{
"USGS Publications Warehouse": {
"@context": "https://schema.org",
"@type": "Article",
"additionalType": "Journal Article",
"name": "Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure",
"identifier": [
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse IndexID",
"value": "70180022",
"url": "https://pubs.usgs.gov/publication/70180022"
},
{
"@type": "PropertyValue",
"propertyID": "USGS Publications Warehouse Internal ID",
"value": 70180022
},
{
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12899-017-0028-5",
"url": "https://doi.org/10.1186/s12899-017-0028-5"
}
],
"journal": {
"@type": "Periodical",
"name": "BMC Physiology",
"volumeNumber": "17",
"issueNumber": "2"
},
"inLanguage": "en",
"isPartOf": [
{
"@type": "CreativeWorkSeries",
"name": "BMC Physiology"
}
],
"datePublished": "2017",
"dateModified": "2017-01-23",
"abstract": "BackgroundIn preparation for migration from freshwater to marine habitats, Atlantic salmon (Salmo salar L.) undergo smoltification, a transformation that includes the acquisition of hyposmoregulatory capacity. The growth hormone (Gh)/insulin-like growth-factor (Igf) axis promotes the development of branchial ionoregulatory functions that underlie ion secretion. Igfs interact with a suite of Igf binding proteins (Igfbps) that modulate hormone activity. In Atlantic salmon smolts, igfbp4,\u22125a,\u22125b1,\u22125b2,\u22126b1 and\u22126b2 transcripts are highly expressed in gill. We measured mRNA levels of branchial and hepatic igfbps during smoltification (March, April, and May), desmoltification (July) and following seawater (SW) exposure in March and May. We also characterized parallel changes in a broad suite of osmoregulatory (branchial Na+/K+-ATPase (Nka) activity, Na+ /K + /2Cl \u2212 cotransporter 1 (nkcc1) and cystic fibrosis transmembrane regulator 1 (cftr1) transcription) and endocrine (plasma Gh and Igf1) parameters.ResultsIndicative of smoltification, we observed increased branchial Nka activity, nkcc1 and cftr1 transcription in May. Branchial igfbp6b1 and -6b2 expression increased coincidentally with smoltification. Following a SW challenge in March, igfbp6b1 showed increased expression while igfbp6b2 exhibited diminished expression. igfbp5a,\u22125b1 and\u22125b2 mRNA levels did not change during smolting, but each had lower levels following a SW exposure in March.ConclusionsSalmonids express an especially large suite of igfbps. Our data suggest that dynamic expression of particular igfbps accompanies smoltification and SW challenges; thus, transcriptional control of igfbps may provide a mechanism for the local modulation of Igf activity in salmon gill.",
"description": "11 p.",
"publisher": {
"@type": "Organization",
"name": "BioMed Central"
},
"author": [
{
"@type": "Person",
"name": "McCormick, Stephen D. smccormick@usgs.gov",
"givenName": "Stephen D.",
"familyName": "McCormick",
"email": "smccormick@usgs.gov",
"identifier": {
"@type": "PropertyValue",
"propertyID": "ORCID",
"value": "0000-0003-0621-6200",
"url": "https://orcid.org/0000-0003-0621-6200"
},
"affiliation": [
{
"@type": "Organization",
"name": "Leetown Science Center",
"url": "https://www.usgs.gov/centers/eesc"
}
]
},
{
"@type": "Person",
"name": "Breves, Jason P.",
"givenName": "Jason P.",
"familyName": "Breves",
"affiliation": [
{
"@type": "Organization",
"name": "University of Massachusetts, Amherst"
}
]
},
{
"@type": "Person",
"name": "Fujimoto, Chelsea K.",
"givenName": "Chelsea K.",
"familyName": "Fujimoto"
},
{
"@type": "Person",
"name": "Phipps-Costin, Silas K.",
"givenName": "Silas K.",
"familyName": "Phipps-Costin"
},
{
"@type": "Person",
"name": "Einarsdottir, Ingibj\u00f6rg E.",
"givenName": "Ingibj\u00f6rg E.",
"familyName": "Einarsdottir"
},
{
"@type": "Person",
"name": "Bj\u00f6rnsson, Bj\u00f6rn Thrandur",
"givenName": "Bj\u00f6rn Thrandur",
"familyName": "Bj\u00f6rnsson"
}
],
"funder": [
{
"@type": "Organization",
"name": "Leetown Science Center",
"url": "https://www.usgs.gov/centers/eesc"
}
]
},
"OpenAlex": {
"abstract_inverted_index": {
"In": [
0,
57
],
"preparation": [
1
],
"for": [
2,
224
],
"migration": [
3
],
"from": [
4
],
"freshwater": [
5
],
"to": [
6
],
"marine": [
7
],
"habitats,": [
8
],
"Atlantic": [
9,
58
],
"salmon": [
10,
59,
232
],
"(Salmo": [
11
],
"salar": [
12
],
"L.)": [
13
],
"undergo": [
14
],
"smoltification,": [
15,
136
],
"a": [
16,
46,
101,
159,
188,
222
],
"transformation": [
17
],
"that": [
18,
39,
53,
204
],
"includes": [
19
],
"the": [
20,
33,
225
],
"acquisition": [
21
],
"of": [
22,
35,
48,
73,
104,
135,
199,
207,
218,
228
],
"hyposmoregulatory": [
23
],
"capacity.": [
24
],
"The": [
25
],
"growth": [
26
],
"hormone": [
27,
55
],
"(Gh)/insulin-like": [
28
],
"growth-factor": [
29
],
"(Igf)": [
30
],
"axis": [
31
],
"promotes": [
32
],
"development": [
34
],
"branchial": [
36,
74,
140
],
"ionoregulatory": [
37
],
"functions": [
38
],
"underlie": [
40
],
"ion": [
41
],
"secretion.": [
42
],
"Igfs": [
43
],
"interact": [
44
],
"with": [
45,
156
],
"suite": [
47,
103,
198
],
"Igf": [
49,
229
],
"binding": [
50
],
"proteins": [
51
],
"(Igfbps)": [
52
],
"modulate": [
54
],
"activity.": [
56
],
"smolts,": [
60
],
"igfbp4,\u22125a,\u22125b1,\u22125b2,\u22126b1": [
61
],
"and\u22126b2": [
62
],
"transcripts": [
63
],
"are": [
64
],
"highly": [
65
],
"expressed": [
66
],
"in": [
67,
91,
100,
147,
162,
191,
231
],
"gill.": [
68,
233
],
"We": [
69,
95
],
"measured": [
70
],
"mRNA": [
71,
175
],
"levels": [
72,
176,
186
],
"and": [
75,
82,
86,
93,
119,
127,
131,
144,
151,
212
],
"hepatic": [
76
],
"igfbps": [
77,
209,
219
],
"during": [
78,
180
],
"smoltification": [
79,
211
],
"(March,": [
80
],
"April,": [
81
],
"May),": [
83
],
"desmoltification": [
84
],
"(July)": [
85
],
"following": [
87,
187
],
"seawater": [
88
],
"(SW)": [
89
],
"exposure": [
90,
190
],
"March": [
92
],
"May.": [
94,
148
],
"also": [
96
],
"characterized": [
97
],
"parallel": [
98
],
"changes": [
99
],
"broad": [
102
],
"osmoregulatory": [
105
],
"(branchial": [
106
],
"Na+/K+-ATPase": [
107
],
"(Nka)": [
108
],
"activity,": [
109,
142
],
"Na": [
110
],
"+": [
111,
113
],
"/K": [
112
],
"/2Cl": [
114
],
"\u2212": [
115
],
"cotransporter": [
116
],
"1": [
117,
124
],
"(nkcc1)": [
118
],
"cystic": [
120
],
"fibrosis": [
121
],
"transmembrane": [
122
],
"regulator": [
123
],
"(cftr1)": [
125
],
"transcription)": [
126
],
"endocrine": [
128
],
"(plasma": [
129
],
"Gh": [
130
],
"Igf1)": [
132
],
"parameters.": [
133
],
"Indicative": [
134
],
"we": [
137
],
"observed": [
138
],
"increased": [
139,
154,
166
],
"Nka": [
141
],
"nkcc1": [
143
],
"cftr1": [
145
],
"transcription": [
146
],
"Branchial": [
149
],
"igfbp6b1": [
150,
164
],
"-6b2": [
152
],
"expression": [
153,
167,
206
],
"coincidentally": [
155
],
"smoltification.": [
157
],
"Following": [
158
],
"SW": [
160,
189,
213
],
"challenge": [
161
],
"March,": [
163
],
"showed": [
165
],
"while": [
168
],
"igfbp6b2": [
169
],
"exhibited": [
170
],
"diminished": [
171
],
"expression.": [
172
],
"igfbp5a,\u22125b1": [
173
],
"and\u22125b2": [
174
],
"did": [
177
],
"not": [
178
],
"change": [
179
],
"smolting,": [
181
],
"but": [
182
],
"each": [
183
],
"had": [
184
],
"lower": [
185
],
"March.": [
192
],
"Salmonids": [
193
],
"express": [
194
],
"an": [
195
],
"especially": [
196
],
"large": [
197
],
"igfbps.": [
200
],
"Our": [
201
],
"data": [
202
],
"suggest": [
203
],
"dynamic": [
205
],
"particular": [
208
],
"accompanies": [
210
],
"challenges;": [
214
],
"thus,": [
215
],
"transcriptional": [
216
],
"control": [
217
],
"may": [
220
],
"provide": [
221
],
"mechanism": [
223
],
"local": [
226
],
"modulation": [
227
],
"activity": [
230
]
},
"apc_list": null,
"apc_paid": null,
"authorships": [
{
"author_position": "first",
"author": {
"id": "https://openalex.org/A5048061632",
"display_name": "Jason P. Breves",
"orcid": "https://orcid.org/0000-0003-1193-4389"
},
"institutions": [
{
"id": "https://openalex.org/I21104390",
"display_name": "Skidmore College",
"ror": "https://ror.org/04nzrzs08",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I21104390"
]
}
],
"countries": [
"US"
],
"is_corresponding": true,
"raw_author_name": "Jason P. Breves",
"raw_affiliation_strings": [
"Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA",
"institution_ids": [
"https://openalex.org/I21104390"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5056771440",
"display_name": "Chelsea Fujimoto",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I21104390",
"display_name": "Skidmore College",
"ror": "https://ror.org/04nzrzs08",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I21104390"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Chelsea K. Fujimoto",
"raw_affiliation_strings": [
"Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA",
"institution_ids": [
"https://openalex.org/I21104390"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5091725994",
"display_name": "Silas K. Phipps-Costin",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I21104390",
"display_name": "Skidmore College",
"ror": "https://ror.org/04nzrzs08",
"country_code": "US",
"type": "education",
"lineage": [
"https://openalex.org/I21104390"
]
}
],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Silas K. Phipps-Costin",
"raw_affiliation_strings": [
"Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA"
],
"affiliations": [
{
"raw_affiliation_string": "Department of Biology, Skidmore College, 815 N Broadway, Saratoga Springs, 12866, NY, USA",
"institution_ids": [
"https://openalex.org/I21104390"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5035250812",
"display_name": "Ingibj\u00f6rg Eir Einarsd\u00f3ttir",
"orcid": null
},
"institutions": [
{
"id": "https://openalex.org/I881427289",
"display_name": "University of Gothenburg",
"ror": "https://ror.org/01tm6cn81",
"country_code": "SE",
"type": "education",
"lineage": [
"https://openalex.org/I881427289"
]
}
],
"countries": [
"SE"
],
"is_corresponding": false,
"raw_author_name": "Ingibj\u00f6rg E. Einarsdottir",
"raw_affiliation_strings": [
"Fish Endocrinology Laboratory, Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE-40530, Gothenburg, Sweden"
],
"affiliations": [
{
"raw_affiliation_string": "Fish Endocrinology Laboratory, Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE-40530, Gothenburg, Sweden",
"institution_ids": [
"https://openalex.org/I881427289"
]
}
]
},
{
"author_position": "middle",
"author": {
"id": "https://openalex.org/A5022934878",
"display_name": "Bj\u00f6rn Thr\u00e1ndur Bj\u00f6rnsson",
"orcid": "https://orcid.org/0000-0002-1310-9756"
},
"institutions": [
{
"id": "https://openalex.org/I881427289",
"display_name": "University of Gothenburg",
"ror": "https://ror.org/01tm6cn81",
"country_code": "SE",
"type": "education",
"lineage": [
"https://openalex.org/I881427289"
]
}
],
"countries": [
"SE"
],
"is_corresponding": false,
"raw_author_name": "Bj\u00f6rn Thrandur Bj\u00f6rnsson",
"raw_affiliation_strings": [
"Fish Endocrinology Laboratory, Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE-40530, Gothenburg, Sweden"
],
"affiliations": [
{
"raw_affiliation_string": "Fish Endocrinology Laboratory, Department of Biological and Environmental Sciences, University of Gothenburg, Box 463, SE-40530, Gothenburg, Sweden",
"institution_ids": [
"https://openalex.org/I881427289"
]
}
]
},
{
"author_position": "last",
"author": {
"id": "https://openalex.org/A5054146102",
"display_name": "Stephen D. McCormick",
"orcid": "https://orcid.org/0000-0003-0621-6200"
},
"institutions": [],
"countries": [
"US"
],
"is_corresponding": false,
"raw_author_name": "Stephen D. McCormick",
"raw_affiliation_strings": [
"USGS, Leetown Science Center, S.O. Conte Anadromous Fish Research Center, P.O. Box 796, One Migratory Way, Turners Falls, 01376, MA, USA"
],
"affiliations": [
{
"raw_affiliation_string": "USGS, Leetown Science Center, S.O. Conte Anadromous Fish Research Center, P.O. Box 796, One Migratory Way, Turners Falls, 01376, MA, USA",
"institution_ids": []
}
]
}
],
"best_oa_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1186/s12899-017-0028-5",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S190311413",
"display_name": "BMC Physiology",
"issn_l": "1472-6793",
"issn": [
"1472-6793"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319900",
"host_organization_name": "Springer Science+Business Media",
"host_organization_lineage": [
"https://openalex.org/P4310319965",
"https://openalex.org/P4310319900"
],
"host_organization_lineage_names": [
"Springer Nature",
"Springer Science+Business Media"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"biblio": {
"volume": "17",
"issue": "1",
"first_page": null,
"last_page": null
},
"citation_normalized_percentile": {
"value": 0.999952,
"is_in_top_1_percent": true,
"is_in_top_10_percent": true
},
"cited_by_api_url": "https://api.openalex.org/works?filter=cites:W2574072118",
"cited_by_count": 29,
"cited_by_percentile_year": {
"min": 94,
"max": 95
},
"concepts": [
{
"id": "https://openalex.org/C2778427672",
"wikidata": "https://www.wikidata.org/wiki/Q3487056",
"display_name": "Smoltification",
"level": 5,
"score": 0.9470915
},
{
"id": "https://openalex.org/C134018914",
"wikidata": "https://www.wikidata.org/wiki/Q162606",
"display_name": "Endocrinology",
"level": 1,
"score": 0.6807105
},
{
"id": "https://openalex.org/C86803240",
"wikidata": "https://www.wikidata.org/wiki/Q420",
"display_name": "Biology",
"level": 0,
"score": 0.6801956
},
{
"id": "https://openalex.org/C126322002",
"wikidata": "https://www.wikidata.org/wiki/Q11180",
"display_name": "Internal medicine",
"level": 1,
"score": 0.6642581
},
{
"id": "https://openalex.org/C2777940460",
"wikidata": "https://www.wikidata.org/wiki/Q310436",
"display_name": "Salmo",
"level": 3,
"score": 0.6195497
},
{
"id": "https://openalex.org/C161153951",
"wikidata": "https://www.wikidata.org/wiki/Q132390",
"display_name": "Gill",
"level": 3,
"score": 0.4699115
},
{
"id": "https://openalex.org/C71315377",
"wikidata": "https://www.wikidata.org/wiki/Q11364",
"display_name": "Hormone",
"level": 2,
"score": 0.45685107
},
{
"id": "https://openalex.org/C2779911052",
"wikidata": "https://www.wikidata.org/wiki/Q184238",
"display_name": "Salmonidae",
"level": 4,
"score": 0.2561258
},
{
"id": "https://openalex.org/C505870484",
"wikidata": "https://www.wikidata.org/wiki/Q180538",
"display_name": "Fishery",
"level": 1,
"score": 0.17623338
},
{
"id": "https://openalex.org/C2909208804",
"wikidata": "https://www.wikidata.org/wiki/Q127282",
"display_name": "Fish <Actinopterygii>",
"level": 2,
"score": 0.07410529
},
{
"id": "https://openalex.org/C71924100",
"wikidata": "https://www.wikidata.org/wiki/Q11190",
"display_name": "Medicine",
"level": 0,
"score": 0.0
}
],
"corresponding_author_ids": [
"https://openalex.org/A5048061632"
],
"corresponding_institution_ids": [
"https://openalex.org/I21104390"
],
"countries_distinct_count": 2,
"counts_by_year": [
{
"year": 2024,
"cited_by_count": 4
},
{
"year": 2023,
"cited_by_count": 1
},
{
"year": 2022,
"cited_by_count": 7
},
{
"year": 2021,
"cited_by_count": 3
},
{
"year": 2020,
"cited_by_count": 5
},
{
"year": 2019,
"cited_by_count": 3
},
{
"year": 2018,
"cited_by_count": 5
},
{
"year": 2017,
"cited_by_count": 1
}
],
"created_date": "2017-01-26",
"datasets": [],
"display_name": "Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure",
"doi": "https://doi.org/10.1186/s12899-017-0028-5",
"fulltext_origin": "pdf",
"fwci": 2.446,
"grants": [
{
"funder": "https://openalex.org/F4320312566",
"funder_display_name": "Skidmore College",
"award_id": "Start-Up"
}
],
"has_fulltext": true,
"id": "https://openalex.org/W2574072118",
"ids": {
"openalex": "https://openalex.org/W2574072118",
"doi": "https://doi.org/10.1186/s12899-017-0028-5",
"mag": "2574072118",
"pmid": "https://pubmed.ncbi.nlm.nih.gov/28100217",
"pmcid": "https://www.ncbi.nlm.nih.gov/pmc/articles/5242021"
},
"indexed_in": [
"crossref",
"pubmed"
],
"institutions_distinct_count": 2,
"is_paratext": false,
"is_retracted": false,
"keywords": [
{
"id": "https://openalex.org/keywords/smoltification",
"display_name": "Smoltification",
"score": 0.9470915
},
{
"id": "https://openalex.org/keywords/metabolic-rate",
"display_name": "Metabolic Rate",
"score": 0.456695
}
],
"language": "en",
"locations": [
{
"is_oa": true,
"landing_page_url": "https://doi.org/10.1186/s12899-017-0028-5",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S190311413",
"display_name": "BMC Physiology",
"issn_l": "1472-6793",
"issn": [
"1472-6793"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319900",
"host_organization_name": "Springer Science+Business Media",
"host_organization_lineage": [
"https://openalex.org/P4310319965",
"https://openalex.org/P4310319900"
],
"host_organization_lineage_names": [
"Springer Nature",
"Springer Science+Business Media"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": true,
"landing_page_url": "https://europepmc.org/articles/pmc5242021",
"pdf_url": "https://europepmc.org/articles/pmc5242021?pdf=render",
"source": {
"id": "https://openalex.org/S4306400806",
"display_name": "Europe PMC (PubMed Central)",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1303153112",
"host_organization_name": "European Bioinformatics Institute",
"host_organization_lineage": [
"https://openalex.org/I1303153112"
],
"host_organization_lineage_names": [
"European Bioinformatics Institute"
],
"type": "repository"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": true,
"landing_page_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242021",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S2764455111",
"display_name": "PubMed Central",
"issn_l": null,
"issn": null,
"is_oa": true,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
{
"is_oa": false,
"landing_page_url": "https://pubmed.ncbi.nlm.nih.gov/28100217",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S4306525036",
"display_name": "PubMed",
"issn_l": null,
"issn": null,
"is_oa": false,
"is_in_doaj": false,
"is_core": false,
"host_organization": "https://openalex.org/I1299303238",
"host_organization_name": "National Institutes of Health",
"host_organization_lineage": [
"https://openalex.org/I1299303238"
],
"host_organization_lineage_names": [
"National Institutes of Health"
],
"type": "repository"
},
"license": null,
"license_id": null,
"version": null,
"is_accepted": false,
"is_published": false
}
],
"locations_count": 4,
"mesh": [
{
"descriptor_ui": "D000064",
"descriptor_name": "Acclimatization",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": true
},
{
"descriptor_ui": "D005618",
"descriptor_name": "Fresh Water",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D005880",
"descriptor_name": "Gills",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D018969",
"descriptor_name": "Insulin-Like Growth Factor Binding Proteins",
"qualifier_ui": "Q000096",
"qualifier_name": "biosynthesis",
"is_major_topic": true
},
{
"descriptor_ui": "D020317",
"descriptor_name": "Salmo salar",
"qualifier_ui": "Q000378",
"qualifier_name": "metabolism",
"is_major_topic": true
},
{
"descriptor_ui": "D012623",
"descriptor_name": "Seawater",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": true
},
{
"descriptor_ui": "D000064",
"descriptor_name": "Acclimatization",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D000818",
"descriptor_name": "Animals",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D017753",
"descriptor_name": "Ecosystem",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D005880",
"descriptor_name": "Gills",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D018969",
"descriptor_name": "Insulin-Like Growth Factor Binding Proteins",
"qualifier_ui": "Q000097",
"qualifier_name": "blood",
"is_major_topic": false
},
{
"descriptor_ui": "D018969",
"descriptor_name": "Insulin-Like Growth Factor Binding Proteins",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D064587",
"descriptor_name": "Osmoregulation",
"qualifier_ui": "Q000502",
"qualifier_name": "physiology",
"is_major_topic": false
},
{
"descriptor_ui": "D064587",
"descriptor_name": "Osmoregulation",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
},
{
"descriptor_ui": "D020317",
"descriptor_name": "Salmo salar",
"qualifier_ui": "Q000097",
"qualifier_name": "blood",
"is_major_topic": false
},
{
"descriptor_ui": "D020317",
"descriptor_name": "Salmo salar",
"qualifier_ui": "",
"qualifier_name": null,
"is_major_topic": false
}
],
"ngrams_url": "https://api.openalex.org/works/W2574072118/ngrams",
"open_access": {
"is_oa": true,
"oa_status": "hybrid",
"oa_url": "https://doi.org/10.1186/s12899-017-0028-5",
"any_repository_has_fulltext": true
},
"primary_location": {
"is_oa": true,
"landing_page_url": "https://doi.org/10.1186/s12899-017-0028-5",
"pdf_url": null,
"source": {
"id": "https://openalex.org/S190311413",
"display_name": "BMC Physiology",
"issn_l": "1472-6793",
"issn": [
"1472-6793"
],
"is_oa": false,
"is_in_doaj": false,
"is_core": true,
"host_organization": "https://openalex.org/P4310319900",
"host_organization_name": "Springer Science+Business Media",
"host_organization_lineage": [
"https://openalex.org/P4310319965",
"https://openalex.org/P4310319900"
],
"host_organization_lineage_names": [
"Springer Nature",
"Springer Science+Business Media"
],
"type": "journal"
},
"license": "cc-by",
"license_id": "https://openalex.org/licenses/cc-by",
"version": "publishedVersion",
"is_accepted": true,
"is_published": true
},
"primary_topic": {
"id": "https://openalex.org/T11056",
"display_name": "Metabolic Theory of Ecology and Climate Change Impacts",
"score": 0.9975,
"subfield": {
"id": "https://openalex.org/subfields/2303",
"display_name": "Ecology"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
"publication_date": "2017-01-18",
"publication_year": 2017,
"referenced_works": [
"https://openalex.org/W127668916",
"https://openalex.org/W1785071502",
"https://openalex.org/W1967356215",
"https://openalex.org/W1972087461",
"https://openalex.org/W1980787381",
"https://openalex.org/W1982184548",
"https://openalex.org/W1982585367",
"https://openalex.org/W1983688242",
"https://openalex.org/W1989842337",
"https://openalex.org/W1990215537",
"https://openalex.org/W1993980747",
"https://openalex.org/W2003749940",
"https://openalex.org/W2004268618",
"https://openalex.org/W2004600519",
"https://openalex.org/W2010462626",
"https://openalex.org/W2011893763",
"https://openalex.org/W2014328392",
"https://openalex.org/W2016083557",
"https://openalex.org/W2016640892",
"https://openalex.org/W2017700000",
"https://openalex.org/W2023294979",
"https://openalex.org/W2023358438",
"https://openalex.org/W2028591807",
"https://openalex.org/W2029570357",
"https://openalex.org/W2029744067",
"https://openalex.org/W2031559647",
"https://openalex.org/W2032252362",
"https://openalex.org/W2035888594",
"https://openalex.org/W2036466897",
"https://openalex.org/W2046194164",
"https://openalex.org/W2047448341",
"https://openalex.org/W205261907",
"https://openalex.org/W2053148770",
"https://openalex.org/W2054055618",
"https://openalex.org/W2059328349",
"https://openalex.org/W2059682533",
"https://openalex.org/W2061401834",
"https://openalex.org/W2063698219",
"https://openalex.org/W2064651108",
"https://openalex.org/W2069401875",
"https://openalex.org/W2071333805",
"https://openalex.org/W2075351051",
"https://openalex.org/W2075660826",
"https://openalex.org/W2076035859",
"https://openalex.org/W2076466803",
"https://openalex.org/W2076610939",
"https://openalex.org/W2077151521",
"https://openalex.org/W2078325918",
"https://openalex.org/W2082634247",
"https://openalex.org/W2085908073",
"https://openalex.org/W2094309558",
"https://openalex.org/W2097420574",
"https://openalex.org/W2099117463",
"https://openalex.org/W2104998259",
"https://openalex.org/W2107572909",
"https://openalex.org/W2108244474",
"https://openalex.org/W2108493743",
"https://openalex.org/W2112932301",
"https://openalex.org/W2119754583",
"https://openalex.org/W2120710750",
"https://openalex.org/W2122502918",
"https://openalex.org/W2123982004",
"https://openalex.org/W2124329191",
"https://openalex.org/W2126387882",
"https://openalex.org/W2128121492",
"https://openalex.org/W2128252910",
"https://openalex.org/W2134744377",
"https://openalex.org/W2137151563",
"https://openalex.org/W2140454681",
"https://openalex.org/W2142446788",
"https://openalex.org/W2143690152",
"https://openalex.org/W2151516793",
"https://openalex.org/W2153450298",
"https://openalex.org/W2159554154",
"https://openalex.org/W2159930373",
"https://openalex.org/W2166141412",
"https://openalex.org/W2167408013",
"https://openalex.org/W2169999185",
"https://openalex.org/W2173879523",
"https://openalex.org/W2184902638",
"https://openalex.org/W2207152872",
"https://openalex.org/W2278376335",
"https://openalex.org/W2329577694",
"https://openalex.org/W2336862130",
"https://openalex.org/W2401193001",
"https://openalex.org/W2501194856",
"https://openalex.org/W3010915326"
],
"referenced_works_count": 87,
"related_works": [
"https://openalex.org/W4240501618",
"https://openalex.org/W3211066314",
"https://openalex.org/W3117671016",
"https://openalex.org/W3089267846",
"https://openalex.org/W2942511853",
"https://openalex.org/W2802899064",
"https://openalex.org/W2601978429",
"https://openalex.org/W2039798229",
"https://openalex.org/W2033160772",
"https://openalex.org/W2030629371"
],
"sustainable_development_goals": [
{
"score": 0.88,
"display_name": "Life below water",
"id": "https://metadata.un.org/sdg/14"
}
],
"title": "Variation in branchial expression among insulin-like growth-factor binding proteins (igfbps) during Atlantic salmon smoltification and seawater exposure",
"topics": [
{
"id": "https://openalex.org/T11056",
"display_name": "Metabolic Theory of Ecology and Climate Change Impacts",
"score": 0.9975,
"subfield": {
"id": "https://openalex.org/subfields/2303",
"display_name": "Ecology"
},
"field": {
"id": "https://openalex.org/fields/23",
"display_name": "Environmental Science"
},
"domain": {
"id": "https://openalex.org/domains/3",
"display_name": "Physical Sciences"
}
},
{
"id": "https://openalex.org/T10450",
"display_name": "Metabolism and Nutrition in Aquaculture Feeds",
"score": 0.9925,
"subfield": {
"id": "https://openalex.org/subfields/1104",
"display_name": "Aquatic Science"
},
"field": {
"id": "https://openalex.org/fields/11",
"display_name": "Agricultural and Biological Sciences"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
}
},
{
"id": "https://openalex.org/T10290",
"display_name": "Pathophysiology and Management of Preeclampsia",
"score": 0.9821,
"subfield": {
"id": "https://openalex.org/subfields/2729",
"display_name": "Obstetrics and Gynecology"
},
"field": {
"id": "https://openalex.org/fields/27",
"display_name": "Medicine"
},
"domain": {
"id": "https://openalex.org/domains/4",
"display_name": "Health Sciences"
}
}
],
"type": "article",
"type_crossref": "journal-article",
"updated_date": "2024-08-12T05:33:19.396864",
"versions": []
}
}