OpenAlex: !!python/object/new:pyalex.api.Topic
dictitems:
cited_by_count: 809819
created_date: '2024-01-23'
description: This cluster of papers focuses on the genetic basis and clinical
manifestations of primary immunodeficiency disorders, including immune dysregulation,
Th17 cell deficiency, common variable immunodeficiency, and defects in the interferon-?
pathway. It also discusses the use of hematopoietic stem cell transplantation
and immunoglobulin replacement therapy in the management of these disorders.
display_name: Genetic Basis of Primary Immunodeficiency Disorders
domain:
display_name: Life Sciences
id: https://openalex.org/domains/1
field:
display_name: Immunology and Microbiology
id: https://openalex.org/fields/24
id: https://openalex.org/T11725
ids:
openalex: https://openalex.org/T11725
wikipedia: https://en.wikipedia.org/wiki/Primary_immunodeficiency
keywords:
- Primary Immunodeficiency
- Genetic Mutations
- Immune Dysregulation
- Human Inborn Errors
- Th17 Cell Deficiency
- Common Variable Immunodeficiency
- Hematopoietic Stem Cell Transplantation
- Interferon-? Pathway Defects
- B Cell Abnormalities
- Immunoglobulin Replacement Therapy
siblings:
- display_name: Human T-cell Leukemia Virus Type 1 Infection
id: https://openalex.org/T12159
- display_name: Immunobiology of Dendritic Cells
id: https://openalex.org/T10580
- display_name: Immunogenicity of Biosimilar Therapeutics in Drug Development
id: https://openalex.org/T12255
- display_name: Immunological Mechanisms in Atherosclerosis Development
id: https://openalex.org/T12955
- display_name: Immunological Mechanisms in Pregnancy and Fetal-Maternal Interface
id: https://openalex.org/T11510
- display_name: Immunological Responses in Aquatic Organisms
id: https://openalex.org/T10506
- display_name: Immunotoxicology in Toxicologic Pathology Research
id: https://openalex.org/T14072
- display_name: Immunotoxin Therapy for Cancer Treatment
id: https://openalex.org/T12477
- display_name: Innate Immune Recognition and Signaling Pathways
id: https://openalex.org/T10371
- display_name: Innate Immunity to Viral Infection
id: https://openalex.org/T11668
- display_name: Innate Lymphoid Cells in Immunity
id: https://openalex.org/T12528
- display_name: Invertebrate Immunity and Host Defense Mechanisms
id: https://openalex.org/T11403
- display_name: Macrophage Activation and Polarization
id: https://openalex.org/T11313
- display_name: Mechanisms of Apoptotic Cell Clearance and Immune Regulation
id: https://openalex.org/T12672
- display_name: Natural Killer Cells in Immunity
id: https://openalex.org/T11020
- display_name: Reciprocal Development of TH17 and Treg Cells
id: https://openalex.org/T10469
- display_name: Regulatory T Cell Development and Function
id: https://openalex.org/T10031
- display_name: Role of Complement System in Immune Response
id: https://openalex.org/T10993
- display_name: Role of Galectins in Immunity and Disease
id: https://openalex.org/T12387
- display_name: Role of Macrophage Migration Inhibitory Factor
id: https://openalex.org/T13254
- display_name: Role of Mast Cells in Immunoregulation and Disease
id: https://openalex.org/T11346
- display_name: Role of Neutrophil Extracellular Traps in Immunity
id: https://openalex.org/T11597
- display_name: Role of Pentraxins in Innate Immunity and Inflammation
id: https://openalex.org/T14245
- display_name: Role of TREM-1 and Endocan in Inflammation
id: https://openalex.org/T14165
- display_name: Trained Immunity in Health and Disease
id: https://openalex.org/T13410
subfield:
display_name: Immunology
id: https://openalex.org/subfields/2403
updated_date: '2024-05-20T05:16:48.357137'
works_count: 87314