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The extended period of low Great Lakes water levels from 2000 to 2013 created conditions for large expansions of\u00a0Phragmites\u00a0in the Great Lakes coastal zone. The following extended period of high water in the Great Lakes during late 2010\u2019s, culminating in record high lake levels in 2020 allowed managers to take advantage of high water by using a cut-to-drown management strategy (i.e., cutting plants below the water surface to stop the flow of atmospheric gases) to control\u00a0Phragmites\u00a0populations. To examine the efficacy of a cut-to-drown control strategy, we conducted a controlled-greenhouse study that tested the effect of submergence and timing of cutting (early or late in growing season) on\u00a0Phragmites\u00a0growth and viability post treatment. To evaluate\u00a0Phragmites\u00a0growth and viability, we measured belowground biomass, rhizome non-structural carbohydrate content (NSC), and rhizome viability following a cut-to-drown treatment. Applying a cut-to-drown treatment reduced average belowground biomass production up to 99%, limited rhizome NSC content up to 83%, and inhibited rhizome viability, regardless of timing of cutting treatments. These results suggest that under high-water conditions, utilizing a cut-to-drown strategy has potential for being a useful control mechanism for\u00a0Phragmites. 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