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{
{
   "id": "https://openalex.org/T12255",
   "OpenAlex": {
  "display_name": "Immunogenicity of Biosimilar Therapeutics in Drug Development",
    "cited_by_count": 213124,
  "description": "This cluster of papers focuses on the immunogenicity of biosimilar therapeutics, including the validation of bioanalytical methods for assessing immunogenicity, the impact of manufacturing changes on immunogenicity, and the clinical outcomes and safety of switching from reference biologics to biosimilars. The use of dried blood spots for bioanalysis and the regulatory considerations for biosimilars are also prominent topics within this cluster.",
    "created_date": "2024-01-23",
  "keywords": [
    "description": "This cluster of papers focuses on the immunogenicity of biosimilar therapeutics, including the validation of bioanalytical methods for assessing immunogenicity, the impact of manufacturing changes on immunogenicity, and the clinical outcomes and safety of switching from reference biologics to biosimilars. The use of dried blood spots for bioanalysis and the regulatory considerations for biosimilars are also prominent topics within this cluster.",
    "Biosimilars",
    "display_name": "Immunogenicity of Biosimilar Therapeutics in Drug Development",
    "Immunogenicity",
     "domain": {
    "Bioanalytical Methods",
      "id": "https://openalex.org/domains/1",
    "Therapeutic Proteins",
      "display_name": "Life Sciences"
    "Dried Blood Spots",
    "Erythropoietin Antibodies",
    "Monoclonal Antibodies",
    "Regulatory Guidelines",
    "Biopharmaceuticals",
    "Clinical Outcomes"
  ],
  "ids": {
    "openalex": "https://openalex.org/T12255",
    "wikipedia": "https://en.wikipedia.org/wiki/Biosimilar"
  },
  "subfield": {
    "id": "https://openalex.org/subfields/2403",
    "display_name": "Immunology"
  },
  "field": {
     "id": "https://openalex.org/fields/24",
    "display_name": "Immunology and Microbiology"
  },
  "domain": {
    "id": "https://openalex.org/domains/1",
    "display_name": "Life Sciences"
  },
  "siblings": [
    {
      "id": "https://openalex.org/T11725",
      "display_name": "Genetic Basis of Primary Immunodeficiency Disorders"
     },
     },
     {
     "field": {
       "id": "https://openalex.org/T12159",
       "id": "https://openalex.org/fields/24",
       "display_name": "Human T-cell Leukemia Virus Type 1 Infection"
       "display_name": "Immunology and Microbiology"
     },
     },
     {
     "id": "https://openalex.org/T12255",
       "id": "https://openalex.org/T10580",
    "ids": {
       "display_name": "Immunobiology of Dendritic Cells"
       "openalex": "https://openalex.org/T12255",
       "wikipedia": "https://en.wikipedia.org/wiki/Biosimilar"
     },
     },
     {
     "keywords": [
       "id": "https://openalex.org/T12955",
      "Biosimilars",
       "display_name": "Immunological Mechanisms in Atherosclerosis Development"
      "Immunogenicity",
      "Bioanalytical Methods",
      "Therapeutic Proteins",
      "Dried Blood Spots",
      "Erythropoietin Antibodies",
      "Monoclonal Antibodies",
      "Regulatory Guidelines",
      "Biopharmaceuticals",
      "Clinical Outcomes"
    ],
    "siblings": [
      {
        "id": "https://openalex.org/T11725",
        "display_name": "Genetic Basis of Primary Immunodeficiency Disorders"
       },
      {
        "id": "https://openalex.org/T12159",
        "display_name": "Human T-cell Leukemia Virus Type 1 Infection"
      },
      {
        "id": "https://openalex.org/T10580",
        "display_name": "Immunobiology of Dendritic Cells"
      },
      {
        "id": "https://openalex.org/T12955",
        "display_name": "Immunological Mechanisms in Atherosclerosis Development"
       },
      {
        "id": "https://openalex.org/T11510",
        "display_name": "Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface"
      },
      {
        "id": "https://openalex.org/T10506",
        "display_name": "Immunological Responses in Aquatic Organisms"
      },
      {
        "id": "https://openalex.org/T14072",
        "display_name": "Immunotoxicology in Toxicologic Pathology Research"
      },
      {
        "id": "https://openalex.org/T12477",
        "display_name": "Immunotoxin Therapy for Cancer Treatment"
      },
      {
        "id": "https://openalex.org/T10371",
        "display_name": "Innate Immune Recognition and Signaling Pathways"
      },
      {
        "id": "https://openalex.org/T11668",
        "display_name": "Innate Immunity to Viral Infection"
      },
      {
        "id": "https://openalex.org/T12528",
        "display_name": "Innate Lymphoid Cells in Immunity"
      },
      {
        "id": "https://openalex.org/T11403",
        "display_name": "Invertebrate Immunity and Host Defense Mechanisms"
      },
      {
        "id": "https://openalex.org/T11313",
        "display_name": "Macrophage Activation and Polarization"
      },
      {
        "id": "https://openalex.org/T12672",
        "display_name": "Mechanisms of Apoptotic Cell Clearance and Immune Regulation"
      },
      {
        "id": "https://openalex.org/T11020",
        "display_name": "Natural Killer Cells in Immunity"
      },
      {
        "id": "https://openalex.org/T10469",
        "display_name": "Reciprocal Development of TH17 and Treg Cells"
      },
      {
        "id": "https://openalex.org/T10031",
        "display_name": "Regulatory T Cell Development and Function"
      },
      {
        "id": "https://openalex.org/T10993",
        "display_name": "Role of Complement System in Immune Response"
      },
      {
        "id": "https://openalex.org/T12387",
        "display_name": "Role of Galectins in Immunity and Disease"
      },
      {
        "id": "https://openalex.org/T13254",
        "display_name": "Role of Macrophage Migration Inhibitory Factor"
      },
      {
        "id": "https://openalex.org/T11346",
        "display_name": "Role of Mast Cells in Immunoregulation and Disease"
      },
      {
        "id": "https://openalex.org/T11597",
        "display_name": "Role of Neutrophil Extracellular Traps in Immunity"
      },
      {
        "id": "https://openalex.org/T14245",
        "display_name": "Role of Pentraxins in Innate Immunity and Inflammation"
      },
      {
        "id": "https://openalex.org/T14165",
        "display_name": "Role of TREM-1 and Endocan in Inflammation"
      },
      {
        "id": "https://openalex.org/T13410",
        "display_name": "Trained Immunity in Health and Disease"
      }
    ],
    "subfield": {
      "id": "https://openalex.org/subfields/2403",
      "display_name": "Immunology"
     },
     },
     {
     "updated_date": "2024-08-19T05:22:07.617249",
      "id": "https://openalex.org/T11510",
     "works_count": 30289,
      "display_name": "Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface"
    "oa_id": "T12255"
    },
   }
    {
      "id": "https://openalex.org/T10506",
      "display_name": "Immunological Responses in Aquatic Organisms"
    },
    {
      "id": "https://openalex.org/T14072",
      "display_name": "Immunotoxicology in Toxicologic Pathology Research"
    },
    {
      "id": "https://openalex.org/T12477",
      "display_name": "Immunotoxin Therapy for Cancer Treatment"
    },
    {
      "id": "https://openalex.org/T10371",
      "display_name": "Innate Immune Recognition and Signaling Pathways"
    },
    {
      "id": "https://openalex.org/T11668",
      "display_name": "Innate Immunity to Viral Infection"
    },
    {
      "id": "https://openalex.org/T12528",
      "display_name": "Innate Lymphoid Cells in Immunity"
    },
    {
      "id": "https://openalex.org/T11403",
      "display_name": "Invertebrate Immunity and Host Defense Mechanisms"
    },
    {
      "id": "https://openalex.org/T11313",
      "display_name": "Macrophage Activation and Polarization"
    },
    {
      "id": "https://openalex.org/T12672",
      "display_name": "Mechanisms of Apoptotic Cell Clearance and Immune Regulation"
    },
    {
      "id": "https://openalex.org/T11020",
      "display_name": "Natural Killer Cells in Immunity"
    },
    {
      "id": "https://openalex.org/T10469",
      "display_name": "Reciprocal Development of TH17 and Treg Cells"
    },
    {
      "id": "https://openalex.org/T10031",
      "display_name": "Regulatory T Cell Development and Function"
    },
    {
      "id": "https://openalex.org/T10993",
      "display_name": "Role of Complement System in Immune Response"
    },
    {
      "id": "https://openalex.org/T12387",
      "display_name": "Role of Galectins in Immunity and Disease"
    },
    {
      "id": "https://openalex.org/T13254",
      "display_name": "Role of Macrophage Migration Inhibitory Factor"
    },
    {
      "id": "https://openalex.org/T11346",
      "display_name": "Role of Mast Cells in Immunoregulation and Disease"
    },
    {
      "id": "https://openalex.org/T11597",
      "display_name": "Role of Neutrophil Extracellular Traps in Immunity"
    },
    {
      "id": "https://openalex.org/T14245",
      "display_name": "Role of Pentraxins in Innate Immunity and Inflammation"
    },
    {
      "id": "https://openalex.org/T14165",
      "display_name": "Role of TREM-1 and Endocan in Inflammation"
    },
    {
      "id": "https://openalex.org/T13410",
      "display_name": "Trained Immunity in Health and Disease"
     }
  ],
  "works_count": 30310,
  "cited_by_count": 213605,
  "updated_date": "2024-08-26T05:29:10.382859",
   "created_date": "2024-01-23"
}
}
Retrieved from "https://geokb.wikibase.cloud/wiki/Special:MobileDiff/1404898"