Infectious canine hepatitis in a brown bear (Ursus arctos horribilis) from Alaska.
We diagnosed infectious canine hepatitis in a free-ranging brown bear (Ursus arctos horribilis) cub from Alaska, US, found dead in October 2015. Intranuclear inclusion bodies were present in hepatocytes, and immunohistochemistry showed reactivity to adenoviral antigens. Sequencing of the hexon protein of adenovirus showed 100% identity to canine adenovirus 1.