{
"USGS Publications Warehouse": { "@context": "https://schema.org", "@type": "Article", "additionalType": "Journal Article", "name": "In vitro immune functions in thiamine-replete and -depleted lake trout (Salvelinus namaycush)", "identifier": [ { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse IndexID", "value": "70101773", "url": "https://pubs.usgs.gov/publication/70101773" }, { "@type": "PropertyValue", "propertyID": "USGS Publications Warehouse Internal ID", "value": 70101773 }, { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.fsi.2014.03.024", "url": "https://doi.org/10.1016/j.fsi.2014.03.024" } ], "journal": { "@type": "Periodical", "name": "Fish & Shellfish Immunology", "volumeNumber": "38", "issueNumber": "1" }, "inLanguage": "en", "isPartOf": [ { "@type": "CreativeWorkSeries", "name": "Fish & Shellfish Immunology" } ], "datePublished": "2014", "dateModified": "2017-07-21", "abstract": "In this study we examined the impacts of in vivo thiamine deficiency on lake trout leukocyte function measured in vitro. When compared outside the context of individual-specific thiamine concentrations no significant differences were observed in leukocyte bactericidal activity or in concanavalin A (Con A), and phytohemagglutinin-P (PHA-P) stimulated leukocyte proliferation. Placing immune functions into context with the ratio of in vivo liver thiamine monophosphate (TMP \u2013 biologically inactive form) to thiamine pyrophosphate (TPP \u2013 biologically active form) proved to be the best indicator of thiamine depletion impacts as determined using regression modeling. These observed relationships indicated differential effects on the immune measures with bactericidal activity exhibiting an inverse relationship with TMP to TPP ratios, Con A stimulated mitogenesis exhibiting a positive relationship with TMP to TPP ratios and PHA-P stimulated mitogenesis exhibiting no significant relationships. In addition, these relationships showed considerable complexity which included the consistent observation of a thiamine-replete subgroup with characteristics similar to those seen in the leukocytes from thiamine-depleted fish. When considered together, our observations indicate that lake trout leukocytes experience cell-type specific impacts as well as an altered physiologic environment when confronted with a thiamine-limited state.", "description": "10 p.", "publisher": { "@type": "Organization", "name": "Elsevier" }, "author": [ { "@type": "Person", "name": "Ottinger, Christopher A. cottinger@usgs.gov", "givenName": "Christopher A.", "familyName": "Ottinger", "email": "cottinger@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-2551-1985", "url": "https://orcid.org/0000-0003-2551-1985" }, "affiliation": [ { "@type": "Organization", "name": "Leetown Science Center", "url": "https://www.usgs.gov/centers/eesc" } ] }, { "@type": "Person", "name": "Honeyfield, Dale C. honeyfie@usgs.gov", "givenName": "Dale C.", "familyName": "Honeyfield", "email": "honeyfie@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0003-3034-2047", "url": "https://orcid.org/0000-0003-3034-2047" }, "affiliation": [ { "@type": "Organization", "name": "Leetown Science Center", "url": "https://www.usgs.gov/centers/eesc" } ] }, { "@type": "Person", "name": "Densmore, Christine L. cdensmore@usgs.gov", "givenName": "Christine L.", "familyName": "Densmore", "email": "cdensmore@usgs.gov", "identifier": { "@type": "PropertyValue", "propertyID": "ORCID", "value": "0000-0001-6440-0781", "url": "https://orcid.org/0000-0001-6440-0781" }, "affiliation": [ { "@type": "Organization", "name": "Leetown Science Center", "url": "https://www.usgs.gov/centers/eesc" } ] }, { "@type": "Person", "name": "Iwanowicz, Luke R.", "givenName": "Luke R.", "familyName": "Iwanowicz" } ], "funder": [ { "@type": "Organization", "name": "Coop Res Unit Leetown", "url": "https://www1.usgs.gov/coopunits/unit/Virginia" } ] }, "OpenAlex": { "abstract_inverted_index": { "In": [ 0, 135 ], "this": [ 1 ], "study": [ 2 ], "we": [ 3 ], "examined": [ 4 ], "the": [ 5, 23, 56, 80, 99, 144, 158 ], "impacts": [ 6, 86, 176 ], "of": [ 7, 25, 58, 83, 147 ], "in": [ 8, 18, 34, 39, 59, 157 ], "vivo": [ 9, 60 ], "thiamine": [ 10, 27, 62, 70, 84 ], "deficiency": [ 11 ], "on": [ 12, 98 ], "lake": [ 13, 170 ], "trout": [ 14, 171 ], "leukocyte": [ 15, 35, 48 ], "function": [ 16 ], "measured": [ 17 ], "vitro.": [ 19 ], "When": [ 20, 163 ], "compared": [ 21 ], "outside": [ 22 ], "context": [ 24, 54 ], "individual-specific": [ 26 ], "concentrations": [ 28 ], "no": [ 29, 132 ], "significant": [ 30, 133 ], "differences": [ 31 ], "were": [ 32 ], "observed": [ 33, 93 ], "bactericidal": [ 36, 103 ], "activity": [ 37, 104 ], "or": [ 38 ], "concanavalin": [ 40 ], "A": [ 41, 115 ], "(Con": [ 42 ], "A),": [ 43 ], "and": [ 44, 127 ], "phytohemagglutinin-P": [ 45 ], "(PHA-P)": [ 46 ], "stimulated": [ 47, 116, 129 ], "proliferation.": [ 49 ], "Placing": [ 50 ], "immune": [ 51, 100 ], "functions": [ 52 ], "into": [ 53 ], "with": [ 55, 102, 109, 122, 151, 186 ], "ratio": [ 57 ], "liver": [ 61 ], "monophosphate": [ 63 ], "(TMP": [ 64 ], "\u2013": [ 65, 73 ], "biologically": [ 66, 74 ], "inactive": [ 67 ], "form)": [ 68, 76 ], "to": [ 69, 78, 111, 124, 154 ], "pyrophosphate": [ 71 ], "(TPP": [ 72 ], "active": [ 75 ], "proved": [ 77 ], "be": [ 79 ], "best": [ 81 ], "indicator": [ 82 ], "depletion": [ 85 ], "as": [ 87, 177, 179 ], "determined": [ 88 ], "using": [ 89 ], "regression": [ 90 ], "modeling.": [ 91 ], "These": [ 92 ], "relationships": [ 94, 138 ], "indicated": [ 95 ], "differential": [ 96 ], "effects": [ 97 ], "measures": [ 101 ], "exhibiting": [ 105, 118, 131 ], "an": [ 106, 180 ], "inverse": [ 107 ], "relationship": [ 108, 121 ], "TMP": [ 110, 123 ], "TPP": [ 112, 125 ], "ratios,": [ 113 ], "Con": [ 114 ], "mitogenesis": [ 117, 130 ], "a": [ 119, 148, 187 ], "positive": [ 120 ], "ratios": [ 126 ], "PHA-P": [ 128 ], "relationships.": [ 134 ], "addition,": [ 136 ], "these": [ 137 ], "showed": [ 139 ], "considerable": [ 140 ], "complexity": [ 141 ], "which": [ 142 ], "included": [ 143 ], "consistent": [ 145 ], "observation": [ 146 ], "thiamine-replete": [ 149 ], "subgroup": [ 150 ], "characteristics": [ 152 ], "similar": [ 153 ], "those": [ 155 ], "seen": [ 156 ], "leukocytes": [ 159, 172 ], "from": [ 160 ], "thiamine-depleted": [ 161 ], "fish.": [ 162 ], "considered": [ 164 ], "together,": [ 165 ], "our": [ 166 ], "observations": [ 167 ], "indicate": [ 168 ], "that": [ 169 ], "experience": [ 173 ], "cell-type": [ 174 ], "specific": [ 175 ], "well": [ 178 ], "altered": [ 181 ], "physiologic": [ 182 ], "environment": [ 183 ], "when": [ 184 ], "confronted": [ 185 ], "thiamine-limited": [ 188 ], "state.": [ 189 ] }, "apc_list": { "value": 4420, "currency": "USD", "value_usd": 4420, "provenance": "doaj" }, "apc_paid": { "value": 4420, "currency": "USD", "value_usd": 4420, "provenance": "doaj" }, "authorships": [ { "author_position": "first", "author": { "id": "https://openalex.org/A5034340447", "display_name": "Christopher A. Ottinger", "orcid": "https://orcid.org/0000-0003-2551-1985" }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] }, { "id": "https://openalex.org/I4210121297", "display_name": "NOAA National Marine Fisheries Service Northeast Fisheries Science Center", "ror": "https://ror.org/02nc0ck44", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I106745318", "https://openalex.org/I1308126019", "https://openalex.org/I1343035065", "https://openalex.org/I4210121297" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Christopher A Ottinger", "raw_affiliation_strings": [ "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA. Electronic address: ottingerfamily@hughes.net." ], "affiliations": [ { "raw_affiliation_string": "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA. Electronic address: ottingerfamily@hughes.net.", "institution_ids": [ "https://openalex.org/I1286329397", "https://openalex.org/I4210121297" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5025936401", "display_name": "Dale C. Honeyfield", "orcid": "https://orcid.org/0000-0003-3034-2047" }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Dale C Honeyfield", "raw_affiliation_strings": [ "U.S. Geological Survey, Leetown Science Center, Northern Appalachian Research Laboratory, Wellsboro, PA 16901, USA." ], "affiliations": [ { "raw_affiliation_string": "U.S. Geological Survey, Leetown Science Center, Northern Appalachian Research Laboratory, Wellsboro, PA 16901, USA.", "institution_ids": [ "https://openalex.org/I1286329397" ] } ] }, { "author_position": "middle", "author": { "id": "https://openalex.org/A5068103691", "display_name": "Christine L. Densmore", "orcid": "https://orcid.org/0000-0001-6440-0781" }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Christine L Densmore", "raw_affiliation_strings": [ "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA." ], "affiliations": [ { "raw_affiliation_string": "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA.", "institution_ids": [ "https://openalex.org/I1286329397" ] } ] }, { "author_position": "last", "author": { "id": "https://openalex.org/A5012293449", "display_name": "Luke R. Iwanowicz", "orcid": "https://orcid.org/0000-0002-1197-6178" }, "institutions": [ { "id": "https://openalex.org/I1286329397", "display_name": "United States Geological Survey", "ror": "https://ror.org/035a68863", "country_code": "US", "type": "government", "lineage": [ "https://openalex.org/I1286329397", "https://openalex.org/I1335927249" ] } ], "countries": [ "US" ], "is_corresponding": false, "raw_author_name": "Luke R Iwanowicz", "raw_affiliation_strings": [ "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA." ], "affiliations": [ { "raw_affiliation_string": "U.S. Geological Survey, Leetown Science Center, National Fish Health Research Laboratory, Leetown, WV 25430, USA.", "institution_ids": [ "https://openalex.org/I1286329397" ] } ] } ], "best_oa_location": { "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.fsi.2014.03.024", "pdf_url": null, "source": { "id": "https://openalex.org/S185787987", "display_name": "Fish & Shellfish Immunology", "issn_l": "1050-4648", "issn": [ "1050-4648", "1095-9947" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": [ "https://openalex.org/P4310320990" ], "host_organization_lineage_names": [ "Elsevier BV" ], "type": "journal" }, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true }, "biblio": { "volume": "38", "issue": "1", "first_page": "211", "last_page": "220" }, "citation_normalized_percentile": { "value": 0.818821, "is_in_top_1_percent": false, "is_in_top_10_percent": false }, "cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2056945465", "cited_by_count": 15, "cited_by_percentile_year": { "min": 89, "max": 90 }, "concepts": [ { "id": "https://openalex.org/C2776203871", "wikidata": "https://www.wikidata.org/wiki/Q83187", "display_name": "Thiamine", "level": 2, "score": 0.8840523 }, { "id": "https://openalex.org/C2779363728", "wikidata": "https://www.wikidata.org/wiki/Q2258881", "display_name": "Trout", "level": 3, "score": 0.793368 }, { "id": "https://openalex.org/C86803240", "wikidata": "https://www.wikidata.org/wiki/Q420", "display_name": "Biology", "level": 0, "score": 0.75301886 }, { "id": "https://openalex.org/C2780047943", "wikidata": "https://www.wikidata.org/wiki/Q415003", "display_name": "Thiamine pyrophosphate", "level": 4, "score": 0.731277 }, { "id": "https://openalex.org/C2779343474", "wikidata": "https://www.wikidata.org/wiki/Q3109175", "display_name": "Context (archaeology)", "level": 2, "score": 0.6624794 }, { "id": "https://openalex.org/C8891405", "wikidata": "https://www.wikidata.org/wiki/Q1059", "display_name": "Immune system", "level": 2, "score": 0.6594278 }, { "id": "https://openalex.org/C207001950", "wikidata": "https://www.wikidata.org/wiki/Q141124", "display_name": "In vivo", "level": 2, "score": 0.59195983 }, { "id": "https://openalex.org/C202751555", "wikidata": "https://www.wikidata.org/wiki/Q221681", "display_name": "In vitro", "level": 2, "score": 0.52080333 }, { "id": "https://openalex.org/C55493867", "wikidata": "https://www.wikidata.org/wiki/Q7094", "display_name": "Biochemistry", "level": 1, "score": 0.42598647 }, { "id": "https://openalex.org/C126322002", "wikidata": "https://www.wikidata.org/wiki/Q11180", "display_name": "Internal medicine", "level": 1, "score": 0.4044893 }, { "id": "https://openalex.org/C134018914", "wikidata": "https://www.wikidata.org/wiki/Q162606", "display_name": "Endocrinology", "level": 1, "score": 0.39248168 }, { "id": "https://openalex.org/C203014093", "wikidata": "https://www.wikidata.org/wiki/Q101929", "display_name": "Immunology", "level": 1, "score": 0.33142948 }, { "id": "https://openalex.org/C2909208804", "wikidata": "https://www.wikidata.org/wiki/Q127282", "display_name": "Fish <Actinopterygii>", "level": 2, "score": 0.19102463 }, { "id": "https://openalex.org/C197957613", "wikidata": "https://www.wikidata.org/wiki/Q407280", "display_name": "Cofactor", "level": 3, "score": 0.15071711 }, { "id": "https://openalex.org/C181199279", "wikidata": "https://www.wikidata.org/wiki/Q8047", "display_name": "Enzyme", "level": 2, "score": 0.1263246 }, { "id": "https://openalex.org/C505870484", "wikidata": "https://www.wikidata.org/wiki/Q180538", "display_name": "Fishery", "level": 1, "score": 0.080863655 }, { "id": "https://openalex.org/C71924100", "wikidata": "https://www.wikidata.org/wiki/Q11190", "display_name": "Medicine", "level": 0, "score": 0.06624398 }, { "id": "https://openalex.org/C151730666", "wikidata": "https://www.wikidata.org/wiki/Q7205", "display_name": "Paleontology", "level": 1, "score": 0.0 }, { "id": "https://openalex.org/C150903083", "wikidata": "https://www.wikidata.org/wiki/Q7108", "display_name": "Biotechnology", "level": 1, "score": 0.0 } ], "corresponding_author_ids": [], "corresponding_institution_ids": [], "countries_distinct_count": 1, "counts_by_year": [ { "year": 2023, "cited_by_count": 3 }, { "year": 2021, "cited_by_count": 2 }, { "year": 2020, "cited_by_count": 1 }, { "year": 2019, "cited_by_count": 3 }, { "year": 2018, "cited_by_count": 1 }, { "year": 2017, "cited_by_count": 2 }, { "year": 2016, "cited_by_count": 1 }, { "year": 2015, "cited_by_count": 2 } ], "created_date": "2016-06-24", "datasets": [], "display_name": "In vitro immune functions in thiamine-replete and -depleted lake trout (Salvelinus namaycush)", "doi": "https://doi.org/10.1016/j.fsi.2014.03.024", "fulltext_origin": "ngrams", "fwci": 1.146, "grants": [ { "funder": "https://openalex.org/F4320309328", "funder_display_name": "Great Lakes Fishery Commission", "award_id": null } ], "has_fulltext": true, "id": "https://openalex.org/W2056945465", "ids": { "openalex": "https://openalex.org/W2056945465", "doi": "https://doi.org/10.1016/j.fsi.2014.03.024", "mag": "2056945465", "pmid": "https://pubmed.ncbi.nlm.nih.gov/24680830" }, "indexed_in": [ "crossref", "pubmed" ], "institutions_distinct_count": 2, "is_paratext": false, "is_retracted": false, "keywords": [ { "id": "https://openalex.org/keywords/thiamine-pyrophosphate", "display_name": "Thiamine pyrophosphate", "score": 0.731277 }, { "id": "https://openalex.org/keywords/thiamine-deficiency", "display_name": "Thiamine Deficiency", "score": 0.525205 } ], "language": "en", "locations": [ { "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.fsi.2014.03.024", "pdf_url": null, "source": { "id": "https://openalex.org/S185787987", "display_name": "Fish & Shellfish Immunology", "issn_l": "1050-4648", "issn": [ "1050-4648", "1095-9947" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": [ "https://openalex.org/P4310320990" ], "host_organization_lineage_names": [ "Elsevier BV" ], "type": "journal" }, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true }, { "is_oa": false, "landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/24680830", "pdf_url": null, "source": { "id": "https://openalex.org/S4306525036", "display_name": "PubMed", "issn_l": null, "issn": null, "is_oa": false, "is_in_doaj": false, "is_core": false, "host_organization": "https://openalex.org/I1299303238", "host_organization_name": "National Institutes of Health", "host_organization_lineage": [ "https://openalex.org/I1299303238" ], "host_organization_lineage_names": [ "National Institutes of Health" ], "type": "repository" }, "license": null, "license_id": null, "version": null, "is_accepted": false, "is_published": false } ], "locations_count": 2, "mesh": [ { "descriptor_ui": "D013831", "descriptor_name": "Thiamine", "qualifier_ui": "Q000494", "qualifier_name": "pharmacology", "is_major_topic": true }, { "descriptor_ui": "D013832", "descriptor_name": "Thiamine Deficiency", "qualifier_ui": "Q000662", "qualifier_name": "veterinary", "is_major_topic": true }, { "descriptor_ui": "D014337", "descriptor_name": "Trout", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": true }, { "descriptor_ui": "D000821", "descriptor_name": "Animal Feed", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D000821", "descriptor_name": "Animal Feed", "qualifier_ui": "Q000032", "qualifier_name": "analysis", "is_major_topic": false }, { "descriptor_ui": "D000824", "descriptor_name": "Animal Nutritional Physiological Phenomena", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D000818", "descriptor_name": "Animals", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D004032", "descriptor_name": "Diet", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D004032", "descriptor_name": "Diet", "qualifier_ui": "Q000662", "qualifier_name": "veterinary", "is_major_topic": false }, { "descriptor_ui": "D007962", "descriptor_name": "Leukocytes", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D007962", "descriptor_name": "Leukocytes", "qualifier_ui": "Q000502", "qualifier_name": "physiology", "is_major_topic": false }, { "descriptor_ui": "D013831", "descriptor_name": "Thiamine", "qualifier_ui": "Q000378", "qualifier_name": "metabolism", "is_major_topic": false }, { "descriptor_ui": "D013831", "descriptor_name": "Thiamine", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D013832", "descriptor_name": "Thiamine Deficiency", "qualifier_ui": "Q000276", "qualifier_name": "immunology", "is_major_topic": false }, { "descriptor_ui": "D013832", "descriptor_name": "Thiamine Deficiency", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false }, { "descriptor_ui": "D014337", "descriptor_name": "Trout", "qualifier_ui": "", "qualifier_name": null, "is_major_topic": false } ], "ngrams_url": "https://api.openalex.org/works/W2056945465/ngrams", "open_access": { "is_oa": true, "oa_status": "hybrid", "oa_url": "https://doi.org/10.1016/j.fsi.2014.03.024", "any_repository_has_fulltext": false }, "primary_location": { "is_oa": true, "landing_page_url": "https://doi.org/10.1016/j.fsi.2014.03.024", "pdf_url": null, "source": { "id": "https://openalex.org/S185787987", "display_name": "Fish & Shellfish Immunology", "issn_l": "1050-4648", "issn": [ "1050-4648", "1095-9947" ], "is_oa": false, "is_in_doaj": false, "is_core": true, "host_organization": "https://openalex.org/P4310320990", "host_organization_name": "Elsevier BV", "host_organization_lineage": [ "https://openalex.org/P4310320990" ], "host_organization_lineage_names": [ "Elsevier BV" ], "type": "journal" }, "license": "cc-by-nc-nd", "license_id": "https://openalex.org/licenses/cc-by-nc-nd", "version": "publishedVersion", "is_accepted": true, "is_published": true }, "primary_topic": { "id": "https://openalex.org/T12494", "display_name": "Diagnosis and Management of Wernicke-Korsakoff Syndrome", "score": 0.9898, "subfield": { "id": "https://openalex.org/subfields/2728", "display_name": "Neurology" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } }, "publication_date": "2014-05-01", "publication_year": 2014, "referenced_works": [ "https://openalex.org/W1544353721", "https://openalex.org/W1758127460", "https://openalex.org/W1763518723", "https://openalex.org/W1945975559", "https://openalex.org/W1967206527", "https://openalex.org/W1968780935", "https://openalex.org/W1970608829", "https://openalex.org/W1973101085", "https://openalex.org/W1973405995", "https://openalex.org/W1977356076", "https://openalex.org/W1986867555", "https://openalex.org/W1991547342", "https://openalex.org/W1991569353", "https://openalex.org/W1995853729", "https://openalex.org/W2003234780", "https://openalex.org/W2004806562", "https://openalex.org/W2007919042", "https://openalex.org/W2009730335", "https://openalex.org/W2013742341", "https://openalex.org/W2020640566", "https://openalex.org/W2022720370", "https://openalex.org/W2025149910", "https://openalex.org/W2026894918", "https://openalex.org/W2030355203", "https://openalex.org/W2030680975", "https://openalex.org/W2038262027", "https://openalex.org/W2040112602", "https://openalex.org/W2043124457", "https://openalex.org/W2045559921", "https://openalex.org/W2047278249", "https://openalex.org/W2052380638", "https://openalex.org/W2057416706", "https://openalex.org/W2057451998", "https://openalex.org/W2059476578", "https://openalex.org/W2062672775", "https://openalex.org/W2065765007", "https://openalex.org/W2070210595", "https://openalex.org/W2073118744", "https://openalex.org/W2075565654", "https://openalex.org/W2087040208", "https://openalex.org/W2096686378", "https://openalex.org/W2120146359", "https://openalex.org/W2121358285", "https://openalex.org/W2134053452", "https://openalex.org/W2134585782", "https://openalex.org/W2138233516", "https://openalex.org/W2141583309", "https://openalex.org/W2154591315", "https://openalex.org/W2159079989", "https://openalex.org/W2162873738", "https://openalex.org/W2175431922", "https://openalex.org/W2280960802", "https://openalex.org/W2525883629", "https://openalex.org/W2808322819", "https://openalex.org/W29767629", "https://openalex.org/W3086969671", "https://openalex.org/W4236023822", "https://openalex.org/W657665785" ], "referenced_works_count": 58, "related_works": [ "https://openalex.org/W2422242742", "https://openalex.org/W2418780220", "https://openalex.org/W2335205889", "https://openalex.org/W2095419453", "https://openalex.org/W2072857293", "https://openalex.org/W2014923634", "https://openalex.org/W2011303969", "https://openalex.org/W1985456307", "https://openalex.org/W1602278473", "https://openalex.org/W1497933649" ], "sustainable_development_goals": [ { "id": "https://metadata.un.org/sdg/14", "score": 0.82, "display_name": "Life below water" } ], "title": "In vitro immune functions in thiamine-replete and -depleted lake trout (Salvelinus namaycush)", "topics": [ { "id": "https://openalex.org/T12494", "display_name": "Diagnosis and Management of Wernicke-Korsakoff Syndrome", "score": 0.9898, "subfield": { "id": "https://openalex.org/subfields/2728", "display_name": "Neurology" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } }, { "id": "https://openalex.org/T11072", "display_name": "Peroxisome Proliferator-Activated Receptors", "score": 0.989, "subfield": { "id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology" }, "field": { "id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" } }, { "id": "https://openalex.org/T10760", "display_name": "Diagnosis and Management of Pancreatitis", "score": 0.9706, "subfield": { "id": "https://openalex.org/subfields/2746", "display_name": "Surgery" }, "field": { "id": "https://openalex.org/fields/27", "display_name": "Medicine" }, "domain": { "id": "https://openalex.org/domains/4", "display_name": "Health Sciences" } } ], "type": "article", "type_crossref": "journal-article", "updated_date": "2024-08-13T22:55:48.817322", "versions": [] }
}