{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Induction of anti-viral genes during acute infection with Viral hemorrhagic septicemia virus (VHSV) genogroup IVa in Pacific herring (Clupea pallasii)",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70032666",
"url": "https://pubs.usgs.gov/publication/70032666"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70032666
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.fsi.2011.11.010",
"url": "https://doi.org/10.1016/j.fsi.2011.11.010"
},
{
"@type": "PropertyValue",
"propertyID": "ISSN",
"value": "10504648"
}
],
"journal": {
"@type": "Periodical",
"name": "Fish and Shellfish Immunology",
"volumeNumber": "32",
"issueNumber": "2"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "Fish and Shellfish Immunology"
}
],
"datePublished": "2012",
"dateModified": "2016-12-19",
"abstract": "Infection with the aquatic rhabdovirus\u00a0Viral hemorrhagic septicemia virus\u00a0(VHSV) genogroup IVa results in high mortality in Pacific herring (Clupea pallasii) and is hypothesized to be a potential limiting factor for herring recovery. To investigate anti-viral immunity in the Pacific herring, four immune response genes were identified: the myxovirus resistance (Clpa-Mx), a major histocompatibility complex IB (named\u00a0Clpa-UAA.001), the inducible immunoproteosome subunit 9 (Clpa-PSMB9) and the neutrophil chemotactic factor (Clpa-LECT2). Reverse transcriptase quantitative PCR (RT-qPCR) assays were developed based on these gene sequences to investigate the host immune response to acute VHSV infection following both injection and immersion challenge. Virus levels were measured by both plaque assay and RT-qPCR and peaked at day 6 during the 10-day exposure period for both groups of fish. The interferon stimulated genes (Clpa-Mx,\u00a0\u2212UAA.001, and\u00a0\u2212PSMB9) were significantly up-regulated in response to VHSV infection at both 6 and 10 days post-infection in both spleen and fin. Results from this study indicate that Pacific herring mount a robust, early antiviral response in both fin and spleen tissues. The immunological tools developed in this study will be useful for future studies to investigate antiviral immunity in Pacific herring.",
"description": "9 p.",
"publisher": {
"@type": "Organization",
"name": "Elsevier"
},
"author": [
{
"@type": "Person",
"name": "Woodson, James C. jwoodson@usgs.gov",
"givenName": "James C.",
"familyName": "Woodson",
"email": "jwoodson@usgs.gov"
},
{
"@type": "Person",
"name": "Hershberger, Paul K. phershberger@usgs.gov",
"givenName": "Paul K.",
"familyName": "Hershberger",
"email": "phershberger@usgs.gov",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Purcell, Maureen K. mpurcell@usgs.gov",
"givenName": "Maureen K.",
"familyName": "Purcell",
"email": "mpurcell@usgs.gov",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Gregg, Jacob L. jgregg@usgs.gov",
"givenName": "Jacob L.",
"familyName": "Gregg",
"email": "jgregg@usgs.gov",
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
{
"@type": "Person",
"name": "Grady, Courtney",
"givenName": "Courtney",
"familyName": "Grady"
},
{
"@type": "Person",
"name": "Hansen, John D. jhansen@usgs.gov",
"givenName": "John D.",
"familyName": "Hansen",
"email": "jhansen@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0002-3006-2734",
"url": "https://orcid.org/0000-0002-3006-2734"
},
"affiliation": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
}
],
"funder": [
{
"@type": "Organization",
"name": "Western Fisheries Research Center",
"url": "https://www.usgs.gov/centers/western-fisheries-research-center"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"Infection": [
0
],
"with": [
1
],
"the": [
2,
38,
47,
58,
65,
85,
115
],
"aquatic": [
3
],
"rhabdovirus": [
4
],
"Viral": [
5
],
"hemorrhagic": [
6
],
"septicemia": [
7
],
"virus": [
8
],
"(VHSV)": [
9
],
"genogroup": [
10
],
"IVa": [
11
],
"results": [
12
],
"in": [
13,
16,
37,
135,
147,
166,
176,
189
],
"high": [
14
],
"mortality": [
15
],
"Pacific": [
17,
39,
158,
190
],
"herring": [
18,
31,
159
],
"(Clupea": [
19
],
"pallasii)": [
20
],
"and": [
21,
64,
96,
107,
109,
130,
143,
150,
169
],
"is": [
22
],
"hypothesized": [
23
],
"to": [
24,
83,
89,
137,
185
],
"be": [
25,
180
],
"a": [
26,
51,
161
],
"potential": [
27
],
"limiting": [
28
],
"factor": [
29,
68
],
"for": [
30,
119,
182
],
"recovery.": [
32
],
"To": [
33
],
"investigate": [
34,
84,
186
],
"anti-viral": [
35
],
"immunity": [
36,
188
],
"herring,": [
40
],
"four": [
41
],
"immune": [
42,
87
],
"response": [
43,
88,
136,
165
],
"genes": [
44,
127
],
"were": [
45,
76,
101,
132
],
"identified:": [
46
],
"myxovirus": [
48
],
"resistance": [
49
],
"(Clpa-Mx),": [
50
],
"major": [
52
],
"histocompatibility": [
53
],
"complex": [
54
],
"IB": [
55
],
"(named": [
56
],
"Clpa-UAA.001),": [
57
],
"inducible": [
59
],
"immunoproteosome": [
60
],
"subunit": [
61
],
"9": [
62
],
"(Clpa-PSMB9)": [
63
],
"neutrophil": [
66
],
"chemotactic": [
67
],
"(Clpa-LECT2).": [
69
],
"Reverse": [
70
],
"transcriptase": [
71
],
"quantitative": [
72
],
"PCR": [
73
],
"(RT-qPCR)": [
74
],
"assays": [
75
],
"developed": [
77,
175
],
"based": [
78
],
"on": [
79
],
"these": [
80
],
"gene": [
81
],
"sequences": [
82
],
"host": [
86
],
"acute": [
90
],
"VHSV": [
91,
138
],
"infection": [
92,
139
],
"following": [
93
],
"both": [
94,
104,
120,
141,
148,
167
],
"injection": [
95
],
"immersion": [
97
],
"challenge.": [
98
],
"Virus": [
99
],
"levels": [
100
],
"measured": [
102
],
"by": [
103
],
"plaque": [
105
],
"assay": [
106
],
"RT-qPCR": [
108
],
"peaked": [
110
],
"at": [
111,
140
],
"day": [
112
],
"6": [
113,
142
],
"during": [
114
],
"10-day": [
116
],
"exposure": [
117
],
"period": [
118
],
"groups": [
121
],
"of": [
122
],
"fish.": [
123
],
"The": [
124,
172
],
"interferon": [
125
],
"stimulated": [
126
],
"(Clpa-Mx,": [
128
],
"\u2212UAA.001,": [
129
],
"\u2212PSMB9)": [
131
],
"significantly": [
133
],
"up-regulated": [
134
],
"10": [
144
],
"days": [
145
],
"post-infection": [
146
],
"spleen": [
149,
170
],
"fin.": [
151
],
"Results": [
152
],
"from": [
153
],
"this": [
154,
177
],
"study": [
155,
178
],
"indicate": [
156
],
"that": [
157
],
"mount": [
160
],
"robust,": [
162
],
"early": [
163
],
"antiviral": [
164,
187
],
"fin": [
168
],
"tissues.": [
171
],
"immunological": [
173
],
"tools": [
174
],
"will": [
179
],
"useful": [
181
],
"future": [
183
],
"studies": [
184
],
"herring.": [
191
]
},
"apc_list": {
"value": 4420,
"currency": "USD",
"value_usd": 4420,
"provenance": "doaj"
},
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5066824903",
"display_name": "John D. Hansen",
"orcid": "https://orcid.org/0000-0002-3006-2734"
},
"institutions": [
{
"id": "https://openalex.org/I4210166920",
"display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
"ror": "https://ror.org/05r7z1k40",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065",
"https://openalex.org/I4210166920"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "John D. Hansen",
"raw_affiliation_strings": [
"US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA",
"institution_ids": [
"https://openalex.org/I4210166920",
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5036689111",
"display_name": "James C. Woodson",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I4210166920",
"display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
"ror": "https://ror.org/05r7z1k40",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065",
"https://openalex.org/I4210166920"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "James C. Woodson",
"raw_affiliation_strings": [
"US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA",
"institution_ids": [
"https://openalex.org/I4210166920",
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5031210377",
"display_name": "Paul K. Hershberger",
"orcid": "https://orcid.org/0000-0002-2261-7760"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Paul K. Hershberger",
"raw_affiliation_strings": [
"US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5035963776",
"display_name": "Courtney Grady",
"orcid": "https://orcid.org/0000-0003-0244-9816"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Courtney Grady",
"raw_affiliation_strings": [
"US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5025348095",
"display_name": "Jacob L. Gregg",
"orcid": "https://orcid.org/0000-0001-5328-5482"
},
"institutions": [
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Jacob L. Gregg",
"raw_affiliation_strings": [
"US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Marrowstone Marine Field Station, 616 Marrowstone Point Road, Nordland, WA 98358, USA",
"institution_ids": [
"https://openalex.org/I1286329397"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5065071885",
"display_name": "Maureen K. Purcell",
"orcid": "https://orcid.org/0000-0003-0154-8433"
},
"institutions": [
{
"id": "https://openalex.org/I4210166920",
"display_name": "NOAA National Marine Fisheries Service Northwest Fisheries Science Center",
"ror": "https://ror.org/05r7z1k40",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I106745318",
"https://openalex.org/I1308126019",
"https://openalex.org/I1343035065",
"https://openalex.org/I4210166920"
]
},
{
"id": "https://openalex.org/I1286329397",
"display_name": "United States Geological Survey",
"ror": "https://ror.org/035a68863",
"country_code": "US",
"type": "government",
"lineage": [
"https://openalex.org/I1286329397",
"https://openalex.org/I1335927249"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Maureen K. Purcell",
"raw_affiliation_strings": [
"US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA"
],
"affiliations": [
{
"raw_affiliation_string": "US Geological Survey, Western Fisheries Research Center, 6505 NE 65th Street, Seattle, WA 98115, USA",
"institution_ids": [
"https://openalex.org/I4210166920",
"https://openalex.org/I1286329397"
]
}
]
}
],
"best_oa_location": null,
"biblio": {
"volume": "32",
"issue": "2",
"first_page": "259",
"last_page": "267"
},
"citation_normalized_percentile": {
"value": 0.71572,
"is_in_top_1_percent": false,
"is_in_top_10_percent": false
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2016390673",
"cited_by_count": 16,
"cited_by_percentile_year": {
"min": 88,
"max": 89
},
"concepts": [
{
"id": "https://openalex.org/C2911191659",
"wikidata": "https://www.wikidata.org/wiki/Q1510347",
"display_name": "Pacific herring",
"level": 5,
"score": 0.9632182
},
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.9141638
},
{
"id": "https://openalex.org/C159047783",
"wikidata": "https://www.wikidata.org/wiki/Q7215",
"display_name": "Virology",
"level": 1,
"score": 0.75882983
},
{
"id": "https://openalex.org/C2777997422",
"wikidata": "https://www.wikidata.org/wiki/Q209907",
"display_name": "Clupea",
"level": 4,
"score": 0.74109054
},
{
"id": "https://openalex.org/C2522874641",
"wikidata": "https://www.wikidata.org/wiki/Q808",
"display_name": "Virus",
"level": 2,
"score": 0.5932275
},
{
"id": "https://openalex.org/C2779341262",
"wikidata": "https://www.wikidata.org/wiki/Q182581",
"display_name": "Immunity",
"level": 3,
"score": 0.5445344
},
{
"id": "https://openalex.org/C8891405",
"wikidata": "https://www.wikidata.org/wiki/Q1059",
"display_name": "Immune system",
"level": 2,
"score": 0.534701
},
{
"id": "https://openalex.org/C2779290800",
"wikidata": "https://www.wikidata.org/wiki/Q3127419",
"display_name": "Herring",
"level": 3,
"score": 0.512476
},
{
"id": "https://openalex.org/C104317684",
"wikidata": "https://www.wikidata.org/wiki/Q7187",
"display_name": "Gene",
"level": 2,
"score": 0.43681255
},
{
"id": "https://openalex.org/C89423630",
"wikidata": "https://www.wikidata.org/wiki/Q7193",
"display_name": "Microbiology",
"level": 1,
"score": 0.3862223
},
{
"id": "https://openalex.org/C203014093",
"wikidata": "https://www.wikidata.org/wiki/Q101929",
"display_name": "Immunology",
"level": 1,
"score": 0.3211578
},
{
"id": "https://openalex.org/C505870484",
"wikidata": "https://www.wikidata.org/wiki/Q180538",
"display_name": "Fishery",
"level": 1,
"score": 0.08943251
},
{
"id": "https://openalex.org/C54355233",
"wikidata": "https://www.wikidata.org/wiki/Q7162",
"display_name": "Genetics",
"level": 1,
"score": 0.087732166
},
{
"id": "https://openalex.org/C2909208804",
"wikidata": "https://www.wikidata.org/wiki/Q127282",
"display_name": "Fish <Actinopterygii>",
"level": 2,
"score": 0.07547304
}
],
"corresponding_author_ids": [],
"corresponding_institution_ids": [],
"countries_distinct_count": 1,
"counts_by_year": [
{
"year": 2023,
"cited_by_count": 2
},
{
"year": 2021,
"cited_by_count": 1
},
{
"year": 2020,
"cited_by_count": 1
},
{
"year": 2017,
"cited_by_count": 2
},
{
"year": 2016,
"cited_by_count": 1
},
{
"year": 2014,
"cited_by_count": 2
},
{
"year": 2013,
"cited_by_count": 5
},
{
"year": 2012,
"cited_by_count": 2
}
],
"created_date": "2016-06-24",
"datasets": [],
"display_name": "Induction of anti-viral genes during acute infection with Viral hemorrhagic septicemia virus (VHSV) genogroup IVa in Pacific herring (Clupea pallasii)",
"doi": "https://doi.org/10.1016/j.fsi.2011.11.010",
"fulltext_origin": "ngrams",
"fwci": 1.296,
"grants": [],
"has_fulltext": true,
"id": "https://openalex.org/W2016390673",
"ids": {
"openalex": "https://openalex.org/W2016390673",
"doi": "https://doi.org/10.1016/j.fsi.2011.11.010",
"mag": "2016390673",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/22155011"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 2,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/pacific-herring",
"display_name": "Pacific herring",
"score": 0.9632182
},
{
"id": "https://openalex.org/keywords/fish-immunology",
"display_name": "Fish Immunology",
"score": 0.510699
}
],
"language": "en",
"locations": [
{
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.fsi.2011.11.010",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S185787987",
"display_name": "Fish & Shellfish Immunology",
"issn_l": "1050-4648",
"issn": [
"1050-4648",
"1095-9947"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/22155011",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 2,
"mesh": [
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D005786",
"descriptor_name": "Gene Expression Regulation",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D031941",
"descriptor_name": "Hemorrhagic Septicemia, Viral",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": true
},
{
"descriptor_ui": "D058500",
"descriptor_name": "Animal Fins",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D058500",
"descriptor_name": "Animal Fins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000821",
"qualifier_name": "virology",
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "Q000401",
"qualifier_name": "mortality",
"is_major_topic": false
},
{
"descriptor_ui": "D005393",
"descriptor_name": "Fish Diseases",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005399",
"descriptor_name": "Fishes",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020869",
"descriptor_name": "Gene Expression Profiling",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D031941",
"descriptor_name": "Hemorrhagic Septicemia, Viral",
"qualifier_ui": "Q000821",
"qualifier_name": "virology",
"is_major_topic": false
},
{
"descriptor_ui": "D031941",
"descriptor_name": "Hemorrhagic Septicemia, Viral",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D029141",
"descriptor_name": "Novirhabdovirus",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D029141",
"descriptor_name": "Novirhabdovirus",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D013154",
"descriptor_name": "Spleen",
"qualifier_ui": "Q000276",
"qualifier_name": "immunology",
"is_major_topic": false
},
{
"descriptor_ui": "D013154",
"descriptor_name": "Spleen",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D019562",
"descriptor_name": "Viral Load",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2016390673/ngrams",
"open_access": {
"is_oa": false,
"oa_status": "closed",
"oa_url": null,
"any_repository_has_fulltext": false
},
"primary_location": {
"is_oa": false,
"landing_page_url": "https://doi.org/10.1016/j.fsi.2011.11.010",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S185787987",
"display_name": "Fish & Shellfish Immunology",
"issn_l": "1050-4648",
"issn": [
"1050-4648",
"1095-9947"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310320990",
"host_organization_name": "Elsevier BV",
"host_organization_lineage": [
"https://openalex.org/P4310320990"
],
"host_organization_lineage_names": [
"Elsevier BV"
],
"type": "journal"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
},
"primary_topic": {
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 1.0,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
"publication_date": "2012-02-01",
"publication_year": 2012,
"referenced_works": [
"https://openalex.org/W1161899150",
"https://openalex.org/W1490200235",
"https://openalex.org/W1903612480",
"https://openalex.org/W1964480909",
"https://openalex.org/W1969727001",
"https://openalex.org/W1974244733",
"https://openalex.org/W1977555346",
"https://openalex.org/W1983779089",
"https://openalex.org/W1985050849",
"https://openalex.org/W1986738097",
"https://openalex.org/W1989370133",
"https://openalex.org/W1994052050",
"https://openalex.org/W1997939418",
"https://openalex.org/W2002954007",
"https://openalex.org/W2003818382",
"https://openalex.org/W2007474216",
"https://openalex.org/W2007735128",
"https://openalex.org/W2010055142",
"https://openalex.org/W2011903133",
"https://openalex.org/W2013206554",
"https://openalex.org/W2016039354",
"https://openalex.org/W2016996110",
"https://openalex.org/W2020101005",
"https://openalex.org/W2022862669",
"https://openalex.org/W2027971649",
"https://openalex.org/W2028570104",
"https://openalex.org/W2031758569",
"https://openalex.org/W2036032710",
"https://openalex.org/W2040265849",
"https://openalex.org/W2041842205",
"https://openalex.org/W2041868142",
"https://openalex.org/W2043697415",
"https://openalex.org/W2048872121",
"https://openalex.org/W2053220296",
"https://openalex.org/W2053896857",
"https://openalex.org/W2057618376",
"https://openalex.org/W2060660052",
"https://openalex.org/W2082665670",
"https://openalex.org/W2086023076",
"https://openalex.org/W2090023448",
"https://openalex.org/W2090367228",
"https://openalex.org/W2090879812",
"https://openalex.org/W2092528359",
"https://openalex.org/W2101204002",
"https://openalex.org/W2103749584",
"https://openalex.org/W2109883473",
"https://openalex.org/W2113043550",
"https://openalex.org/W2121575693",
"https://openalex.org/W2137518728",
"https://openalex.org/W2138560966",
"https://openalex.org/W2141603917",
"https://openalex.org/W2150598751",
"https://openalex.org/W2154260479",
"https://openalex.org/W2166432924",
"https://openalex.org/W2323267657",
"https://openalex.org/W3163348161"
],
"referenced_works_count": 56,
"related_works": [
"https://openalex.org/W4379879167",
"https://openalex.org/W4206594289",
"https://openalex.org/W3092427837",
"https://openalex.org/W3006475697",
"https://openalex.org/W2761784400",
"https://openalex.org/W2753633496",
"https://openalex.org/W2052102886",
"https://openalex.org/W2036106539",
"https://openalex.org/W1970430190",
"https://openalex.org/W1968181017"
],
"sustainable_development_goals": [
{
"id": "https://metadata.un.org/sdg/14",
"display_name": "Life below water",
"score": 0.7
}
],
"title": "Induction of anti-viral genes during acute infection with Viral hemorrhagic septicemia virus (VHSV) genogroup IVa in Pacific herring (Clupea pallasii)",
"topics": [
{
"id": "https://openalex.org/T10506",
"display_name": "Immunological Responses in Aquatic Organisms",
"score": 1.0,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11668",
"display_name": "Innate Immunity to Viral Infection",
"score": 0.9975,
"subfield": {
"id": "https://openalex.org/subfields/2403",
"display_name": "Immunology"
},
"field": {
"id": "https://openalex.org/fields/24",
"display_name": "Immunology and Microbiology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T11495",
"display_name": "Viral Diseases in Livestock and Poultry",
"score": 0.9974,
"subfield": {
"id": "https://openalex.org/subfields/1103",
"display_name": "Animal Science and Zoology"
},
"field": {
"id": "https://openalex.org/fields/11",
"display_name": "Agricultural and Biological Sciences"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-15T05:47:14.521629",
"versions": []
}
}