Item talk:Q255543
From geokb
{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Evolution of a minimal cell",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70246695",
"url": "https://pubs.usgs.gov/publication/70246695"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70246695
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41586-023-06288-x",
"url": "https://doi.org/10.1038/s41586-023-06288-x"
}
],
"journal": {
"@type": "Periodical",
"name": "Nature",
"volumeNumber": "620",
"issueNumber": null
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Nature"
}
],
"datePublished": "2023",
"dateModified": "2023-08-08",
"abstract": "Possessing only essential genes, a minimal cell can reveal mechanisms and processes that are critical for the persistence and stability of life1,2. Here we report on how an engineered minimal cell3,4\u00a0contends with the forces of evolution compared with the\u00a0Mycoplasma mycoides\u00a0non-minimal cell from which it was synthetically derived. Mutation rates were the highest among all reported bacteria, but were not affected by genome minimization. Genome streamlining was costly, leading to a decrease in fitness of greater than 50%, but this deficit was regained during 2,000 generations of evolution. Despite selection acting on distinct genetic targets, increases in the maximum growth rate of the synthetic cells were comparable. Moreover, when performance was assessed by relative fitness, the minimal cell evolved 39% faster than the non-minimal cell. The only apparent constraint involved the evolution of cell size. The size of the non-minimal cell increased by 80%, whereas the minimal cell remained the same. This pattern reflected epistatic effects of mutations in\u00a0ftsZ, which encodes a tubulin-homologue protein that regulates cell division and morphology5,6. Our findings demonstrate that natural selection can rapidly increase the fitness of one of the simplest autonomously growing organisms. Understanding how species with small genomes overcome evolutionary challenges provides critical insights into the persistence of host-associated endosymbionts, the stability of streamlined chassis for biotechnology and the targeted refinement of synthetically engineered cells2,7,8,9.",
"description": "6 p.",
"publisher": {
"@type": "Organization",
"name": "Nature"
},
"author": [
{
"@type": "Person",
"name": "Moger-Reischer, Roy Z.",
"givenName": "Roy Z.",
"familyName": "Moger-Reischer",
"affiliation": [
{
"@type": "Organization",
"name": "Indiana University Bloomington"
}
]
},
{
"@type": "Person",
"name": "Sun, Lijie",
"givenName": "Lijie",
"familyName": "Sun",
"affiliation": [
{
"@type": "Organization",
"name": "Novartis Gene Therapy"
}
]
},
{
"@type": "Person",
"name": "Bittencourt, Daniela M.C.",
"givenName": "Daniela M.C.",
"familyName": "Bittencourt",
"affiliation": [
{
"@type": "Organization",
"name": "Embrapa Genetic Resources and Biotechnology, Brazil"
}
]
},
{
"@type": "Person",
"name": "Lehmkuhl, Brent K.",
"givenName": "Brent K.",
"familyName": "Lehmkuhl",
"affiliation": [
{
"@type": "Organization",
"name": "Embrapa Genetic Resources and Biotechnology, Brazil"
}
]
},
{
"@type": "Person",
"name": "Schoolmaster, Donald",
"givenName": "Donald",
"familyName": "Schoolmaster",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0003-0910-4458",
"url": "https://orcid.org/0000-0003-0910-4458"
},
"affiliation": [
{
"@type": "Organization",
"name": "Wetland and Aquatic Research Center",
"url": "https://www.usgs.gov/centers/wetland-and-aquatic-research-center"
}
]
},
{
"@type": "Person",
"name": "Lynch, Michael",
"givenName": "Michael",
"familyName": "Lynch",
"affiliation": [
{
"@type": "Organization",
"name": "Arizona State University"
}
]
},
{
"@type": "Person",
"name": "Lennon, Jay T.",
"givenName": "Jay T.",
"familyName": "Lennon",
"affiliation": [
{
"@type": "Organization",
"name": "Indiana University Bloomington"
}
]
},
{
"@type": "Person",
"name": "Glass, John I.",
"givenName": "John I.",
"familyName": "Glass",
"affiliation": [
{
"@type": "Organization",
"name": "J. Craig Venter Institute"
}
]
},
{
"@type": "Person",
"name": "Wise, Kim S.",
"givenName": "Kim S.",
"familyName": "Wise",
"affiliation": [
{
"@type": "Organization",
"name": "J. Craig Venter Institute"
}
]
}
],
"funder": [
{
"@type": "Organization",
"name": "Wetland and Aquatic Research Center",
"url": "https://www.usgs.gov/centers/wetland-and-aquatic-research-center"
}
]
},
"OpenAlex": {
"_id": "https://openalex.org/W4383198532",
"abstract_inverted_index": {
"Abstract": [
0
],
"Possessing": [
1
],
"only": [
2,
132
],
"essential": [
3
],
"genes,": [
4
],
"a": [
5,
76,
169
],
"minimal": [
6,
32,
122,
152
],
"cell": [
7,
33,
47,
123,
139,
146,
153,
174
],
"can": [
8,
186
],
"reveal": [
9
],
"mechanisms": [
10
],
"and": [
11,
19,
176,
224
],
"processes": [
12
],
"that": [
13,
172,
183
],
"are": [
14
],
"critical": [
15,
209
],
"for": [
16,
222
],
"the": [
17,
37,
43,
57,
103,
108,
121,
128,
136,
144,
151,
155,
189,
194,
212,
217,
225
],
"persistence": [
18,
213
],
"stability": [
20,
218
],
"of": [
21,
39,
80,
92,
107,
138,
143,
162,
191,
193,
214,
219,
228
],
"life": [
22
],
"1,2": [
23
],
".": [
24,
179,
233
],
"Here": [
25
],
"we": [
26
],
"report": [
27
],
"on": [
28,
97
],
"how": [
29,
200
],
"an": [
30
],
"engineered": [
31,
230
],
"3,4": [
34
],
"contends": [
35
],
"with": [
36,
42,
202
],
"forces": [
38
],
"evolution": [
40,
137
],
"compared": [
41
],
"Mycoplasma": [
44
],
"mycoides": [
45
],
"non-minimal": [
46,
129,
145
],
"from": [
48
],
"which": [
49,
167
],
"it": [
50
],
"was": [
51,
72,
87,
116
],
"synthetically": [
52,
229
],
"derived.": [
53
],
"Mutation": [
54
],
"rates": [
55
],
"were": [
56,
64,
111
],
"highest": [
58
],
"among": [
59
],
"all": [
60
],
"reported": [
61
],
"bacteria,": [
62
],
"but": [
63,
84
],
"not": [
65
],
"affected": [
66
],
"by": [
67,
118,
148
],
"genome": [
68
],
"minimization.": [
69
],
"Genome": [
70
],
"streamlining": [
71
],
"costly,": [
73
],
"leading": [
74
],
"to": [
75
],
"decrease": [
77
],
"in": [
78,
102,
164
],
"fitness": [
79,
190
],
"greater": [
81
],
"than": [
82,
127
],
"50%,": [
83
],
"this": [
85
],
"deficit": [
86
],
"regained": [
88
],
"during": [
89
],
"2,000": [
90
],
"generations": [
91
],
"evolution.": [
93
],
"Despite": [
94
],
"selection": [
95,
185
],
"acting": [
96
],
"distinct": [
98
],
"genetic": [
99
],
"targets,": [
100
],
"increases": [
101
],
"maximum": [
104
],
"growth": [
105
],
"rate": [
106
],
"synthetic": [
109
],
"cells": [
110,
231
],
"comparable.": [
112
],
"Moreover,": [
113
],
"when": [
114
],
"performance": [
115
],
"assessed": [
117
],
"relative": [
119
],
"fitness,": [
120
],
"evolved": [
124
],
"39%": [
125
],
"faster": [
126
],
"cell.": [
130
],
"The": [
131,
141
],
"apparent": [
133
],
"constraint": [
134
],
"involved": [
135
],
"size.": [
140
],
"size": [
142
],
"increased": [
147
],
"80%,": [
149
],
"whereas": [
150
],
"remained": [
154
],
"same.": [
156
],
"This": [
157
],
"pattern": [
158
],
"reflected": [
159
],
"epistatic": [
160
],
"effects": [
161
],
"mutations": [
163
],
"ftsZ": [
165
],
",": [
166
],
"encodes": [
168
],
"tubulin-homologue": [
170
],
"protein": [
171
],
"regulates": [
173
],
"division": [
175
],
"morphology": [
177
],
"5,6": [
178
],
"Our": [
180
],
"findings": [
181
],
"demonstrate": [
182
],
"natural": [
184
],
"rapidly": [
187
],
"increase": [
188
],
"one": [
192
],
"simplest": [
195
],
"autonomously": [
196
],
"growing": [
197
],
"organisms.": [
198
],
"Understanding": [
199
],
"species": [
201
],
"small": [
203
],
"genomes": [
204
],
"overcome": [
205
],
"evolutionary": [
206
],
"challenges": [
207
],
"provides": [
208
],
"insights": [
210
],
"into": [
211
],
"host-associated": [
215
],
"endosymbionts,": [
216
],
"streamlined": [
220
],
"chassis": [
221
],
"biotechnology": [
223
],
"targeted": [
226
],
"refinement": [
227
],
"2,7\u20139": [
232
]
},
"apc_list": {
"value": 9750,
"currency": "EUR",
"value_usd": 11690,
"provenance": "doaj"
},
"apc_paid": {
"value": 9750,
"currency": "EUR",
"value_usd": 11690,
"provenance": "doaj"
},
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5076444757",
"display_name": "Roy Z. Moger-Reischer",
"orcid": "https://orcid.org/0000-0001-8140-5023"
},
"institutions": [
{
"id": "https://openalex.org/I4210119109",
"display_name": "Indiana University Bloomington",
"ror": "https://ror.org/02k40bc56",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I4210119109",
"https://openalex.org/I592451"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "R. Z. Moger-Reischer",
"raw_affiliation_strings": [
"Department of Biology, Indiana University, Bloomington, IN, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Indiana University, Bloomington, IN, USA",
"institution_ids": [
"https://openalex.org/I4210119109"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5003957553",
"display_name": "John I. Glass",
"orcid": "https://orcid.org/0000-0002-3784-5301"
},
"institutions": [
{
"id": "https://openalex.org/I1301553790",
"display_name": "J. Craig Venter Institute",
"ror": "https://ror.org/049r1ts75",
"country_code": "US",
"type": "nonprofit",
"lineage": [
"https://openalex.org/I1301553790"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "J. I. Glass",
"raw_affiliation_strings": [
"J. Craig Venter Institute, La Jolla, CA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "J. Craig Venter Institute, La Jolla, CA, USA",
"institution_ids": [
"https://openalex.org/I1301553790"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5067110170",
"display_name": "Kim S. Wise",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I1301553790",
"display_name": "J. Craig Venter Institute",
"ror": "https://ror.org/049r1ts75",
"country_code": "US",
"type": "nonprofit",
"lineage": [
"https://openalex.org/I1301553790"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "K. S. Wise",
"raw_affiliation_strings": [
"J. Craig Venter Institute, La Jolla, CA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "J. Craig Venter Institute, La Jolla, CA, USA",
"institution_ids": [
"https://openalex.org/I1301553790"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5051046553",
"display_name": "Miros\u0142aw Firlej",
"orcid": "https://orcid.org/0000-0002-1084-0084"
},
"institutions": [
{
"id": "https://openalex.org/I1301553790",
"display_name": "J. Craig Venter Institute",
"ror": "https://ror.org/049r1ts75",
"country_code": "US",
"type": "nonprofit",
"lineage": [
"https://openalex.org/I1301553790"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "L. Sun",
"raw_affiliation_strings": [
"J. Craig Venter Institute, La Jolla, CA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "J. Craig Venter Institute, La Jolla, CA, USA",
"institution_ids": [
"https://openalex.org/I1301553790"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5017534686",
"display_name": "Daniela Bittencourt",
"orcid": "https://orcid.org/0000-0002-3137-6567"
},
"institutions": [
{
"id": "https://openalex.org/I1301553790",
"display_name": "J. Craig Venter Institute",
"ror": "https://ror.org/049r1ts75",
"country_code": "US",
"type": "nonprofit",
"lineage": [
"https://openalex.org/I1301553790"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "D. M. C. Bittencourt",
"raw_affiliation_strings": [
"J. Craig Venter Institute, La Jolla, CA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "J. Craig Venter Institute, La Jolla, CA, USA",
"institution_ids": [
"https://openalex.org/I1301553790"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5025219850",
"display_name": "B. K. Lehmkuhl",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I199691007",
"display_name": "Brazilian Agricultural Research Corporation",
"ror": "https://ror.org/0482b5b22",
"country_code": "BR",
"type": "government",
"lineage": [
"https://openalex.org/I199691007"
]
}
],
"countries": [
"BR"
],
"is_corresponding": false,
"raw_author_name": "B. K. Lehmkuhl",
"raw_affiliation_strings": [
"Embrapa Genetic Resources and Biotechnology, National Institute of Science and Technology in Synthetic Biology, Bras\u00edlia, Brazil"
],
"affiliations": [
{
"raw_affiliation_string": "Embrapa Genetic Resources and Biotechnology, National Institute of Science and Technology in Synthetic Biology, Bras\u00edlia, Brazil",
"institution_ids": [
"https://openalex.org/I199691007"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5008015721",
"display_name": "Donald R. Schoolmaster",
"orcid": "https://orcid.org/0000-0003-0910-4458"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "D. R. Schoolmaster",
"raw_affiliation_strings": [
"US Geological Survey, Wetland and Aquatic Research Center, Lafayette, LA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Wetland and Aquatic Research Center, Lafayette, LA, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5053297258",
"display_name": "Michael Lynch",
"orcid": "https://orcid.org/0000-0002-1653-0642"
},
"institutions": [
{
"id": "https://openalex.org/I55732556",
"display_name": "Arizona State University",
"ror": "https://ror.org/03efmqc40",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I55732556"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "M. Lynch",
"raw_affiliation_strings": [
"Arizona State University, Tempe, AZ, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Arizona State University, Tempe, AZ, USA",
"institution_ids": [
"https://openalex.org/I55732556"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5072710852",
"display_name": "Jay T. Lennon",
"orcid": "https://orcid.org/0000-0003-3126-6111"
},
"institutions": [
{
"id": "https://openalex.org/I4210119109",
"display_name": "Indiana University Bloomington",
"ror": "https://ror.org/02k40bc56",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I4210119109",
"https://openalex.org/I592451"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "J. T. Lennon",
"raw_affiliation_strings": [
"Department of Biology, Indiana University, Bloomington, IN, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Indiana University, Bloomington, IN, USA",
"institution_ids": [
"https://openalex.org/I4210119109"
]
}
]
}
],
"best_oa_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1038/s41586-023-06288-x",
"pdf_url": "https://www.nature.com/articles/s41586-023-06288-x.pdf",
"source": {
"id": "https://openalex.org/S137773608",
"display_name": "Nature",
"issn_l": "0028-0836",
"issn": [
"0028-0836",
"1476-4687"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319908",
"host_organization_name": "Nature Portfolio",
"host_organization_lineage": [
"https://openalex.org/P4310319908",
"https://openalex.org/P4310319965"
],
"host_organization_lineage_names": [
"Nature Portfolio",
"Springer Nature"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"biblio": {
"volume": "620",
"issue": "7972",
"first_page": "122",
"last_page": "127"
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W4383198532",
"cited_by_count": 35,
"cited_by_percentile_year": {
"min": 99,
"max": 100
},
"concepts": [
{
"id": "https://openalex.org/c61727976",
"wikidata": "https://www.wikidata.org/wiki/Q751748",
"display_name": "Epistasis",
"level": 3,
"score": 0.6630362,
"qid": null
},
{
"id": "https://openalex.org/c86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.6619352,
"qid": "Q158998"
},
{
"id": "https://openalex.org/c141231307",
"wikidata": "https://www.wikidata.org/wiki/Q7020",
"display_name": "Genome",
"level": 3,
"score": 0.6325575,
"qid": null
},
{
"id": "https://openalex.org/c2910387474",
"wikidata": "https://www.wikidata.org/wiki/Q331710",
"display_name": "Genetic Fitness",
"level": 3,
"score": 0.5689735,
"qid": null
},
{
"id": "https://openalex.org/c91852762",
"wikidata": "https://www.wikidata.org/wiki/Q3307742",
"display_name": "Fitness landscape",
"level": 3,
"score": 0.54982734,
"qid": null
},
{
"id": "https://openalex.org/c191908910",
"wikidata": "https://www.wikidata.org/wiki/Q862838",
"display_name": "Synthetic biology",
"level": 2,
"score": 0.54586595,
"qid": null
},
{
"id": "https://openalex.org/c104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.5200848,
"qid": null
},
{
"id": "https://openalex.org/c85813293",
"wikidata": "https://www.wikidata.org/wiki/Q188909",
"display_name": "Cell division",
"level": 3,
"score": 0.49718,
"qid": null
},
{
"id": "https://openalex.org/c87590526",
"wikidata": "https://www.wikidata.org/wiki/Q3592884",
"display_name": "Experimental evolution",
"level": 3,
"score": 0.49248347,
"qid": null
},
{
"id": "https://openalex.org/c501734568",
"wikidata": "https://www.wikidata.org/wiki/Q42918",
"display_name": "Mutation",
"level": 3,
"score": 0.47861475,
"qid": null
},
{
"id": "https://openalex.org/c61271108",
"wikidata": "https://www.wikidata.org/wiki/Q3180866",
"display_name": "Genome size",
"level": 4,
"score": 0.4670018,
"qid": null
},
{
"id": "https://openalex.org/c1491633281",
"wikidata": "https://www.wikidata.org/wiki/Q7868",
"display_name": "Cell",
"level": 2,
"score": 0.46549782,
"qid": null
},
{
"id": "https://openalex.org/c98638677",
"wikidata": "https://www.wikidata.org/wiki/Q2067051",
"display_name": "Mutation rate",
"level": 3,
"score": 0.4319038,
"qid": null
},
{
"id": "https://openalex.org/c176147130",
"wikidata": "https://www.wikidata.org/wiki/Q909622",
"display_name": "Evolvability",
"level": 2,
"score": 0.41493982,
"qid": null
},
{
"id": "https://openalex.org/c54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.40631458,
"qid": "Q158979"
},
{
"id": "https://openalex.org/c70721500",
"wikidata": "https://www.wikidata.org/wiki/Q177005",
"display_name": "Computational biology",
"level": 1,
"score": 0.4026247,
"qid": "Q226210"
},
{
"id": "https://openalex.org/c2908647359",
"wikidata": "https://www.wikidata.org/wiki/Q2625603",
"display_name": "Population",
"level": 2,
"score": 0.0,
"qid": null
},
{
"id": "https://openalex.org/c149923435",
"wikidata": "https://www.wikidata.org/wiki/Q37732",
"display_name": "Demography",
"level": 1,
"score": 0.0,
"qid": "Q166262"
},
{
"id": "https://openalex.org/c144024400",
"wikidata": "https://www.wikidata.org/wiki/Q21201",
"display_name": "Sociology",
"level": 0,
"score": 0.0,
"qid": "Q226182"
}
],
"corresponding_author_ids": [],
"corresponding_institution_ids": [],
"countries_distinct_count": 2,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 25
},
{
"year": 2023,
"cited_by_count": 8
}
],
"created_date": "2023-07-06",
"datasets": [],
"display_name": "Evolution of a minimal cell",
"doi": "https://doi.org/10.1038/s41586-023-06288-x",
"fulltext_origin": "pdf",
"fwci": 23.717,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W4383198532",
"ids": {
"openalex": "https://openalex.org/W4383198532",
"doi": "https://doi.org/10.1038/s41586-023-06288-x",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/37407813"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 5,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/epistasis",
"display_name": "Epistasis",
"score": 0.6630362
},
{
"id": "https://openalex.org/keywords/genetic-fitness",
"display_name": "Genetic Fitness",
"score": 0.5689735
},
{
"id": "https://openalex.org/keywords/fitness-landscape",
"display_name": "Fitness landscape",
"score": 0.54982734
},
{
"id": "https://openalex.org/keywords/evolution",
"display_name": "Evolution",
"score": 0.548503
},
{
"id": "https://openalex.org/keywords/synthetic-biology",
"display_name": "Synthetic biology",
"score": 0.54586595
},
{
"id": "https://openalex.org/keywords/experimental-evolution",
"display_name": "Experimental Evolution",
"score": 0.511296
},
{
"id": "https://openalex.org/keywords/genetic-dynamics",
"display_name": "Genetic Dynamics",
"score": 0.503434
},
{
"id": "https://openalex.org/keywords/genome-size",
"display_name": "Genome size",
"score": 0.4670018
},
{
"id": "https://openalex.org/keywords/evolvability",
"display_name": "Evolvability",
"score": 0.41493982
}
],
"language": "en",
"locations": [
{
"is_oa": true,
"landing_page_url": "https://doi.org/10.1038/s41586-023-06288-x",
"pdf_url": "https://www.nature.com/articles/s41586-023-06288-x.pdf",
"source": {
"id": "https://openalex.org/S137773608",
"display_name": "Nature",
"issn_l": "0028-0836",
"issn": [
"0028-0836",
"1476-4687"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319908",
"host_organization_name": "Nature Portfolio",
"host_organization_lineage": [
"https://openalex.org/P4310319908",
"https://openalex.org/P4310319965"
],
"host_organization_lineage_names": [
"Nature Portfolio",
"Springer Nature"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": true,
"landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10396959",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S2764455111",
"display_name": "PubMed Central",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/37407813",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 3,
"mesh": [
{
"descriptor_ui": "D001709",
"descriptor_name": "Biotechnology",
"qualifier_ui": "Q000379",
"qualifier_name": "methods",
"is_major_topic": false
},
{
"descriptor_ui": "D002455",
"descriptor_name": "Cell Division",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D048429",
"descriptor_name": "Cell Size",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D004843",
"descriptor_name": "Epistasis, Genetic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019143",
"descriptor_name": "Evolution, Molecular",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020043",
"descriptor_name": "Genes, Essential",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D056084",
"descriptor_name": "Genetic Fitness",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D016680",
"descriptor_name": "Genome, Bacterial",
"qualifier_ui": "Q000235",
"qualifier_name": "genetics",
"is_major_topic": false
},
{
"descriptor_ui": "D009154",
"descriptor_name": "Mutation",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D009176",
"descriptor_name": "Mycoplasma mycoides",
"qualifier_ui": "Q000166",
"qualifier_name": "cytology",
"is_major_topic": false
},
{
"descriptor_ui": "D012641",
"descriptor_name": "Selection, Genetic",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013559",
"descriptor_name": "Symbiosis",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D058615",
"descriptor_name": "Synthetic Biology",
"qualifier_ui": "Q000379",
"qualifier_name": "methods",
"is_major_topic": false
},
{
"descriptor_ui": "D014404",
"descriptor_name": "Tubulin",
"qualifier_ui": "Q000737",
"qualifier_name": "chemistry",
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W4383198532/ngrams",
"open_access": {
"is_oa": true,
"oa_status": "hybrid",
"oa_url": "https://www.nature.com/articles/s41586-023-06288-x.pdf",
"any_repository_has_fulltext": true
},
"primary_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1038/s41586-023-06288-x",
"pdf_url": "https://www.nature.com/articles/s41586-023-06288-x.pdf",
"source": {
"id": "https://openalex.org/S137773608",
"display_name": "Nature",
"issn_l": "0028-0836",
"issn": [
"0028-0836",
"1476-4687"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319908",
"host_organization_name": "Nature Portfolio",
"host_organization_lineage": [
"https://openalex.org/P4310319908",
"https://openalex.org/P4310319965"
],
"host_organization_lineage_names": [
"Nature Portfolio",
"Springer Nature"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"primary_topic": {
"id": "https://openalex.org/T11764",
"display_name": "Evolutionary Dynamics of Genetic Adaptation and Mutation",
"score": 0.9986,
"subfield": {
"id": "https://openalex.org/subfields/1311",
"display_name": "Genetics"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2023-07-05",
"publication_year": 2023,
"referenced_works": [
"https://openalex.org/W1496246291",
"https://openalex.org/W1573821798",
"https://openalex.org/W1604756962",
"https://openalex.org/W1753618957",
"https://openalex.org/W1963887462",
"https://openalex.org/W1984248485",
"https://openalex.org/W1989191870",
"https://openalex.org/W1996460711",
"https://openalex.org/W2001924625",
"https://openalex.org/W2008310246",
"https://openalex.org/W2017911769",
"https://openalex.org/W2035761714",
"https://openalex.org/W2036897871",
"https://openalex.org/W2067652815",
"https://openalex.org/W2072059848",
"https://openalex.org/W2074248917",
"https://openalex.org/W2074443723",
"https://openalex.org/W2080229897",
"https://openalex.org/W2085454969",
"https://openalex.org/W2085703567",
"https://openalex.org/W2093246625",
"https://openalex.org/W2099540110",
"https://openalex.org/W2102670556",
"https://openalex.org/W2113350312",
"https://openalex.org/W2119585200",
"https://openalex.org/W2128099419",
"https://openalex.org/W2134370272",
"https://openalex.org/W2137475545",
"https://openalex.org/W2164466305",
"https://openalex.org/W2168917114",
"https://openalex.org/W2169168273",
"https://openalex.org/W2196599367",
"https://openalex.org/W2223866672",
"https://openalex.org/W2230464055",
"https://openalex.org/W2290768068",
"https://openalex.org/W2304674135",
"https://openalex.org/W2409873232",
"https://openalex.org/W2501611887",
"https://openalex.org/W2529873061",
"https://openalex.org/W2531312117",
"https://openalex.org/W2562024645",
"https://openalex.org/W2573446515",
"https://openalex.org/W2595907366",
"https://openalex.org/W2599363266",
"https://openalex.org/W2603382765",
"https://openalex.org/W2776714376",
"https://openalex.org/W2910514964",
"https://openalex.org/W2921247036",
"https://openalex.org/W2957309664",
"https://openalex.org/W2969657247",
"https://openalex.org/W3007864412",
"https://openalex.org/W3010725453",
"https://openalex.org/W3124204293",
"https://openalex.org/W3125528398",
"https://openalex.org/W3146440707",
"https://openalex.org/W3157198058",
"https://openalex.org/W4211125927",
"https://openalex.org/W4230357098",
"https://openalex.org/W4285086810",
"https://openalex.org/W4288056307",
"https://openalex.org/W4294043777"
],
"referenced_works_count": 61,
"related_works": [
"https://openalex.org/W785849228",
"https://openalex.org/W4381187826",
"https://openalex.org/W4362662377",
"https://openalex.org/W4315779511",
"https://openalex.org/W4288010070",
"https://openalex.org/W4224064550",
"https://openalex.org/W4200208592",
"https://openalex.org/W3014664454",
"https://openalex.org/W2768474856",
"https://openalex.org/W2068162395"
],
"sustainable_development_goals": [
{
"score": 0.48,
"display_name": "Responsible consumption and production",
"id": "https://metadata.un.org/sdg/12"
}
],
"title": "Evolution of a minimal cell",
"topics": [
{
"id": "https://openalex.org/T11764",
"display_name": "Evolutionary Dynamics of Genetic Adaptation and Mutation",
"score": 0.9986,
"subfield": {
"id": "https://openalex.org/subfields/1311",
"display_name": "Genetics"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11048",
"display_name": "Ecology and Evolution of Viruses in Ecosystems",
"score": 0.9975,
"subfield": {
"id": "https://openalex.org/subfields/2303",
"display_name": "Ecology"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
{
"id": "https://openalex.org/T10015",
"display_name": "RNA Sequencing Data Analysis",
"score": 0.9967,
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-08T15:31:03.028921",
"versions": [],
"qid": null
}
}
