Item talk:Q317015
From geokb
{
"OpenAlex": {
"id": "https://openalex.org/T12104",
"display_name": "Protein Tyrosine Phosphatases in Human Health and Disease",
"description": "This cluster of papers explores the role of protein tyrosine phosphatases, particularly PTPN11 and SHP2, in various human health and disease conditions such as Noonan syndrome, cancer, insulin sensitivity, and MAP kinase signaling. It also delves into the redox regulation of protein tyrosine phosphatases and their implications in cell signaling pathways.",
"keywords": [
"Protein Tyrosine Phosphatases",
"PTPN11",
"Noonan Syndrome",
"MAP Kinase Signaling",
"Insulin Sensitivity",
"Cancer",
"Redox Regulation",
"SHP2",
"Mutation",
"Cell Signaling"
],
"ids": {
"openalex": "https://openalex.org/T12104",
"wikipedia": "https://en.wikipedia.org/wiki/Protein_tyrosine_phosphatase"
},
"subfield": {
"id": "https://openalex.org/subfields/1312",
"display_name": "Molecular Biology"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
},
"siblings": [
{
"id": "https://openalex.org/T13526",
"display_name": "14-3-3 Proteins: Structure, Function, and Regulation"
},
{
"id": "https://openalex.org/T10836",
"display_name": "Advances in Metabolomics Research"
},
{
"id": "https://openalex.org/T10887",
"display_name": "Analysis of Gene Interaction Networks"
},
{
"id": "https://openalex.org/T12763",
"display_name": "ATP Synthase Function and Regulation"
},
{
"id": "https://openalex.org/T10593",
"display_name": "Bacterial Biofilms and Quorum Sensing Mechanisms"
},
{
"id": "https://openalex.org/T12685",
"display_name": "Bioactive Limonoids in Medicinal Plants"
},
{
"id": "https://openalex.org/T11561",
"display_name": "Bioactive Peptides in Food and Health"
},
{
"id": "https://openalex.org/T12215",
"display_name": "Bioactivity of Steroidal Saponins in Medicinal Plants"
},
{
"id": "https://openalex.org/T13188",
"display_name": "Biochemical and Pharmacological Functions of Beta-Carboline Alkaloids"
},
{
"id": "https://openalex.org/T13725",
"display_name": "Biochemistry, Pharmacology, and Medical Use of Bromelain"
},
{
"id": "https://openalex.org/T11765",
"display_name": "Biogenesis and Functions of Circular RNAs"
},
{
"id": "https://openalex.org/T12530",
"display_name": "Biological Activities of Diterpenoids from Medicinal Plants"
},
{
"id": "https://openalex.org/T13454",
"display_name": "Biological Activities of Phenothiazines and Related Compounds"
},
{
"id": "https://openalex.org/T12257",
"display_name": "Biological Activities of Prenylated Flavonoids"
},
{
"id": "https://openalex.org/T11385",
"display_name": "Biological Activities of Triterpenoids and Saponins"
},
{
"id": "https://openalex.org/T13221",
"display_name": "Biological Activity of Diterpenoids and Biflavonoids"
},
{
"id": "https://openalex.org/T11515",
"display_name": "Biological Agents for Bioterrorism"
},
{
"id": "https://openalex.org/T12688",
"display_name": "Biological Methane Utilization and Metabolism"
},
{
"id": "https://openalex.org/T12561",
"display_name": "Bioluminescence Imaging and Reporter Systems"
},
{
"id": "https://openalex.org/T11710",
"display_name": "Biomedical Ontologies and Text Mining"
},
{
"id": "https://openalex.org/T11882",
"display_name": "Biosynthesis and Engineering of Terpenoids"
},
{
"id": "https://openalex.org/T12360",
"display_name": "Biosynthesis and Pharmacological Activities of Lignans"
},
{
"id": "https://openalex.org/T12620",
"display_name": "Calcineurin-NFAT Signaling in Transcriptional Regulation"
},
{
"id": "https://openalex.org/T13937",
"display_name": "Challenges and Innovations in Bioinformatics Education"
},
{
"id": "https://openalex.org/T12683",
"display_name": "Chitin Metabolism in Insects and Mammals"
},
{
"id": "https://openalex.org/T12820",
"display_name": "Chromatin Remodeling in Cancer and Development"
},
{
"id": "https://openalex.org/T10878",
"display_name": "Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins"
},
{
"id": "https://openalex.org/T11289",
"display_name": "Comprehensive Integration of Single-Cell Transcriptomic Data"
},
{
"id": "https://openalex.org/T13326",
"display_name": "Cyclotide Bioengineering and Protein Anchoring Mechanisms"
},
{
"id": "https://openalex.org/T10066",
"display_name": "Diversity and Function of Gut Microbiome"
},
{
"id": "https://openalex.org/T12668",
"display_name": "Diversity and Systematics of Yeasts"
},
{
"id": "https://openalex.org/T12388",
"display_name": "DNA Barcoding for Food Authentication and Fraud Detection"
},
{
"id": "https://openalex.org/T10207",
"display_name": "DNA Nanotechnology and Bioanalytical Applications"
},
{
"id": "https://openalex.org/T11845",
"display_name": "DNA Topoisomerases: Structure, Function, and Inhibition"
},
{
"id": "https://openalex.org/T12029",
"display_name": "DNA-based Computing and Data Storage"
},
{
"id": "https://openalex.org/T10240",
"display_name": "Elicitor Signal Transduction for Metabolite Production"
},
{
"id": "https://openalex.org/T10404",
"display_name": "Enzyme Immobilization Techniques"
},
{
"id": "https://openalex.org/T10269",
"display_name": "Epigenetic Modifications and Their Functional Implications"
},
{
"id": "https://openalex.org/T10773",
"display_name": "Exosome Biology and Function in Intercellular Communication"
},
{
"id": "https://openalex.org/T12287",
"display_name": "Fibroblast Growth Factor Signaling Pathway"
},
{
"id": "https://openalex.org/T12610",
"display_name": "Functions and Regulation of RNA Editing by ADARs"
},
{
"id": "https://openalex.org/T10432",
"display_name": "G-Quadruplex DNA Structures and Functions"
},
{
"id": "https://openalex.org/T10497",
"display_name": "Genomic Expression and Function in Yeast Organism"
},
{
"id": "https://openalex.org/T12946",
"display_name": "Genomic Signal Processing and Analysis Techniques"
},
{
"id": "https://openalex.org/T11879",
"display_name": "Global Diversity of Microbial Eukaryotes and Their Evolution"
},
{
"id": "https://openalex.org/T10602",
"display_name": "Glycosylation in Health and Disease"
},
{
"id": "https://openalex.org/T12009",
"display_name": "Hedgehog Signaling in Development and Cancer"
},
{
"id": "https://openalex.org/T11848",
"display_name": "Heme Oxygenase and Carbon Monoxide Research"
},
{
"id": "https://openalex.org/T10505",
"display_name": "Induction and Differentiation of Pluripotent Stem Cells"
},
{
"id": "https://openalex.org/T10407",
"display_name": "Lipid Rafts and Membrane Dynamics"
},
{
"id": "https://openalex.org/T11786",
"display_name": "Magnetosome Formation in Prokaryotes"
},
{
"id": "https://openalex.org/T11533",
"display_name": "Mammalian MAP Kinase Signaling Pathways"
},
{
"id": "https://openalex.org/T10725",
"display_name": "Mechanisms and Applications of RNA Interference"
},
{
"id": "https://openalex.org/T10932",
"display_name": "Metabolic Engineering and Synthetic Biology"
},
{
"id": "https://openalex.org/T13012",
"display_name": "Metabolism and Functions of Coenzyme Q"
},
{
"id": "https://openalex.org/T10885",
"display_name": "Microarray Data Analysis and Gene Expression Profiling"
},
{
"id": "https://openalex.org/T14285",
"display_name": "Microbial Production of Polyglutamic Acid"
},
{
"id": "https://openalex.org/T13736",
"display_name": "Microbial Transformation of Steroids"
},
{
"id": "https://openalex.org/T10301",
"display_name": "Mitochondrial Dynamics and Reactive Oxygen Species Regulation"
},
{
"id": "https://openalex.org/T11956",
"display_name": "Molecular Biology of Steroidogenesis and Disorders"
},
{
"id": "https://openalex.org/T10934",
"display_name": "Molecular Chaperones in Protein Folding and Disease"
},
{
"id": "https://openalex.org/T11889",
"display_name": "Molecular Mechanisms and Medical Applications of Ginseng"
},
{
"id": "https://openalex.org/T11305",
"display_name": "Molecular Mechanisms of Amyloidosis"
},
{
"id": "https://openalex.org/T10422",
"display_name": "Molecular Mechanisms of Angiogenesis and Vascular Function"
},
{
"id": "https://openalex.org/T10294",
"display_name": "Molecular Mechanisms of Apoptosis and Cell Death"
},
{
"id": "https://openalex.org/T10724",
"display_name": "Molecular Mechanisms of Aquaporins in Physiology and Disease"
},
{
"id": "https://openalex.org/T11677",
"display_name": "Molecular Mechanisms of Cardiac Development and Regeneration"
},
{
"id": "https://openalex.org/T10123",
"display_name": "Molecular Mechanisms of DNA Damage Response"
},
{
"id": "https://openalex.org/T11237",
"display_name": "Molecular Mechanisms of Flavonoid Biosynthesis in Plants"
},
{
"id": "https://openalex.org/T12441",
"display_name": "Molecular Mechanisms of Heme Biosynthesis and Related Disorders"
},
{
"id": "https://openalex.org/T11078",
"display_name": "Molecular Mechanisms of Inflammasome Activation and Regulation"
},
{
"id": "https://openalex.org/T11075",
"display_name": "Molecular Mechanisms of Insect Resistance to Xenobiotics"
},
{
"id": "https://openalex.org/T10493",
"display_name": "Molecular Mechanisms of Ion Channels Regulation"
},
{
"id": "https://openalex.org/T12140",
"display_name": "Molecular Mechanisms of Kidney Development and Disease"
},
{
"id": "https://openalex.org/T13437",
"display_name": "Molecular Mechanisms of Metastasis Suppressor Genes"
},
{
"id": "https://openalex.org/T10441",
"display_name": "Molecular Mechanisms of Muscle Regeneration and Atrophy"
},
{
"id": "https://openalex.org/T11219",
"display_name": "Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling"
},
{
"id": "https://openalex.org/T10303",
"display_name": "Molecular Mechanisms of Photosynthesis and Photoprotection"
},
{
"id": "https://openalex.org/T12789",
"display_name": "Molecular Mechanisms of Planarian Regeneration"
},
{
"id": "https://openalex.org/T11927",
"display_name": "Molecular Mechanisms of Pollen Development and Function"
},
{
"id": "https://openalex.org/T10169",
"display_name": "Molecular Mechanisms of Ras Signaling Pathways"
},
{
"id": "https://openalex.org/T10691",
"display_name": "Molecular Mechanisms of Retinal Degeneration and Regeneration"
},
{
"id": "https://openalex.org/T11919",
"display_name": "Molecular Mechanisms of Tooth Development and Morphogenesis"
},
{
"id": "https://openalex.org/T12434",
"display_name": "Molecular Regulation and Clinical Applications of PDEs"
},
{
"id": "https://openalex.org/T12566",
"display_name": "Molecular Regulation of Sulfur Metabolism in Plants"
},
{
"id": "https://openalex.org/T14049",
"display_name": "Molecular Systematics of Gesneriaceae and Allies"
},
{
"id": "https://openalex.org/T10952",
"display_name": "mTOR Signaling in Growth and Disease"
},
{
"id": "https://openalex.org/T10268",
"display_name": "Notch Signaling Pathway in Development and Disease"
},
{
"id": "https://openalex.org/T12827",
"display_name": "Nucleotide Metabolism and Enzyme Regulation"
},
{
"id": "https://openalex.org/T14135",
"display_name": "Oxidation States in Biochemistry and Medicine"
},
{
"id": "https://openalex.org/T10911",
"display_name": "Peptide Synthesis and Drug Discovery"
},
{
"id": "https://openalex.org/T11072",
"display_name": "Peroxisome Proliferator-Activated Receptors"
},
{
"id": "https://openalex.org/T11924",
"display_name": "Polyamines and Biogenic Amines in Biology and Health"
},
{
"id": "https://openalex.org/T12576",
"display_name": "Prediction of Peptide-MHC Binding Affinity"
},
{
"id": "https://openalex.org/T12254",
"display_name": "Prediction of Protein Subcellular Localization"
},
{
"id": "https://openalex.org/T11335",
"display_name": "Prion Diseases: Causes and Molecular Basis"
},
{
"id": "https://openalex.org/T11124",
"display_name": "Protein Aggregation and Biopharmaceutical Stability"
},
{
"id": "https://openalex.org/T13157",
"display_name": "Protein Arginine Methylation in Mammals"
},
{
"id": "https://openalex.org/T11908",
"display_name": "Protein Binding Specificity in Human Serum Albumin"
},
{
"id": "https://openalex.org/T12867",
"display_name": "Protein Microarray Technology and Applications"
},
{
"id": "https://openalex.org/T10044",
"display_name": "Protein Structure Prediction and Analysis"
},
{
"id": "https://openalex.org/T13187",
"display_name": "Protein-DNA Interaction Dynamics in Living Cells"
},
{
"id": "https://openalex.org/T12756",
"display_name": "Pyrrolizidine Alkaloids: Toxicity, Metabolism, and Health Implications"
},
{
"id": "https://openalex.org/T11970",
"display_name": "Real-Time Polymerase Chain Reaction"
},
{
"id": "https://openalex.org/T11663",
"display_name": "Recombinant Protein Production in Mammalian and Insect Cells"
},
{
"id": "https://openalex.org/T11884",
"display_name": "Redox Signaling and Oxidative Stress"
},
{
"id": "https://openalex.org/T12835",
"display_name": "Regulation and Functions of FoxO Transcription Factors"
},
{
"id": "https://openalex.org/T10222",
"display_name": "Regulation of Chromatin Structure and Function"
},
{
"id": "https://openalex.org/T10604",
"display_name": "Regulation of RNA Processing and Function"
},
{
"id": "https://openalex.org/T13651",
"display_name": "Research on Rhodiola rosea and Salidroside"
},
{
"id": "https://openalex.org/T14065",
"display_name": "Research on Synthetic Phosphoethanolamine and its Effects"
},
{
"id": "https://openalex.org/T10521",
"display_name": "Ribosome Structure and Translation Mechanisms"
},
{
"id": "https://openalex.org/T11482",
"display_name": "RNA Methylation and Modification in Gene Expression"
},
{
"id": "https://openalex.org/T10015",
"display_name": "RNA Sequencing Data Analysis"
},
{
"id": "https://openalex.org/T11339",
"display_name": "Role of AMP-Activated Protein Kinase in Cellular Metabolism"
},
{
"id": "https://openalex.org/T12412",
"display_name": "Role of Carbonic Anhydrases in Medicine and Biotechnology"
},
{
"id": "https://openalex.org/T13223",
"display_name": "Role of CCN Proteins in Signaling Pathways"
},
{
"id": "https://openalex.org/T12187",
"display_name": "Role of Glutathione in Oxidative Stress Response"
},
{
"id": "https://openalex.org/T11736",
"display_name": "Role of Histone Deacetylases in Cellular Regulation"
},
{
"id": "https://openalex.org/T11332",
"display_name": "Role of Nrf2 Signaling in Oxidative Stress Response"
},
{
"id": "https://openalex.org/T11559",
"display_name": "Role of Retinoic Acid in Biological Processes"
},
{
"id": "https://openalex.org/T13047",
"display_name": "Role of Sigma Receptors in Cellular Signaling"
},
{
"id": "https://openalex.org/T13426",
"display_name": "Role of Transcription Factors in Cell Regulation"
},
{
"id": "https://openalex.org/T12030",
"display_name": "S100 Proteins: Structure, Function, and Pathology"
},
{
"id": "https://openalex.org/T11308",
"display_name": "Sphingolipid Signalling and Metabolism in Health and Disease"
},
{
"id": "https://openalex.org/T10621",
"display_name": "Stochasticity in Gene Regulatory Networks"
},
{
"id": "https://openalex.org/T11178",
"display_name": "Structure and Function of G Protein-Coupled Receptors"
},
{
"id": "https://openalex.org/T11480",
"display_name": "Structure and Function of Gap Junctions and Connexins"
},
{
"id": "https://openalex.org/T11818",
"display_name": "Structure and Function of Nicotinic Receptors"
},
{
"id": "https://openalex.org/T11841",
"display_name": "Structure and Function of the Nuclear Pore Complex"
},
{
"id": "https://openalex.org/T12534",
"display_name": "Targeted Protein Degradation in Biomedical Research"
},
{
"id": "https://openalex.org/T11501",
"display_name": "Transforming Growth Factor Beta Signaling Pathway"
},
{
"id": "https://openalex.org/T11041",
"display_name": "Ubiquitin-Proteasome Proteolytic Pathway"
},
{
"id": "https://openalex.org/T10929",
"display_name": "Wnt Signaling in Development and Disease"
}
],
"works_count": 23715,
"cited_by_count": 603055,
"updated_date": "2024-08-26T06:13:44.403399",
"created_date": "2024-01-23"
}
}
