids:
openalex: https://openalex.org/T13415
wikipedia: https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling
keywords:
- Lysosomal Calcium Signaling
- Two-pore Channels
- NAADP
- TRPML1
- Endolysosomal Trafficking
- Cyclic ADP-Ribose
- Mucolipidosis Type IV
- Intracellular Calcium Release
- Nicotinic Acid Adenine Dinucleotide Phosphate
- Lysosomal Storage Diseases
siblings:
- display_name: Influence of Magnetic Fields on Biological Systems
id: https://openalex.org/T12976
- display_name: Molecular Physiology of Purinergic Signalling
id: https://openalex.org/T11193
- display_name: Reproductive Physiology and Endocrine Disruption in Fish
id: https://openalex.org/T11505
subfield:
display_name: Physiology
id: https://openalex.org/subfields/1314
updated_date: '2024-05-20T05:18:15.918351'
works_count: 9520