{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Pathological and immunological responses associated with differential survival of Chinook salmon following Renibacterium salmoninarum challenge",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70043692",
"url": "https://pubs.usgs.gov/publication/70043692"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70043692
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3354/dao02214",
"url": "https://doi.org/10.3354/dao02214"
}
],
"journal": {
"@type": "Periodical",
"name": "Diseases of Aquatic Organisms",
"volumeNumber": "90",
"issueNumber": "1"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Diseases of Aquatic Organisms"
}
],
"datePublished": "2010",
"dateModified": "2016-11-04",
"abstract": "Chinook salmon Oncorhynchus tshawytscha are highly susceptible to Renibacterium salmoninarum, the causative agent of bacterial kidney disease (BKD). Previously we demonstrated that introduced Chinook salmon from Lake Michigan, Wisconsin (WI), USA, have higher survival following R. salmoninarum challenge relative to the progenitor stock from Green River, Washington, USA. In the present study, we investigated the pathological and immunological responses that are associated with differential survival in the 2 Chinook salmon stocks following intra-peritoneal R. salmoninarum challenge of 2 different cohort years (2003 and 2005). Histological evaluation revealed delayed appearance of severe granulomatous lesions in the kidney and lower overall prevalence of membranous glomerulopathy in the higher surviving WI stock. The higher survival WI stock had a lower bacterial load at 28 d post-infection, as measured by reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR). However, at all other time points, bacterial load levels were similar despite higher mortality in the more susceptible Green River stock, suggesting the possibility that the stocks may differ in their tolerance to infection by the bacterium. Interferon-\u03b3, inducible nitric oxide synthase (iNOS), Mx-1, and transferrin gene expression were up-regulated in both stocks following challenge. A trend of higher iNOS gene expression at later time points (\u226528 d post-infection) was observed in the lower surviving Green River stock, suggesting the possibility that higher iNOS expression may contribute to greater pathology in that stock.",
"description": "11 p.",
"publisher": {
"@type": "Organization",
"name": "Inter-Research Science Center"
},
"author": [
{
"@type": "Person",
"name": "Elliott, Diane G. dgelliott@usgs.gov",
"givenName": "Diane G.",
"familyName": "Elliott",
"email": "dgelliott@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0002-4809-6692",
"url": "https://orcid.org/0000-0002-4809-6692"
},
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Purcell, Maureen K. mpurcell@usgs.gov",
"givenName": "Maureen K.",
"familyName": "Purcell",
"email": "mpurcell@usgs.gov",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Park, Linda K.",
"givenName": "Linda K.",
"familyName": "Park"
},
{
"@type": "Person",
"name": "Wargo, Andrew",
"givenName": "Andrew",
"familyName": "Wargo"
},
{
"@type": "Person",
"name": "Metzger, David C.",
"givenName": "David C.",
"familyName": "Metzger"
}
],
"funder": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
],
"spatialCoverage": [
{
"@type": "Place",
"additionalType": "country",
"name": "United States",
"url": "https://geonames.org/4074035"
},
{
"@type": "Place",
"additionalType": "state",
"name": "Michigan"
},
{
"@type": "Place",
"additionalType": "unknown",
"name": "Green River",
"url": "https://geonames.org/4239819"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"DAO": [
0,
24,
407
],
"Diseases": [
1
],
"of": [
2,
38,
91,
94,
120,
183,
196,
207,
296,
382
],
"Aquatic": [
3
],
"Organisms": [
4
],
"Contact": [
5
],
"the": [
6,
22,
117,
147,
156,
161,
173,
201,
211,
254,
261,
264,
274,
311,
318
],
"journal": [
7
],
"Facebook": [
8,
398
],
"Twitter": [
9
],
"RSS": [
10,
396
],
"Mailing": [
11
],
"List": [
12
],
"Subscribe": [
13
],
"to": [
14,
114,
146,
271,
326
],
"our": [
15
],
"mailing": [
16
],
"list": [
17
],
"via": [
18
],
"Mailchimp": [
19
],
"HomeLatest": [
20
],
"VolumeAbout": [
21
],
"JournalEditorsSpecials": [
23
],
"90:31-41": [
25
],
"(2010)": [
26,
373
],
"-": [
27,
397,
399,
401
],
"DOI:": [
28
],
"https://doi.org/10.3354/dao02214": [
29,
393
],
"Pathological": [
30,
374
],
"and": [
31,
163,
189,
203,
283,
375
],
"immunological": [
32,
164,
376
],
"responses": [
33,
165,
377
],
"associated": [
34,
168,
378
],
"with": [
35,
169,
379
],
"differential": [
36,
170,
380
],
"survival": [
37,
140,
171,
218,
381
],
"Chinook": [
39,
107,
130,
175,
383
],
"salmon": [
40,
108,
131,
176,
384
],
"following": [
41,
141,
178,
292,
385
],
"Renibacterium": [
42,
115,
386
],
"salmoninarum": [
43,
143,
181,
387
],
"challenge": [
44,
144,
182
],
"David": [
45
],
"C.": [
46
],
"Metzger1,2,": [
47
],
"Diane": [
48
],
"G.": [
49
],
"Elliott1,": [
50
],
"Andrew": [
51
],
"Wargo3,": [
52
],
"Linda": [
53
],
"K.": [
54,
57
],
"Park2,": [
55
],
"Maureen": [
56
],
"Purcell1,*": [
58
],
"1Western": [
59
],
"Fisheries": [
60,
75,
80
],
"Research": [
61
],
"Center,": [
62,
77
],
"US": [
63
],
"Geological": [
64
],
"Survey,": [
65
],
"6505": [
66
],
"NE": [
67
],
"65th": [
68
],
"Street,": [
69
],
"Seattle,": [
70,
86,
98
],
"Washington": [
71,
87,
99
],
"98115,": [
72
],
"USA": [
73,
89,
101
],
"2Northwest": [
74
],
"Science": [
76
],
"National": [
78
],
"Marine": [
79
],
"Service,": [
81
],
"2725": [
82
],
"Montlake": [
83
],
"Boulevard": [
84
],
"East,": [
85
],
"98112,": [
88
],
"3Department": [
90
],
"Biology,": [
92
],
"University": [
93
],
"Washington,": [
95,
153
],
"Box": [
96
],
"351800,": [
97
],
"98195,": [
100
],
"*Corresponding": [
102
],
"author.": [
103
],
"Email:": [
104
],
"mpurcell@usgs.gov": [
105
],
"ABSTRACT:": [
106
],
"Oncorhynchus": [
109
],
"tshawytscha": [
110
],
"are": [
111,
167
],
"highly": [
112
],
"susceptible": [
113,
256
],
"salmoninarum,": [
116
],
"causative": [
118
],
"agent": [
119
],
"bacterial": [
121,
224,
245
],
"kidney": [
122,
202,
335
],
"disease": [
123,
336
],
"(BKD).": [
124
],
"Previously": [
125
],
"we": [
126,
159
],
"demonstrated": [
127
],
"that": [
128,
166,
263,
320,
330
],
"introduced": [
129
],
"from": [
132,
150
],
"Lake": [
133
],
"Michigan,": [
134
],
"Wisconsin": [
135
],
"(WI),": [
136
],
"USA,": [
137
],
"have": [
138
],
"higher": [
139,
212,
217,
251,
297,
321
],
"R.": [
142,
180
],
"relative": [
145
],
"progenitor": [
148
],
"stock": [
149,
220
],
"Green": [
151,
257,
314
],
"River,": [
152
],
"USA.": [
154
],
"In": [
155
],
"present": [
157
],
"study,": [
158
],
"investigated": [
160
],
"pathological": [
162
],
"in": [
172,
200,
210,
253,
268,
289,
310,
329,
356,
406
],
"2": [
174,
184
],
"stocks": [
177,
265,
291
],
"intra-peritoneal": [
179
],
"different": [
185
],
"cohort": [
186
],
"years": [
187
],
"(2003": [
188
],
"2005).": [
190
],
"Histological": [
191
],
"evaluation": [
192
],
"revealed": [
193
],
"delayed": [
194
],
"appearance": [
195
],
"severe": [
197
],
"granulomatous": [
198
],
"lesions": [
199
],
"lower": [
204,
223,
312
],
"overall": [
205
],
"prevalence": [
206
],
"membranous": [
208
],
"glomerulopathy": [
209
],
"surviving": [
213,
313
],
"WI": [
214,
219
],
"stock.": [
215,
331
],
"The": [
216
],
"had": [
221
],
"a": [
222
],
"load": [
225,
246
],
"at": [
226,
240,
301
],
"28": [
227
],
"d": [
228,
306
],
"post-infection,": [
229
],
"as": [
230
],
"measured": [
231
],
"by": [
232,
273,
404
],
"reverse-transcriptase": [
233
],
"quantitative": [
234,
343
],
"polymerase": [
235
],
"chain": [
236
],
"reaction": [
237
],
"(RT-qPCR).": [
238
],
"However,": [
239
],
"all": [
241
],
"other": [
242
],
"time": [
243,
303
],
"points,": [
244
],
"levels": [
247
],
"were": [
248,
287
],
"similar": [
249
],
"despite": [
250
],
"mortality": [
252
],
"more": [
255
],
"River": [
258,
315
],
"stock,": [
259,
316
],
"suggesting": [
260,
317
],
"possibility": [
262,
319
],
"may": [
266,
324
],
"differ": [
267
],
"their": [
269
],
"tolerance": [
270
],
"infection": [
272
],
"bacterium.": [
275
],
"Interferon-\u03b3,": [
276
],
"inducible": [
277
],
"nitric": [
278
],
"oxide": [
279
],
"synthase": [
280
],
"(iNOS),": [
281
],
"Mx-1,": [
282
],
"transferrin": [
284
],
"gene": [
285,
299
],
"expression": [
286,
300,
323
],
"up-regulated": [
288
],
"both": [
290
],
"challenge.": [
293,
388
],
"A": [
294
],
"trend": [
295
],
"iNOS": [
298,
322
],
"later": [
302
],
"points": [
304
],
"(\u226528": [
305
],
"post-infection)": [
307
],
"was": [
308
],
"observed": [
309
],
"contribute": [
325
],
"greater": [
327
],
"pathology": [
328,
349
],
"KEY": [
332
],
"WORDS:": [
333
],
"Bacterial": [
334
],
"\u00b7": [
337,
339,
341,
345,
347,
350,
352
],
"BKD": [
338
],
"Histopathology": [
340
],
"Reverse-transcriptase": [
342
],
"PCR": [
344
],
"Interferon": [
346
],
"Immune-mediated": [
348
],
"Resistance": [
351
],
"Tolerance": [
353
],
"Full": [
354
],
"text": [
355
],
"pdf": [
357
],
"format": [
358
],
"PreviousNextCite": [
359
],
"this": [
360
],
"article": [
361
],
"as:": [
362
],
"Metzger": [
363
],
"DC,": [
364
],
"Elliott": [
365
],
"DG,": [
366
],
"Wargo": [
367
],
"A,": [
368
],
"Park": [
369
],
"LK,": [
370
],
"Purcell": [
371
],
"MK": [
372
],
"Dis": [
389
],
"Aquat": [
390
],
"Org": [
391
],
"90:31-41.": [
392
],
"Export": [
394
],
"citation": [
395
],
"Tweet": [
400
],
"linkedIn": [
402
],
"Cited": [
403
],
"Published": [
405
],
"Vol.": [
408
],
"90,": [
409
],
"No.": [
410
],
"1.": [
411
],
"Online": [
412,
421
],
"publication": [
413
],
"date:": [
414
],
"May": [
415
],
"18,": [
416
],
"2010": [
417,
426
],
"Print": [
418
],
"ISSN:": [
419,
422
],
"0177-5103;": [
420
],
"1616-1580": [
423
],
"Copyright": [
424
],
"\u00a9": [
425
],
"Inter-Research.": [
427
]
},
"apc_list": null,
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5097639276",
"display_name": "DC Metzger",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I4210166920",
"display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
"ror": "https://ror.org/05r7z1k40",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065",
"https://openalex.org/I4210166920"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
},
{
"id": "https://openalex.org/I106745318",
"display_name": "NOAA National Marine Fisheries Service",
"ror": "https://ror.org/033mqx355",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "DC Metzger",
"raw_affiliation_strings": [
"Northwest Fisheries Science Center, National Marine Fisheries Service, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA",
"Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Northwest Fisheries Science Center, National Marine Fisheries Service, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA",
"institution_ids": [
"https://openalex.org/I4210166920",
"https://openalex.org/I106745318"
]
},
{
"raw_affiliation_string": "Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5077168798",
"display_name": "D.C. Elliott",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "DG Elliott",
"raw_affiliation_strings": [
"Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5055387148",
"display_name": "Andrew Wargo",
"orcid": "https://orcid.org/0000-0002-9209-3077"
},
"institutions": [
{
"id": "https://openalex.org/I201448701",
"display_name": "University of Washington",
"ror": "https://ror.org/00cvxb145",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I201448701"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "A Wargo",
"raw_affiliation_strings": [
"Department of Biology, University of Washington, Box 351800, Seattle, Washington 98195, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, University of Washington, Box 351800, Seattle, Washington 98195, USA",
"institution_ids": [
"https://openalex.org/I201448701"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5059553983",
"display_name": "L.K. Park",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I106745318",
"display_name": "NOAA National Marine Fisheries Service",
"ror": "https://ror.org/033mqx355",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065"
]
},
{
"id": "https://openalex.org/I4210166920",
"display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
"ror": "https://ror.org/05r7z1k40",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065",
"https://openalex.org/I4210166920"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "LK Park",
"raw_affiliation_strings": [
"Northwest Fisheries Science Center, National Marine Fisheries Service, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Northwest Fisheries Science Center, National Marine Fisheries Service, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA",
"institution_ids": [
"https://openalex.org/I106745318",
"https://openalex.org/I4210166920"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5065071885",
"display_name": "Maureen K. Purcell",
"orcid": "https://orcid.org/0000-0003-0154-8433"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": true,
"raw_author_name": "MK Purcell",
"raw_affiliation_strings": [
"Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Western Fisheries Research Center, US Geological Survey, 6505 NE 65th Street, Seattle, Washington 98115, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
}
],
"best_oa_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.3354/dao02214",
"pdf_url": "https://www.int-res.com/articles/dao2010/90/d090p031.pdf",
"source": {
"id": "https://openalex.org/S49731288",
"display_name": "Diseases of Aquatic Organisms",
"issn_l": "0177-5103",
"issn": [
"0177-5103",
"1616-1580"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310313773",
"host_organization_name": "Inter-Research",
"host_organization_lineage": [
"https://openalex.org/P4310313773"
],
"host_organization_lineage_names": [
"Inter-Research"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"biblio": {
"volume": "90",
"issue": "1",
"first_page": "31",
"last_page": "41"
},
"citation_normalized_percentile": {
"value": 0.789575,
"is_in_top_1_percent": false,
"is_in_top_10_percent": false
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2031064841",
"cited_by_count": 22,
"cited_by_percentile_year": {
"min": 90,
"max": 91
},
"concepts": [
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.7462847
},
{
"id": "https://openalex.org/C100398564",
"wikidata": "https://www.wikidata.org/wiki/Q898845",
"display_name": "Chinook wind",
"level": 4,
"score": 0.60316443
},
{
"id": "https://openalex.org/C2779140988",
"wikidata": "https://www.wikidata.org/wiki/Q133325",
"display_name": "Oncorhynchus",
"level": 3,
"score": 0.5713813
},
{
"id": "https://openalex.org/C505870484",
"wikidata": "https://www.wikidata.org/wiki/Q180538",
"display_name": "Fishery",
"level": 1,
"score": 0.39383936
},
{
"id": "https://openalex.org/C2909208804",
"wikidata": "https://www.wikidata.org/wiki/Q127282",
"display_name": "Fish <Actinopterygii>",
"level": 2,
"score": 0.20874557
}
],
"corresponding_author_ids": [
"https://openalex.org/A5065071885"
],
"corresponding_institution_ids": [
"https://openalex.org/I1286329397"
],
"countries_distinct_count": 1,
"counts_by_year": [
{
"year": 2022,
"cited_by_count": 1
},
{
"year": 2021,
"cited_by_count": 1
},
{
"year": 2020,
"cited_by_count": 5
},
{
"year": 2019,
"cited_by_count": 2
},
{
"year": 2017,
"cited_by_count": 2
},
{
"year": 2016,
"cited_by_count": 1
},
{
"year": 2015,
"cited_by_count": 4
},
{
"year": 2014,
"cited_by_count": 3
},
{
"year": 2013,
"cited_by_count": 1
},
{
"year": 2012,
"cited_by_count": 1
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Pathological and immunological responses associated with differential survival of Chinook salmon following Renibacterium salmoninarum challenge",
"doi": "https://doi.org/10.3354/dao02214",
"fulltext_origin": "ngrams",
"fwci": 0.423,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W2031064841",
"ids": {
"openalex": "https://openalex.org/W2031064841",
"doi": "https://doi.org/10.3354/dao02214",
"mag": "2031064841",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/20597428"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 4,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/chinook-wind",
"display_name": "Chinook wind",
"score": 0.60316443
},
{
"id": "https://openalex.org/keywords/fish-immunology",
"display_name": "Fish Immunology",
"score": 0.577249
},
{
"id": "https://openalex.org/keywords/fisheries-sustainability",
"display_name": "Fisheries Sustainability",
"score": 0.508969
}
],
"language": "en",
"locations": [
{
"is_oa": true,
"landing_page_url": "https://doi.org/10.3354/dao02214",
"pdf_url": "https://www.int-res.com/articles/dao2010/90/d090p031.pdf",
"source": {
"id": "https://openalex.org/S49731288",
"display_name": "Diseases of Aquatic Organisms",
"issn_l": "0177-5103",
"issn": [
"0177-5103",
"1616-1580"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310313773",
"host_organization_name": "Inter-Research",
"host_organization_lineage": [
"https://openalex.org/P4310313773"
],
"host_organization_lineage_names": [
"Inter-Research"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/20597428",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 2,
"mesh": [
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000382",
"qualifier_name": "microbiology",
"is_major_topic": true
},
{
"descriptor_ui": "D006094",
"descriptor_name": "Gram-Positive Bacteria",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": true
},
{
"descriptor_ui": "D016908",
"descriptor_name": "Gram-Positive Bacterial Infections",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": true
},
{
"descriptor_ui": "D012474",
"descriptor_name": "Salmon",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000473",
"qualifier_name": "pathology",
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005786",
"descriptor_name": "Gene Expression Regulation",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D005786",
"descriptor_name": "Gene Expression Regulation",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D006094",
"descriptor_name": "Gram-Positive Bacteria",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D016908",
"descriptor_name": "Gram-Positive Bacterial Infections",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D016908",
"descriptor_name": "Gram-Positive Bacterial Infections",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D016908",
"descriptor_name": "Gram-Positive Bacterial Infections",
"qualifier_ui": "Q000473",
"qualifier_name": "pathology",
"is_major_topic": false
},
{
"descriptor_ui": "D007674",
"descriptor_name": "Kidney Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D007674",
"descriptor_name": "Kidney Diseases",
"qualifier_ui": "Q000382",
"qualifier_name": "microbiology",
"is_major_topic": false
},
{
"descriptor_ui": "D007674",
"descriptor_name": "Kidney Diseases",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D008107",
"descriptor_name": "Liver Diseases",
"qualifier_ui": "Q000382",
"qualifier_name": "microbiology",
"is_major_topic": false
},
{
"descriptor_ui": "D008107",
"descriptor_name": "Liver Diseases",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D008107",
"descriptor_name": "Liver Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D010182",
"descriptor_name": "Pancreatic Diseases",
"qualifier_ui": "Q000382",
"qualifier_name": "microbiology",
"is_major_topic": false
},
{
"descriptor_ui": "D010182",
"descriptor_name": "Pancreatic Diseases",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D010182",
"descriptor_name": "Pancreatic Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013158",
"descriptor_name": "Splenic Diseases",
"qualifier_ui": "Q000382",
"qualifier_name": "microbiology",
"is_major_topic": false
},
{
"descriptor_ui": "D013158",
"descriptor_name": "Splenic Diseases",
"qualifier_ui": "Q000662",
"qualifier_name": "veterinary",
"is_major_topic": false
},
{
"descriptor_ui": "D013158",
"descriptor_name": "Splenic Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2031064841/ngrams",
"open_access": {
"is_oa": true,
"oa_status": "bronze",
"oa_url": "https://www.int-res.com/articles/dao2010/90/d090p031.pdf",
"any_repository_has_fulltext": false
},
"primary_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.3354/dao02214",
"pdf_url": "https://www.int-res.com/articles/dao2010/90/d090p031.pdf",
"source": {
"id": "https://openalex.org/S49731288",
"display_name": "Diseases of Aquatic Organisms",
"issn_l": "0177-5103",
"issn": [
"0177-5103",
"1616-1580"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310313773",
"host_organization_name": "Inter-Research",
"host_organization_lineage": [
"https://openalex.org/P4310313773"
],
"host_organization_lineage_names": [
"Inter-Research"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"primary_topic": {
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9987,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2010-05-18",
"publication_year": 2010,
"referenced_works": [
"https://openalex.org/W1966108514",
"https://openalex.org/W1967747976",
"https://openalex.org/W1970822441",
"https://openalex.org/W1976330705",
"https://openalex.org/W1997939418",
"https://openalex.org/W2006984113",
"https://openalex.org/W2007142514",
"https://openalex.org/W2032908301",
"https://openalex.org/W2034462362",
"https://openalex.org/W2036596126",
"https://openalex.org/W2037325046",
"https://openalex.org/W2051149395",
"https://openalex.org/W2051471670",
"https://openalex.org/W2055621551",
"https://openalex.org/W2061794117",
"https://openalex.org/W2063838707",
"https://openalex.org/W2064964564",
"https://openalex.org/W2071315196",
"https://openalex.org/W2072703039",
"https://openalex.org/W2073586602",
"https://openalex.org/W2078978396",
"https://openalex.org/W2086153092",
"https://openalex.org/W2087437670",
"https://openalex.org/W2091535419",
"https://openalex.org/W2115637608",
"https://openalex.org/W2121073072",
"https://openalex.org/W2126909406",
"https://openalex.org/W2136779956",
"https://openalex.org/W2136992605",
"https://openalex.org/W2139535814",
"https://openalex.org/W2140915230",
"https://openalex.org/W2146345847",
"https://openalex.org/W2158342892",
"https://openalex.org/W2171502217",
"https://openalex.org/W2291099664",
"https://openalex.org/W2396787622",
"https://openalex.org/W2891683561"
],
"referenced_works_count": 37,
"related_works": [
"https://openalex.org/W4293232675",
"https://openalex.org/W2616089359",
"https://openalex.org/W2590808233",
"https://openalex.org/W2587658278",
"https://openalex.org/W2586746005",
"https://openalex.org/W2183291685",
"https://openalex.org/W2064584353",
"https://openalex.org/W1978424279",
"https://openalex.org/W1966910108",
"https://openalex.org/W1654350186"
],
"sustainable_development_goals": [
{
"score": 0.87,
"display_name": "Life below water",
"id": "https://metadata.un.org/sdg/14"
}
],
"title": "Pathological and immunological responses associated with differential survival of Chinook salmon following Renibacterium salmoninarum challenge",
"topics": [
{
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 0.9987,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T10302",
"display_name": "Importance and Conservation of Freshwater Biodiversity",
"score": 0.9968,
"subfield": {
"id": "https://openalex.org/subfields/2309",
"display_name": "Nature and Landscape Conservation"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
{
"id": "https://openalex.org/T13350",
"display_name": "Biology and Evolution of Myxozoan Parasites",
"score": 0.9803,
"subfield": {
"id": "https://openalex.org/subfields/1306",
"display_name": "Cancer Research"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-13T08:47:56.423470",
"versions": []
}
}