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OpenAlex: !!python/object/new:pyalex.api.Topic
{
   dictitems:
  "id": "https://openalex.org/T10755",
    cited_by_count: 1047617
   "display_name": "HER2 Signaling in Breast Cancer Treatment",
    created_date: '2024-01-23'
  "description": "This cluster of papers focuses on the use of HER2-targeted therapies, such as trastuzumab and pertuzumab, in the treatment of HER2-positive breast cancer. It explores the mechanisms of action, resistance, and combination therapies involving chemotherapy and monoclonal antibodies. The cluster also delves into the role of EGFR, neuregulin 1, and ADAM metalloproteinases in HER2 signaling and breast cancer progression.",
    description: This cluster of papers focuses on the use of HER2-targeted therapies,
  "keywords": [
      such as trastuzumab and pertuzumab, in the treatment of HER2-positive breast
     "HER2",
      cancer. It explores the mechanisms of action, resistance, and combination therapies
    "breast cancer",
      involving chemotherapy and monoclonal antibodies. The cluster also delves into
    "trastuzumab",
      the role of EGFR, neuregulin 1, and ADAM metalloproteinases in HER2 signaling
    "EGFR",
      and breast cancer progression.
    "monoclonal antibody",
     display_name: HER2 Signaling in Breast Cancer Treatment
    "chemotherapy",
     domain:
    "metastatic",
      display_name: Health Sciences
    "receptor tyrosine kinases",
      id: https://openalex.org/domains/4
    "neuregulin 1",
     field:
     "ADAM metalloproteinases"
      display_name: Medicine
  ],
      id: https://openalex.org/fields/27
  "ids": {
     id: https://openalex.org/T10755
    "openalex": "https://openalex.org/T10755",
     ids:
     "wikipedia": "https://en.wikipedia.org/wiki/HER2"
      openalex: https://openalex.org/T10755
  },
      wikipedia: https://en.wikipedia.org/wiki/HER2
  "subfield": {
     keywords:
     "id": "https://openalex.org/subfields/2730",
    - HER2
     "display_name": "Oncology"
    - breast cancer
  },
     - trastuzumab
  "field": {
    - EGFR
    "id": "https://openalex.org/fields/27",
    - monoclonal antibody
    "display_name": "Medicine"
    - chemotherapy
  },
    - metastatic
  "domain": {
    - receptor tyrosine kinases
    "id": "https://openalex.org/domains/4",
    - neuregulin 1
     "display_name": "Health Sciences"
    - ADAM metalloproteinases
  },
    siblings:
  "siblings": [
    - display_name: Advancements in Colorectal Cancer Research
     {
       id: https://openalex.org/T11067
      "id": "https://openalex.org/T11067",
    - display_name: Bisphosphonates in Cancer Treatment and Bone Health
      "display_name": "Advancements in Colorectal Cancer Research"
       id: https://openalex.org/T11221
    },
    - display_name: Cancer Chemopreventive Properties of Saffron
    {
       id: https://openalex.org/T12758
       "id": "https://openalex.org/T11221",
    - display_name: Cancer Immunotherapy
      "display_name": "Bisphosphonates in Cancer Treatment and Bone Health"
       id: https://openalex.org/T10158
    },
    - display_name: Cancer of Unknown Primary Site
    {
       id: https://openalex.org/T12379
       "id": "https://openalex.org/T12758",
    - display_name: Cancer Stem Cells and Tumor Metastasis
      "display_name": "Cancer Chemopreventive Properties of Saffron"
       id: https://openalex.org/T10336
    },
    - display_name: Cancer Survivorship and Quality of Life
    {
       id: https://openalex.org/T10178
       "id": "https://openalex.org/T10158",
    - display_name: Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment
      "display_name": "Cancer Immunotherapy"
       id: https://openalex.org/T11752
    },
    - display_name: Chimeric Antigen Receptor T Cell Therapy
    {
       id: https://openalex.org/T11491
       "id": "https://openalex.org/T12379",
    - display_name: Colorectal Cancer Research and Treatment
      "display_name": "Cancer of Unknown Primary Site"
       id: https://openalex.org/T10335
    },
    - display_name: Global Cancer Incidence and Mortality Patterns
    {
       id: https://openalex.org/T10556
       "id": "https://openalex.org/T10336",
    - display_name: Global Trends in Colorectal Cancer Research
      "display_name": "Cancer Stem Cells and Tumor Metastasis"
       id: https://openalex.org/T10552
    },
    - display_name: Impact of COVID-19 on Cancer Patients and Care
    {
       id: https://openalex.org/T11296
       "id": "https://openalex.org/T10178",
    - display_name: Impact of Obesity on Cancer Risk and Prognosis
      "display_name": "Cancer Survivorship and Quality of Life"
       id: https://openalex.org/T12103
    },
    - display_name: Inflammation's Role in Cancer Development and Progression
    {
       id: https://openalex.org/T11355
       "id": "https://openalex.org/T11752",
    - display_name: Lymphangiogenesis in Cancer Metastasis and Disease
      "display_name": "Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment"
       id: https://openalex.org/T11469
    },
    - display_name: Management of Febrile Neutropenia in Cancer Patients
    {
       id: https://openalex.org/T12172
       "id": "https://openalex.org/T11491",
    - display_name: Mechanisms of Multidrug Resistance in Cancer
      "display_name": "Chimeric Antigen Receptor T Cell Therapy"
       id: https://openalex.org/T10570
    },
    - display_name: Melanoma
    {
       id: https://openalex.org/T10392
       "id": "https://openalex.org/T10335",
    - display_name: Nanotechnology in Cancer Treatment and Diagnosis
      "display_name": "Colorectal Cancer Research and Treatment"
       id: https://openalex.org/T13434
    },
    - display_name: Pancreatic Cancer Research and Treatment
    {
       id: https://openalex.org/T10231
       "id": "https://openalex.org/T10556",
    - display_name: Platinum-Based Cancer Chemotherapy
      "display_name": "Global Cancer Incidence and Mortality Patterns"
       id: https://openalex.org/T10163
    },
    - display_name: Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy
    {
       id: https://openalex.org/T11914
       "id": "https://openalex.org/T10552",
    - display_name: Polyomavirus-Associated Carcinogenesis and Clinical Manifestations
      "display_name": "Global Trends in Colorectal Cancer Research"
       id: https://openalex.org/T11827
    },
    - display_name: Role of Chemokine Receptors in Cancer Metastasis
    {
       id: https://openalex.org/T11532
       "id": "https://openalex.org/T11296",
    - display_name: Role of Clusterin in Cancer and Disease
      "display_name": "Impact of COVID-19 on Cancer Patients and Care"
       id: https://openalex.org/T14364
    },
    - display_name: Role of Fibroblast Activation in Cancer Progression
    {
       id: https://openalex.org/T12505
       "id": "https://openalex.org/T12103",
    - display_name: Role of STAT3 in Cancer Inflammation and Immunity
      "display_name": "Impact of Obesity on Cancer Risk and Prognosis"
       id: https://openalex.org/T11503
    },
    - display_name: Small Cell Lung Cancer
    {
       id: https://openalex.org/T12334
       "id": "https://openalex.org/T11355",
    - display_name: The p53 Signaling Network in Cancer Research
      "display_name": "Inflammation's Role in Cancer Development and Progression"
       id: https://openalex.org/T10583
    },
    - display_name: Tumors of the Ear and Temporal Bone
    {
       id: https://openalex.org/T14326
       "id": "https://openalex.org/T11469",
    - display_name: Vascular Tumors and Angiosarcoma
      "display_name": "Lymphangiogenesis in Cancer Metastasis and Disease"
       id: https://openalex.org/T12278
    },
    - display_name: Viral-Related Cancers in Immunocompromised Patients
    {
      id: https://openalex.org/T10685
       "id": "https://openalex.org/T12172",
    subfield:
      "display_name": "Management of Febrile Neutropenia in Cancer Patients"
      display_name: Oncology
    },
      id: https://openalex.org/subfields/2730
    {
    updated_date: '2024-05-20T05:17:25.106234'
       "id": "https://openalex.org/T10570",
    works_count: 43392
      "display_name": "Mechanisms of Multidrug Resistance in Cancer"
    },
    {
       "id": "https://openalex.org/T10392",
      "display_name": "Melanoma"
    },
    {
       "id": "https://openalex.org/T13434",
      "display_name": "Nanotechnology in Cancer Treatment and Diagnosis"
    },
    {
       "id": "https://openalex.org/T10231",
      "display_name": "Pancreatic Cancer Research and Treatment"
    },
    {
       "id": "https://openalex.org/T10163",
      "display_name": "Platinum-Based Cancer Chemotherapy"
    },
    {
       "id": "https://openalex.org/T11914",
      "display_name": "Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy"
    },
    {
       "id": "https://openalex.org/T11827",
      "display_name": "Polyomavirus-Associated Carcinogenesis and Clinical Manifestations"
    },
    {
       "id": "https://openalex.org/T11532",
      "display_name": "Role of Chemokine Receptors in Cancer Metastasis"
    },
    {
       "id": "https://openalex.org/T14364",
      "display_name": "Role of Clusterin in Cancer and Disease"
    },
    {
       "id": "https://openalex.org/T12505",
      "display_name": "Role of Fibroblast Activation in Cancer Progression"
    },
    {
       "id": "https://openalex.org/T11503",
      "display_name": "Role of STAT3 in Cancer Inflammation and Immunity"
    },
    {
       "id": "https://openalex.org/T12334",
      "display_name": "Small Cell Lung Cancer"
    },
    {
       "id": "https://openalex.org/T10583",
      "display_name": "The p53 Signaling Network in Cancer Research"
    },
    {
       "id": "https://openalex.org/T14326",
      "display_name": "Tumors of the Ear and Temporal Bone"
    },
    {
       "id": "https://openalex.org/T12278",
      "display_name": "Vascular Tumors and Angiosarcoma"
    },
    {
       "id": "https://openalex.org/T10685",
      "display_name": "Viral-Related Cancers in Immunocompromised Patients"
    }
  ],
  "works_count": 44057,
  "cited_by_count": 1179573,
  "updated_date": "2024-08-26T05:29:34.476970",
  "created_date": "2024-01-23"
}
Retrieved from "https://geokb.wikibase.cloud/wiki/Special:MobileDiff/1125458"