Item talk:Q138692

{

 "OpenAlex": {
   "id": "https://openalex.org/A5043201622",
   "orcid": "https://orcid.org/0000-0002-2792-5084",
   "display_name": "Martin F. Flajnik",
   "display_name_alternatives": [
     "M. F. Flajnik",
     "Martin F. Flanik",
     "Martin F. Flajnik",
     "M. Flajnik",
     "MartinF. Flajnik",
     "Martin Flajnik",
     "Flajnik MF"
   ],
   "works_count": 230,
   "cited_by_count": 13939,
   "summary_stats": {
     "2yr_mean_citedness": 2.125,
     "h_index": 63,
     "i10_index": 155
   },
   "ids": {
     "openalex": "https://openalex.org/A5043201622",
     "orcid": "https://orcid.org/0000-0002-2792-5084"
   },
   "affiliations": [
     {
       "institution": {
         "id": "https://openalex.org/I126744593",
         "ror": "https://ror.org/04rq5mt64",
         "display_name": "University of Maryland, Baltimore",
         "country_code": "US",
         "type": "education",
         "lineage": [
           "https://openalex.org/I126744593"
         ]
       },
       "years": [
         2024,
         2023,
         2022,
         2021,
         2020,
         2019,
         2018,
         2017,
         2016,
         2015
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I66946132",
         "ror": "https://ror.org/047s2c258",
         "display_name": "University of Maryland, College Park",
         "country_code": "US",
         "type": "education",
         "lineage": [
           "https://openalex.org/I66946132"
         ]
       },
       "years": [
         2023,
         2020,
         2005
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I182534213",
         "ror": "https://ror.org/043pwc612",
         "display_name": "Universidade do Porto",
         "country_code": "PT",
         "type": "education",
         "lineage": [
           "https://openalex.org/I182534213"
         ]
       },
       "years": [
         2023
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I116545467",
         "ror": "https://ror.org/055f0jp24",
         "display_name": "University of Mary",
         "country_code": "US",
         "type": "education",
         "lineage": [
           "https://openalex.org/I116545467"
         ]
       },
       "years": [
         2019,
         2018,
         2017,
         1998
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I6059380",
         "ror": "https://ror.org/024gw2733",
         "display_name": "University of Baltimore",
         "country_code": "US",
         "type": "education",
         "lineage": [
           "https://openalex.org/I6059380"
         ]
       },
       "years": [
         2016,
         2011,
         2005
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I145608581",
         "ror": "https://ror.org/02dgjyy92",
         "display_name": "University of Miami",
         "country_code": "US",
         "type": "education",
         "lineage": [
           "https://openalex.org/I145608581"
         ]
       },
       "years": [
         2007,
         2004,
         2003,
         2001,
         2000,
         1999,
         1998,
         1997,
         1996,
         1995
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I4210118021",
         "ror": "https://ror.org/0275fz765",
         "display_name": "National Aquarium",
         "country_code": "US",
         "type": "nonprofit",
         "lineage": [
           "https://openalex.org/I4210118021"
         ]
       },
       "years": [
         2006,
         2005,
         2004
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I123431417",
         "ror": "https://ror.org/02dxx6824",
         "display_name": "Scripps Research Institute",
         "country_code": "US",
         "type": "nonprofit",
         "lineage": [
           "https://openalex.org/I123431417"
         ]
       },
       "years": [
         2004,
         2001
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I95850191",
         "ror": "https://ror.org/01c8f2y33",
         "display_name": "Moss Landing Marine Laboratories",
         "country_code": "US",
         "type": "facility",
         "lineage": [
           "https://openalex.org/I95850191"
         ]
       },
       "years": [
         2001,
         2000
       ]
     },
     {
       "institution": {
         "id": "https://openalex.org/I145673806",
         "ror": "https://ror.org/046f6cx68",
         "display_name": "Fujita Health University",
         "country_code": "JP",
         "type": "education",
         "lineage": [
           "https://openalex.org/I145673806"
         ]
       },
       "years": [
         2000
       ]
     }
   ],
   "last_known_institutions": [
     {
       "id": "https://openalex.org/I126744593",
       "ror": "https://ror.org/04rq5mt64",
       "display_name": "University of Maryland, Baltimore",
       "country_code": "US",
       "type": "education",
       "lineage": [
         "https://openalex.org/I126744593"
       ]
     }
   ],
   "topics": [
     {
       "id": "https://openalex.org/T10031",
       "display_name": "Regulatory T Cell Development and Function",
       "count": 55,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11020",
       "display_name": "Natural Killer Cells in Immunity",
       "count": 30,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10506",
       "display_name": "Immunological Responses in Aquatic Organisms",
       "count": 24,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11016",
       "display_name": "Therapeutic Antibodies: Development, Engineering, and Applications",
       "count": 21,
       "subfield": {
         "id": "https://openalex.org/subfields/2741",
         "display_name": "Radiology, Nuclear Medicine and Imaging"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10371",
       "display_name": "Innate Immune Recognition and Signaling Pathways",
       "count": 14,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10602",
       "display_name": "Glycosylation in Health and Disease",
       "count": 14,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10580",
       "display_name": "Immunobiology of Dendritic Cells",
       "count": 13,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11668",
       "display_name": "Innate Immunity to Viral Infection",
       "count": 9,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10831",
       "display_name": "Integrin Signaling in Inflammation and Cancer",
       "count": 9,
       "subfield": {
         "id": "https://openalex.org/subfields/2723",
         "display_name": "Immunology and Allergy"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11041",
       "display_name": "Ubiquitin-Proteasome Proteolytic Pathway",
       "count": 8,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11403",
       "display_name": "Invertebrate Immunity and Host Defense Mechanisms",
       "count": 7,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10993",
       "display_name": "Role of Complement System in Immune Response",
       "count": 7,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12576",
       "display_name": "Prediction of Peptide-MHC Binding Affinity",
       "count": 6,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11532",
       "display_name": "Role of Chemokine Receptors in Cancer Metastasis",
       "count": 5,
       "subfield": {
         "id": "https://openalex.org/subfields/2730",
         "display_name": "Oncology"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12387",
       "display_name": "Role of Galectins in Immunity and Disease",
       "count": 5,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11725",
       "display_name": "Genetic Basis of Primary Immunodeficiency Disorders",
       "count": 5,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11685",
       "display_name": "Zebrafish as a Model Organism for Multidisciplinary Research",
       "count": 3,
       "subfield": {
         "id": "https://openalex.org/subfields/1307",
         "display_name": "Cell Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12955",
       "display_name": "Immunological Mechanisms in Atherosclerosis Development",
       "count": 3,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10754",
       "display_name": "Epidemiology and Management of Neuroendocrine Tumors",
       "count": 3,
       "subfield": {
         "id": "https://openalex.org/subfields/2713",
         "display_name": "Epidemiology"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10207",
       "display_name": "DNA Nanotechnology and Bioanalytical Applications",
       "count": 3,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10934",
       "display_name": "Molecular Chaperones in Protein Folding and Disease",
       "count": 2,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11597",
       "display_name": "Role of Neutrophil Extracellular Traps in Immunity",
       "count": 2,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11387",
       "display_name": "Conservation of Sharks and Rays",
       "count": 2,
       "subfield": {
         "id": "https://openalex.org/subfields/2309",
         "display_name": "Nature and Landscape Conservation"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10620",
       "display_name": "Role of Matrix Metalloproteinases in Cancer and Physiology",
       "count": 2,
       "subfield": {
         "id": "https://openalex.org/subfields/1306",
         "display_name": "Cancer Research"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10332",
       "display_name": "Global Amphibian Declines and Extinctions",
       "count": 2,
       "subfield": {
         "id": "https://openalex.org/subfields/2306",
         "display_name": "Global and Planetary Change"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     }
   ],
   "topic_share": [
     {
       "id": "https://openalex.org/T10031",
       "display_name": "Regulatory T Cell Development and Function",
       "value": 0.0001878,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10506",
       "display_name": "Immunological Responses in Aquatic Organisms",
       "value": 0.0001306,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11403",
       "display_name": "Invertebrate Immunity and Host Defense Mechanisms",
       "value": 0.0001129,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12576",
       "display_name": "Prediction of Peptide-MHC Binding Affinity",
       "value": 8.61e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10993",
       "display_name": "Role of Complement System in Immune Response",
       "value": 8.3e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11532",
       "display_name": "Role of Chemokine Receptors in Cancer Metastasis",
       "value": "8e-05",
       "subfield": {
         "id": "https://openalex.org/subfields/2730",
         "display_name": "Oncology"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11020",
       "display_name": "Natural Killer Cells in Immunity",
       "value": 6.87e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11668",
       "display_name": "Innate Immunity to Viral Infection",
       "value": 6.7e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11685",
       "display_name": "Zebrafish as a Model Organism for Multidisciplinary Research",
       "value": 5.72e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1307",
         "display_name": "Cell Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10371",
       "display_name": "Innate Immune Recognition and Signaling Pathways",
       "value": 5.2e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12387",
       "display_name": "Role of Galectins in Immunity and Disease",
       "value": 5.19e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11041",
       "display_name": "Ubiquitin-Proteasome Proteolytic Pathway",
       "value": 4.75e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T13437",
       "display_name": "Molecular Mechanisms of Metastasis Suppressor Genes",
       "value": 4.63e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11016",
       "display_name": "Therapeutic Antibodies: Development, Engineering, and Applications",
       "value": 4.42e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2741",
         "display_name": "Radiology, Nuclear Medicine and Imaging"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10602",
       "display_name": "Glycosylation in Health and Disease",
       "value": 3.82e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10580",
       "display_name": "Immunobiology of Dendritic Cells",
       "value": 3.67e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10831",
       "display_name": "Integrin Signaling in Inflammation and Cancer",
       "value": 3.63e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2723",
         "display_name": "Immunology and Allergy"
       },
       "field": {
         "id": "https://openalex.org/fields/27",
         "display_name": "Medicine"
       },
       "domain": {
         "id": "https://openalex.org/domains/4",
         "display_name": "Health Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12391",
       "display_name": "Artificial Immune Systems in Science and Engineering",
       "value": 3.62e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2204",
         "display_name": "Biomedical Engineering"
       },
       "field": {
         "id": "https://openalex.org/fields/22",
         "display_name": "Engineering"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12824",
       "display_name": "Nosocomial Pathogens: Stenotrophomonas maltophilia and Related Bacteria",
       "value": 2.7e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1310",
         "display_name": "Endocrinology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T12955",
       "display_name": "Immunological Mechanisms in Atherosclerosis Development",
       "value": 2.6e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T10934",
       "display_name": "Molecular Chaperones in Protein Folding and Disease",
       "value": 2.4e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/1312",
         "display_name": "Molecular Biology"
       },
       "field": {
         "id": "https://openalex.org/fields/13",
         "display_name": "Biochemistry, Genetics and Molecular Biology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11725",
       "display_name": "Genetic Basis of Primary Immunodeficiency Disorders",
       "value": 2.06e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11597",
       "display_name": "Role of Neutrophil Extracellular Traps in Immunity",
       "value": 2.05e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T13410",
       "display_name": "Trained Immunity in Health and Disease",
       "value": 2.02e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2403",
         "display_name": "Immunology"
       },
       "field": {
         "id": "https://openalex.org/fields/24",
         "display_name": "Immunology and Microbiology"
       },
       "domain": {
         "id": "https://openalex.org/domains/1",
         "display_name": "Life Sciences"
       }
     },
     {
       "id": "https://openalex.org/T11387",
       "display_name": "Conservation of Sharks and Rays",
       "value": 1.8e-05,
       "subfield": {
         "id": "https://openalex.org/subfields/2309",
         "display_name": "Nature and Landscape Conservation"
       },
       "field": {
         "id": "https://openalex.org/fields/23",
         "display_name": "Environmental Science"
       },
       "domain": {
         "id": "https://openalex.org/domains/3",
         "display_name": "Physical Sciences"
       }
     }
   ],
   "x_concepts": [
     {
       "id": "https://openalex.org/C86803240",
       "wikidata": "https://www.wikidata.org/wiki/Q420",
       "display_name": "Biology",
       "level": 0,
       "score": 100.9
     },
     {
       "id": "https://openalex.org/C54355233",
       "wikidata": "https://www.wikidata.org/wiki/Q7162",
       "display_name": "Genetics",
       "level": 1,
       "score": 97.0
     },
     {
       "id": "https://openalex.org/C185592680",
       "wikidata": "https://www.wikidata.org/wiki/Q2329",
       "display_name": "Chemistry",
       "level": 0,
       "score": 92.6
     },
     {
       "id": "https://openalex.org/C55493867",
       "wikidata": "https://www.wikidata.org/wiki/Q7094",
       "display_name": "Biochemistry",
       "level": 1,
       "score": 92.2
     },
     {
       "id": "https://openalex.org/C71924100",
       "wikidata": "https://www.wikidata.org/wiki/Q11190",
       "display_name": "Medicine",
       "level": 0,
       "score": 90.4
     },
     {
       "id": "https://openalex.org/C203014093",
       "wikidata": "https://www.wikidata.org/wiki/Q101929",
       "display_name": "Immunology",
       "level": 1,
       "score": 87.8
     },
     {
       "id": "https://openalex.org/C104317684",
       "wikidata": "https://www.wikidata.org/wiki/Q7187",
       "display_name": "Gene",
       "level": 2,
       "score": 86.5
     },
     {
       "id": "https://openalex.org/C8891405",
       "wikidata": "https://www.wikidata.org/wiki/Q1059",
       "display_name": "Immune system",
       "level": 2,
       "score": 68.3
     },
     {
       "id": "https://openalex.org/C147483822",
       "wikidata": "https://www.wikidata.org/wiki/Q103537",
       "display_name": "Antigen",
       "level": 2,
       "score": 60.9
     },
     {
       "id": "https://openalex.org/C159654299",
       "wikidata": "https://www.wikidata.org/wiki/Q79460",
       "display_name": "Antibody",
       "level": 2,
       "score": 43.5
     },
     {
       "id": "https://openalex.org/C207936829",
       "wikidata": "https://www.wikidata.org/wiki/Q423163",
       "display_name": "Major histocompatibility complex",
       "level": 3,
       "score": 41.3
     },
     {
       "id": "https://openalex.org/C78458016",
       "wikidata": "https://www.wikidata.org/wiki/Q840400",
       "display_name": "Evolutionary biology",
       "level": 1,
       "score": 33.9
     },
     {
       "id": "https://openalex.org/C126322002",
       "wikidata": "https://www.wikidata.org/wiki/Q11180",
       "display_name": "Internal medicine",
       "level": 1,
       "score": 32.6
     },
     {
       "id": "https://openalex.org/C95444343",
       "wikidata": "https://www.wikidata.org/wiki/Q7141",
       "display_name": "Cell biology",
       "level": 1,
       "score": 32.2
     },
     {
       "id": "https://openalex.org/C2776090121",
       "wikidata": "https://www.wikidata.org/wiki/Q193529",
       "display_name": "T cell",
       "level": 3,
       "score": 30.0
     },
     {
       "id": "https://openalex.org/C202751555",
       "wikidata": "https://www.wikidata.org/wiki/Q221681",
       "display_name": "In vitro",
       "level": 2,
       "score": 28.3
     },
     {
       "id": "https://openalex.org/C2779535977",
       "wikidata": "https://www.wikidata.org/wiki/Q1342298",
       "display_name": "Xenopus",
       "level": 3,
       "score": 27.8
     },
     {
       "id": "https://openalex.org/C153911025",
       "wikidata": "https://www.wikidata.org/wiki/Q7202",
       "display_name": "Molecular biology",
       "level": 1,
       "score": 27.4
     },
     {
       "id": "https://openalex.org/C154317977",
       "wikidata": "https://www.wikidata.org/wiki/Q376266",
       "display_name": "Cytotoxic T cell",
       "level": 3,
       "score": 26.5
     },
     {
       "id": "https://openalex.org/C167672396",
       "wikidata": "https://www.wikidata.org/wiki/Q417800",
       "display_name": "CD8",
       "level": 3,
       "score": 25.2
     },
     {
       "id": "https://openalex.org/C170627219",
       "wikidata": "https://www.wikidata.org/wiki/Q13218497",
       "display_name": "MHC class I",
       "level": 4,
       "score": 22.6
     }
   ],
   "counts_by_year": [
     {
       "year": 2024,
       "works_count": 1,
       "cited_by_count": 433
     },
     {
       "year": 2023,
       "works_count": 8,
       "cited_by_count": 916
     },
     {
       "year": 2022,
       "works_count": 1,
       "cited_by_count": 857
     },
     {
       "year": 2021,
       "works_count": 7,
       "cited_by_count": 1021
     },
     {
       "year": 2020,
       "works_count": 6,
       "cited_by_count": 830
     },
     {
       "year": 2019,
       "works_count": 5,
       "cited_by_count": 795
     },
     {
       "year": 2018,
       "works_count": 8,
       "cited_by_count": 924
     },
     {
       "year": 2017,
       "works_count": 4,
       "cited_by_count": 766
     },
     {
       "year": 2016,
       "works_count": 9,
       "cited_by_count": 679
     },
     {
       "year": 2015,
       "works_count": 3,
       "cited_by_count": 766
     },
     {
       "year": 2014,
       "works_count": 12,
       "cited_by_count": 764
     },
     {
       "year": 2013,
       "works_count": 4,
       "cited_by_count": 597
     },
     {
       "year": 2012,
       "works_count": 6,
       "cited_by_count": 640
     }
   ],
   "works_api_url": "https://api.openalex.org/works?filter=author.id:A5043201622",
   "updated_date": "2024-08-20T15:10:16.073556",
   "created_date": "2023-07-21",
   "_id": "https://openalex.org/A5043201622"
 },
 "ORCID": {
   "@context": "http://schema.org",
   "@type": "Person",
   "@id": "https://orcid.org/0000-0002-2792-5084",
   "mainEntityOfPage": "https://orcid.org/0000-0002-2792-5084",
   "name": "Martin Flajnik",
   "givenName": "Martin Francis",
   "familyName": "Flajnik",
   "alternateName": "Flajnik MF",
   "address": {
     "addressCountry": "US",
     "@type": "PostalAddress"
   },
   "@reverse": {
     "creator": [
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.2318995121",
         "name": "The immunoglobulin J chain is an evolutionarily co-opted chemokine",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.1073/pnas.2318995121"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-023-01319-3",
         "name": "Genomic view of the origins of cell-mediated immunity",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.1007/s00251-023-01319-3"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.2300361",
         "name": "An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.4049/jimmunol.2300361"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1089/zeb.2021.0071",
         "name": "From IgZ to IgT: A Call for a Common Nomenclature for Immunoglobulin Heavy Chain Genes of Ray-Finned Fish",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.1089/zeb.2021.0071"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.202149383",
         "name": "Identification of the Fc\u2010alpha/mu receptor in Xenopus provides insight into the emergence of the poly\u2010Ig receptor (pIgR) and mucosal Ig transport",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.1002/eji.202149383"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.2000851",
         "name": "A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.4049/jimmunol.2000851"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-021-01209-6",
         "name": "Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.1007/s00251-021-01209-6"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.1901025",
         "name": "An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "doi",
           "value": "10.4049/jimmunol.1901025"
         }
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.1401905",
         "name": "CXCL13 responsiveness but not CXCR5 expression by late transitional B cells initiates splenic white pulp formation.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "25662995"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.1401905"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/25662995"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.cub.2014.09.070",
         "name": "Re-evaluation of the immunological Big Bang.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.cub.2014.09.070"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "25517375"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/25517375"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.1400531",
         "name": "Putting J chain back on the map: how might its expression define plasma cell development?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.1400531"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "25240020"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/25240020"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/nature13447",
         "name": "Venkatesh et al. reply.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "25008535"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/nature13447"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/25008535"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.1321502111",
         "name": "The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "24830426"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.1321502111"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "4050542"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/24830426",
           "https://europepmc.org/article/pmc/4050542"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/nature12826",
         "name": "Elephant shark genome provides unique insights into gnathostome evolution.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3964593"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/nature12826"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "24402279"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/3964593",
           "https://pubmed.ncbi.nlm.nih.gov/24402279"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.201343416",
         "name": "Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.201343416"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "23897025"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "4046329"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/23897025",
           "https://europepmc.org/article/pmc/4046329"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.fsi.2012.08.020",
         "name": "Humoral response of captive zebra sharks Stegostoma fasciatum to salivary gland proteins of the leech Branchellion torpedinis.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "22963935"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.fsi.2012.08.020"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/22963935"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-012-0616-2",
         "name": "Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "22488247"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3709836"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-012-0616-2"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/22488247",
           "https://europepmc.org/article/pmc/3709836"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.dci.2011.10.007",
         "name": "Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias).",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.dci.2011.10.007"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "22040740"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/22040740"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.dci.2011.09.008",
         "name": "Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21996610"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3260380"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.dci.2011.09.008"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/21996610",
           "https://europepmc.org/article/pmc/3260380"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-011-0558-0",
         "name": "Comparative genomic analysis of the proteasome \u03b25t subunit gene: implications for the origin and evolution of thymoproteasomes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-011-0558-0"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3805029"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21748441"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/3805029",
           "https://pubmed.ncbi.nlm.nih.gov/21748441"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.molimm.2011.06.437",
         "name": "Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21752470"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.molimm.2011.06.437"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/21752470"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.1101671",
         "name": "The multiple shark Ig H chain genes rearrange and hypermutate autonomously.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3190574"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.1101671"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21804022"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/3190574",
           "https://pubmed.ncbi.nlm.nih.gov/21804022"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1371/journal.pbio.1001120",
         "name": "A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21829328"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3149040"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1371/journal.pbio.1001120"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/21829328",
           "https://europepmc.org/article/pmc/3149040"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.cub.2011.01.066",
         "name": "Immunology: the origin of sweetbreads in lampreys?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21419986"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.cub.2011.01.066"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/21419986"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.1003933",
         "name": "Primordial linkage of \u03b22-microglobulin to the MHC.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.1003933"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "21321107"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3805034"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/21321107",
           "https://europepmc.org/article/pmc/3805034"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/ni0910-777",
         "name": "All GOD's creatures got dedicated mucosal immunity.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "20720582"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/ni0910-777"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/20720582"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.201040515",
         "name": "The dynamic TCR\u03b4: TCR\u03b4 chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "20486124"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3086071"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.201040515"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/20486124",
           "https://europepmc.org/article/pmc/3086071"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.1005475107",
         "name": "A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.1005475107"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "20616002"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2922149"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/20616002",
           "https://europepmc.org/article/pmc/2922149"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.0902774",
         "name": "Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3222143"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "20488795"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.0902774"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/3222143",
           "https://pubmed.ncbi.nlm.nih.gov/20488795"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/nrg2703",
         "name": "Origin and evolution of the adaptive immune system: genetic events and selective pressures.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "19997068"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "3805090"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/nrg2703"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/19997068",
           "https://europepmc.org/article/pmc/3805090"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.molimm.2010.08.015",
         "name": "Emergence of the acute-phase protein hemopexin in jawed vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "20884052"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2993785"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.molimm.2010.08.015"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/20884052",
           "https://europepmc.org/article/pmc/2993785"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.0904443106",
         "name": "High-affinity lamprey VLRA and VLRB monoclonal antibodies.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2722331"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.0904443106"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "19625627"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/2722331",
           "https://pubmed.ncbi.nlm.nih.gov/19625627"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/978-1-60327-302-2_6",
         "name": "The generation and selection of single-domain, v region libraries from nurse sharks.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/978-1-60327-302-2_6"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "19554288"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/19554288"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1371/journal.pbio.0060157",
         "name": "Immunoglobulin heavy chain exclusion in the shark.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1371/journal.pbio.0060157"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "18578572"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2435157"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/18578572",
           "https://europepmc.org/article/pmc/2435157"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-007-0268-9",
         "name": "Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "18214467"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-007-0268-9"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/18214467"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.179.10.6783",
         "name": "Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.179.10.6783"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "17982068"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/17982068"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.200737263",
         "name": "Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.200737263"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "17899545"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/17899545"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.coi.2007.07.013",
         "name": "Immunogenetics: alternative strategies in adaptive immunity and the rise of comparative immunogenomics.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.coi.2007.07.013"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "17719759"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/17719759"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.jmb.2006.12.045",
         "name": "Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "17258766"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.jmb.2006.12.045"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/17258766"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.0601407103",
         "name": "IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.0601407103"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "1636022"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16818885"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/1636022",
           "https://pubmed.ncbi.nlm.nih.gov/16818885"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1111/j.0105-2896.2006.00366.x",
         "name": "The plasticity of immunoglobulin gene systems in evolution.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2569000"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1111/j.0105-2896.2006.00366.x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16623761"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/2569000",
           "https://pubmed.ncbi.nlm.nih.gov/16623761"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.0507074103",
         "name": "An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "1458790"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.0507074103"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16549799"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/1458790",
           "https://pubmed.ncbi.nlm.nih.gov/16549799"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.176.6.3674",
         "name": "Ancestral organization of the MHC revealed in the amphibian Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.176.6.3674"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16517736"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/16517736"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.0508341103",
         "name": "First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16446445"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.0508341103"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "1413636"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/16446445",
           "https://europepmc.org/article/pmc/1413636"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.dci.2005.06.022",
         "name": "Antibody repertoire development in cartilaginous fish.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.dci.2005.06.022"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16146649"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/16146649"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1186/1471-2164-7-106",
         "name": "Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "1513397"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16672057"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1186/1471-2164-7-106"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/1513397",
           "https://pubmed.ncbi.nlm.nih.gov/16672057"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.placenta.2005.11.013",
         "name": "Histology and immunology of the placenta in the Atlantic sharpnose shark, Rhizoprionodon terraenovae.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16503351"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.placenta.2005.11.013"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/16503351"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.175.12.8105",
         "name": "Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.175.12.8105"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "16339548"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/16339548"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.200425760",
         "name": "Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15688348"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.200425760"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15688348"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/ni0305-229",
         "name": "The last flag unfurled? A new immunoglobulin isotype in fish expressed in early development.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/ni0305-229"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15716968"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15716968"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.dci.2004.12.004",
         "name": "Cloning and characterization of Xenopus beta2-microglobulin.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.dci.2004.12.004"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15854684"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15854684"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.dci.2004.08.007",
         "name": "Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratum.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15707663"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.dci.2004.08.007"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15707663"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/j.it.2004.10.001",
         "name": "Evolution of innate and adaptive immunity: can we draw a line?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15530832"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/j.it.2004.10.001"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15530832"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.173.9.5574",
         "name": "Shark Ig light chain junctions are as diverse as in heavy chains.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15494507"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.173.9.5574"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15494507"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.173.7.4553",
         "name": "Homologs of CD83 from elasmobranch and teleost fish.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15383588"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.173.7.4553"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15383588"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1126/science.1101148",
         "name": "Crystal structure of a shark single-domain antibody V region in complex with lysozyme.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1126/science.1101148"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15319492"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15319492"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/430157a",
         "name": "Immunology: another manifestation of GOD.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/430157a"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15241401"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15241401"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.173.2.1129",
         "name": "Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.173.2.1129"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15240702"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/15240702"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1186/1471-2172-5-8",
         "name": "Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "420240"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1186/1471-2172-5-8"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "15132758"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/420240",
           "https://pubmed.ncbi.nlm.nih.gov/15132758"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-003-0608-3",
         "name": "Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "14579105"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-003-0608-3"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/14579105"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.200324207",
         "name": "Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "14579270"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.200324207"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/14579270"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.171.5.2461",
         "name": "Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.171.5.2461"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12928394"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12928394"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s0161-5890(03)00084-1",
         "name": "Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12909128"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s0161-5890(03)00084-1"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12909128"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.170.12.6016",
         "name": "J chain in the nurse shark: implications for function in a lower vertebrate.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12794129"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.170.12.6016"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12794129"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-002-0479-z",
         "name": "Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12389098"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-002-0479-z"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12389098"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s0145-305x(02)00034-4",
         "name": "Xenopus class II A genes: studies of genetics, polymorphism, and expression.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s0145-305x(02)00034-4"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12206837"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12206837"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/nri889",
         "name": "Comparative analyses of immunoglobulin genes: surprises and portents.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/nri889"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12209137"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12209137"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1046/j.1365-3083.2002.01116.x",
         "name": "The development of primary and secondary lymphoid tissues in the nurse shark Ginglymostoma cirratum: B-cell zones precede dendritic cell immigration and T-cell zone formation during ontogeny of the spleen.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12121433"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1046/j.1365-3083.2002.01116.x"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12121433"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s00251-002-0469-1",
         "name": "The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s00251-002-0469-1"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "12136341"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/12136341"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s1074-7613(02)00300-x",
         "name": "Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11970880"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s1074-7613(02)00300-x"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11970880"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.168.2.771",
         "name": "Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11777971"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.168.2.771"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11777971"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s1074-7613(01)00198-4",
         "name": "Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s1074-7613(01)00198-4"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11567626"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11567626"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.4049/jimmunol.167.1.327",
         "name": "Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11418667"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.4049/jimmunol.167.1.327"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11418667"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s1074-7613(01)00142-x",
         "name": "The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s1074-7613(01)00142-x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11371365"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11371365"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.98.4.1775",
         "name": "A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11172027"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "29333"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.98.4.1775"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/11172027",
           "https://europepmc.org/article/pmc/29333"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1098/rstb.2000.0750",
         "name": "Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "1087693"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1098/rstb.2000.0750"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "11205333"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/1087693",
           "https://pubmed.ncbi.nlm.nih.gov/11205333"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1084/jem.191.10.1637",
         "name": "Rearrangement of immunoglobulin genes in shark germ cells.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2193156"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1084/jem.191.10.1637"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10811858"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/2193156",
           "https://pubmed.ncbi.nlm.nih.gov/10811858"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.97.9.4712",
         "name": "Primitive synteny of vertebrate major histocompatibility complex class I and class II genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10781076"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "18298"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.97.9.4712"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/10781076",
           "https://europepmc.org/article/pmc/18298"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s002510050030",
         "name": "Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s002510050030"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10752627"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10752627"
       },
       {
         "@type": "CreativeWork",
         "name": "Early and natural antibodies in non-mammalian vertebrates.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "11125480"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/11125480"
       },
       {
         "@type": "CreativeWork",
         "name": "The immune system of cartilaginous fish.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "10793481"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10793481"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s002510050582",
         "name": "Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s002510050582"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10501841"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10501841"
       },
       {
         "@type": "CreativeWork",
         "name": "Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "10490981"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10490981"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1093/intimm/11.5.825",
         "name": "Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10330287"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1093/intimm/11.5.825"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10330287"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/s002510050478",
         "name": "Identification and genetic mapping of Xenopus TAP2 genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9914331"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/s002510050478"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9914331"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1111/j.1600-065x.1999.tb01382.x",
         "name": "Insight into the primordial MHC from studies in ectothermic vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1111/j.1600-065x.1999.tb01382.x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "10319251"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/10319251"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1111/j.1600-065x.1998.tb01248.x",
         "name": "Churchill and the immune system of ectothermic vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1111/j.1600-065x.1998.tb01248.x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9914898"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9914898"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.95.24.14343",
         "name": "Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "24375"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.95.24.14343"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9826702"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/24375",
           "https://pubmed.ncbi.nlm.nih.gov/9826702"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.95.20.11804",
         "name": "Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.95.20.11804"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9751746"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "21721"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/9751746",
           "https://europepmc.org/article/pmc/21721"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1111/j.1600-065x.1998.tb01425.x",
         "name": "Evolution of somatic hypermutation and gene conversion in adaptive immunity.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9602348"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1111/j.1600-065x.1998.tb01425.x"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9602348"
       },
       {
         "@type": "CreativeWork",
         "name": "Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "9510188"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9510188"
       },
       {
         "@type": "CreativeWork",
         "name": "Somatic mutation in ectothermic vertebrates: musings on selection and origins.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "9479856"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9479856"
       },
       {
         "@type": "CreativeWork",
         "name": "Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "9550410"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9550410"
       },
       {
         "@type": "CreativeWork",
         "name": "Evolution of proteasome subunits delta and LMP2: complementary DNA cloning and linkage analysis with MHC in lower vertebrates.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "9218589"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9218589"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.94.11.5789",
         "name": "Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.94.11.5789"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "20858"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9159152"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/20858",
           "https://pubmed.ncbi.nlm.nih.gov/9159152"
         ]
       },
       {
         "@type": "CreativeWork",
         "name": "IgM-mediated opsonization and cytotoxicity in the shark.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "9021918"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/9021918"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1155/1997/38464",
         "name": "Involvement of thyroid hormones in the expression of MHC class I antigens during ontogeny in Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2275975"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "9587714"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1155/1997/38464"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/2275975",
           "https://pubmed.ncbi.nlm.nih.gov/9587714"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s0165-2427(96)05685-1",
         "name": "The immune system of ectothermic vertebrates.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s0165-2427(96)05685-1"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8988858"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8988858"
       },
       {
         "@type": "CreativeWork",
         "name": "Isolation of low molecular mass polypeptide complementary DNA clones from primitive vertebrates. Implications for the origin of MHC class I-restricted antigen presentation.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "8666794"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8666794"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0923-2494(96)89640-4",
         "name": "Origin and evolution of the class I gene family: why are some of the mammalian class I genes encoded outside the major histocompatibility complex?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0923-2494(96)89640-4"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8876055"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8876055"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.1830260525",
         "name": "A novel \"chimeric\" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.1830260525"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8647177"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8647177"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0305-0491(95)02081-0",
         "name": "Isolation and characterization of a cDNA encoding a Xenopus 70-kDa heat shock cognate protein, Hsc70.I.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8925437"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0305-0491(95)02081-0"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8925437"
       },
       {
         "@type": "CreativeWork",
         "name": "Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "7636247"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7636247"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/374168a0",
         "name": "A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7877689"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/374168a0"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7877689"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0966-3274(95)80001-8",
         "name": "Evolution of the major histocompatibility complex: a current overview.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7551974"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0966-3274(95)80001-8"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7551974"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/bf00191225",
         "name": "Duplication of the MHC-linked Xenopus complement factor B gene.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7642231"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/bf00191225"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7642231"
       },
       {
         "@type": "CreativeWork",
         "name": "Evolution and developmental regulation of the major histocompatibility complex.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "8519422"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8519422"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/bf00179399",
         "name": "Exon-intron organization of Xenopus MHC class II beta chain genes.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7590971"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/bf00179399"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7590971"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1038/nsb1294-915",
         "name": "Structural conservation of hypervariable regions in immunoglobulins evolution.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7773781"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1038/nsb1294-915"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7773781"
       },
       {
         "@type": "CreativeWork",
         "name": "Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "7963526"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7963526"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/bies.950160913",
         "name": "Advances in immunology.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/bies.950160913"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7980494"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7980494"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/bf00171790",
         "name": "Hsp70 genes are linked to the Xenopus major histocompatibility complex.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7901155"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/bf00171790"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7901155"
       },
       {
         "@type": "CreativeWork",
         "name": "Primitive vertebrate immunity: what is the evolutionary derivative of molecules that define the adaptive immune system?",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "7768153"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7768153"
       },
       {
         "@type": "CreativeWork",
         "name": "A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "413735"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8223448"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/413735",
           "https://pubmed.ncbi.nlm.nih.gov/8223448"
         ]
       },
       {
         "@type": "CreativeWork",
         "name": "Isolation of a classical MHC class I cDNA from an amphibian. Evidence for only one class I locus in the Xenopus MHC.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "8228232"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8228232"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.90.22.10603",
         "name": "Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.90.22.10603"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "47825"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8248152"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/47825",
           "https://pubmed.ncbi.nlm.nih.gov/8248152"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.1830230917",
         "name": "The evolutionary origin of the major histocompatibility complex: polymorphism of class II alpha chain genes in the cartilaginous fish.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "8370399"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.1830230917"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8370399"
       },
       {
         "@type": "CreativeWork",
         "name": "Evolution of the MHC: isolation of class II beta-chain cDNA clones from the amphibian Xenopus laevis.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "8454860"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/8454860"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0145-305x(93)90034-n",
         "name": "MHC restriction of T-cell proliferative responses in Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0145-305x(93)90034-n"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "7505753"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/7505753"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0161-5890(92)90050-8",
         "name": "Nucleotide sequence of a nurse shark immunoglobulin heavy chain cDNA clone.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "1495502"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0161-5890(92)90050-8"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/1495502"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.89.15.6688",
         "name": "Evolution of the major histocompatibility complex: isolation of class II A cDNA clones from the cartilaginous fish.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "49568"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.89.15.6688"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "1495958"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/49568",
           "https://pubmed.ncbi.nlm.nih.gov/1495958"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1073/pnas.88.2.537",
         "name": "Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "1703301"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1073/pnas.88.2.537"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "50846"
           }
         ],
         "sameAs": [
           "https://pubmed.ncbi.nlm.nih.gov/1703301",
           "https://europepmc.org/article/pmc/50846"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/bf00216688",
         "name": "Which came first, MHC class I or class II?",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2050387"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/bf00216688"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/2050387"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0161-5890(90)90170-5",
         "name": "Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0161-5890(90)90170-5"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2366760"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/2366760"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1111/j.1600-065x.1990.tb00036.x",
         "name": "The major histocompatibility complex of frogs.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1111/j.1600-065x.1990.tb00036.x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2180810"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/2180810"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1155/1990/67913",
         "name": "Expression of MHC class II antigens during Xenopus development.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmc",
             "value": "2275821"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1155/1990/67913"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2136209"
           }
         ],
         "sameAs": [
           "https://europepmc.org/article/pmc/2275821",
           "https://pubmed.ncbi.nlm.nih.gov/2136209"
         ]
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/s0012-1606(89)80003-x",
         "name": "Experimental analysis of ventral blood island hematopoiesis in Xenopus embryonic chimeras.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/s0012-1606(89)80003-x"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2463944"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/2463944"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1146/annurev.immunol.7.1.251",
         "name": "The immune system of Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1146/annurev.immunol.7.1.251"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "2653371"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/2653371"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0012-1606(88)90282-5",
         "name": "MHC class I antigens as surface markers of adult erythrocytes during the metamorphosis of Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0012-1606(88)90282-5"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "3384174"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3384174"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0167-5699(87)90240-4",
         "name": "Changes in the immune system during metamorphosis of Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0167-5699(87)90240-4"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "25291685"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/25291685"
       },
       {
         "@type": "CreativeWork",
         "name": "Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "3537126"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3537126"
       },
       {
         "@type": "CreativeWork",
         "name": "A third immunoglobulin class in amphibians.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "3926893"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3926893"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1002/eji.1830150603",
         "name": "Immune responses of thymus/lymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "3874068"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1002/eji.1830150603"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3874068"
       },
       {
         "@type": "CreativeWork",
         "name": "Xenopus MHC class II molecules. I. Identification and structural characterization.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "3156930"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3156930"
       },
       {
         "@type": "CreativeWork",
         "name": "Xenopus MHC class II molecules. II. Polymorphism as determined by two-dimensional gel electrophoresis.",
         "identifier": {
           "@type": "PropertyValue",
           "propertyID": "pmid",
           "value": "3980992"
         },
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/3980992"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0145-305x(85)90043-6",
         "name": "Studies on the Xenopus major histocompatibility complex.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "4085679"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0145-305x(85)90043-6"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/4085679"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1016/0012-1606(84)90052-6",
         "name": "A flow cytometric analysis of the embryonic origin of lymphocytes in diploid/triploid chimeric Xenopus laevis.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "6734938"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1016/0012-1606(84)90052-6"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/6734938"
       },
       {
         "@type": "CreativeWork",
         "@id": "https://doi.org/10.1007/bf00345617",
         "name": "Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus.",
         "identifier": [
           {
             "@type": "PropertyValue",
             "propertyID": "doi",
             "value": "10.1007/bf00345617"
           },
           {
             "@type": "PropertyValue",
             "propertyID": "pmid",
             "value": "6490110"
           }
         ],
         "sameAs": "https://pubmed.ncbi.nlm.nih.gov/6490110"
       }
     ]
   },
   "url": "http://medschool.umaryland.edu/FACULTYRESEARCHPROFILE/viewprofile.aspx?id=5216"
 }

}