Item talk:Q167231

{

 "id": "https://openalex.org/T10725",
 "display_name": "Mechanisms and Applications of RNA Interference",
 "description": "This cluster of papers explores the mechanisms, delivery methods, and therapeutic applications of RNA interference (RNAi) in mammalian cells. It covers topics such as siRNA delivery, gene silencing, non-viral vectors, cell-penetrating peptides, lipid nanoparticles, and the potential of RNAi for gene therapy. The research also delves into the challenges and future directions of RNAi-based therapeutics.",
 "keywords": [
   "RNA Interference",
   "siRNA Delivery",
   "Gene Silencing",
   "Non-viral Vectors",
   "Therapeutic RNAi",
   "Cell-penetrating Peptides",
   "Lipid Nanoparticles",
   "siRNA Therapeutics",
   "Gene Therapy",
   "Nucleic Acid Delivery"
 ],
 "ids": {
   "openalex": "https://openalex.org/T10725",
   "wikipedia": "https://en.wikipedia.org/wiki/RNA_interference"
 },
 "subfield": {
   "id": "https://openalex.org/subfields/1312",
   "display_name": "Molecular Biology"
 },
 "field": {
   "id": "https://openalex.org/fields/13",
   "display_name": "Biochemistry, Genetics and Molecular Biology"
 },
 "domain": {
   "id": "https://openalex.org/domains/1",
   "display_name": "Life Sciences"
 },
 "siblings": [
   {
     "id": "https://openalex.org/T13526",
     "display_name": "14-3-3 Proteins: Structure, Function, and Regulation"
   },
   {
     "id": "https://openalex.org/T10836",
     "display_name": "Advances in Metabolomics Research"
   },
   {
     "id": "https://openalex.org/T10887",
     "display_name": "Analysis of Gene Interaction Networks"
   },
   {
     "id": "https://openalex.org/T12763",
     "display_name": "ATP Synthase Function and Regulation"
   },
   {
     "id": "https://openalex.org/T10593",
     "display_name": "Bacterial Biofilms and Quorum Sensing Mechanisms"
   },
   {
     "id": "https://openalex.org/T12685",
     "display_name": "Bioactive Limonoids in Medicinal Plants"
   },
   {
     "id": "https://openalex.org/T11561",
     "display_name": "Bioactive Peptides in Food and Health"
   },
   {
     "id": "https://openalex.org/T12215",
     "display_name": "Bioactivity of Steroidal Saponins in Medicinal Plants"
   },
   {
     "id": "https://openalex.org/T13188",
     "display_name": "Biochemical and Pharmacological Functions of Beta-Carboline Alkaloids"
   },
   {
     "id": "https://openalex.org/T13725",
     "display_name": "Biochemistry, Pharmacology, and Medical Use of Bromelain"
   },
   {
     "id": "https://openalex.org/T11765",
     "display_name": "Biogenesis and Functions of Circular RNAs"
   },
   {
     "id": "https://openalex.org/T12530",
     "display_name": "Biological Activities of Diterpenoids from Medicinal Plants"
   },
   {
     "id": "https://openalex.org/T13454",
     "display_name": "Biological Activities of Phenothiazines and Related Compounds"
   },
   {
     "id": "https://openalex.org/T12257",
     "display_name": "Biological Activities of Prenylated Flavonoids"
   },
   {
     "id": "https://openalex.org/T11385",
     "display_name": "Biological Activities of Triterpenoids and Saponins"
   },
   {
     "id": "https://openalex.org/T13221",
     "display_name": "Biological Activity of Diterpenoids and Biflavonoids"
   },
   {
     "id": "https://openalex.org/T11515",
     "display_name": "Biological Agents for Bioterrorism"
   },
   {
     "id": "https://openalex.org/T12688",
     "display_name": "Biological Methane Utilization and Metabolism"
   },
   {
     "id": "https://openalex.org/T12561",
     "display_name": "Bioluminescence Imaging and Reporter Systems"
   },
   {
     "id": "https://openalex.org/T11710",
     "display_name": "Biomedical Ontologies and Text Mining"
   },
   {
     "id": "https://openalex.org/T11882",
     "display_name": "Biosynthesis and Engineering of Terpenoids"
   },
   {
     "id": "https://openalex.org/T12360",
     "display_name": "Biosynthesis and Pharmacological Activities of Lignans"
   },
   {
     "id": "https://openalex.org/T12620",
     "display_name": "Calcineurin-NFAT Signaling in Transcriptional Regulation"
   },
   {
     "id": "https://openalex.org/T13937",
     "display_name": "Challenges and Innovations in Bioinformatics Education"
   },
   {
     "id": "https://openalex.org/T12683",
     "display_name": "Chitin Metabolism in Insects and Mammals"
   },
   {
     "id": "https://openalex.org/T12820",
     "display_name": "Chromatin Remodeling in Cancer and Development"
   },
   {
     "id": "https://openalex.org/T10878",
     "display_name": "Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins"
   },
   {
     "id": "https://openalex.org/T11289",
     "display_name": "Comprehensive Integration of Single-Cell Transcriptomic Data"
   },
   {
     "id": "https://openalex.org/T13326",
     "display_name": "Cyclotide Bioengineering and Protein Anchoring Mechanisms"
   },
   {
     "id": "https://openalex.org/T10066",
     "display_name": "Diversity and Function of Gut Microbiome"
   },
   {
     "id": "https://openalex.org/T12668",
     "display_name": "Diversity and Systematics of Yeasts"
   },
   {
     "id": "https://openalex.org/T12388",
     "display_name": "DNA Barcoding for Food Authentication and Fraud Detection"
   },
   {
     "id": "https://openalex.org/T10207",
     "display_name": "DNA Nanotechnology and Bioanalytical Applications"
   },
   {
     "id": "https://openalex.org/T11845",
     "display_name": "DNA Topoisomerases: Structure, Function, and Inhibition"
   },
   {
     "id": "https://openalex.org/T12029",
     "display_name": "DNA-based Computing and Data Storage"
   },
   {
     "id": "https://openalex.org/T10240",
     "display_name": "Elicitor Signal Transduction for Metabolite Production"
   },
   {
     "id": "https://openalex.org/T10404",
     "display_name": "Enzyme Immobilization Techniques"
   },
   {
     "id": "https://openalex.org/T10269",
     "display_name": "Epigenetic Modifications and Their Functional Implications"
   },
   {
     "id": "https://openalex.org/T10773",
     "display_name": "Exosome Biology and Function in Intercellular Communication"
   },
   {
     "id": "https://openalex.org/T12287",
     "display_name": "Fibroblast Growth Factor Signaling Pathway"
   },
   {
     "id": "https://openalex.org/T12610",
     "display_name": "Functions and Regulation of RNA Editing by ADARs"
   },
   {
     "id": "https://openalex.org/T10432",
     "display_name": "G-Quadruplex DNA Structures and Functions"
   },
   {
     "id": "https://openalex.org/T10497",
     "display_name": "Genomic Expression and Function in Yeast Organism"
   },
   {
     "id": "https://openalex.org/T12946",
     "display_name": "Genomic Signal Processing and Analysis Techniques"
   },
   {
     "id": "https://openalex.org/T11879",
     "display_name": "Global Diversity of Microbial Eukaryotes and Their Evolution"
   },
   {
     "id": "https://openalex.org/T10602",
     "display_name": "Glycosylation in Health and Disease"
   },
   {
     "id": "https://openalex.org/T12009",
     "display_name": "Hedgehog Signaling in Development and Cancer"
   },
   {
     "id": "https://openalex.org/T11848",
     "display_name": "Heme Oxygenase and Carbon Monoxide Research"
   },
   {
     "id": "https://openalex.org/T10505",
     "display_name": "Induction and Differentiation of Pluripotent Stem Cells"
   },
   {
     "id": "https://openalex.org/T10407",
     "display_name": "Lipid Rafts and Membrane Dynamics"
   },
   {
     "id": "https://openalex.org/T11786",
     "display_name": "Magnetosome Formation in Prokaryotes"
   },
   {
     "id": "https://openalex.org/T11533",
     "display_name": "Mammalian MAP Kinase Signaling Pathways"
   },
   {
     "id": "https://openalex.org/T10932",
     "display_name": "Metabolic Engineering and Synthetic Biology"
   },
   {
     "id": "https://openalex.org/T13012",
     "display_name": "Metabolism and Functions of Coenzyme Q"
   },
   {
     "id": "https://openalex.org/T10885",
     "display_name": "Microarray Data Analysis and Gene Expression Profiling"
   },
   {
     "id": "https://openalex.org/T14285",
     "display_name": "Microbial Production of Polyglutamic Acid"
   },
   {
     "id": "https://openalex.org/T13736",
     "display_name": "Microbial Transformation of Steroids"
   },
   {
     "id": "https://openalex.org/T10301",
     "display_name": "Mitochondrial Dynamics and Reactive Oxygen Species Regulation"
   },
   {
     "id": "https://openalex.org/T11956",
     "display_name": "Molecular Biology of Steroidogenesis and Disorders"
   },
   {
     "id": "https://openalex.org/T10934",
     "display_name": "Molecular Chaperones in Protein Folding and Disease"
   },
   {
     "id": "https://openalex.org/T11889",
     "display_name": "Molecular Mechanisms and Medical Applications of Ginseng"
   },
   {
     "id": "https://openalex.org/T11305",
     "display_name": "Molecular Mechanisms of Amyloidosis"
   },
   {
     "id": "https://openalex.org/T10422",
     "display_name": "Molecular Mechanisms of Angiogenesis and Vascular Function"
   },
   {
     "id": "https://openalex.org/T10294",
     "display_name": "Molecular Mechanisms of Apoptosis and Cell Death"
   },
   {
     "id": "https://openalex.org/T10724",
     "display_name": "Molecular Mechanisms of Aquaporins in Physiology and Disease"
   },
   {
     "id": "https://openalex.org/T11677",
     "display_name": "Molecular Mechanisms of Cardiac Development and Regeneration"
   },
   {
     "id": "https://openalex.org/T10123",
     "display_name": "Molecular Mechanisms of DNA Damage Response"
   },
   {
     "id": "https://openalex.org/T11237",
     "display_name": "Molecular Mechanisms of Flavonoid Biosynthesis in Plants"
   },
   {
     "id": "https://openalex.org/T12441",
     "display_name": "Molecular Mechanisms of Heme Biosynthesis and Related Disorders"
   },
   {
     "id": "https://openalex.org/T11078",
     "display_name": "Molecular Mechanisms of Inflammasome Activation and Regulation"
   },
   {
     "id": "https://openalex.org/T11075",
     "display_name": "Molecular Mechanisms of Insect Resistance to Xenobiotics"
   },
   {
     "id": "https://openalex.org/T10493",
     "display_name": "Molecular Mechanisms of Ion Channels Regulation"
   },
   {
     "id": "https://openalex.org/T12140",
     "display_name": "Molecular Mechanisms of Kidney Development and Disease"
   },
   {
     "id": "https://openalex.org/T13437",
     "display_name": "Molecular Mechanisms of Metastasis Suppressor Genes"
   },
   {
     "id": "https://openalex.org/T10441",
     "display_name": "Molecular Mechanisms of Muscle Regeneration and Atrophy"
   },
   {
     "id": "https://openalex.org/T11219",
     "display_name": "Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling"
   },
   {
     "id": "https://openalex.org/T10303",
     "display_name": "Molecular Mechanisms of Photosynthesis and Photoprotection"
   },
   {
     "id": "https://openalex.org/T12789",
     "display_name": "Molecular Mechanisms of Planarian Regeneration"
   },
   {
     "id": "https://openalex.org/T11927",
     "display_name": "Molecular Mechanisms of Pollen Development and Function"
   },
   {
     "id": "https://openalex.org/T10169",
     "display_name": "Molecular Mechanisms of Ras Signaling Pathways"
   },
   {
     "id": "https://openalex.org/T10691",
     "display_name": "Molecular Mechanisms of Retinal Degeneration and Regeneration"
   },
   {
     "id": "https://openalex.org/T11919",
     "display_name": "Molecular Mechanisms of Tooth Development and Morphogenesis"
   },
   {
     "id": "https://openalex.org/T12434",
     "display_name": "Molecular Regulation and Clinical Applications of PDEs"
   },
   {
     "id": "https://openalex.org/T12566",
     "display_name": "Molecular Regulation of Sulfur Metabolism in Plants"
   },
   {
     "id": "https://openalex.org/T14049",
     "display_name": "Molecular Systematics of Gesneriaceae and Allies"
   },
   {
     "id": "https://openalex.org/T10952",
     "display_name": "mTOR Signaling in Growth and Disease"
   },
   {
     "id": "https://openalex.org/T10268",
     "display_name": "Notch Signaling Pathway in Development and Disease"
   },
   {
     "id": "https://openalex.org/T12827",
     "display_name": "Nucleotide Metabolism and Enzyme Regulation"
   },
   {
     "id": "https://openalex.org/T14135",
     "display_name": "Oxidation States in Biochemistry and Medicine"
   },
   {
     "id": "https://openalex.org/T10911",
     "display_name": "Peptide Synthesis and Drug Discovery"
   },
   {
     "id": "https://openalex.org/T11072",
     "display_name": "Peroxisome Proliferator-Activated Receptors"
   },
   {
     "id": "https://openalex.org/T11924",
     "display_name": "Polyamines and Biogenic Amines in Biology and Health"
   },
   {
     "id": "https://openalex.org/T12576",
     "display_name": "Prediction of Peptide-MHC Binding Affinity"
   },
   {
     "id": "https://openalex.org/T12254",
     "display_name": "Prediction of Protein Subcellular Localization"
   },
   {
     "id": "https://openalex.org/T11335",
     "display_name": "Prion Diseases: Causes and Molecular Basis"
   },
   {
     "id": "https://openalex.org/T11124",
     "display_name": "Protein Aggregation and Biopharmaceutical Stability"
   },
   {
     "id": "https://openalex.org/T13157",
     "display_name": "Protein Arginine Methylation in Mammals"
   },
   {
     "id": "https://openalex.org/T11908",
     "display_name": "Protein Binding Specificity in Human Serum Albumin"
   },
   {
     "id": "https://openalex.org/T12867",
     "display_name": "Protein Microarray Technology and Applications"
   },
   {
     "id": "https://openalex.org/T10044",
     "display_name": "Protein Structure Prediction and Analysis"
   },
   {
     "id": "https://openalex.org/T12104",
     "display_name": "Protein Tyrosine Phosphatases in Human Health and Disease"
   },
   {
     "id": "https://openalex.org/T13187",
     "display_name": "Protein-DNA Interaction Dynamics in Living Cells"
   },
   {
     "id": "https://openalex.org/T12756",
     "display_name": "Pyrrolizidine Alkaloids: Toxicity, Metabolism, and Health Implications"
   },
   {
     "id": "https://openalex.org/T11970",
     "display_name": "Real-Time Polymerase Chain Reaction"
   },
   {
     "id": "https://openalex.org/T11663",
     "display_name": "Recombinant Protein Production in Mammalian and Insect Cells"
   },
   {
     "id": "https://openalex.org/T11884",
     "display_name": "Redox Signaling and Oxidative Stress"
   },
   {
     "id": "https://openalex.org/T12835",
     "display_name": "Regulation and Functions of FoxO Transcription Factors"
   },
   {
     "id": "https://openalex.org/T10222",
     "display_name": "Regulation of Chromatin Structure and Function"
   },
   {
     "id": "https://openalex.org/T10604",
     "display_name": "Regulation of RNA Processing and Function"
   },
   {
     "id": "https://openalex.org/T13651",
     "display_name": "Research on Rhodiola rosea and Salidroside"
   },
   {
     "id": "https://openalex.org/T14065",
     "display_name": "Research on Synthetic Phosphoethanolamine and its Effects"
   },
   {
     "id": "https://openalex.org/T10521",
     "display_name": "Ribosome Structure and Translation Mechanisms"
   },
   {
     "id": "https://openalex.org/T11482",
     "display_name": "RNA Methylation and Modification in Gene Expression"
   },
   {
     "id": "https://openalex.org/T10015",
     "display_name": "RNA Sequencing Data Analysis"
   },
   {
     "id": "https://openalex.org/T11339",
     "display_name": "Role of AMP-Activated Protein Kinase in Cellular Metabolism"
   },
   {
     "id": "https://openalex.org/T12412",
     "display_name": "Role of Carbonic Anhydrases in Medicine and Biotechnology"
   },
   {
     "id": "https://openalex.org/T13223",
     "display_name": "Role of CCN Proteins in Signaling Pathways"
   },
   {
     "id": "https://openalex.org/T12187",
     "display_name": "Role of Glutathione in Oxidative Stress Response"
   },
   {
     "id": "https://openalex.org/T11736",
     "display_name": "Role of Histone Deacetylases in Cellular Regulation"
   },
   {
     "id": "https://openalex.org/T11332",
     "display_name": "Role of Nrf2 Signaling in Oxidative Stress Response"
   },
   {
     "id": "https://openalex.org/T11559",
     "display_name": "Role of Retinoic Acid in Biological Processes"
   },
   {
     "id": "https://openalex.org/T13047",
     "display_name": "Role of Sigma Receptors in Cellular Signaling"
   },
   {
     "id": "https://openalex.org/T13426",
     "display_name": "Role of Transcription Factors in Cell Regulation"
   },
   {
     "id": "https://openalex.org/T12030",
     "display_name": "S100 Proteins: Structure, Function, and Pathology"
   },
   {
     "id": "https://openalex.org/T11308",
     "display_name": "Sphingolipid Signalling and Metabolism in Health and Disease"
   },
   {
     "id": "https://openalex.org/T10621",
     "display_name": "Stochasticity in Gene Regulatory Networks"
   },
   {
     "id": "https://openalex.org/T11178",
     "display_name": "Structure and Function of G Protein-Coupled Receptors"
   },
   {
     "id": "https://openalex.org/T11480",
     "display_name": "Structure and Function of Gap Junctions and Connexins"
   },
   {
     "id": "https://openalex.org/T11818",
     "display_name": "Structure and Function of Nicotinic Receptors"
   },
   {
     "id": "https://openalex.org/T11841",
     "display_name": "Structure and Function of the Nuclear Pore Complex"
   },
   {
     "id": "https://openalex.org/T12534",
     "display_name": "Targeted Protein Degradation in Biomedical Research"
   },
   {
     "id": "https://openalex.org/T11501",
     "display_name": "Transforming Growth Factor Beta Signaling Pathway"
   },
   {
     "id": "https://openalex.org/T11041",
     "display_name": "Ubiquitin-Proteasome Proteolytic Pathway"
   },
   {
     "id": "https://openalex.org/T10929",
     "display_name": "Wnt Signaling in Development and Disease"
   }
 ],
 "works_count": 91280,
 "cited_by_count": 2752532,
 "updated_date": "2024-08-26T06:12:46.399281",
 "created_date": "2024-01-23"

}