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We first estimate an econometric model to project effects of weather fluctuations on crop and livestock net returns and then use a semi-reduced form land-use share model to study agricultural land-use changes under future climate and socio-economic scenarios. Estimation results show that crop net returns are more sensitive to thermal and less sensitive to moisture variability than livestock net returns; other agricultural land uses substitute cropland use when 30-year averaged degree-days or precipitation are not beneficial for crop production. Under future climate and socio-economic scenarios, we project that crop and livestock net returns are both increasing, but with crop net returns increasing at a higher rate; cropland increases with declines of marginal and pastureland by the end of the twenty-first century. 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