{
"id": "https://openalex.org/T10725", "display_name": "Mechanisms and Applications of RNA Interference", "description": "This cluster of papers explores the mechanisms, delivery methods, and therapeutic applications of RNA interference (RNAi) in mammalian cells. It covers topics such as siRNA delivery, gene silencing, non-viral vectors, cell-penetrating peptides, lipid nanoparticles, and the potential of RNAi for gene therapy. The research also delves into the challenges and future directions of RNAi-based therapeutics.", "keywords": [ "RNA Interference", "siRNA Delivery", "Gene Silencing", "Non-viral Vectors", "Therapeutic RNAi", "Cell-penetrating Peptides", "Lipid Nanoparticles", "siRNA Therapeutics", "Gene Therapy", "Nucleic Acid Delivery" ], "ids": { "openalex": "https://openalex.org/T10725", "wikipedia": "https://en.wikipedia.org/wiki/RNA_interference" }, "subfield": { "id": "https://openalex.org/subfields/1312", "display_name": "Molecular Biology" }, "field": { "id": "https://openalex.org/fields/13", "display_name": "Biochemistry, Genetics and Molecular Biology" }, "domain": { "id": "https://openalex.org/domains/1", "display_name": "Life Sciences" }, "siblings": [ { "id": "https://openalex.org/T13526", "display_name": "14-3-3 Proteins: Structure, Function, and Regulation" }, { "id": "https://openalex.org/T10836", "display_name": "Advances in Metabolomics Research" }, { "id": "https://openalex.org/T10887", "display_name": "Analysis of Gene Interaction Networks" }, { "id": "https://openalex.org/T12763", "display_name": "ATP Synthase Function and Regulation" }, { "id": "https://openalex.org/T10593", "display_name": "Bacterial Biofilms and Quorum Sensing Mechanisms" }, { "id": "https://openalex.org/T12685", "display_name": "Bioactive Limonoids in Medicinal Plants" }, { "id": "https://openalex.org/T11561", "display_name": "Bioactive Peptides in Food and Health" }, { "id": "https://openalex.org/T12215", "display_name": "Bioactivity of Steroidal Saponins in Medicinal Plants" }, { "id": "https://openalex.org/T13188", "display_name": "Biochemical and Pharmacological Functions of Beta-Carboline Alkaloids" }, { "id": "https://openalex.org/T13725", "display_name": "Biochemistry, Pharmacology, and Medical Use of Bromelain" }, { "id": "https://openalex.org/T11765", "display_name": "Biogenesis and Functions of Circular RNAs" }, { "id": "https://openalex.org/T12530", "display_name": "Biological Activities of Diterpenoids from Medicinal Plants" }, { "id": "https://openalex.org/T13454", "display_name": "Biological Activities of Phenothiazines and Related Compounds" }, { "id": "https://openalex.org/T12257", "display_name": "Biological Activities of Prenylated Flavonoids" }, { "id": "https://openalex.org/T11385", "display_name": "Biological Activities of Triterpenoids and Saponins" }, { "id": "https://openalex.org/T13221", "display_name": "Biological Activity of Diterpenoids and Biflavonoids" }, { "id": "https://openalex.org/T11515", "display_name": "Biological Agents for Bioterrorism" }, { "id": "https://openalex.org/T12688", "display_name": "Biological Methane Utilization and Metabolism" }, { "id": "https://openalex.org/T12561", "display_name": "Bioluminescence Imaging and Reporter Systems" }, { "id": "https://openalex.org/T11710", "display_name": "Biomedical Ontologies and Text Mining" }, { "id": "https://openalex.org/T11882", "display_name": "Biosynthesis and Engineering of Terpenoids" }, { "id": "https://openalex.org/T12360", "display_name": "Biosynthesis and Pharmacological Activities of Lignans" }, { "id": "https://openalex.org/T12620", "display_name": "Calcineurin-NFAT Signaling in Transcriptional Regulation" }, { "id": "https://openalex.org/T13937", "display_name": "Challenges and Innovations in Bioinformatics Education" }, { "id": "https://openalex.org/T12683", "display_name": "Chitin Metabolism in Insects and Mammals" }, { "id": "https://openalex.org/T12820", "display_name": "Chromatin Remodeling in Cancer and Development" }, { "id": "https://openalex.org/T10878", "display_name": "Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins" }, { "id": "https://openalex.org/T11289", "display_name": "Comprehensive Integration of Single-Cell Transcriptomic Data" }, { "id": "https://openalex.org/T13326", "display_name": "Cyclotide Bioengineering and Protein Anchoring Mechanisms" }, { "id": "https://openalex.org/T10066", "display_name": "Diversity and Function of Gut Microbiome" }, { "id": "https://openalex.org/T12668", "display_name": "Diversity and Systematics of Yeasts" }, { "id": "https://openalex.org/T12388", "display_name": "DNA Barcoding for Food Authentication and Fraud Detection" }, { "id": "https://openalex.org/T10207", "display_name": "DNA Nanotechnology and Bioanalytical Applications" }, { "id": "https://openalex.org/T11845", "display_name": "DNA Topoisomerases: Structure, Function, and Inhibition" }, { "id": "https://openalex.org/T12029", "display_name": "DNA-based Computing and Data Storage" }, { "id": "https://openalex.org/T10240", "display_name": "Elicitor Signal Transduction for Metabolite Production" }, { "id": "https://openalex.org/T10404", "display_name": "Enzyme Immobilization Techniques" }, { "id": "https://openalex.org/T10269", "display_name": "Epigenetic Modifications and Their Functional Implications" }, { "id": "https://openalex.org/T10773", "display_name": "Exosome Biology and Function in Intercellular Communication" }, { "id": "https://openalex.org/T12287", "display_name": "Fibroblast Growth Factor Signaling Pathway" }, { "id": "https://openalex.org/T12610", "display_name": "Functions and Regulation of RNA Editing by ADARs" }, { "id": "https://openalex.org/T10432", "display_name": "G-Quadruplex DNA Structures and Functions" }, { "id": "https://openalex.org/T10497", "display_name": "Genomic Expression and Function in Yeast Organism" }, { "id": "https://openalex.org/T12946", "display_name": "Genomic Signal Processing and Analysis Techniques" }, { "id": "https://openalex.org/T11879", "display_name": "Global Diversity of Microbial Eukaryotes and Their Evolution" }, { "id": "https://openalex.org/T10602", "display_name": "Glycosylation in Health and Disease" }, { "id": "https://openalex.org/T12009", "display_name": "Hedgehog Signaling in Development and Cancer" }, { "id": "https://openalex.org/T11848", "display_name": "Heme Oxygenase and Carbon Monoxide Research" }, { "id": "https://openalex.org/T10505", "display_name": "Induction and Differentiation of Pluripotent Stem Cells" }, { "id": "https://openalex.org/T10407", "display_name": "Lipid Rafts and Membrane Dynamics" }, { "id": "https://openalex.org/T11786", "display_name": "Magnetosome Formation in Prokaryotes" }, { "id": "https://openalex.org/T11533", "display_name": "Mammalian MAP Kinase Signaling Pathways" }, { "id": "https://openalex.org/T10932", "display_name": "Metabolic Engineering and Synthetic Biology" }, { "id": "https://openalex.org/T13012", "display_name": "Metabolism and Functions of Coenzyme Q" }, { "id": "https://openalex.org/T10885", "display_name": "Microarray Data Analysis and Gene Expression Profiling" }, { "id": "https://openalex.org/T14285", "display_name": "Microbial Production of Polyglutamic Acid" }, { "id": "https://openalex.org/T13736", "display_name": "Microbial Transformation of Steroids" }, { "id": "https://openalex.org/T10301", "display_name": "Mitochondrial Dynamics and Reactive Oxygen Species Regulation" }, { "id": "https://openalex.org/T11956", "display_name": "Molecular Biology of Steroidogenesis and Disorders" }, { "id": "https://openalex.org/T10934", "display_name": "Molecular Chaperones in Protein Folding and Disease" }, { "id": "https://openalex.org/T11889", "display_name": "Molecular Mechanisms and Medical Applications of Ginseng" }, { "id": "https://openalex.org/T11305", "display_name": "Molecular Mechanisms of Amyloidosis" }, { "id": "https://openalex.org/T10422", "display_name": "Molecular Mechanisms of Angiogenesis and Vascular Function" }, { "id": "https://openalex.org/T10294", "display_name": "Molecular Mechanisms of Apoptosis and Cell Death" }, { "id": "https://openalex.org/T10724", "display_name": "Molecular Mechanisms of Aquaporins in Physiology and Disease" }, { "id": "https://openalex.org/T11677", "display_name": "Molecular Mechanisms of Cardiac Development and Regeneration" }, { "id": "https://openalex.org/T10123", "display_name": "Molecular Mechanisms of DNA Damage Response" }, { "id": "https://openalex.org/T11237", "display_name": "Molecular Mechanisms of Flavonoid Biosynthesis in Plants" }, { "id": "https://openalex.org/T12441", "display_name": "Molecular Mechanisms of Heme Biosynthesis and Related Disorders" }, { "id": "https://openalex.org/T11078", "display_name": "Molecular Mechanisms of Inflammasome Activation and Regulation" }, { "id": "https://openalex.org/T11075", "display_name": "Molecular Mechanisms of Insect Resistance to Xenobiotics" }, { "id": "https://openalex.org/T10493", "display_name": "Molecular Mechanisms of Ion Channels Regulation" }, { "id": "https://openalex.org/T12140", "display_name": "Molecular Mechanisms of Kidney Development and Disease" }, { "id": "https://openalex.org/T13437", "display_name": "Molecular Mechanisms of Metastasis Suppressor Genes" }, { "id": "https://openalex.org/T10441", "display_name": "Molecular Mechanisms of Muscle Regeneration and Atrophy" }, { "id": "https://openalex.org/T11219", "display_name": "Molecular Mechanisms of Osteoclast Differentiation and Bone Remodeling" }, { "id": "https://openalex.org/T10303", "display_name": "Molecular Mechanisms of Photosynthesis and Photoprotection" }, { "id": "https://openalex.org/T12789", "display_name": "Molecular Mechanisms of Planarian Regeneration" }, { "id": "https://openalex.org/T11927", "display_name": "Molecular Mechanisms of Pollen Development and Function" }, { "id": "https://openalex.org/T10169", "display_name": "Molecular Mechanisms of Ras Signaling Pathways" }, { "id": "https://openalex.org/T10691", "display_name": "Molecular Mechanisms of Retinal Degeneration and Regeneration" }, { "id": "https://openalex.org/T11919", "display_name": "Molecular Mechanisms of Tooth Development and Morphogenesis" }, { "id": "https://openalex.org/T12434", "display_name": "Molecular Regulation and Clinical Applications of PDEs" }, { "id": "https://openalex.org/T12566", "display_name": "Molecular Regulation of Sulfur Metabolism in Plants" }, { "id": "https://openalex.org/T14049", "display_name": "Molecular Systematics of Gesneriaceae and Allies" }, { "id": "https://openalex.org/T10952", "display_name": "mTOR Signaling in Growth and Disease" }, { "id": "https://openalex.org/T10268", "display_name": "Notch Signaling Pathway in Development and Disease" }, { "id": "https://openalex.org/T12827", "display_name": "Nucleotide Metabolism and Enzyme Regulation" }, { "id": "https://openalex.org/T14135", "display_name": "Oxidation States in Biochemistry and Medicine" }, { "id": "https://openalex.org/T10911", "display_name": "Peptide Synthesis and Drug Discovery" }, { "id": "https://openalex.org/T11072", "display_name": "Peroxisome Proliferator-Activated Receptors" }, { "id": "https://openalex.org/T11924", "display_name": "Polyamines and Biogenic Amines in Biology and Health" }, { "id": "https://openalex.org/T12576", "display_name": "Prediction of Peptide-MHC Binding Affinity" }, { "id": "https://openalex.org/T12254", "display_name": "Prediction of Protein Subcellular Localization" }, { "id": "https://openalex.org/T11335", "display_name": "Prion Diseases: Causes and Molecular Basis" }, { "id": "https://openalex.org/T11124", "display_name": "Protein Aggregation and Biopharmaceutical Stability" }, { "id": "https://openalex.org/T13157", "display_name": "Protein Arginine Methylation in Mammals" }, { "id": "https://openalex.org/T11908", "display_name": "Protein Binding Specificity in Human Serum Albumin" }, { "id": "https://openalex.org/T12867", "display_name": "Protein Microarray Technology and Applications" }, { "id": "https://openalex.org/T10044", "display_name": "Protein Structure Prediction and Analysis" }, { "id": "https://openalex.org/T12104", "display_name": "Protein Tyrosine Phosphatases in Human Health and Disease" }, { "id": "https://openalex.org/T13187", "display_name": "Protein-DNA Interaction Dynamics in Living Cells" }, { "id": "https://openalex.org/T12756", "display_name": "Pyrrolizidine Alkaloids: Toxicity, Metabolism, and Health Implications" }, { "id": "https://openalex.org/T11970", "display_name": "Real-Time Polymerase Chain Reaction" }, { "id": "https://openalex.org/T11663", "display_name": "Recombinant Protein Production in Mammalian and Insect Cells" }, { "id": "https://openalex.org/T11884", "display_name": "Redox Signaling and Oxidative Stress" }, { "id": "https://openalex.org/T12835", "display_name": "Regulation and Functions of FoxO Transcription Factors" }, { "id": "https://openalex.org/T10222", "display_name": "Regulation of Chromatin Structure and Function" }, { "id": "https://openalex.org/T10604", "display_name": "Regulation of RNA Processing and Function" }, { "id": "https://openalex.org/T13651", "display_name": "Research on Rhodiola rosea and Salidroside" }, { "id": "https://openalex.org/T14065", "display_name": "Research on Synthetic Phosphoethanolamine and its Effects" }, { "id": "https://openalex.org/T10521", "display_name": "Ribosome Structure and Translation Mechanisms" }, { "id": "https://openalex.org/T11482", "display_name": "RNA Methylation and Modification in Gene Expression" }, { "id": "https://openalex.org/T10015", "display_name": "RNA Sequencing Data Analysis" }, { "id": "https://openalex.org/T11339", "display_name": "Role of AMP-Activated Protein Kinase in Cellular Metabolism" }, { "id": "https://openalex.org/T12412", "display_name": "Role of Carbonic Anhydrases in Medicine and Biotechnology" }, { "id": "https://openalex.org/T13223", "display_name": "Role of CCN Proteins in Signaling Pathways" }, { "id": "https://openalex.org/T12187", "display_name": "Role of Glutathione in Oxidative Stress Response" }, { "id": "https://openalex.org/T11736", "display_name": "Role of Histone Deacetylases in Cellular Regulation" }, { "id": "https://openalex.org/T11332", "display_name": "Role of Nrf2 Signaling in Oxidative Stress Response" }, { "id": "https://openalex.org/T11559", "display_name": "Role of Retinoic Acid in Biological Processes" }, { "id": "https://openalex.org/T13047", "display_name": "Role of Sigma Receptors in Cellular Signaling" }, { "id": "https://openalex.org/T13426", "display_name": "Role of Transcription Factors in Cell Regulation" }, { "id": "https://openalex.org/T12030", "display_name": "S100 Proteins: Structure, Function, and Pathology" }, { "id": "https://openalex.org/T11308", "display_name": "Sphingolipid Signalling and Metabolism in Health and Disease" }, { "id": "https://openalex.org/T10621", "display_name": "Stochasticity in Gene Regulatory Networks" }, { "id": "https://openalex.org/T11178", "display_name": "Structure and Function of G Protein-Coupled Receptors" }, { "id": "https://openalex.org/T11480", "display_name": "Structure and Function of Gap Junctions and Connexins" }, { "id": "https://openalex.org/T11818", "display_name": "Structure and Function of Nicotinic Receptors" }, { "id": "https://openalex.org/T11841", "display_name": "Structure and Function of the Nuclear Pore Complex" }, { "id": "https://openalex.org/T12534", "display_name": "Targeted Protein Degradation in Biomedical Research" }, { "id": "https://openalex.org/T11501", "display_name": "Transforming Growth Factor Beta Signaling Pathway" }, { "id": "https://openalex.org/T11041", "display_name": "Ubiquitin-Proteasome Proteolytic Pathway" }, { "id": "https://openalex.org/T10929", "display_name": "Wnt Signaling in Development and Disease" } ], "works_count": 91280, "cited_by_count": 2752532, "updated_date": "2024-08-26T06:12:46.399281", "created_date": "2024-01-23"
}