Item talk:Q227515

{

 "@context": "http://schema.org/",
 "@type": "WebPage",
 "additionalType": "Project",
 "url": "https://www.usgs.gov/centers/nwhc/science/advancing-use-rt-quic-applications-cwd-management",
 "headline": "Advancing the Use of RT-QuIC for Applications in CWD Management",
 "datePublished": "August 23, 2021",
 "author": [
   {
     "@type": "Person",
     "name": "Allen Herbst",
     "url": "https://www.usgs.gov/staff-profiles/allen-herbst",
     "identifier": {
       "@type": "PropertyValue",
       "propertyID": "orcid",
       "value": "0000-0001-6601-1245"
     }
   },
   {
     "@type": "Person",
     "name": "Daniel P. Walsh, PhD",
     "url": "https://www.usgs.gov/staff-profiles/daniel-p-walsh",
     "identifier": {
       "@type": "PropertyValue",
       "propertyID": "orcid",
       "value": "0000-0002-7772-2445"
     }
   }
 ],
 "description": [
   {
     "@type": "TextObject",
     "text": "Chronic wasting disease (CWD) is an emerging infectious disease that is fatal to free-ranging and captive animals in Cervidae, the deer family. The development of the real-time quaking-induced conversion (RT-QuIC) assay has the potential to transform laboratory research of prions and provide new opportunities for improved surveillance and management."
   },
   {
     "@type": "TextObject",
     "text": "However, the widespread application of RT-QuIC has been hampered by 1) the lack of well-characterized reference samples to ensure proper assay functioning, identify optimal tissues for ante-mortem sampling, and determine biological relevance of results and 2) the absence of an appropriate modeling framework to leverage the information produced by RT-QuIC. In collaboration with the University of Wisconsin, state and federal partners, the USGS National Wildlife Health Center (NWHC) is working to fill these gaps by using RT-QuIC to fully characterize a range of biological tissues, body fluids, and excreta that are CWD-positive and -negative and comparing those results against the gold standard animal bioassay (a transgenic mouse bioassay).  NWHC is also building a modeling framework that will help managers determine appropriate control strategies by assessing the relative importance of environmental transmission, as measured by RT-QuIC, in CWD dynamics. The availability of reference samples and a robust modeling framework for CWD diagnostic labs and managers will help promote the rigorous application of RT-QuIC, identify optimal tissues for ante-mortem sampling, assess biological relevancy of findings, and provide a mechanism to leverage RT-QuIC information to aid CWD control efforts."
   }
 ],
 "funder": {
   "@type": "Organization",
   "name": "National Wildlife Health Center",
   "url": "https://www.usgs.gov/centers/nwhc"
 },
 "about": [
   {
     "@type": "Thing",
     "name": "RT-QuIC"
   },
   {
     "@type": "Thing",
     "name": "Science Technology"
   },
   {
     "@type": "Thing",
     "name": "Chronic Wasting Disease"
   },
   {
     "@type": "Thing",
     "name": "Information Systems"
   },
   {
     "@type": "Thing",
     "name": "Diagnostic"
   },
   {
     "@type": "Thing",
     "name": "Biology"
   },
   {
     "@type": "Thing",
     "name": "NWHC research project"
   },
   {
     "@type": "Thing",
     "name": "Methods and Analysis"
   },
   {
     "@type": "Thing",
     "name": "Fish and Wildlife Disease"
   },
   {
     "@type": "Thing",
     "name": "Geology"
   },
   {
     "@type": "Thing",
     "name": "Ecosystems"
   },
   {
     "@type": "Thing",
     "name": "Water"
   },
   {
     "@type": "Thing",
     "name": "Terrestrial Wildlife Diseases"
   },
   {
     "@type": "Thing",
     "name": "Energy"
   },
   {
     "@type": "Thing",
     "name": "chronic wasting disease (CWD)"
   },
   {
     "@type": "Thing",
     "name": "Environmental Health"
   }
 ]

}