{
"id": "https://openalex.org/T13415", "display_name": "Lysosomal Calcium Signaling in Physiology and Pathology", "description": "This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.", "keywords": [ "Lysosomal Calcium Signaling", "Two-pore Channels", "NAADP", "TRPML1", "Endolysosomal Trafficking", "Cyclic ADP-Ribose", "Mucolipidosis Type IV", "Intracellular Calcium Release", "Nicotinic Acid Adenine Dinucleotide Phosphate", "Lysosomal Storage Diseases" ], "ids": { "openalex": "https://openalex.org/T13415", "wikipedia": "https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling" }, "subfield": { "id": "https://openalex.org/subfields/1314", "display_name": "Physiology" }, "field": { "id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" }, "siblings": [ { "id": "https://openalex.org/T12976", "display_name": "Influence of Magnetic Fields on Biological Systems" }, { "id": "https://openalex.org/T11193", "display_name": "Molecular Physiology of Purinergic Signalling" }, { "id": "https://openalex.org/T11505", "display_name": "Reproductive Physiology and Endocrine Disruption in Fish" } ], "works_count": 9663, "cited_by_count": 288243, "updated_date": "2024-08-26T05:32:36.297173", "created_date": "2024-01-23"
}