Item talk:Q269481
From geokb
{
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"name": "Plants as vectors for environmental prion transmission",
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"abstract": "Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In\u00a0chronic wasting disease\u00a0of deer, elk, moose, and reindeer and in\u00a0scrapie\u00a0of sheep and goats, prions are transmitted via environmental routes and the ability of plants to accumulate and subsequently transmit prions has been hypothesized, but not previously demonstrated. Here, we establish the ability of several crop and other\u00a0plant species\u00a0to take up prions via their roots and translocate them to above-ground tissues from various growth media including soils. We demonstrate that plants can accumulate prions in above-ground tissues to levels sufficient to transmit disease after oral\u00a0ingestion\u00a0by mice. Our results suggest plants may serve as vectors for prion transmission in the environment\u2014a finding with implications for wildlife conservation, agriculture, and public health.",
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