{
"OpenAlex": {
"id": "https://openalex.org/T13971",
"display_name": "Chemistry and Biology of Antitumor Antibiotics",
"description": "This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.",
"keywords": [
"Tetrahydroisoquinoline",
"Ecteinascidin",
"Total Synthesis",
"Anticancer Drug",
"Marine-derived Compound",
"Cycloaddition Reactions",
"Asymmetric Synthesis",
"Isocoumarins",
"Pharmacology",
"DNA Binding"
],
"ids": {
"openalex": "https://openalex.org/T13971",
"wikipedia": "https://en.wikipedia.org/wiki/Tetrahydroisoquinoline_antitumor_antibiotics"
},
"subfield": {
"id": "https://openalex.org/subfields/1306",
"display_name": "Cancer Research"
},
"field": {
"id": "https://openalex.org/fields/13",
"display_name": "Biochemistry, Genetics and Molecular Biology"
},
"domain": {
"id": "https://openalex.org/domains/1",
"display_name": "Life Sciences"
},
"siblings": [
{
"id": "https://openalex.org/T11547",
"display_name": "Biological Activities of Sesquiterpene Lactones in Cancer"
},
{
"id": "https://openalex.org/T13350",
"display_name": "Biology and Evolution of Myxozoan Parasites"
},
{
"id": "https://openalex.org/T13943",
"display_name": "Development of Protein Phosphatase Inhibitors as Anticancer Agents"
},
{
"id": "https://openalex.org/T11287",
"display_name": "Genomic Landscape of Cancer and Mutational Signatures"
},
{
"id": "https://openalex.org/T10433",
"display_name": "Genotoxicity and Carcinogenesis Mechanisms"
},
{
"id": "https://openalex.org/T12465",
"display_name": "Lipid Metabolism in Cancer Pathogenesis"
},
{
"id": "https://openalex.org/T10631",
"display_name": "Metabolic Reprogramming in Cancer Biology"
},
{
"id": "https://openalex.org/T10062",
"display_name": "MicroRNA Regulation in Cancer and Development"
},
{
"id": "https://openalex.org/T10183",
"display_name": "Molecular Research on Breast Cancer"
},
{
"id": "https://openalex.org/T11591",
"display_name": "NF-?B Signaling in Inflammation and Cancer"
},
{
"id": "https://openalex.org/T10515",
"display_name": "Role of Long Noncoding RNAs in Cancer and Development"
},
{
"id": "https://openalex.org/T10620",
"display_name": "Role of Matrix Metalloproteinases in Cancer and Physiology"
}
],
"works_count": 10482,
"cited_by_count": 128741,
"updated_date": "2024-08-26T05:30:42.634750",
"created_date": "2024-01-23"
}
}