Vegetation has been effectively monitored using remote sensing time-series vegetation index (VI) data for several decades. Drought monitoring has been a common application with algorithms tuned to capturing anomalous temporal and spatial vegetation patterns. Drought stress models, such as the Vegetation Drought Response Index (VegDRI), often use VIs like the Normalized Difference Vegetation Index (NDVI). The EROS expedited Moderate Resolution Imaging Spectroradiometer (eMODIS)-based, 7-day NDVI composites are integral to the VegDRI. As MODIS satellite platforms (Terra and Aqua) approach mission end, the Visible Infrared Imaging Radiometer Suite (VIIRS) presents an alternate NDVI source, with daily collection, similar band passes, and moderate spatial resolution. This study provides a statistical comparison between EROS expedited VIIRS (eVIIRS) 375-m and eMODIS 250-m and tests the suitability of replacing MODIS NDVI with VIIRS NDVI for drought monitoring and vegetation anomaly detection. For continuity with MODIS NDVI, we calculated a geometric mean regression adjustment algorithm using 375-m resolution for an eMODIS-like NDVI (eVIIRS’) eVIIRS’ = 0.9887 × eVIIRS − 0.0398. The resulting statistical comparisons (eVIIRS’ vs. eMODIS NDVI) showed correlations consistently greater than 0.84 throughout the three years studied. The eVIIRS’ VegDRI results characterized similar drought patterns and hotspots to the eMODIS-based VegDRI, with near zero bias.